Document gbEGp4g0X0nw3mbD4GGedbrqG

Oct ober 11 1930 Dr . A. L. Kenne, depar t ment of Chemi s t r y, Ohi o St at e Uni ver s i t y, Col umbus , Ohi o. Dear Dr . Henne: I cal l ed Ml dgl ey yes t er day eveni ng l at e t o t el l hi m t he r es ul t s of our obs er vat i ons on t he l as t compound whi ch you sent , namel y, t he CC1P: CC1F. When t hi s mat er i al ar r i ved at t he l abor at or y i t was unpacked and i mmedi at el y put i nt o t he i ce box i n t he dar k. I t was abs ol ut el y wat er whi t e on ar r i val , and cont i nued s o unt i l we wor ked wi t h i t yes t er day. However , when i t was uncover ed t her e*was a f ai r amount of pr es s ur e wi t hi n t he bot t l e, and t he gas whi ch es caped had exact l y t he s ame odor as t hat whi ch I des cr i bed pr evi ous l y. The odor was s omewhat acr i d or acet i c i n char act er , and pr oduced an as t r i ngent ef f ect upon t he nas al mu cous membr anes i n s uch a way as t o gi ve one t he s ens at i on of i nhal i ng dus t . I t i s a di s t i nct l y unpl eas ant odor , t hough i t i s mor e of an I r r i t at i on t han an odor * We expos ed t hr ee ani mal s . The f i r s t of t hes e at a concent r at i on of 42$. An ef f ect was seen al mos t I mmedi at e l y, and i n t wo mi nut es t he ani mal was def i ni t el y s l eepy and ver y s hor t l y af t er r ol l ed t o one s i de i n t he cage and l ay qui et l y f r om t hat t i me on. Af t er ei ght mi nut es hi s br eat hi ng became J er ky and di f f i cul t , and af t er ni ne mi nut es was ver y I r r egul ar . At t en mi nut es he ceas ed br eat hi ng, and t hough he was r emoved f r om t he cage qui ckl y we wer e unabl e t o r es us ci t at e hi m by ar t i f i ci al r es pi r at i on. At 20$ concent r at i on, much t he sani e t hi ng oc cur r ed, t he ani mal ceas i ng t o br eat he af t er t en mi nut es of expo sur e. Qui ck r emoval s er ved t o s ave hi s l i f e, s i nce he gas ped and began t o br eat he al mos t at once. Recover y was r api d, and i n f our mi nut es t he ani mal was abl e t o r un away. The exper i ment was f i ni s hed at 5s 30. Unhappi l y f or t he s at i s f act or y char act er of t hi s mat er i al as an anaes t het i c i n i t s pr es ent f or m, t he ani mal di ed t hi s mor ni ng at about 9 o*cl ock. Necr ops y s howed an acut e edema of t he l ungs, wi t h a cons i der abl e I r r i t at i on of t he upper r es pi r at or y pas s ages . Thi s condi t i on r es embl ed ver y s t r i ki ngl y t hat s een when et hyl ene di chl or i de or di br omi de i s us ed. Thi s del ayed deat h i s a s er i ous mat t er . Thi s di d not occur bef or e wi t h t he compound you s ent me some weeks ago, and i t s eems t o 2 me t hat i t i s pos s i bl e t hat t her e mi ght have been s ome i mpur i t y or oxi dat i on pr oduct r es pons i bl e f or t hi s del ayed I nj ur y* Anot her ani mal was expos ed t o 9$ concent r et i on f or a f ul l hour * The ani mal devel oped a ver y good s t at e of anaes t hes i a i n about t en mi nut es * Pr om t hat t i me on he l ay qui et l y. Af t er f i f t een mi nut es he devel oped a ver y, r api d r es pi r at i on, and f r om t hat t i me on no change t ook pl ace t o t he end of t he hour . On r emoval f r om t he cage t he. ani mal began t o r ecover , and by t en mi nut es was appar ent l y ent i r el y nor mal . Thi s ani mal was f ound dead i n t he Cage: t hi s mor ni ng wi t h t he s ame pat hol ogi c f i ndi ngs pr evi ous l y des cr i bed Thi s r es ul t put s a s omewhat di f f er ent l i ght on t he mat t er f r om t hat I f el t when I t al ked t o Ml dgl ey yes t er day*. I s houl d s ay t hat i t woul d be neces s ar y t o go s l owl y i n t he pr epar at i on of cons i der abl e quant i t i es of. t hi s mat er i al unt i l we Can as s ur e our s el ves as t o whet her t hes e del ayed deat hs ar e an i nt r i ns i c pr oper t y of t he mat er i al i t s el f , or whet her t hey ar e t he r es ul t of i mpur i t i es or i ns t abi l i t i es on t he par t of t he compound. Thes e ar e mat t er s whi ch I s hal l have t o l eave t o you* ' ... .' : . Wi t h ki ndes t r egar ds . . Ver y t r ul y your s , RAKr EJ