Document gb64Yz28yLGZYO5r5bDRBbm6q

LIVER AtGIOSAROOMA CASES OONFIDENnAL RECEIVED MAR 3 1987 CIRCULATION OF REGISTER BAGSHAW DrIMM BAM) Dr R R BARNES Jnr W C BARR Dr J'T BARRAT Dr G BAXTER Dr Peter BAYLAC Dr BEADPRE M BELLEC Dr BENECH Dr M BENLETT Dr B BERIAZZI Dr P BESCHE Dr BISHOP Dt C BORRELLI F E BOYER R W BRYSON Dr D D BURGESS Mr David BYREN Dr David CAR3ER Dr J T CELIA Mr C CHANCE Mr M CLAUS Mr P G CLAYTON Mr H OONTASSOT Dr J C DAVIES Mr J G DEPLAN Dr .DE VOS Mr A J DIETZ Dr H W DOLL Sir Richard DQMBRCWSKI S L DUPONT Mr G EMHN3ER Mr H ERNST Dr W EVANS Dr A E J FALK, Dr H FAVRE Dr FERGUSON Dr D M FORMAN Dr D FRASE R W FRIEDEL Dr H P GOLBERG Prof L GOSZTONYI Jnr Dr GOTTESMAN R T HARRIS Dr W D HILL Dr G B HILLMAN Dr D W HINDERER Dr R K HOGG Dr W A HOWARD Dr J K HUMPHRY Dr N F JADVEKT Mr J JERVIS Mr H R JONES Dr R D R. W. PRASE Norsk Hydro, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vancouver, Canada Monsanto, St Louis, Missouri, USA Air Products, Allentown, Pa, USA AECRP, Coamentry, France University of Cambridge, IK Atochem, Chauny, France Government of Quebec Cancer Registry, Canada Rhone Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy Dynamit Nobel, TToisdorf, Germany EMAS, Cardiff, IK Georgia Gulf, Delaware City, USA Formosa Plastics, Delaware City, USA ICI Billingbam, UK ICI Americas, Wilmington, Delaware USA Kemanord, Stockholm, Sweden EMAS, London, IK Enichem Polimeri, Milan, Italy ICI Runcorn, IK APME, Brussels, Belgian Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France ICI, Everberg, Belgian Atochem, Jarrie, France EVC, Welwyn Garden City, UK B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, IK Dow Chemical, Midland, Michigan, USA APME, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chemischen Industries, Numberg, Germany Lever Bros, Warrington, UK Chronic Diseases Div, US Dept of Health & Honan Services, Atlanta, USA Atochem, Montluel, France ICI Americas, Wilmington, Delaware, USA Imperial Cancer Research Fund, Oxford University, UK DiversiTech General, Akron, Ohio, USA Berufsgenossenschaft der Chemischen Industries, Heidelberg, Gemany Duke Urdv Medical Center, IXirham, North Carolina, USA R E Tenneco Chemicals, Piscataway, New Jersey, USA The Vinyl Institute, Wayne, NJ, USA Uniroyal Inc, Middlebury, Connecticut, USA Alberta Cancer Board, Edmonton, Canada Diamond Shamrock Corp, Dallas, Texas, USA BF Goodrich, Cleveland, Ohio, USA Imperial Oil Ltd, Sarnia, Ontario, Canada University of Otago School of Medicine, Wellington, New Zealand ICI Australia, Melbourne, Australia Chloe Chimie, Paris, France ICI Millbank, London IK EMAS, Bootle, UK WPX/ASL - ASL ADDRESS,! KARKH Dr Bruce KORSGAARD Dr K J KREUGER Dr R A LAGAST Dr H LALODC Dr J P LANHAM Dr John LANOUZIERE Dr LAWRENCE Mr J LAWREMGE-JONES LEE Dr F I LELBACH Prof WK LEVEQUE Dr G LEVISON Dr D A LEWIS Dr P LOUVIER Mr LUSSA1D Dr J MMTJARD Dr J M MALHOTRA Anna MALTONI Prof C MARGETTS, Mr R J MAXIKE Prof Lo MA3TTUSSI Dr R MIDDLETON D MKKA Mr MONTESANO Dr R MJTTI Dr A A MUNDZ MDUTON Dr M MacSWEEN Prof ENM NAKAMJRA S OLSON H G CWEN Dr R PADDLE Dr G M PAGLIALUNGA Dr S PAQUET Dr PATERSON Dr J C PIRASIU Dr Roberta POPPER Dr Hans FOSSBERG Dr J FUECH Dr A M PUKDHAM Dr J RAMBAUD Dr J RANGNES P RICHARD Dr P ROBSON Mrs D RODRIGUES Dr MJF ROUSH Dr G RUIY Dr J SALG Dr J SARAOCI Dr R SCHEFFERS Dr M L SOUPPER Dr H SERONNE Dr D SHAH Dr Has SIGRIST Dr J SMTIH Dr E SMITH Dr P M SMITH Prof Allan H SMITH Mr J S SPIRTAS Dr R STAFFORD Dr J SIAHNECKER Mr 2- - Dupont, Wilmington, Delaware USA Norsk Hydro, Porsgrunn, Norway BF Goodrich, Akron, Ohio, USA Solvay, Brussels, Belgium Solvay, Brussels, Belgian Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France SPI, New York, USA Sir Christopher, Chief Medical Officer, ICI, London UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, West Germany CDF ChimLe, AZF, Bully-les-Mines, France St Bartholomew's Hospital, London, UK Chemical Industries Association, London, IK Solvay, Brussels, Belgiun Atochem, France Suva, Luzern, Switzerland Statistics Canada, Ottawa Institute di Oncologia, Bologna, Italy ICI Directorate, Wilton HQ, UK Medil-Anic-S, Milan, Italy Montedison, Milan, Italy Norsk Hydro, Newton Aycliffe, IK Neste Oy, Espoo, Finland IARC, Lyons, France Duperial SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese FVC Association, Tokyo VC Safety Association, Louisiana, USA Trades Union Congress, London, IK ICI Central Medical Group, Alderley Park, IK Montedison, Novara, Italy Atochem, Serquigny, France ICI Runcorn, IK Istituto Superiore di Sanita, Rome, Italy Mount Sinai Medical Center, New York, USA Wacker-Chemie, Munich, Germany Atochem, Brlgnoud, France Canadian Centre for Occupational Health & Safety, Hamilton, Canada RP Rechenches, Antony, France Norsk Hydro, Porsgrunn, Norway Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada ICI, Sao Paulo, Brazil Monsanto, St Louis, Missouri, USA Atochem, St Auban, France NIOSH, Cincinnati, USA IARC, Lyons, France DSM/CVMD, Geleen, Holland University of Manitoba, Winnipeg, Canada Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chimie, Berre L'Etang, France Division of Environmental Health, World Health Organisation, Geneva, Switzerland Llandough Hospital, Penarth, UK University of California, Berkeley, USA ICI Hillhouse, UK NCl/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany WPX/ASL - ASL ADDRESS,2 GEMC 003633 TAMBURRO Prof CH ten EERGE Dr W F TQKH3FF Dr N 1ER HAAR Dr Gary TERWIESCH Dr B THERIAULT Dr Gilles THIESS Prof Dr A M THIIS-EVENSEN Dr E THOMSON Dr D H TCEDOIR Dr W VAN DER MERWE Dr WALLACE J R WALTEMATE H WEJDLING S 0 WHEELER Dr D J WHEELER R N WHITE K H WILINSKI 0 WILLIAMS Dr DMJ WILSON Prof R WRIGHT Dr A P YORK J -3- University of Louisville, USA DSM, Geleen, Holland Huls AG, Marl, Germany Ethyl Corporation, Baton Rouge, Louisiana, USA Chanische Werke Huls, Kreis Recklinghausen, Germany McGill University, Montreal, Canada BASF, Ludwigshhafen, Germany Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Shell, An Den Haag, Holland H J AECI, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, Usa Norsk Hydro, Stenungsund, Sweden ICI Hillhouse, IK Union Carbide, South Charleston, USA Duperlal, Buenos Aires, Argentina Electrochemical Industries, Acre, Israel BP Chemicals, Penarth, IK Harvard University, Cambridge, Massachusetts, USA ICI Wflton, IK ICI Everberg, Belgium Fran: Dr B Bennett, Occupational Health Department, ICI Chemicals & Polymers Group, Hillhouse Site, PO Box 4, Thomton-Cleveleys, Blackpool FY5 4QD, England February 1987 WPX/ASL - ASL_ADDRESS,3 SEHr 008^'3^ CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 198? PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1. The 10 new cases in the Register are the following: France 19i 20, 21; Germany 28, 29, 30, 31, 32; UK 13; USA 39- 2. There are amendments from the previous Register against the following cases: France 15; Germany 23, 26. 3- I would like to thank the following for informing me of new cases - Dr Contassot, Dr Barrat, Dr Landers, Dr Friedel, Dr Williams and Mr John E Ertel. 4. For the case corrections I thank Dr Contassot and Dr Friedel. 5. For other corrections and information thanks to Mr John T Barr, Mr John E Ertel, Mr R T Gottesman, Mr A King and Dr N A Sulaiman. 