Document gbOvDY7NEX5wqeROM5OxjeZka

AATTTTAACCHHMMEENNTT AA 1737 11773377..00000011 3M Gener Offices 3M General Offices 0 Cane 3M Center Sr s1001000 St. Patti, ~41~' 55i44-!000 Sine 65] 733 1110 eT] AAuugguusstt2211. ,22000000 OODfoofcciucuemmeoefnntPtolPPlrruoeticcoeenss,ssiiPnnrggevCCeenentntiteeornr ((a77n44d0077T))oxics 4OUU0S.fS1f.ic. MeEEnonSvfviiriPreroosontlnl,mumtSeeioWnnnat.,allPPPrreroovteteencctttioiioonnnaAAnggdeenTncccyyxics VA4Wti0taa1essnhthMiiinonnSgg:ittrooenneS,,et,cDDtSCCi.oWn22.800(44e66)00Coordinator Attention: Section 8(e) Coordinator Re TDToSScCCkAAetSSeNecoctst.iioonn8E88H((Qee)-) 1SS1uu8pp0pp-ll3ee7mm3eenantntaadll BSSEuuHbbQmm-i1sis1ssi8io0on-ns3s:7: 4 Docket Nos. 8EHQ-1180-373 and 8EHQ-1180-374 DDeeaarr SSiirt/MMaadcaamm: - 81) docke:, t33hMMyCCSootmumdppiaeansnywyh((i""3c3hMM""3))Mrreepqqruueeevsistotssusttlhhyaatst uEEbPPmiAAttrreeedddeetssoiiggEnnaPatAtee,,anttoodttahhreee TTpSSreCCsAAentSSleeyccttiioonn c8cioon(enfn)totaardiimonnaceeikddoenitin,nst~"uh'FpFiropotryrlYYesmoo~euuunrdrtieIInsn3ffowoMrrhmmiacaothrtiieoo3vnnMi""o(u(pFFsrYYeB!Iv())ieodd)ueosscclukkybeetmstiunnsbuusmmimiobtbtneeesrdri11nto33D778aE8.cP.kAeTTthahneeNdssueemabrsseetturupddsriieeeSsssEeaanHnntQlddy- i1n1f8o0rm-3a7:i5onansdupBpElHemQ.e1nt1830M-3's74p.revious 8(e) submissions in Docket Numbers 8EHQ- 1180-373 and 8EHQ-1 ! 80-374. We have enceAAattvttaoacrchehmdmeetnnottinOOcnnleeudlleiisssttsusfftthihceeiessntttuuddiidieeessntffioofrryiwwnhghiiiccnhhfo33rMmMatrrieeoqqnuueteossttcssilrreeiddaeetssei!ggtnnhaaett!ioonn. arW reenddeceeshsciiahggevnnmeaaitctieiaoonlnnd.,~eaiinTvncncolleruuesdcdeiinnstggotuddidnaaicrteeleusdoocfefonssssttuuiufsddftiyycoissefunuhbtbemmaidliesstsshniitooiafnnyn:;idnssgettunuinvddifyyorrttoimltnllemae;etinosstttnauulddtoyyeffddafaacettcieeiti;;tsasstdettautuadtdh.yyeytyppee;; v"aenann~rvvziiicrrcouohnsnemmfmeleniucntoatraalol.lchffTaeahttmeeiecsiianenlffsoos;rrtmmuatdathiiteeioossnne.c,doaaannntsddaishaht ruuoemmf ocahroensn,asaalitnnhsddtaeneentndnvvwieiirrntoohvnnimrimoneenfnnomtrtaaemllanteetiaxxolppnoeoasfsflueurrcreeetasddaydaiatiaatanc,oolnnuded in tttvhhhaeeerisoTTeuSSsdCCafAAtluaoSSmreeoaccctythiiooennnomt&8ic((baeee,))lsdd;soortchcckeklelsetyet ffsdooparrettctahkheieanssrgeee,oocr`orcnrroeesrllirasaotttbeeeodndrtacctwooiivmmthepp'oiounounffondprdsmrs,e,avtibbioouuutnts3l3ayMMlrreehhapaadossyrtccienoodcnnlccuollrduuedddeeddin tphuessleisdheadtainmfaoyrmnaotit obnea, sstdriecftilynesdpeinakEiPnAg', s"croerproorbtoinragtigvuei"doanf cpereviously reported or puulished information as defined in EPA's repoddng guidance. contact the un33cMMerasapippgprnreeecdciiaaifttyeeossuEEhPPaAAv''ess