Document gbLGB0KnOz16gy873LjLD9LxV

Memoraridum for the Record Dr. J. C. Wagner, Medical Research C01 Pneumoconiosis Unit, Lianaough Hospital Penarth, Glamorgan, Wales, U.K. ana Dr. Raymond E. Shapiro, BF-5 c^* Dr. Wagner is conducting feeding studies, at his laboratory, with blue asbestos, crocidolite. This study has been under way about six months. This "will be a two year study with a talc control as well. Of the feeding studies Dr. Wagner is aware of almost all have been done with crocidolite. No one has reported on studies (feeding) with chrysotile, but several investigators are supposed to be starting up work in this area. With respect to feeding studies with tremolite, Dr. Wagner said he knew of no work reported on any intentions to start work with this material. Dr. Wagner stated that they will look, shortly at his laboratory, at in dustrial talc, in reality a low grade asbestos. In discussing malignaxit tumors, Dr. Wagner claimed that there are no malignant tumors associated with talc, while the case is cleanly clearcut with respect to asbestos. With respect to his South Africian studies, Dr. Wagner stated there appeared to be a dose-response relationship with respect to pulmonarycarcinoma, but not with respect to mesothelioma. * Dr. Wagner stated in discussion, that food grade and cosmetic grade talc containing less than 1% tremolite and no chrysotile, anthophillite and crocidolite would be a reasonable temporary approach to-"the problem. However, during this temporary period, he advocated a research program to resolve present uncertainties. About half-way through the conversation, Dr. Wagner seemed very anxious to terminate the dialogue; stating he had an important interview to at tend. He did promise, however, to keep us informed of all new develop ments in this subject area. On behalf of FDA and the Bureau of Foods, I thanked Dr. Wagner for his help and cooperation. / / '7'72 U\ '3> <3 -J_' ^S- 7oX l) cnd '