6. I should be very grateful if all recipients of the Register could continue to keep me fully informed of any new cases or, if they hear of other Companies who have acquired a case of ASL, it would be much appreciated if I could be notified by the appropriate person. It is very helpful if new information is supplied in tabulated form, using the headings in the Register as far as possible. For this purpose I have added a blank form at the back of the Register. ?. I would also be glad of help to keep the mailing list correct, with news of retirements and successors, etc. 8. Research: (a) I am enclosing a letter which explains a research project in which I and Professor Carlo Tamburro hope you will be able to co-operate in the interest of knowledge. (b) I shall be very grateful if all individuals involved in research or surveys could keep me informed and if possible send me copies when they become available. From: Dr Brian Bennett Occupational Health Department ICI Chemicals & Polymers Group Hillhouse Site P 0 Box 4 Thornton-Cleveleys Blackpool FY5 4QD England February 198? SENC 003635 I Cl CH ^^ALS LYMERS GROUP WPX/ASO - Index LIYER ANGIOSARCOMA CASES (REVIEW DATE - I JANUARY 1987) Table Sequence Page Page Belgium Canada Czechoslovakia 1 2-3 4 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) 44 45 France Germany I taly 5-9 10-15 16 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) 46 47+48 Japan Norway Sweden 17 Canadian PVC Producers - Start-up Dates vs ASL Cases 49 (Table 10) 18 East European PVC Producers - Start-up Dates vs ASL Cases 50 19 (Table 11) UK USA Yugoslavia 20-23 24-30 31 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) 51 52 Incidence of Cases per annum (Table i) Distribution of Cases by Country (Table 2) 32 33 Australasian PVC Producers - Start-up Dates (Table 14) Middle Eastern PVC Producers - Start-up Dates (Table 15) 53 54 Pattern of Cases by Fac tory (Table 3) 34 Blank form for notifying new cases - Latency Periods (Table 4A) 35 Distribution of Latency Period s (Tables 4B-4H) 36-42 Annual Geographical Incidence (Table 5) 43 6ENC 008636 l MFLi.llIM ICI CHEMICALS A POLYMERS CROUP I.IVER Angiosarcoma Caac9 - (Review Dale : 3 January 190?) UPX/ASL - LANClOCASES.fi 1 12 1A COUNTRY AND 1 NAME OR REFERENCE 1 INITIALS NO DATE OF BIRTH COMPANY BELLI <JH 0] 13.01. n Solvay it? | SR 29 09 AO Solvay 57 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS Jemeppe 00.07.5fl 00.05.76 r Je*eppe 20 OH 62 00.10.79 8 ACE AT DIAGNOSIS 63 39 9 YEARS OF EXPOSURE TO DIAGNOSIS ia j JO J1 YEARS OF EXPOSURE DATE OF DEATH 7 29.06.76 9 25 10 03 12 HISTOLOGICAL CONFIRMATION Yes Yea if 13 1 14 1 15 1 16 11 1 1 ESTIMATED \ 1 J OTHER | 01H F R EXPOSURE | OCCUPATION I CAREER | LEVEL f | HIGHLIGHTS [ COMMENTS 11 1 11 \1 High \1 [ lAutocleaner ^Driller In a (HepatIc teKin 1 1A yrs j foundry 11n Oct 1974 1958-1960 f exposed to|Polyworker 200 ppoi j 3 yra for 8 hra | 1 (2 yre) JParser |(15 yra) [Work In glass 1 were norma 1. I Ret 1 red I Feb 1975 |Hoap)t a 1led per day | and | certainly t under | 500 ppm In 6 t o | | 9.3 1 autoclaveal 1968-1972 I exposed to| 50-200 ppn I 8 hra per | day In | 25.J 1 autoclaves| 1972-1974 | exposed to| 50-200 ppm 1 In auto- I clave rooa| l974-100 1 |Lnd. 6 chenl|cal lnduat ry 1 1 1 [ 1 1 1 1 1 1 1 l 1 1 1 1 1 1 1 I May |976 1 1Complete [Clinical and {career detalla J a re given In a Ipaper by IHublet et al lIn Arch. Helg. |Med. Soc., IHyg. Hed. ITrav, Med. 1 Leg. 11977 pages 1601-622 1 [ i 1 I 1 PP* 1 1975- 50 | PP<* 1 RETIRED | J Feb 19751 1 1 08.62-03. [Autocleaner } \ 1 1 1 f j |FI reman since J 1 1 1 ] 1 list algn JnJ y 63 01.67 |5 yrs 5 rathe[10 71. I 79: ThoracIc -10.71 * [Operator J 200 ppm |3 yes 9mths.| [pain 07.79. IHepatlr testa 0h/day OA.63-12. 66 * 200 ppm | t I I 1 1 1 1 1 \ 1 1 ! GENC 008637 J altereil J 0.79. 1Poalt1vc J echography 111.79. Hep*J tectomy 02.80. 1 Chemotherapy. 11 nf ormat loti [given In 11et ter 12 Nov 1198A from Dr |De Sloove r. U CHEMICALS & POLYMERS GROUP All elates use um system DAY - MONTH - YEAR WPX/AKI. - I.ANCIOCASKSJ i: AN AHA Sheri I E.IVKK AjirI oa rcoma Cam'* - (Review Dates I Jam 198 7) l COUNTRY AND RKPERKNOfc NO CANADA 0l 02 01 04 05 06 07 OH 09 11 2 13| 11 11 NAME OR | DATE OF | INITIALS | BIRTH | 11 11 11 1 1 I5.l2.il | 1 1 1 106.03*14 1 1 1 j 11 I 1j J1 126.08.19 I 11 I1 11 11 105.04.19 * 11 ii ii ti 11 +07.05.1l | 11 11 11 11 I 15.12.19 | 11 11 11 11 109.il.19 1 11 11 11 11 M3.05.20 | \1 11 ii 1 19.07,21 l 11 11 11 1i 4 I5i6 COMPANY 1i ii i t FIRST VC | FACTORY EXPOSURE i 1 1 SHAWINICAN 1 1 ) i t 1944 1 1 1 . 1943 1 1 1 1 r 1941 i i i i i 1945 i i i i ii i i 1944 i i i i i 1947 it ii ii t \ 1946 i i i i i i 1961 ii 1I ii i ) 1946 ii ii ii 7 DATE OF DIAGNOSIS 1955 1957 i 1962 1967 1968 t ' 1971 1972 1973 1974 8 ACE AT DIAGNOSIS 41 43 1 i 42 | 48 : 1 57 1 1 51 I 51 1 53 1 1 t 51 1 | 1 9 YEARS OF EXPOSURE TO DIAGNOSIS 11 14 21 i i i 22 24 24 i i i 1 26 12 1 \ 1 28 } \ t 10 1 11 i 12 YEARS OF 1 DATE OF EXPOSURE | DEATH HISTOLOGICAL CONFIRMATION 11 102.09.55 14 (21.12.57 Yes 1 Yea j J 20 123.03.62 Y Yea 22 121.01.68 Yea | 1 i1 05 105.07,68 1 23 |10.04.71 Yea Yea 1 | 25 124,12,72 1 Yes 05 1 12.06.73 Yes | i 26 104.09.74 Yes j | ______ 1 11 13 1 14 1 15 1 1 h 11 1 ESTIMATED 1 1 | EXPOSURE | OCCUPATION j LEVEL 1 l OTHER CAREER HIGHLIGHTS | f OTHER COMMENTS 1f 11 \ 1 |Reactor 1 1 |Operator |Smoker |cleaner IpolymerlaationJ 1\ 11 |Maintenance ,|Operator |nl1lwrlght, 1 (pipe! Ltter 1 * 1 (Operator, (foreman 1 ( t i 1i 1 1 |Reactor i 1 |Operator, |cleaner |foreman, i |water cooling i |unlt i 1 |Reactor i 1 [Water cooling Icleaner | unit 11 1 |Wo rked |overtlme |Smoker i |Worked |overtlme |Non-smoker j Worked loverclme |Smoker | Worked lover.lme j Smoker 1 1 \Reactor 1 ( |Halntenanee, IWorked * |c leaner 1 |ml1lwrlght 1 |overtlme | Smoker 1 1 IReactor 1 1 |Mechine shop | Worked |c leaner 1 (operator and |overClme [poly unit f Smoker 1 1 1 Reactor |c leaner i 1 j Maintenance Imachlne shop j In plant 125 yrsT Smoker 1f 11 |Furnace op. ( Iplpefltter 1 (maintenance 1 j________________ J | Worked (overtlme |Smoker * by Ur K DM.ORHK In Annales ri'Anatomle pathologlque Paris, 1978 Voi 23 No 2 ppl05-M4 claims this case had both a hepatoma and ASL simultaneously. GENC 003638 -XL CANADA Sheet 2 1C I CHEMICALS 4 POLYMERS GROUP LIVER Angiosarcoma Casas - (Review Date: 1 Jan 1987) DAY - HONTH - YEAH AIL date* u UK syste wpx/asl - i.ancuk;ases,h COUNTRY AND REFERENCE NO CANADA 10 11 NAME OR t DATE OF | INITIALS | BIRTH | ii !L 11 11 COMPANY 11 I 1 1 FIRST VC f DATE OF f ACE AT | FACTORY | EXPOSURE | DIAGNOSIS | DIAGNOSIS {* i L1 11 i 1 11 1 1 16,05.15 j ! i 1953 | 1976 1 61 YEARS OF EXPOSURE TO DIAGNOSIS 23 10 J 2 1 YEARS OF | DATE OF | EXPOSURE | DEATH J 1 1 1 f J 14 | 00.04.77 | 1 HISTOLOGICAL | CONFIRMATION | I 1 1 f Yes | ESTIMATED EXPOSURE LEVEL | OCCUPATION 1 |Reactor OTH ER [ CAREER HIGHLIGHTS 1 | Furnace op. maintenance, packaging 1 f OTHER l COMMENTS f 1 i 1 l |Ex-smoke r GENC 00863? Pago 4 CZECHOSLOVAKIA ICI CHEMICALS f, POLYMERS GROUP LIVER Angiosarcoma Cases - (Review Date.' I Jan 87) WPXMSL - LANC10CASKS.9 1 2 3 4 56 7 8 11 9 10 1 12 n I 14 1 13 1 !1 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRKATION 1 ESTIMATED | EXPOSURE | OCCUPATION 1 . LEVEL | OTHER CAREER HIGHLIGHTS 1 | | | 11 CZECHOSLOV AK.IA 1 |IARC letter 1 o f 1-4-82 1 j | 01 28.06.26 State Co Novaky 01.07.57 24.12.73 45 16 16 24.12.73 Yea |AutocLave |Cleaner Iglvlng detalIsf |ftorn Prof | |A David of | (Centre Ind IHyglene and | | lOcc diseases, t 11 1 02 06.07.27 State Co Novaky 01.11.50 27.11,64 37 14 5 26.11.64 Yes I Autoclave 11 |IARC letter of| ICleaner 11-4-82 gave |somewhat | | (altered dates | t for this case.| |l have | laccepted the | Ichanges since | |the dates cornel (from Prof 1 [A David of che| [Centre of | [Industrial j (Hygiene and | (Occupational | |Diseases. My | (dates come j loriginally | _______ 1t 1 11 1 ________ 1I L til t || Ifrou NIOSH. 1 | | 1 | 1 1f 11 1 1 J III || | | i i ir j i i ill ii t f i i ii i i i ill ii i j i ti ti i i i lit it i i i ii ii i i i ill ii i i i ii ii i i i ill ji i j i ii ii i 1 i \ \ ill i i ill iir ii i' i i i i i 1 fl l1 1 1 i III II t l 1 J1 11 1 1 1 III f| | | >>111111 III II | t 1 11 III | f III F| | | Ih OTHER COMMENTS GENC 008640 I'^K1' *> hWANi K Sheet I ICl CHEMI CALS 6 POLYMERS GROUP LIVER Angi osar coma Caues - (Review Date: L Jah 87) WPX/ASL - I^ANGIOCASES, 3(1 1 ]j 1 1 COUNTRY AND | REFERENCE I NO | 1 FRANCK 1 l 1 2S 1 i NAME OR | INITIALS | 1 1 1 1 1 3t 1 1 DATE OF | BIRTH | 1 1 1 1 4 COMPANY 1 t5 16 11 1 1 1 FIRST VC | FACTORY 1 EXPOSURE 11 11 11 11 01 | H 1 1 1 1 1 J 02 |SIM 1 f ! 1 l 1 1 \ 03 | NAV 1 ) 1 1 1 1 1 04 fttOH 1 1 1 1 1 t 1 1 0* |B 1 1 1 1 1 ! 