aaatntttyeennqttuiioeonsntttiooontthsiissofmmartaettqteuerir.r. e PPfluleretaahsseeer ddionofonnrootmtahhteiesosinittaattee to to rcreeoggnaatrarddciitnntgghetthhuiissndssuuebbrmsmiigis,n~seisoidonn.if. you have any questions or require further information VVeLerryyittrrtuullyyhyyoouEur.rss,R..ud. @) DEDx"r.ecKKuaatttihhveeerriiDnnieereEEc.toRRreeeedd,, PPhA_DD A33EMnMxdeEEcSnunavtvfiivierretooynnDmmSiereeenrnctvttaiaolclreTTseecchhnnoollooggyy And Safety Services 7173377..00000022 Sqttuuddiieess TToo BBee MMoovveedd ttoo 8g((ee)) DDoocekkeett EPEPA Submision Chemical! Study Submission c Date ProductNamei Suds Tide IRi Lat boratoryAOSud.yNo.BO s DaWte icStudy TypeSN Date ChemicabI Product Name Study Title Laboratory Stu@ No. Study Date Study Type M --s_--ean Kors oS n weee T n ay. mlarmena a, o = ovis BSfeyones 04/2112000 KPFOS Oral (Stomach Tube) Developmental Toxicity Study of PFOS in Rabbits Argus Research Laboratories, Inc. 418-012 01/11/1999 Health Effects: Developmental Toxicity ive girEosree SSSerigeennoatmessrtmwtsoas | Somme | frAOL AE taeemmSeaeass,s 0412112000 K PFOS; T-~246; FC-95 Single Dose Intravenous Pharamacokinetic Study of T6246 in Rabbits. 3M Environmental Laboratory Study #AM DT-042095.1 3M -ect~nical AMDT042095.1 11/1111995 Health Effects: Pharmacokinetic & Metabolism Studies rae bHRPpa5oeainserlosen gSpFarnommsTm]mitiooNucs aBtelEssYa roms our SSS rptreomnehnatcoae manst as 04121/2000 PFOS; PFHS; PFOA; NEtFOSAA; FOSA: N-MeFOSAA: PFOSAA; M570; M556 Fluorochemical Exposure Assessment of Decatur Chemical and Film Plant Employees Medical Department, 3M Company EPI-0006 08/11/1999 Human Data & Inddents: Medical Surveys, Clinical Studies, Reports or Allegations of Worker or Consumer Effects coun mTDeEeeAtrS aFo aR Tavst ear ie sus hes, TRGE 027570 HponoEtc ce 05/04i2000 DEA PFOS; FC-99 New ForTnula; T- Two Week Oral Rangefinding Toxicity Study Riker Laboratories, Inc. 179RR023 02/25/1980 Health Effects: Acute Toxicity aso 0510412000 cso 05/04/2000 Gham 05104/2000 2509 CoC xoros K PFOS keen K PFQS KPFOS Ta K PFQS; T-6295 of %2509 CoC in Rats rSeteOnn To1t00) Acute Oral Toxicity (LD50) Study in Rats ros Avmmicl PFQS: A Dietary LCS0 vu maramen Study with the Northern Ss Bobwhite 106sDayConc !04 Week Dietary Chronic Tortseasons Toxicity and Carcinogenicity seots Study with PFOS Potassium rato l~temational frie Research and Bann Development Ss Corporation vbinaonara W~ldlife International aCsocianre. ne .~ovance . Labcratories, Inc. - css 137-083 okie pHeoa etEseAce 05/31/1978 Health Effects: Acute Toxicity isos 454-103 se 6329-183 oummann 04/26/2000 Enomenifae Environmental Fate orem ou & Toxicity Data: STR are Avian & Other Wildlife ea Etec Health Effects: Shanon Carcinogenicity Se Studies cour 05/04/2000 KEFOSTENS K PFOS; T-6295 Salt in Rats 28 heokCapma Torey 26 Week Capsule Toxicity Svcs Tate Study with PFOS; T-6295 in SSieayn: Cynomolgus Monkeys Catomros. Covance Laboratories, Inc. sm 6329-223 ounzan vf r es ese res 04/12/2000 Health Effects: ChemicaF'Rssue Observations cons 05/04/2000 Gotan 05/0412000 KPOSTENE K PFOS; T-6295; i Telomer Alcohol; Telomer Acrylate; FEE PFBS; PFHS Putuccomyioh Perfluoroethylcyclo ipa hexyl sulfonate Smeatss DEA Salt; FC-90; T-2960 CoC (Volume I and II) Geum monOn ~Exploratory 28-Day Oral eRe. Toxicity Study with Teiomer Alcohol, Telomer Acrylate, BRASwef PFBS. PFHS and PFOS poslgntai ey (positive control) By Daily CAe RSe Garage In The Rat Followed 5 TeoyrRecno by a 14/28 Day Recovery HasPeriod hete Oc rioTnes Acute Ocular Irritation Test wml Nagi with T-2960 CoC in Albino Rabbits LMeIwSeTsS | PACWIETOL 3M Environmental Laboratory (FACT) FACT-TOX120.3 StyErekmien Safety Evaluation vioyk Laboratories, Riker dh Laboraties, Inc. HSOES0%8 0880EB0598 0810S 06fl 1/1 99 E eum fec n Health Effects: Subchronic Toxicity (2101561 SepamsianEtecsm: en 0~18/1981 Health Effects: Dermal/Eye Irritation pae1or3 P~ge I of 3 11773377..00000033 SSuubbEEmDmPiPaistAAssesiioonn Date [--_-- 05/04/2000 Coon 05/04/2000 mio C5t04/2000 on 05/04/2000 rer 05/12/2000 rem 05/18/2000 Gem 05/18/2000 nee 05/18/2000 GEC 05!18/2000 consaon 05/18/2000 Corsa 05/18/2000 come 05/18/2000 aeras Page 2 of3 PCCrhhoeemdmiuciccaalNl//ame Product Name PFOS StudyTie Laboratory SudyNo. SDuatse StudsType Study Title Laboratory J O----iATi eves s conei me. e Fiuorochemica! (FC) Levels 3M Cr a Soom in Nafve Rats - Further pice S foR Investigation of Rat Chow Study No. Study Date Stud); Type T-6318.9; DT21 05/1411999 Environmental Fate & Toxicity Data: Other Environmental ms TrT ama R (Cows PFOS Fluorochemical (FC) Leve!s in Naive Rats, T.-6316.9 MOSES PFOS; PFHS: JesJ PFDS; PFOA; iEaSR PFOSAA; M556: M570; M463; M513 AeivsdiConsinges Analysis of FCs in Samples of Children's Sera Wiis 3M Medical Department, foToxicology oo Services MEwmewal 3M Environmental fears Technology & a Services Teves T-6316.9 fGCoIGEN FACT-GEN- 011 Pome feos Toy Potassium vere Si 4H Ee ped]uoroethylcyclo RBaUsEe. 