1 1 l 1 \ 1 15.04.24 | RP ii 11 ii 11 JL ii f03.06.11 | PCUK ti !1 11 11 I1 l1 11 11 [06.01.20 | RP j1 ii 11 11 J1 f1 11 127.01.27 | PCUK 11 11 11 ii 1I 1I 11 j1 j29.0l.3fl | 11 11 1\ t1 11 11 J1 il PCUK ll 11 11 |Rouasj illon 1 00.01.46 1i 1 ! J 1 |Brlgnoud i 06.07,59 1 i i 1 i 1 1 ) | St Pone 00.00.46 t 1( 1 1 1i J _L 1 |Brlgnoud L9.10.49 1 1 1 1 1 f f 1 |Brlgnoud 18.01.65 1 11 11 11 t 1t 11 11 11 l1 11 11 1 7I 1 1 DATE OF | DIAGNOSIS $ 1 1 1 1 13.02.67 15.01.75 15.01.75 16.01.76 13.05.76 | 1 1 1 J t i 1 1 1 1 1 1 1 1 1 | 1 i 1 i 1 1 i | 1 1 1 1 1 1 1 1 | J 1 1 1 1 1 t 1 1 1 1 8 ACE AT DIAGNOSIS 43 63 i i i 55 49 1 36 1 1 1 1 1 I 1 1 1 ( 1 1 9 YEARS OF EXPOSURE TO DIAGNOSIS 21 16 ! 1 1 29 26 1 1 11 1 1 1 i 1 1 1 1 1 1 1 1 10 1 11 1 l 12 | 1J f1 YEARS OF | DATE OF HISTOLOGICAL | EXPOSURE | DEATH CONFIRMATION | 19 119.02.67 1 1 1 1 \ Yea | it i1 i1 1 1 12 124,01.75 Yes | i {NIOSR no | comment) | 29 129.06.75 1 1 1 1 1 1 Yes | 1 1 1 1 1 26 104.01,76 1 1 Yes f 1 1 1 L L 113.05.76 f i l l i f i l i I l i Yes 1 1 1 1 1 | t t 1 1 1 1 i 1 I 1 f 11 13 1 14 t 15 1 16 f ESTIMATED 1 j OTHER l | OTHER EXPOSURE | OCCUPATION l CAREER | COMMENTS LEVEL | HIGHLIGHTS ! 1 1 1) High )Autoclave |worker and Idea ner 115 yes 1 1 i 1 1 i |Ref. Ravler et fal Arch. Mai. [Prof. 1 30 n' |3 Nov 75 IP 171-177 High |2 yrs on i t {Italian 1 | Ref. Imonomer {origin |C Bonneton et 110 yrs on |potywer11 sat Ion i | | Jal "Nouvelle |presae |nedIca 3 e" i 15 Nov 1977 1 IP 735 1 High | Polyworker |10 yra as lautoclave leleaner |Compounding 11 |VCM product Ion|Ref. Rely et 116 yrs fal Arch. Mai. {Italian POW {Prof, 1 37 n' | Shepherd, |6 June 7^ iSawyer, Mason |p 551-555 13 yra i | 1 High |Monomer Iproduction {worker j6 yrs | PVC |f111 rat ion |16 yra 1 i | | | | ] | E 1 i l 1 1 l High f Polyworker Ml yrs |1)Thoracotomy JRef. P Coudere {9th Feb 1976 Jet al "Seraalne |coatal Idea hoHpltfinx |angiosarcoma f 10 Septerabre 12)Scinttgraphy | 1976 {found ASL |Previously had J3)Haemorrhage J bone |f ro ASL | angi r>earr dihh" 14)Right 1 Al ho thepatectomy |PIllchnwskl el | j al "La Nonvel1f I J Preeae Med(cat* |71 h July ]979 | lJn>;<* 248 5 GENC 008641 1'"KP fr EHAN<1 Ml,'ft ? I Cl CIIKMJ CALS 6 POLYMERS CROUP LEVER AnR 1 ok a rr oma Cases - (Review Date: I Jan 1987) WPX/ASL - LANGIOCASES , l I COUNTRY AND KKKhHENCE NO NAME OR INITIALS DATE OF 8IRTH FRANCE 14.04*34 PCl^K t 07 |ClR \ 1 1 1 1 l 126 04.27 1 1 1 1 1 ( | RP 1 1 1 1 1_________ 01.04.34 Solv^y FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOC1CAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 15 X 1 OTHER | OTHER CAREER \ COMMENTS H1CHLJCHTS | _____________ 1____________ Brlgnoud 01.03,56 12.08.76 42 1i i | St Auban | 01 07.50 | After 11 11 1 11 | death | NIOSH 1 says 1 00.07.76 11 1 1 1 1 1 1 1 23.05,57 03.12.75 49 26 ________ 42 19 13 11.09.76 (NIOSH says 12.09.76) 1 I1 1 22 102.07 76 | Yes 1 1 1 (NIOSH no \ 1 1 coonent) \ 11 1 1\ 1 1f 19 30.01.77 Moderate 1958-J 960) yra titration lO-H yrs polyworker and works lab? i JThle nan had |A0L prior to |AS. Ann. de 1 Mai. Prof. | JuIy *77 |p 645 6 6. |AOL was found )1n 1S71 five |yrs before | ASL High 1i 1 |Plant fore- |1972-6 admin [Died of loan In leectton In \septlcaeml a I polymer- |St Auban |SmalI 1lver tlaatIon 1 | 1 es Ion. f on ml 11 |after autopsy -J J Moderate 6 yrs packer j___________________ 1 |Had been 6 autoclave |tunnel worker c Inr |previouely 14 yrs i autoclave worker 10.01.48 26.04.76 63 28 25.12.77 Very High 1948-1966 Leaser Exposure J 966-1976 Polymerlsatlon operator, autocleaner. autoclave alntenance 10 yrs In Operated 4.76 sulphuric for removal of acid factory, ^turnout from storekeeper 6 |llver and general Idled after services f second | surglca1 loperation for fbillo |b ronrhi a I | f 1 still a IPaper hy J Dr Ret y el 1 |in Archives tit |Ma1arles | prof ess I...... . s | Vij I 411 No 6 119 79 pajies 174 1-1, GENC 008832 _L PHtfi? 7 I Cl CHEMICALS 6 POLYMERS CROUP WPX/ASL - LANCIOCASKS,I 2 FRANCK Shed J LIVER Angiosarcoma Canes - (Review Hater I Jan 19ft?) 1 E1 1 l COUNTRY AND | REFERENCE | NO 1 1 France 1 1 1 21 1 1 NAME OR | INITIALS | 1 1 1 1 3 DATE OF BIRTH i t 4 COMPANY 1 E5 1 1 1 | FACTORY 1 1 i I in 1 VP 1 1 1 1 \ 11 1L l 1 i i i i i j i l i \ \ l \ i i 12 l i i t 13 i i i i i i i i l i i 1 4 |MJ 1 1 1 1 1 1 124.03.19 \ 1 1 1 MS.02. 12 1 1 J 1 1 1 1 1 1 1 i 1 1 1 { i 1 |16.08.14 1 1 1 1 119.01.31 1 1 1 1 I 1 1 1 1 1 103-04-24 | 1 1 1 11 11 RP HP PCUK Solvay Chloe Chin!e (Formerly RP) | St Pons i 1 1 1 1 (St Pons 1 t i i 1 l 1 1 1 i l 1 1 1 1 l \ 1 Brlgnoud t t i i | Tavaux 1 1 1 1 1 1 f 1 1 1 | Sc Forts 1 \ 1 [ \ i 1 6 78 FIRST VC EXPOSURE 1 DATE OF t AGE AT DIAGNOSIS 1 DIAGNOSIS 00.12.56 1 1 10.01.78 1 1 56 00.01.61 11.08.78 1 66 | J i 1 1 | i l 1 l 1 11 l l 09.02.49 00.05.79 1 1 65 1 | 1 1 | 23.09.63 26.06,79 1 1 1 t i 1l i i 60 1 1 | | | | f J 1 | wl 00.07.81 i l l i i i i l | 57 1 1 1 | | | l1 9 YEARS OF EXPOSURE TO DIAGNOSIS 21 37 30 16 J | 38 1 f 1 1 J | 1 10 1 u 1f 12 1 1 3 1 14 1 15 11 YEARS OF E DATE OF XPOSURE f DEATH 11 HISTOLOGICAL \ ESTIMATED l | CONFIRMATION EXPOSURE | OCCUPATION | OTHER CAREER 1 LEVEL | HIGHLIGHTS 1| 1 11 1 J 2 L 110.01.78 Yea !1 High |Autoclave | 10 yrB In 1 Icleaner (mechanical |engineering |industry (L946-1956 1 16 | OTHER | COMMENTS 1 1 1 IDied of |pulmonary ]embolism 5 |d ays after |surgery 31 111.U.78 Yes |' 27 123.06.79 Yes 13 122.08.79 Yes 36 129.07.81 Yes * t 11 | GENC 008643 High 11961-1966 |polymer|isatLon |general |purpose |worker 11946-1972 |VCM | | | ! I 1 | | | | | 1 | | l | |synthesis |(HC] 6 |Acetylene) |Foreman I 1 | I | | | | 1 (.gent | | |de maltrlse)| | | 1972 | | | retired ! i High |Monomer I I production i t f | | land polymer- I |Lsatlon ( \ | i loperator ! | i |Autocleaner 12 yrs as eyele|Cigarette |2 yrs, |mechanic* |smoker unt 11 |Auto- j 90 yrs ss |1974. Ill all i ^operator |enameller In fof 1977 due to 19 yrs, Issnltary ware |Oesophageal | Copolymers manufacture 14 yrs | |varices. |Surglcal | (1nterventIon 1 125.05.79 1 1 (right |hepatectomy) 1 Very High 1 1963-1975 11975-1979 1 1943-1975 |A1X types of}mslntenance 1 and IJobs on | work 1 Intemil tt - |msnufscture | 1 ent ly |6 maintenance i 1975-1979 |In VCH Poly ( - l |Process | 1 | | | | 1 j H FRANCE Sheet 4 LIVER Ang1 os arcoma Cases - (Review Date: i Jan 1987) UPX/ASt, - langiocasfs,i3 10 n CruiNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF YEARS OF EXPOSURE TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS France 15 1f> 1 1 | DEP 1 1 ! 1 1 1 | CIM 1i i ii 1i i 1 1 ! 103,01.37 Chloe |St Fone 1 Chlnle r 1 i (formerly i 1 RP) i 1i 1i 1 1 113.07.22 Chloe 1 i 1 st Fone Chlmle (For rly RP) 1 07.07.SS 128.09.82 ii 1i 11 i1 ii ii i1 i 17.10.41 t 05.01.83 1 i i 1 1 t t 1 1 45 6l 1 1 1 27 1 1 1 1 1 | 1 1 41 i1 11 1 t i 27 |Alive 1 l1 1 t1 1 t1 r 11 11 i i | f 1 1 i i l 38 103.04 83 I Yea Yes i1 11 j E IHlgh-20 yr I Autoclave 1 1Moderate Itleaner | 1? yrs 11955-1962 t 1 | autoclave t I (operator 1 1 11962-1982 i 11 1 11 1 |Hlgh-33 yrs | Polymer!sat-| Moderate- ion Process Low - 5 yrs Man Maintenance Worker (Left Hepatectomy 11983 1 |J C Contasaot ILetter of |5 10 1983 1 1 1 I E |Retired Jan 1979. J C Contasaot Letters of 5 JO 1983 and 25 7 84. Health A Safety Agent 17 jHAR 22.02.23 Chloe Chlmle (Formerly RP) St Fona | 17.06.48 | 03.04.83 J1 11 11 1 1 1 1 60 1 34 1 1 1 1 28 103.04 83 | 11 1 *1 1 l1 1 Yea 1 High 123 yra 1 1 tAutoclave ICleaner 11948-1971 1 |Other sectors Jof St Fona jFactory 197111978 j Retired [01.01.79 [J C Contassot ILetter of 5 10 J 983 Solvay | Tavaux 1 1 1 1 1 1 1 1 1 1 1 I 1 F ri 1 09.09.63 I 21 .03.84 11 11 i1 I1 I1 I1 I1 I1 I1 i1 i1 iE iF iE i | 1 1 1 1 1 1 l \ \ 1 1 J 1 1 42 1 21 1 1 1 1 1 1 1 1 ii i 1 21 127.12.64 1 11 1 1i 1 1i 1i 1 1 1i 1 1i 1 1i ! 