3 hexyl sulfonate; Acute Inhalation Toxicity Study of %2308 CoC in the Rat FC-98; T-2308 CoC IoRsRo PFOS; FOSA: PFOA; PFHS mGuam mamysadfs Quantitative Analysis of FCs in Environmental Samples FOSTIE FOSA; T-342: ners N-EtFOSA sAskehwTaoySrcum Acute Oral Toxicity Screen with T-3421 in Albino Rats ASDnem cmea wocy A Developmental Toxicity Study of 313401 in Rats Somme Bio/dynamics. Inc. STE 78-7187 Mew | FCT 3M Eqvironmental NOSEE LofTaOsh Laboratory IFACT) FACT Gen021, Gen024, Gen030, Gen033 Rarosres SEAR Riker Lal3oratories 0883AR0287 Inc. WEisTse. W1L Researc~q Laboratories, Inc. 506 157016 Nero N-EtFOSA NEON N-EtFOSA; NfMrEeAtLr,en EtFQSE ,aJcohol; tmeemme | Poms | Primary Eye Irntation SecomimndfCn | Woeywoows Bioaccumulation of FC in mame Mi Tennessee River Fish Product Safety Labs 3M Environmental Laboratory Wn3871 ENC 78-2740 csr 05114!1999 0STUS 05121/1999 Gunaiers 04/12/1979 Information seamen Health Effects: mSmoss Pharmacokinetic & Metabolism Studies NmmOmd Human Data & nian Incidents: Medical Ses Surveys, Clinical na Studies, Reports or poco Allegations of Worker Sem or Consumer Effects test Stecs dots Health Effects: Acute we Toxic4ty Gam 05/10/2000 Somiese Environmental Fate Smo & Toxicity Data: pS General GRATIS 01/17/1984 oon 05i30t1997 vss 11/0311995 OSES 05122/197 jese)tes Ack Health Effects: Acute Toxi~ty fesmches Health Effects: Rares Developmental wu Toxicity tem Health Effects: Semin Dermal/Eye Irritation Emme Environmental Fate oLrtEpe & Toxicity Data: N-MeFOSE AJcohol Bioaccumulation/Persi nerosEName N-EtFOSE .aJcohcl Svan me Absorption and foci 13iotransformation of N-ethyl Sra FOSE and qqssue Sane os main Distribution and Elimination free of Carbon 14 after e Hnn Administration of N-ethyl serene. Riker Laboratories Inc. stence [--m B-- emt 01/19/1983 Health Effects: Pharmacokinetic & Metabolism Studies nerost ara N-EtFQSE AJcohol NerGSEMG N-EtFOSE Alcohol FOSE14C in Feed un Gone) Oral (Gavage) Sons oxen Developmental Toxicity SEER he Study of N-EtFOSE in Rats OuwSorane Oral (Stomach Tube) ty Developmental Toxicity S RaTR Study of N-EtFQSE in Aegaa ta Argus Research Laboratedes, Inc. ra aver T-8316.7; 418-011 WwOe 41 ~-01 0; 6316.8 ree tefeeonsocdhiees] 12/17/1998 Health Effects: Developmental Toxicity ouims 01/1111999 heen thas HeaJth Effects: Sonora Developmental oy Toxicity Rabbits 11773377..00000044 EPA EPA Submission Chemicall Study Submission Date Product Name Study Tile Laboratory Study No. Date Study Type Date Chemical~ Product Name Study Title Laboratory _ ouimano NweorncassFaz EASaucaaEantceannvositoen Potenalcle LEaseras tmaye(FArCT) GTS ORBASTS BTEoonswvcerarcmOaosrmiaeoFanolpers 05/18/2000 N-EtFSE Alcohol; FM-3422 Evaluation of the Bioconcentration Potential of FM 3422 3M Environmental Laboratory (FACT) e-- oees-- m --Hwoesoo-- nseotr-- a -- CPR-- ooSaamantnpioaas-- nhrivCoaomoran) unio-- fcefahnieTt8en8:-- 74 oy -- norox------fa-- s rowon-- sss -- S8EBaSTnonOovsocccueeace-- mueiemrnsOsaitiaa-- Fnapeers 05/18t2000 N-EtFOSE Alcohol; T-5874 Determination of