1i 1 fi 1 1i 1 1I 1 1I 1 1F 1 11 1 i( 21.03.84 |Hlgh-L2 yraI Autoclave (Low - 9 yralCleener 11 j{ 11 11 11 11 11 11 11 11 11 11 11 i I I 1 1 1 1 1 1 1 1 1 1 1 t t GENC 008444 1 109.03.84 |Right |Hepatectomy 105.05.84J 24.09.04 |c heliotherapy |for lung]metastas is : |partia1 | remlsslon. J 08.84 - live |recurrence. |10.84 - lung levolutlon of J the d 1 sease I Cl CHEMICALS & POLYMERS CROUP WPX/ASL - LANGIOCASES,I 4 FKANf K StlE'fL 5 LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1987) 1 1 1 1 COUNTRY AND | REFERENCE | MO l FRANCE [ \ 1 1 19 | 1 1 1 1 2 NAME OR INITIALS MAZ 3 DATE OF BIRTH 15.12.32 02.03.23 4 COMPANY At ochea 1 I5 1 1 1 | FACTORY 1 1 t 1 1 |Brlgnoud i 1 1 1 6 FIRST VC EXPOSURE 07.04.59 ________ 7 DATE OF DIAGNOSIS 26.10.84 Brlgnoud 1951 27.12.85 8 AGE AT DIAGNOSIS 52 9 YEARS OF EXPOSURE TO DIAGNOSIS 25 34 [0 11 YSARS OF EXPOSURE DATE OF DEATH 25 06.11.85 22 26.12.85 11 12 13 1 14 | 15 1 16 f1 1 HISTOLOGICAL CONFIRMATION 11 ESTIMATED 1 1 EXPOSURE | OCCUPATION | OTHER CAREER | OTHER | COMMENTS LEVEL 1 1 HIGHLIGHTS 1 1 i |Autoclave 1 i j |Myocardial |1nfarction loperator and| 11980.Coronary Yes High Icleaner | 1 bypass 1981. 11 |Letter from I1 1 Dr Contassot 11 15.4.86 _L 1 1 1 Autoclave In other psrts|Porta) High operator and of factory (fibrosis from cleaner since 1946 t 26 .04.74. The 111 lneas was Idiagnoaed as | presumably |work related [on 20.04.74. |Let ter from |t)r Contaasnl 105.04.86 1 1l 2 1 1 Pa 101.10.40 | RP 1 11 1 11 1 11 1 11 1 1i 1 11 f 11 1 I1 1 I SEP t1 i | 1959 I 03.06.86 i 45 27 |Hontlucon( 1 1 i ii ( i i i't ii i1i ii i 1 ii i i ii i 1 ii t 1 1 11 1 4 128.06.86 1 1 i1 ) 11 1 t1 1 it 1 1t 1 ii t 11 1 l1 1 Yes 1 High 1 1 1 1 1 1 i __ L_ 1 |Autocleaner 14 years 1 1 1 1 1 1 1 | Maintenance |worker 1 1 t t 1 1 t 1 IHepatlc test |May 84 norma 1. IHepatlc test I May 86 showed |abnorma11tlea. |Letter f rom 1 Dr Ba rrat 118.07.86. QENC 008645 PflRe 10 CLKMANY Sheet i ICI CHEMICALS & POLYMERS GROUP LIVER Angioearcoma Cases - (Review Date: 1 Jan J9B7) WPX/ASL - LANGIOCAShSJ5 1 COUNTRY AMD REFERENCE NO GERMANY 01 02 01 1 1 1 1 1 1 1 1 1 1 1 1 1 1 04 | { 1 1 1 ! 1 t { 1 1 1 1 1 J 1 i! 2 ! NAME OR INITIALS i i DATE OF J BIRTH | 4 COMPANY _____________L 00*00.30 | 4 00.00.31 00,00.30 | t t 1 I \ ! 1 1 1 1 1 1 1 1 1 1 1 1 i 1 00.00.30 1 1 1 1 1 I i 4 12 S \ i f 1I 11 1 1 t i516 1 I | FIRST VC 1 FACTORY J EXPOSURE i i i j 1 1 4 | 01.10*56 14 1 12 t i 1 19. 10.57 1 1 1 09.06.52 1 i t I 1 i l i i t * i i i i i i l 1 e I 16.04*57 1 i i I i i1 1 1 1 1 1 1 11 1 1 1 78 DATE OF DIAGNOSIS ACE AT DIAGNOSIS 19.09*68 25.09.70 00.03.73 38 39 43 1 1 26.11.74 44 9 YEARS OF EXPOSURE TO DIAGNOSIS 12 13 21 17 10 i ii l 12 i1 1J YEARS OF 1 DATE OF | HISTOLOGICAL EXPOSURE | DEATH | CONFIRMATION 11 11 i1 t it n 1 19 1 11 11 ESTIMATED | | EXPOSURE | OCCUPATION | LEVEL | | 11 11 1\ 15 OTHER CAREER HICHLICHTS J 1 \ \ | | 1 i 16 OTHER COMMENTS 12 25.01.69 1 Yes (NIOSH) |Polyworker j 1 11 t 1 14.12.71 I Ye. (NIOSH) it 1 Polyworker | t \ 1 11 \ 16 10.10.73 Ycb (NIOSH) 1 I Filling 1 | 1 \Reported under Ipeaticide | |non polymer- laeroaol canal 11aatlon |with VC | ^workers in 11 11 11 |NIOSH list of 131 *3.77. |This of course 11 1% ii 11 | Is strictly Icorrect, |However I |wonder 11 {whether this 11 ii 1| |nan had high lexposure to |VCM In his 11 11 lean filling (operation? L __________ 1 __ 11 17 25*11.74 Yes (NIOSH) 200-500 ppm|Polyworker 4|1958 was t ICLlnfcal but high I temporary (autocleaner Idetails In during 1 yrlautocleaner |for 1 yr Ipaper by autocleanerl | jGokel et al 11 |Virchows Arch 11 fA Path 1976 11 1372 p 195-20 ! !1 !1 11 1! 11 11 1 t1 t1 1 _______ _____________ L J____________ 1_____ _______ J___________________ G^NC 008646 ***** 11 1CI CHEKI CALS 6 POLYMERS CROUP WPX/ASL - LANOIOCAShS, I h GERMANY Sheet 2 LIVER Angiosarcoma Cases - (Review Date: 1 Jart J987) 1\ 1 12 I3 COUNTRY AND REFERENCE NO GERMANY L 11 | NAME OR | | INITIALS | |1 I1 1J |1 !i DATE OF BIRTH j 05 | 1 ( NIOSH gives| as Case 06) I J 1 J 1 1 1 1 1 1 1 l 1 1 I 1 1 06 | 100.00.36 1 1 1 1 1 1 1 11 1 1 1 1 1 11 1 1 1 1 1 100.00.32 (NIOSH gives as Case 05) 00.00.26 4 COMPANY i1 i 5| 6 ii 1i 1 \ FIRST VC 1 FACTORY J EXPOSURE 1i L f* t1 1 1H | 02.04.60 11 11 !1 1 1 1 1 1 1 1 1 1 1 1 1 i i 1 7 7 | 16.12.62 15.04.54 79 9 10 tn i 12 n1 14 15 1 Lb ii i DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF | DATE OF 1 HISTOLOGICAL EXPOSURE | DEATH 1 CONFIRMATION 11 ESTIMATED EXPOSURE | OCCUPATION LEVEL 11 10.12.73 38 i i j ! 1 1 1 1 I 1 1 I 1 1 I 13 ! 116.12.74 | 05 Yes (NIOSH) || I| 11 11 || 11 1 -1 1| 11 1 || 1| 1| || 1| 1 1| || |BG Chenie |aays |"chemist ry J1aboratorlanj Jin the 1Techno(logical |Research | Department" |(NIOSH says (assistant | factory Icheaist |vhlch may be| |wrong 11 ranslatlon| 1 ti ii - i OTHER CAREER HICHLICHTS | | 1 OTHER COMMENTS J Confirmed (Reported under (non-polyme i-- |1aatIon | workers hi |NIOSH List of 131,3.77 ami 11.70. L don't Ithlnk this la fa correct (class ifteatlorn (by NIOSH. The |man may have (been Involved |ln VCM |polymerisation Jin pilot pi ant |or In main J plant. 1 00.00.75 43 | 13 12 109.01.75 | Yea l |PVC - Hanufacture Shift Leader 12.11.75 _L 1 21 M3.11.75 (NIOSH | aaya 12) | _L PVC Manu facture and all work lncl autocleaning 12 yrs (1954-66) Foreaan Tech Dev 6 yrs (J 967-1975) 00.00.17 19,07.54 06.04.75 50 20 125.12,75 Polyvorker OENC 00864? Page 12 GERMANY Sheet 3 1CI CHEMICALS f POLYMERS CROUP LIVER Anglo&arcona Cases - (Review Date; I Jan 1987) WPX/ASL - LANCIOCASFS,\) JO 12 I5 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE BATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COHKENTS 00.00.34 10 (NIOSH gIves as Case 1l) 00,00.36 l1 (NIOSH gives as Case 10) 00.00.29 00.00.38 20.02.61 16.06.76 41 13 24.03.78 0t.Ql.6l 00.01.77 40 16 07.03.77 10.10.55 28.06.77 47 21 22 28.06.77 00.00.61 00,10.77 39 16 07.10.77 High peaks 12 yra poly worker incl 17X auto clave cleaning Control rooa 1 yr High peak 10 yra poly worker incl [7X autoc lave cleaning High 3 yrs auto clave cleaner 19 yrs filter operator PVC Manu facture Autoclave worker for 6 yrs 10/78 Conf1raed Average exposure fire 9 yrs 150 ppm occ 1001) ppm Next 3 yrs av 75 ppm. Last yr av 35 ppm Average exposure f1rs t 9 yrs 150 pfw, occ 1000 ppm. Last yr av 75 ppm. CWH letter of 21.04.78 GENC QQ864S Page 1? GERMANY Sheet 4 TCI CHEW CALS t. POLYMERS GROUP LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1987) WPJC/ASL - LANCIOCASESJft 1 2 31 4 COUNTRY AND | REFERENCE NO NAME OR INITIALS GERMANY DATE OF 1 BIRTH | COMPANY L 13 00.00.14 | 7 14 15 (NIOSH glvesl this as Case 13) 16 no.00.29 I 8 00.00.23 | 4 5 FACTORY J ____________ 8 4 6 FIRST VC EXPOSURE 00.00.60 7 DATE OF DIAGNOSIS 06.04.78 . 8 1 9 1 10 i n 1 12 AGE AT 1 YEARS OF 1 YEARS OF DIAGNOSIS EXPOSURE TO K.mSURK 1 DATE OF 1 HIST0L0C1CAL, DEATH 1 CONKUtMATION DIAGNOSIS 1 1 t 1 1 63 18 14 19.05.78 I Yes t \ * 1 |Not an |Angiosarcoma |In his letter 1 o f 21 12 81, |Mr Frledei lasid this was |a "Plattenepi|thelkartlnoa | Der |Spelserohre" |(a carcinoma |of the joeaophagua) (not attribute |able to VCK 4 |not recognised |aa an lnduattrial disease 13 1 1 ESTIMATED EXPOSURE | LEVEL t 1 1 1 1 1 1 1 1 I 1 1 1 i 1 i 1 i ( 1 1 1 1 1 1 1 1 1 i i 14 OCCUPATION 1 | | ( 15 OTHER CAREER HIGHLIGHTS I 16 J___________ I OTHER f COMMENTS 1 J J t F W Best lletter of I30th June 1980 (enclosing data I f rom I Mr H P Frledei |of SC Chenle IF V Best lletter of 130th June 1980 |enclosing data I f rom |H P Frledei of IBG Cheoile Iwithdrawing |this case I I I I I I _______________ 1 19.10.53 09.10.J8 49 25 25 23.10.78 I Yea | | i 7 1Autoclave Icleaner and (worker. 1 1 Deter 1 (operator. t |Later shift i 1 leader i1 i1 10.01.55 07.08.78 55 23 20 07.08.78 1 Yea High |Autoclave (Lei bach |ASL and Iworker till suspected |Hepatocellular (1964. ASL at {Carcinoma |Leader and Feb 1975 | {master laparotomy) \1 11 1 |Angiosarcoma [conf irmed J 09/79. Some Idetall of this ft also cases 19, 11, 15, If) I & J ? given In |NRW Report for 1197ft_____________ I Angiosarcoma Iconf 1 nneci, (full details (of 11 lness {since March 11973 given 1 n |NRW Med Insp J Rep for IV7H. |f>If ferenl t I1 fdet a IJs given 1 I In NVC GENC 00864? f Ah hoi I nleit 1 (Din rant*" by | Eel hac-h and f 1I fHa rate]Ier _______________ jL j_________________ i__________________ i<1981) P?I 14 GERMANY Sh**i"i 5 ZCl CHEMICALS A POLYMERS GROUP LIVER Angioh*rennui Cjimch - (Review Datej S Jan 1987) WPX/ASL - LANClOCAStS,19 l COUNTRY AND REFERENCE NO GERMANY I 2 i3 1 1 NAME OR | DATE OF t INITIALS | BIRTH i 1i 1t 1\ i 17 (NIOSH gives| as Case 15) 18 19 i 20 21 3? 