the Partition Coefficient (noctanoliwater) of T-5874 by high performance liquid chromatography (HPLC) NOTOX Study No. 9970612623 121275 Study Date Study Type 08/16/1978 Environmental Fate & Toxicity Data: Bioaccumulation/Persi stence 04/07/1994 Environmental Fate & Toxicity Data: Bioaccumulation/Persi stence osnaz0 wesoser OveminsionctPryscs. Misubsn E2047 Crensss EnvcomensiFae 05/18/2000 N-EtFQSEA e-- r051e8200-- 0 sNEzF-- CSTAT. -- SpDrSToaiewemnen-- ergGynlt-Ce1PgTonnodpnhaeay-- ayrRuSedTshpfoae|3ys2ae3!s_-- CRnLheaBesvaoseearetmrroea-- eecnrUSes2soe -- BR-- C 0-- iEs -- BsSTHoesoosncencvwaeounErmfuceco-- scsTatsteornnapyotrs 05/18/2000 N-EtFOS EA; T6322 Determination of PhysicoChemic,a] Properties of Sample D-1 Mitsubishi Chemical Safet~ Institute, Ltd. Twenty-eight-day Repeated Dose Oral Toxicity Study of Sample D-1 in Rats, T-6322 Bio-Medical Research Laboratories 4B223-4B227 02/14/1996 Environmental Fate & Toxicity Data: Bioaccumulation/Persi stence BMR 143C 02/16/1993 Health Effects: Subchronic Toxicity osneas 05/18/2000 marose DionConficaricl Fl MEnvcomens N-MeFOSE Reino, F325 3028 m NOG War Lavra (FACT) Alcohol; FM-3925 Distribution Coefficient of FM3925 in N-Octano} Water 3M Environmental Laboratory (FACT) SSTUCI2I00 9970012600 QSINGTS 01/10/1979 E&&SEnTnavTvsoioirxoocuincniimrtmmyeoeinDnutaaalstnlaFF:paaeteers BioaccumulationtPersi 182000 05/18/2000 SNE) ,35/18/2000 sso 05/25/2000 csas200 05i25/2000 sNNu-MMeSseFFOOSSEE~ATT- 5869 PFOSMT20 PFQSAA; T-3290 acCoC WNMrPuROrACT NH4 PFOA; T- 3974; FC-126 TPRrOAAemFusIteOr PFOA emulsifier, T-6564; FC-1015 Oswminsiorne Determination of the 2aivion Count Pollution Coefficient (nocnoimatenof 74888 4 octanol/water) of T-5869.4 57 ign atomante [sus by high performance liquid exomaegasny (LC) chromatography (HPLC) Ate Ow Tost Swen Acute Oral Toxicity Screen wn LCC ARS with T-3290 CoC in Albino Fanos Rabbits RPeamwaSTiSmEmer Primary Eye Irritation In Rabbits, T-3974 PrayEre Primary Eye ImmeniConosen Sugyof Irritation/Corrosion Study of Taki names(OFCO %6564 in Rabbits (OECD Guduines Guidelines) Norox NOTOX Tessa %5869.4 RikerLovers, | C8O2ARGIG Riker Laboratories, IeInc. 0882AR0362 bGaossmien s " Hazelton Laboratories ICno:mngHazelon Corning Hazelton Inc. i00s208 61005209 acaCCoHHiWAsTe 60504574 uo 04107/1994 Eneomars Fan Environmental Fate Touchyoats & Toxicity Data: Sasaamusonpor Bioaccumulation/Persi oer stence TUOSAGS HeTaortahyEbecs Acute 11105/1982 Health Effects: Acute Toxicity OUIASAT HDoeamrEaltect:ascn 01/14/1987 - Health Effects: Den'nal/Eye Irritation 3081895 HDoomlaiEteici:aion 09/05/1996 Health Effects: Dermal/Eye Irntation pagesors Page 3 of 3 11773377..00000055