100.00,37 1 1t l 1 l 1 l l l 1 l 11 1l 11 1l 11 11 l l 1 i1 100.00.13 1 1 1 100.00.25 t 1 1 l 1 *00.00.15 1 i t1 1 1 1 100,00,13 1 l 1 l I i mo .oo. 2i 1 1 1 f1 4 COMPANY 4 5 4 4 4 4 11 t t5 6ti 8 1E 11 9 10 1 1 1 12 | 13 1 14 1 15 11 i 1! 11 1 l) 1 i 11 11 1 i FIRST VC \ DATE OF ACE AT i YEARS OF YEARS OF | DATE OF t HISTOLOGICAL | ESTIMATED 1 | i FACTORY EXPOSURE | DIAGNOSIS i DIAGNOSIS EXPOSURE TO i EXPOSURE | DEATH | CONFIRMATION | EXPOSURE | OCCUPATION | OTHER CAREER 1i DIAGNOSIS 1t 1 LEVEL 1 l HIGHLIGHTS It 11 11 I it i 1i ii t ii 1i it ! i 11 } 14 01.11.61 1 14.08.78 41 16 11 128,08.78 I Yes | High |Autoclave 1 No 1i 1 11 1 |worker 1 11 11 11 1 11 11 11 i 1 ii \1 11 t 11 t1 11 i 11 11 11 l 11 f1 11 E 11 1 11 f1 i 1i it 1i ii t f1 i1 11 t i tii \1 11 i i 11 11 1 ii 11 11 ( 1 11 11 1 i )11 1 \1 11 1 i I1 i i1 11 ( I1 i1 11 ! Ii i i1 11 1 il i i5 00.00.55 1 25.12.79 68 ii 1 i i i i 24 i ii i 21 (25.12.79 1 i ii Yes ' i | i i |Autoclave (Worker t 1 1 ii 1, i i i 4 i 18.10.54 1 00.08.79 54 i 25 ii 1 i ii 1 I it if 1 i 18 122.02.80 1 Yes | High |Autoclave 1 1 (Heteataelng | (Worker 1 i |ASL | 1 1 i1 11 rI 1 i1 i4 14.02.61 1 00.04.80 i 65 ii 1 i1 1 i 19 1* t1 1 i 13 119.10.80 1 Yes | High |Autoclave 1 1 [Haenanglo | |Worker i 1 (Endothelioma | 1 i 1 jof liver vlth | 1 f 1 1 IMetastaaee | I [ 1f 11 1! 1 4 01.01.62 I 00.09,79 1 66 1 18 1 13 j19.06.80 1 Yea | High |Autoclave 1 |pronouneed |c1inlcsl ]1lver \ aynt oms ) 1 1 1 1 t1 4 1 15.10.61 ! 28.08.80 f 59 1 1 1 1 1 f 1 1 |Haenanglo | |Worker and 1 1 1 |Endothelioma f Iworked In 1 1 1 |of liver with j [drying shop \ | 1 jMetaatasee j 1 I 1 JL } 1 f 11 106.12.81 1 Yes | High |Autoclave |Chargehand, !1 f 1 11 1 1 1 1 IMetastaslng | 1 1 |ASL | |Worker 1 |subsequently |Foreman 11 i i 1 J1 11 j 1 16 \ 1 \ OTHER | COMMENrS ] | (Angiosarcoma | cotjf i rmed. |Annual report |of the North |Rhine |Westphalia j Medical |Inspectorate (for 1978 (pages 347-377 |glvea full Idetslls. Vinyl Ichlortde |d1aease fd lagnosed 102-02-73. |Oesophagea1 Ivarlces. |Radiologlcal 1 y Icon firmed aero loBteolysls. | r 1 |Dr Besche lletter of [13-04-82 to |Dr U G F Adams l [Dr Beache lletter of |13-04-82 to | Dr W G K Adams ; [Dr Besche lletter of |13-04-82 to 1 Dr W G F Ail.uns ; J Dr Besche lletter of ||1-04-H2 to |Dr W (i K Ad,uns GENC 003650 pa^e 15 GERMANY Sheet 6 I Cl CHEMICALS 6 POLYMERS CROUP LIVER Angloaarcoma Cases { Rev Date: 1 Jan 19ft 7) WPX/ASL - LANCIOCASKS t2f> 10 12 13 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP BIRTH FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS GERMANY 23 00.00.27 1955 26*03.79 52 21 29.09.81 High Chenl st ry <*300 ppm) Worker Primary hepatocellar carcinoma; proliferation of the slaualodal cells with sinusoidal ectasia. Friedel letter 23.12.86. 24 1 1 1 1 25 1 1 ! 1 1 26 ! 1 1 1 1 27 t 1 1 1 28 1 100.00.28 1 1 1 100.00.23 t 1 1 1 100.00.22 1 I 3 \ \00.00.28 l 1 l |21.11.23 1 1 1 1 1 1 1 J f 1 1 1 1 1 i i i i 1 8 8 2 4 7 8 1 1969 ! 11.10.82 I 54 l1 1 1t 1 t 8 | 1960 11 1 28.09.81 I 58 11 11 1 l1 1 1 2 I 1953 11 1 14.06.76 T 5i 11 i 11 1 11 1 1 4 1 1955 l1 1 18.01.83 I 55 fl 1 11 1 11 I 7 l 01.10 60 1 ll.08.S5 | 61 13 1 12 J 28.05.83 I Yes High {Autoclave j ! Il <*300 ppm) |Clesner | 1 11 1 11 21 4 13 114.01.83 I Yes High 1 1 IPolyclave 1 i | 1 11 1 11 1 11 |Worker and | Autoclave ICleaner ] { \ 1 11 22 | 22 122.11.82 | Yes High *, 1 |Polyworker | 1 11 1 11 1 11 tI 11 11 I \1 28 1 18 102.03.Si | Yes 1 11 i 11 High 1 |Autoclave 1 | ICleaner till/ 11972 l ) 11 25 1 25 125.08.85 1 Yea High 1 |Process i | worker 1947- 64 <01.10.60 -31.03.84 PVC product ion, agltator area). jProf Eder <Munich) (letter 22*08.81. |Friedel letter 19.04.85. 1 |Prof Selnalr <Munfch) |letter 22.08.83. iFrledel letter (9.04.B5 1 1 |Chronic hepatitis, langlomatosIs, sinusoidal lectasla. Friedel letter 123.12.86. 1 1Lelbach. /Friedel letter 1 19.04.85 1 lAnnusl VCM screening 24.04.85: no complaint, no abnormality detected. 1970 two-thirds gastrectomy for ulcers. 1971 Coronary thrombosis 1983 Femoral lraplantat Ion 1984 Pulmonary embolism and pleuropneumonia. Landers letters 18.U9.K5 and 04.02.87. 00.00.22 1962 15.02.83 61 19 15.02.84 High Chenl st ry worker Haema ng losa rkorna. Prledel letter 23.l2.Hb. 00.00.17 1951 07,01,80 62 29 25 25.05.83 High Polyworker Shift leader HaeoangiosarkoTea, Friedel letter 23.12.86. no.no.23 30.06,85 61 A1 Ive AutocIave r leaner Haema ng I nsfirkoma. Frl eile 1 li'iiii 2 1.1 >. Mb, on. OO. Vi I 8 | 8 | 19 Vi 00.04.85 I 55 All v GEHC GOS*51 Polyworker Am or lave c leaner ilaemangt naarknma. Prtede I letter 2 !. I 7 .Mr. Page 16 ITALY H'A CliKMl i ALS A PULYMI-K:* l.HUUI' LIVER Angiosarcoma Cases - (Review Hate: 1 Jan 1987) wpx/asl - langiocasks.ji - 13 15 COUNTRY AND REFERENCE NO ITALY NAME OR INITIALS DATE OF BIRTH FIRST VC | DATE OF EXPOSURE j DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE II DATE OF | HISTOLOGICAL | ESTIMATED DEATH | CONFIRMATION | EXPOSURE } | LEVEL ______ !___________ !___ OCCUPATION J OTHER CAREER HIGHLIGHTS OTHFK COKMKNIS 01 (On N1 OSH supplementery list) LG 15.06.34 Ml ra Venice 00.00.65 | J9.04.71 36 03 16.04.71 Montedison Porto Ha rghera _L 00.00.57 t 13.12.72 15 27.12.72 \ PVC Bag ext ruder Polyworker | i | Prima ry t union r [may have been f perl card I urn. |Not homoIgeiu'ooa with (other cases. j* J___________________ 14.03.20 Solvay 20.07.57 00.01.53 | 10.07.75 I 55 00.04.59 | 00.01.81 43 22 10.07.75 f x I no.03.81 I t j Danesln 19.03.37 Ml ra Venice 00.00.67 07.03.83 X 16 06.04.83 | Yea I ____________ I oni Med dl Lflvoro AS p44S t 1974 . Further details In letter from Dr Montesano of 1 ARC on April 1st 1982. ________ High Autocleaner | 8 yrs (1953-1 I 1972-5 did | a variety of| 161) Autoclave Jobs | (operator | Including 1 (12 yra (1961 - PVC packing. 1 (72) 1i 1 12 yra - 11 yr | Very High I Mononer 1 1 5 yrs | Hedlua loperator 1 |20 yrs - 1 |Never cleaned |autoclavea. |See paper by |CHIAPPINO et |al Med Lavoro 1 E 1 ! | Non-amoker |Consumed I | 4 yra 1 Low 1 I 1 |Autoclave 1Voi 6 (1982) (operator A |pp 555-563 jother dutlesi |ln suapens- 1 |ion polymer- | jlsation. i 111tt le Ja 1cohol. \ AOL. 1 | i i ! I 1 | Mediun-? I High |Area Forenanl 11n sane Dept| lalnce 1975. t XX I1 I Bag extruderl 11967-1975 | i l i I |S PagJia[Lunga telex |Commercial | |2 Aug J9H1 IDept 1976- f (1983 | I J___________ L Also .nee Maltoni and Rondlnella In Acta Oncologlca Vol 1 1980 pages 35 - 49. GEHC 003652 17Page IAPAN JCI CHEMICALS A rol,YHt.KS (.KtHfr LIVER Angiosarcoma Cases - (Review Date: I Jan 1987) UPX/ASE, - LANG IOCASES , / l 1 1! > 1 2 13 1 4 *5 6 1 \1 1 11 i COUNTRY AND | REFERENCE J NO i NAME OK | DATE OP 1 INITIALS \ BIRTH \ 1t COMPANY i FIRST VC | FACTORY i EXPOSURE \1 1 11 i JAPAN 1 11 1 11 01 f Tomoli 101.08.22 j Mitsui fNagoya 00*04.53 | Mori 1 (Toatsu 1 1 f(no comment 1 1 iby Jap PVC r 1 j Assoc) i 11 i 11 i 11 i fl ! 11 1 1] 1 11 J! 1 11 1i 02 | SO f02.08.39 1 00.11.58 \ 1 11 \ 11 \ i1 1 1 11 1 1J j____________ _L_____________ 7 8I i DATE OF i AGE AT | DIAGNOSIS DIAGNOSIS | * 24.10.75 *1 53 I 10.08*76 1 1 1 1 | 1 37 i I 1 f ______________ L 9 YEARS OF EXPOSURE TO DIAGNOSIS * 22 17 11 10 1 l 12 i n 1 J4 1I 1 11 YEARS OF | DATE OF HISTOLOGICAL | ESTIMATED E EXPOSURE 1 DEATH CONFIRMATION } EXPOSURE | OCCUPATION 1 1 1 LEVEL ; 11 1 I] ti [ i1 13 124.10.75 Yes | PVC Assoc 11 3 yrs auto- 1 Isays not | clave 1 1 |known. | cleaner 1 |* Japan 11964 - 1 j Times lassigned to 1 |indlcated |different 1 |on 25.10.75|work since 1 (exposures [had ill 11 |of ten at |health 1 13000 ppm up| f 11 Ito 1974 i 1| 1i 1 11 13 \10*08.76 Ycb 1 (Not known 1 In polymer- 1 | liaatlon work 1 I 1 Inc Ludlng 1 | |autoclave 1 |c leaning _____________ J________ _L j_______________ 1 15 OTHER CAREER H1GKLICHTS 1 1 1 | | ] lf> OTHhK COMMENT j | | Japan Timet* [25. JO.75 h |Japanese HVC |As soc letter (of 31.03.78 | | 1 \ l 1 1 IJapanese PVC | Assnc 1 at 1 or> |L et t e r of |31.03.78 1 * In his letter of 1st April 1982* Dr Montesano of IARC says Japanese Ministry of Labour give Date of diagnosis Age of diagnosis Years of exposure 21-08-74 52 22 GENC 008653 18Pa Re NORWAY LIVER Angiosarcoma Cases - (Review Date; I Jan 1987) WHX/ASL - LANCiOCASKS,l i ai COUNTRY AND \ REFERENCE 1 NO | 2 1 31 1 1 NAME OR | DATE OF | INITIALS | BIRTH | 1 1 4 COMPANY 1 5I 6 I 7| 8 11 1 1 ti 1 1 i i FIRST VC \ DATE OF | ACE AT 1 FACTOR* | EXPOSURE | DIAGNOSIS t DIAGNOSIS 11 t * 11 i 1 NORWAY 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE LI DATE OF DEATH 12 H1ST0L0CICAL CONFIRMATION 13 14 | f 15 | ESTIMATED EXPOSURE LEVEL OCCUPATION | OTHER CAREER HIGHLIGHTS | | f 16 OTHER COMMENTS 23.12.15 Norsk Hydro Heroya 00.03.50 21.12.7 l 56 22 04.01.72 High Foretaan 6 Autoclave supervisor \ | | t f 1 1 1 1 1 1 1 1 1 \ |Conf1rmed by {Dr ThlisfEvansen of NH. ] At APME Mtg {Jf |9 June 1978 | Mr P (tangoes | stated that AH jhad been a | menher of a Istart-up team. |VCM 4 PVC were Icaade 1 n same jbulldlng. The |VCM was made | f rom fleet y t trie i genc 0S<S54 Pan*1 19 SWEDEN 1 CL CKbMI CALS A POLYMERS CROUP LIVER Angiosarcoma Cases - {Review Date: 1 Jan 1987) WPX/ASL - LANCLOCAStS , IU COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF 1 BIRTH] COMPANY 1 1 | \ FACTORY I I I FIRST VC | EXPOSURE Ii l II I DATE OF | ACE AT 1 YEARS OF | YEARS OF DIAGNOSIS |DIAGNOSIS | EXPOSURE TO | EXPOSURE | | DIAGNOSIS i Ii DATE OF | HISTOLOGICAL DEATH | CONFIRMATION n ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS i I | | | OTHER COMMENTS 0 \ [NU 02 |BL 1 1 1 tn | NE 1 1 04 | AL 1 1 1 1 1 1 i 1 1 1 1 1 4 1 05 l l f 1 J l 1 123.06.27 | Keanord | Sundsvail | 14*08.51 20.10.70 | 43 11 11 127.11,11 | Kenanord tj _____________L______________ 1 a| |Sundsval11 00.01.45 00.08.72 | 61 1I 11 1j 11 11 11 j1 11 11 11 11 1t 1 1 1 1 1 1 11 r1 1J 1j l J 11 11 11 11 1 11 11 1 1 1 I____________ L fi J_____________ L n0.06.10 i Kemanord |Sundsvallf 00.05.47 i 18.03.76 | 65 ii ii J_____________ L I 16.11.14 | Kemanord |Sundavall} 00.00.46 12.05.77 1 1 | 62 11 11 11 11 11 11 11 11 ii 11 11 1 1 ^1 1 1 1 1 1 J1 11 11 11 1f 11 11 11 11 11 1l t1 11 1 1 1 [ 1 | 11 1 12.03.19 I Kemanord |Sundsval1| 11.05.64 22.11.80 I 61 1 I ;1 1f [1 1f 11 }4 ii Jf 1f 11 J1 1J fJ 1I f I1 1f 1 1 1 19 27 29 31 16 1 18 120.10.70 | 11 11 1 27 1 16.08.72 | 1 11 1 11 t 11 1 i1 4 $1 1 11 1 11 1 11 1 11 1 1f 1 11 14 i t 1 21 11 11 119.03.76 I 1 i } 31 !1 11 112.05.77 | 1 11 1 1t 1 11 1 11 1 11 1 11 1 11 4 11 1 t1 1 11 1 11 j 11 1t !1 1 16 j 22. M.80 | 1 11 1 11 1 1J 1 11 1 41 1 41 Yea Yea Yes Yes Yea i i t 1 High 1 | 1 1 | \ 1 1 1 1 | t t 1 1 High 1 1 ! High | 1 1 | | 1 1 1 1 1 | 1 1 | High | 6 Years f Low 4 10 Years J ; IPolyworker | 1 1 4 VCH (production 1 1 1 1 1 1 1 1 t 1 4 1 1 IPolyworker 1 1 | J 1 1 1 1 1 f 4 4 i 4 1 1 1 | f 1 1 1946-1958 1 1 | (polymer- | [lsatlon | |worker (12 | lyre) 6 1950-1 11977 .foreman| 1(19 yre) | 1| 11 1| 1| ir ii ti i f1964-I 970 i J [centrifuge ( (operator | (1970-1980 | (drier | (operator | 1! ` [IL his letter >f 1st AprlI 1982 [)r Konteaano of [ARC say In Sweden's National Board of OS Health gives 20-02- 70 as date of diagnoais for Case 01 and 15-05-72 for Case 02. 1 |Mr S Joelin'a j1et ter of 128 Marrh 1978 Iconflrna KL | wan a uni mere r Iworker who wan fheavlly |exposed, IprobaMy even (ore so than |a normal (reactor |cleaner 1 j l |In first 12 |yrs of (employment had |been heavlly lexposed. In 11974. liver {abnorma111 y (and necrosis Ed lag nosed. |Data conf1rmed |ln Dr D Byren |1etter 1B .8,7 7 fto CKFIC 4 f Let ter of |2nd Nov 19H l (f rom t Dr David byreci 1 1 ! GENC 008655 20Prige Ll.i UJhMH.AL.S h i, run, I UPX/ASL - LANClOCAShS^1) UK Sheet ] LIVER Angiosarcoma Cases - (Review Date: I Jan 1987) COUNTRY AND REFERENCE NO UK 1 1 1 1 1 | 1 1 1 1 2 NAME OR INITIALS 3 DATE OF BIRTH 0 1 jWJ F 1 1 1 1 1 f ! 1 02 1 1 1 1 03 | BJU 1 1 [ 1 04 | JSR 1 1 1 1 i 1 1 1 1 1 1 f t 1 1 1 1 1 f t 1 1 1 20.04*01 02.06.37 23.06.20 4 COMPANY 11 15| 6 11 11 1 1 FIRST VC | FACTORY 1 EXPOSURE ii ii 11 11 ICl BP ICI |HllLhouse| 04.04.44 11 11 11 11 11 11 1! 11 11 11 11 1 i 1 Barry ! i 1 00.02.66 11 1( 11 11 |Hillhouael 26.04.54 !! 1I ti 11 11 t1 11 11 ii 11 11 11 11 11 11 11 11 11 tI F1 F1 1F 11 r- do 78 DATE OF DIAGNOSIS ACE AT DIAGNOSIS 03.12.72 {Fox 4 Collier paper aaye 23.L2.72> 71 37 00.06.79 59 9 YEARS OF EXPOSURE TO DIAGNOSIS 28 09 25 1 10 11 12 YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION 22 03.12.72 ( Fox & Col 1ler paper aaye 23.12.72) . Yea 3.5 24.12.74 Yes 18 12,10.79 Yes 1 n 1 14 ! 1 1 ESTIMATED 1 | EXPOSURE | OCCUPATION | LEVEL 1 | i i i 15 OTHER CAREER HIGHLIGHTS 1 | 1 1 | | 1 F f J 16 OTHFK COMMENTS 500 ppm High Mediumhigh 11944-7 VCM 11947-8 Drier! 11948-61 tAutoclave [operator I 1961-66 |Drier f i i i i i 1 | Autoc Lave Idea ner 1 1 1 154-5 |Sagging |Plant 155-6 1 Drier Plant 156-58 1 Autoclave (worker 158-61 | Chargehand |Drier |Plant 161-72 | Foreman |C 2/3 Plant |Pre-war f tsh t packer |1939-45 aray Ivehlcle |maintenance J J 945-54 jfish packer 1 f 1 1 1 } i 1 1 |Lee and Harr/ |Lancet t29-06074 |pages 1316-8 1 1 1 1 1 t Dubious |f abr teat ion J case 1 1 | Exposu re 111ml ted to 12.66 - 9.69 1 1 1 l 1 1 1 1 1 1 1 1 F t 1 1 1 { 1 1 1 F 1 1 1 1 GENC 003656 Page 21 UK Sheet 2 l COUNTRY AND REFERENCE NO UK 05 NAME OR t DATE OF INITIALS ] BIRTH | 30.03.I 4 f 126.04.20 08 {08.05.24 BP i Barry Barry Barry Barry 1CI CHEMICALS & POLYMERS CROUP tfPX/ASL - LANGIOCASES.26 LIVER Angiosarcoma Cases - (Review Date; ] Jan 1987) FIRST VC EXPOSURE 08.01.51 DATE OF DIAGNOSIS 00.10.79 AGE AT DIAGNOSIS 65 YEARS OF EXPOSURE TO DIAGNOSIS 28 10 YEARS OF EXPOSURE DATE OF DEATH 21 19.11,79 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL OCCUPATION 1951-52 Polycleaner 1952-55 Latex 1955-60 Polyfloor 1960-64 Poly Chargehand 1964-70 Charging operator 1970-72 Drier operator OTHER CAREER HIGHLIGHTS OTHER COMMENTS 1962 09.01.80 48/9 18 1963 00.00.80 60 17 12 09.01,80 8.2 13.06.80 7 yrs Poly Floor Operator 5 yrs Greaser on Poly Floor Polyclesner 1963-5 Recovery 1965-1971 19.09.50 27.11.81 | 57 31 24 25.12.81 1 1950-1958 500 ppa 1968-1974 200 ppm 1950-51 Autoclave operator 1951-1957 Chargenan autoclave building 1957-1974 Shift supervisor autoclave building Never cleaned autoclaves but supervisor'a Job entailed ent erlng autoclaves t o 1nspect t hem 1938-1948 Motor Mechanic 1948-1950 Operator on Acetylene Production Plant GENC 008657 Page 22 UK Sliei-I 1 ICI CHEMICALS 6 POLYMERS CROUP LIVER AngloNArroma Cawe* - (KhvIpw Date: l Jati 1987) WPX/ASL - I.ANCiGCASES y2 7 ] COUNTRY AND REFERENCE NO UK NAME OR INITIALS DATE OF BIRTH 07.05.25 COMPANY J FIRST VC FACTORY | EXPOSURE ___________ I_____________ Barry 15.02.50 Ii ]0 11 22 I 23 24 15 DATE OF J ACE AT | YEARS OF DIAGNOSIS | DIAGNOSIS j EXPOSURE TO I I DIAGNOSIS 02.03.83 58 1 33 YEARS OF | DATE OF | EXPOSURE | DEATH | _____________ 1_____________ | II 29 124.02.83 t HISTOLOGICAL | CONFIRMATION | | Yes ESTIMATED EXPOSURE LEVEL Medium tI It Ii OCCUPATION OTHER CAREER HIGHLIGHTS Polyworker 2 years on Acrylonltrlle Resin Plant, Also prior Co 1950. 4 years RAF asintensnce. 3 years motor car palntshop. 2 years in Craving Dock. OTHER COMMENTS 1 10 I CJT 3 1 1 1 1 1 1 1 1 1 1 11 | CLP 1 104.04.47 1 1 ! f 1 1 1 1 1 1 1 108.05.28 BP BP 24.01,37 1 JBa rry ( 27,04.66 OJ 05 84 | 37 18 Jt I i1 | 1| | 1| | 1| |i i| i | 1| 1 11 1 1i 1 1( |Barry | 19.L 2.65 02.06.85 I 57 19 Klilhousel 16.09.57 ,,( 03.06.85 I 48 28 I j1 1 4.2 | 16.05.84 j Yes 11 (High - 11 |Polycleaner [Heavy goods 1 (Information 1 1F (onths (500(1966-67. (vehicle driverlgiven In 1 1F 1 1! fppm). Low -| Spray-drier (until final f18 months |bagger 1967-11 lines * 11et ter f J 8.06.84 f rum 1 11 1 || 1(50 pp.). 168. j Med Lin - | Blow-down I | IDr D M J 1W11llams 1 1t | 2 L months Istrlpper t 1 1 |l J(200 ppm) (operator | 1 1 1 11968-70. | 1 1 11 11 I 1 I 11 1! 1 4 1 11 1 16 (02.06.85 I Yes IHigh 1f |Polycleaner j- 4 ILetter of (1965 -69 1965-68. 04.06.85 |Med 69-79 Service Dr Paul Smith (Low 79-82 operator and letter of I 66-69. Poly 04.06.85 Dr D M D Evans Operator Oesophagea 1 69-79. haemorrhage Leading Hand due to 79-62. oesophagea t varices due to Angiosarcoma of liver _L 28 106.12.85 f |Low 1957-59 Spare nan, IHigh 59-74 bagging |Low 74-85 f loot \ 1957-59. Autoclave fOperator 1959-85 Letter 26,06.85 Dr F 1 f.ee SBC 003658 Page 25 UK Sheet 4 1C I CHEMICALS A POLYMERS CROUP LIVER Angiosarcoma Cases - (Review Date ; I January 2987) PLASTICS DIVISION WPX/ASL2 - LANGt OCASKS,1 COUNTRY AND REFERENCE NO 21 1 1 NAME OR | INIT1 ALS| 1 31 1 t DATE OF 1 BIRTH | 1 4 COMPANY i5 1 1 1 1 FACTORY 1 6 FIRST VC EXPOSURE 7 8 * 9 10 1 111 1 | YEARS OF | 1 DATE OF {ACE AT {EXPOSURE YEARS 0F| DIAGNOSIS) DIACNOSISI TO EXPOSUREF |DIACNOSISI 1 1 DATE OF DEATH 1 12 1 (3 1 U 11 JHISTO- 1 |LOGICAL |ESTIMATED! t CONFIRM-| EXPOSURE |OCCUPATION |ATION 1 LEVEL 1 ( 15 1 t\ 1 (OTHER 1 I tCAREER 1 |HIGHLIGHTS! 1 OTHER COMMENTS UK | MJ 13 1 1 1 1 { 1 102 03.48 |BP 1 1 l 1 1 1 |Barry | L96B | Jan B6 1 37 1 18 1 I1 1 l 1 11 1 1 1 111 i \11i 111j * 1111 l 3 (02.06 36 | Yea 11 11 11 11 11 11 High Low High -" |Polycleaner | Moved to jRemained 11968-69 |Acryloni- }Jan 1986 |Cent ral 11 rile ! j Depot {Plant 1 1L969-7Q {until left! I Poly floor IBP 1983. 1 \l970-71 |Manager of| IC * SS Ltd at Ca rd i f f Ai rport 1983-86 well, working actively mt l l it l t 1 1 Q0S45? gewc Page 21* USA Sheet I ICI CHEMICALS f. POLYMERS GROUP LIVER Angiosarcoma Garten - (Review Date: I Jan 1987) UK system of dates DAY - MONTH - YEAR WPX/ASL - LANCIOCASES, 2H COUNTRY AND REFERENCE NO I rI NAME OK J DATE OF | INITIALS f BIRTH f II COMPANY Earl Parks 117.10.23 J BFG | FIRST VC FACTORY | EXPOSURE Loula- | 09.12.48 vllle | DATE OF DIAGNOSIS 03.03.73 ACE AT DIAGNOSIS 49 YEARS OF EXPOSURE TO DIACNOSIS 24 JO YEARS OF J DATE OF EXPOSURE i DEATH 21 103.03.73 12 HISTOLOGICAL CONFIRMATION ESTIMATED \ EXPOSURE | OCCUPATION LEVEL | _______!________ OTHER \ OTHER CAREER t COMMENTS HIGHLIGHTS J __________________j_________________ |Pot Cleaner |(Block Jana J 1974) P 53 i I History given [Rolling Stone In Annala NY |Art ACAD SCIENCES |Ref 1 NY Acad Vol 329 (l979)|of Sc Symp page 190 in |1974 Paper by |Also Block B R Cottlne of|Jama 1.7.74 OSKA Jp 51 1 02 1 |19.08.33 BFC |Louis-- 11 J 5. I.55 1 00.05.70 ! 37 1f | vllle 11 1 1 \1 11 1 ii ff f\ 0] f Edwa rd i25.05.15 BFG [Dinwiddle | i |Louis| vllle i I 28. 1.45 1 19.12.73 1 \ t l i 58 11 1 1i 1 1 04 \ i 1 115,01.24 BFG i 1 |Louis- i 1 06.07.52 | 19.08.67 t i i 43 i 11 | vllle ri J 1 Jt l 05 i 125.01.12 BFG 1 |Louis- l 19.06.44 | 09.04.64 r 52 i t i | vllle tt i i! 1 tfi l 06 IRay |23*11.2B BFG 1 |Louis- 1I 17.01.62 | 00.02.74 r 45 |Austin |Jonea? 1 I | vllle i i i1 11 1 iI 1I 1 1I 1| 1 1 1I 1 1I 1f 07 |Charles 103.05.22 UCC t 1I |S Charle-| 27.08.44 i 00.00.68 I 45 | T Smart | ston | 1 I 11 11 t | 1f 11 1 I 1 nh 1 106.05.20 Goodyear |NlagnrA | 07. KJ.46 | 00.08.61 i 41 i 14 28 15 20 12 24 15 1 11 1 n 127.09,71 f 1 | (NIOSK [ 1 |aays | \ (28.09.71)| I ti J ii I 28 119.12.73 | f 11 ! J1 i ti * 11 1 15 $07.01.68 l 1 J1 1 J1 t ij t 20 409.04.64 $ t ii i ii t I1 i 12 124.07.75 I t ii 1 *4 i 1t 1 11 1 11 1 11 1 11 f 17 123.03.68 | 1 E1 f f1 j 11 1 15 129,08.61 I Yes Yes Yes Yea Yes Yes Yes | l 1 1 i 1 | 1 1 i 1 | 1 1 1 |` i i 1 | 1 i 1 1 \ ! 1 | 1 1 1 j I Pot Cleaner 1 < Cf Block) 1 1 1 Pot 1 { Cf | 1 1 I Pot 1 < Cf Cleaner Block) Cleaner Block) |Louisville (Courier (Journal J02-09-60 1 1 Pot Cleaner l(cf Block) i 1 |US Air Force| 1 I Pot Cleaner HCf Block) | ; i i ii f [Ref 1 (Also Block |JAMA 1.7.74 Ip 53 1 1 [Ref L |Also Block 1 | ! Ref 1 |Also Block 1 (Ref 1 |Also Block 1 1 Re/ 1 + \Lou lav 111e |Times 23.7.76 J Retired April 1 1974 JAlao Block 1 1 | Ref 1 1 f | Ref 1 GENC 008660 Page 25 USA 'JltCft 7 COUNTRY AND REFERENCE NO 2 NAME OR INITIALS 1 3( i DATE OF i BIRTH 1 4 COMPANY 11 1 5 16 1 ii i i FIRST VC 1 FACTORY i EXPOSURE 1 ICl CHEMICALS 6 POLYMERS CROUP TVER Ana Job a room* Cn sew - (Review Date: 1 Jan 1987) UK systen of dates DAY - MONTH - YEAH WPX/ASL 2 - LANGIOCASKSJ 7 DATE OF DIAGNOSIS a ACE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE 11 12 i DATE OF i HISTOLOGICAL DEATH CONFIRMATION n 14 | t i ESTIMATED i EXPOSURE i OCCUPATION | LEVEL 15 OTHER CAREER HICHLICHTS 16 OTHER COMMENTS USA 09 1 Raymond |Cet tle- | FI nger? i f08.ll 31 | BFC lr 1i t J Louls| vllle 1 i i 28.OS.45 | 01.1)3.74 i1 i1 i1 t 1 1 1 43 1 in 1 l 116.08.13 Goodyear |N1agara 12.06.51 1 00.05.68 t 55 \ { 11 i 1 1 127.05.09 i Goodyear |Niagara - L4.10.46 00.03.70 1 1 | 61 11 1 11 1 l2 k Francis A | 17.11.18 FI restone |Pottstown 13.07.49 02.05.69 | 50 |Bachnan 1 1 P* 1 11 1 11 1 if i f1 i 11 1 11 1 11 1 Richard Edwa rd Clendenin 01.12.21 S Charle 11.12.42 ston 00.05.74 52 14 29 1 24 1 11 03.75 | Yea 1 2000 ppm t 1f 1 1 11 i ii 1 i | Ref 1 ha is {wrong figures |re first lexposure. |Loulsvtile (Tines |29.10,74, \ 12*. 3-75, 110.3,76 1 ii l 17 l 17 |10.05.68 | Yea 1 i i i i 1 | Ref 1 1 11 1 1 11 1 23 1 23 | 16.03.70 | Yea 1 i i i i i i 1 1 |Ref l ! 11 1 1! 1 11 11 1 20 1 19 102.05.69 1 Yes IHigh 10 yrs|L0 yrs aa (Utility 6 I Ref 1 + letter i ii 1 (reactor op. 1 Service op. |of 26 April 1 11 1 {(not cleaner!Bagger 11978 from 1 ii 1 |- separate |Dryer op. |Ruseel 1 A Park 1 ii 1 |crew cleanedlStripping op. |to J T Seawe11 i ii i (autoclaves) (3 yrs prior {of MCA 1 ii 1| leervlce in 1 1 ii 1 1 Ityre plant ! 1 !! 07.04.74 1 2000 ppa 1 1 1 I |Charleston |Dai ly Ma M I 21.7.75 1\ |Never diag|nosed as angllosarcoma of |1iver. Tnform|at Ion given E n 11et t er 22 May 11984 f rnm |J A SaIg. i |Accountant ; |ASL - No evlIdenre of Vt'rt {exposure, J___________________ QEHC 008661 Page 26 USA Sheet 3 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY 1CI CHEMICALS & POLYMERS CROUP LIVER Angiosarcoma Cases - (Review Date: J Jan 19ft7) UK System of dates DAY - MONTH - YEAR kJPX/ASLJ - LANG IOCASES, 2 - U 13 14 13 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL COMF1RMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS James Howard 04.tl.27 Pee renboom 06.05.31 Charlie Arthur 22.04.28 Louisvllle 08.05.50 00.00.69 19 04 27.03.69 1951-4 VCM polymer isation From 1954 jTable 4 In onwards in |Uagone r Army and othe r|Testlmony tn aervlce. |US Senate 46-50 Army |Confirmed in |M N Johnson 111 r 07.0fi.78 Louis ville 23.06.55 11.10.74 43 Avon Lake 15.09.54 00.00.75 21 Yes 19 16.10.80 on 11.10.74 but no post-mortem 16.10*80 13 02.11,75 13 yra Navy autocleancr 8 yrs on Eatol Tyre Store plasticiser & Carboset operation | Dr H N Johnson [letter of 124.2.Bj con firmed death [6 years after |d lagrtosla I [Confirmed in [M N Johnson [11 r 07.Ofi.7B fAlso Rolling IStone mag. 115.01.76 t Virgil 00.00.1 5 UCC S Charle 00.00.43 19.06.75 60 32 32 06.04.76 Christian ston 20 11.08.17 Goodyear N1 agara 00.00.55 30.01.76 58 30.01.76 Cheat er 111 nk 1 e 02.09.09 S Charle 00.12.46 ston Early 77 30 22 02.01.77 2000 ppm J |WiIiiamsport |Sun Gazette J 21 June 1973 |Char 1eston |Dally Mall 121.7.75 I__________________ [NiOSII letter |of 25.10.79 J_________________ 1 |2H yrs with 1UCC at SC f Retlred I News re f 123.2.77 f ______ _ GENC 008662 Pa^e 21 USA Sheet 4 ICl CIIKHI CALS A POLYMERS GROUP LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1987) UK system of dates DAY - MONTH - YEAR WPX/ASL 2 ~ LANGtOCASKS , J L 23 COUNTRY AND REFERENCE NO USA 22 NAME OR INITIALS DATE OF BIRTH 102.10,23 1 1 1 1 23 J 1 1 1 1 1 1 I 1 { f 1 100.00.23 4 COMPANY 11 13I 6 11 11 1 1 FIRST VC ! FACTORY | EXPOSURE J1 11 11 BFG |Loula- | Ll.07.A7 Ivllle t 1t t1 f1 Great American Chemical ii | PI tchburgl 06.09.58 7 DATE OF DIAGNOSIS 00.01.76 E 8 1 9 1 LO 1 1 1 1 ACE AT 1 | YEARS OF !1 l YEARS OF j DATE OF DIAGNOSIS | EXPOSURE TO EXPOSURE | DEATH DIAGNOSIS l 1 \1 1 52 | 29 1 28 104.12.76 1 | 12 HISTOLOGICAL CONFIRMATION Yea 1 1 I 1 l 06.04.73 1 1 1 i | 30 | 15 t 1 1 J 1 1 | | | I 1 I1 i U 106.04.73 t Yes 13 ESTIMATED EXPOSURE LEVEL 14 | ] OCCUPATION | f f 1 15 OTHER CAREER HIGHLIGHTS 1 1 1 1 | | ; 1 J6 OTHER COMMENTS - 1 | 1 | | 1 | | | | | ! | i| | | | 1 1 t1 l 1 Louitiv i 1 L e |Times 26.1.76 laaid he was 11 he EOth AS | vlctin at [Bells l.ane nt |whom 8 had Idled by ]26.1.76 |In his letter |of I6.09.fl] |Dr M N Johnson | coni 1 rms this J la the jcaae described | by Dannaher |Tamburro 4 Yam |in Feh 1980 |Am J Medicine |Vol 70 p280 t 24 < 25) |Charles |Edward | Moore 1 1 1 1 1 1 1 1 1 1 1 E f 1 1 1 j 1 \ M7.05.t7 | UCC 11 11 1t 11 11 11 11 11 1J 11 !1 11 11 11 11 ft \I ia ii ji | Removal from |S" Ch.rU-| 1939 1 ston I 1i 11 11 1i 1i Jt 1i 11 11 11 11 11 11 1f \ 11 a1 a1 i1 register confirmed In R 1 27.05.77 | 11 I1 11 ai ii ai ii ii ii ii ii ii ii fa ai ii ii ii ii fj Kaminski letter 60 of 5 | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 t 1 1 1 1 November 38 1980 1 2?7 |(NIOSH Isaya 26) 1 | a | | | 1 1 1 | f 1 | 127.05.77 |Cholanglo| [sarcoma | }(R Kaminski 1 1 26/2/79) |\ 11 11 ia ia ia ii ia fi ai ii ii Ii 1 ii f ii 1 1 ii |Medlw to |hlgh lor 124 yrs 1 1 1 1 i i i i 1 1 1 1 i i 1 1 1 1 J1941-65 non -11937-39 was f N M Wheeler |solvent |off and on Ivinyl reain | labourer (unit and IJ939-41 may |1etter of |18.8.77 to EJ Stafford fdleperslon |have been fg Ives details (vinyl resins|exposed as J Rose Kaminsk1 {unit first | reactor |letter of tas fitter |cleaner Ihelper, then)1943 became (26/2/79 |R Kaminski |shift | shift fitter 1(5 Nou 1980) lutlllty man |I946 became Isuggests that 1 |shlft utility |NIOSH will 1 fitan jretaln on f 126.04.65 |register since t (employment wasfthls neoplasm 1 |termlnated |may be assoc 1 - 1* 1 1 |ated with ASL. |R N Wheel or 11 elt rr u\ 1 ! a\ 120/2/79 and \ Rose Kaminsk[ j1et ters of \ 26/2/ 74 atul GENC 009663 I 5/1 l/BO P"** 28 USA Sheet S ICl CHEMICALS A POLYHERiJ CROUP LIVER Angiosarcoma Cases - (Review Date: l Jan 1987) LFK system of daces DAY - MONTH - YEAR WPX/ASL 2 - LANGWCAShS t4 1 1| 1 COUNTRY AND | REFERENCE | NO USA 1 1 1 21 1 NAME OR | INITIALS | 1 1 1 31 1 DATE OF t BIRTH 1 1 4 COMPANY t1 151 6 1i 1 1 FIRST VC | FACTORY | EXPOSURE 11 11 7 DATE OF DIAGNOSIS 26 [John Berry107.07*23 BFG 11 11 11 11 11 11 1( if l1 l1 1l l1 l1 l 27 \J L 11 | 11.05.16 UCC |Forrest | |Louis| vllle | 03.L0.47 | 11 11 11 11 11 11 11 11 11 11 11 11 11 |S Charle-i 01.07.41 | ston | 00.00.77 (up to 2 years after death) 30.11.78 1 lt 1\ j1 11 1j t1 11 11 11 11 1 28 1 f 1 29 1 1 11 111.04.17 UCC 1 f 112.10.07 UCC l 11 1 |S Oarle^f 00.08.44 03.11.78 | aton | 1t |S Charle-| 00.03.42 | ston | 00.03.60 l 1 30 |UVN i 1 1 i 1 1 1 11 11 122.07.22 Tenneco 11 |Flemlngton 11.06.64 \ 1 Chemicals 1 1 11 11 1 t1 1 11 1 11 S 11 30.12.80 1 31 f 1 11 I08.1L.23 UCC 1 i1 |S Chacle-| 12.05.46 | ston [ 01.08.61 11 11 11 t1 11 11 11 t1 1t 11 I1 1t 1t 1\ 11 11 11 1l I1 11 1t 1t \f f 1i 1 11 1\ 1t t1 11 81 9 1 10 1 11 1 12 1 13 1 14 1 AGE AT t 1 YEARS OF 11 | YEARS OF | DATE OF HISTOLOGICAL | ESTIMATED 1 DIAGNOSIS EXPOSURE TO | EXPOSURE | DEATH CONFIRMATION | EXPOSURE | OCCUPATION | t DIAGNOSIS 1 | LEVEL ( 11 15 OTHER CAREER HLCHLICHTS 1 | 1 16 OTHER COMMENTS 52 (death) 1 1 t 1 62 1 1 6L 1 72 1 1 58 1 57 1 1 1 1 1 1 1 1 1 1 1 1 1 1 / 1 28 (death) 37 34 36 17 35 t 18 \ 11*1)2.75 l 1 11 ii 1 11 11 11 11 1 1 1 1 1 20 KNIOSH 1 125.11.78 t Isays 27 land C (Dally Halil 125) 1t 1 i i. t 33 103.11.78 1 11 1 16 101.03.80 1 1 11 \ 15 130.12.80 1 11 11 1 1 1 1 1 13 102.04.82 1 1 1 1 1 11 11 1! 11 11 11 1I 11 J1 11 Yes y Yes Yes Yea Yes Yea (Exposed In |Various Jobs E | a one degree 1 In PVC \ to 22 IpLaats from Ichenlcala (cold root to| [R Kaminski j1et ter of 12672/79 and |Prof. Tamburro {but main | paste (1et ter of {exposure 1 recovery to 19/1/79 |waa to VCM, |PVC charglagl tprobably (operator to (high | paste Ichargl rtg. |11L August 11965. |Terminated |employment fjan 1966 1 High (Operator to I Exposure In | R N Wheel er 110.10.76 Ibutk and jltr of 4 Jan Idlspersion PVC | 1979 and (manufacture | Charleston j Dal 1y Kali |30. II .78 and |R Kaminsk1 128/2/79 |R Kaminski (letter of 16/4/79 |R Kaminsk1 (Letters of | 19th June I960 1i |6 - Unknown | Maintenance \& 5th Nov 1980 |9 - Hlnlmal | Mechanic 16 yrs 1 Elsewhere lit yr IBoller house) |Operator |9 yra (High (But | Chemical 1 From 1959 to |Dr Dacey (not as high (Operator In (1976 Allphatlc 11etter |as reactor Icharge I Chemi cals |16.10.HI and |cleaner I reactor loperator and |R N Whee1er {would |f rom July 1976 |1et ter of (experience) |to date (9.11.8 t. | Norked as 1Foreman (Also Dr Dafey | Labourer |Allphat1c 11et t er of | f rom 1Chenlcal |07.0 1.8 l re IJune 1941 |to May 1946 |OperatIon | d ai e of deniU. land nay | have ' If li-niii-d | reae i ora 1 it 11 hat Lime _________ GENC 008664 _ Pgc 29 USA Sheet ft [Cl CHKMI CAI.S A POLYMERS (JWOl)P D LIVER Angiosarcoma Cases - (Review Date: l Jan 1987} IJK system of dates DAY - MONTH - YEAR WPX/ASL 2 - LANGtOCAShS, 13 14 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH l FIRST VC FACTORY | EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPGSURE DATE OF | HISTOLOGICAL | ESTIMATED | I DEATH | CONFIRMATION | EXPOSURE | OCCUPATION | OTHER CAREER HIGHLIGHTS [ | OTHhR COMMhNCn US 32 1 if t1 1C W Clrouxj 22-02 -08 | Monsanto Springfield 15-10-51 1 00-07-79 | 71 28 r 11 | Mass | 1 i E1 11 i i [1 ii t i 1 1f i i 11 11 i i 11 f1 1 i 11 ii 1 i fi 11 1 i 11 11 1 11 J1 1 11 11 1i 11 ii 1 11 ii 1 11 ii 1 11 1! 1 11 1f 1 11 1t 1 US 33 1l 1 11 j S Fe rgu son108-10-27 i BFC 11 11 |Louisville 09-09-54 i 11-05-82 | 54 28 | Jnr | 1 11 1 11 it i j 11 ij 1 1 11 it t US 34 1 1 | Mr Byrum 11 1[ |2 9--01--34 j BFC ii 11 |Louisville 1955 ti [ 03-11-82 f 48 27 US 35 09-03-1 2 S Charle-| 23-07-44 f 18-07-83 ston | | 1 1 14 |{in PVC lautoclave {area} i j i 1 1 1 1 1 1 1 1 1 1 1 i 1 \ 28 1 1 1 1 1 1 1 10 17-05-80 | An autopsy 1 j The death |1940-1951 | | was done and 1 certificate!Various Jobe| | Immediate iB.ve {In polymer f | cause of I Mr Giroux* {manufacture | | death given |usual |BUTVAR | J as (occupation |LUSTREX |"Angiosarcoma" | as "kettle|1951-1964 I | 1 loperator" |Various jobs| I |ln |1n and | i ^ |"chemicals |around PVC | | |industry". {autoclaves | I I 11964-1973 | | | | Various | I 1 Iclerlcal | 1 | |jobs In PVC | | | | polymerisation I I Ifaclllty/ | | | | Red red 1 1 lAllve 1 1 1 1 | Yes 1 1 j______________ 1 { 101-03-73. |Multiple | jobs (including I | | | (1 1 Poly i 11 1 I Operator + \ ii 11 104.08*83 [Yea . |Polycleaner.| 1 1 1 Poly |1965 left BFC {Operator + |to become a | Autoclave |Clergyman. |Cleaner 11955-65. { \ _____ High from | 1944 to | 1955, | Medium fromf 1955-1958 | 1 |Inf ormatton |given In 11et ter of 24 [February 1982 1 f rcm Dr |Ualter C |Ba rnes of |Honsanto |Spring!letd to |Dr A Munn of |Monsanto |u rope. 1 I 1 | 1 1 | \ Prof Tambu rrrj [letter of [12 Aug 1982 + [Dr h N Johnson |let ter of 128 Feb 1983. [Dr H N Johnson |]et ter of 13 Nov 1982, \28 Feb 1983 [and 9 Aug 11984 . I I |Dr Dacey (letter of |5 Sept 1983. I 1 27-08-32 The General Ashteb 111-06-56 121-08-83 50 2? 27 Alive Tire and Ula Moderate IJ956-56 |1abourer Rubber Co 11956-57 |prod helper 11957-70 J operator I 1970-75 GENC 008661 |e leetriel an 11975-present | operator f _________ | ft W [.aundr t < 11 e t t e t o f []2 Sept I9H l fspot led at | raed 11 a I | Hay ] 98 ). | lest 1 rig | comment- ni J May t 9 Hi I Page JO USA Sheet 7 Cl CHEMICALS 6 POLYMERS GROUP LIVER Angiosarcoma Cases (Review Date: t January 1987) VPX/ASL2 - LANCIOCASPS;* UK system of dates DAY - MONTH - YEAR 12 31 L J 4 5 t <> COUNTRY AND j NAME OR DATE OPj REFERENCE ]INITIALS BIRTH | NO j USA ______ 37 | Mr J 29.0B.29| |Payton COMPANY BFC JFIRST VC FACTORY |EXPOSURE ______ Louisvllle 1 1953 j 38 j JUB 28.08.221 A1 r Products Calvert 100.02.63 City 1 jL 39 | J Hem ice 27.06.181 Pantaaote Passaic 1 1960 J i i1 7 8 19 | 1 0 1 It 13 1 14 15 J6 DATE OF ACE AT 1 11 JYEARS OF | 1 |EXPOSURE | YEARS 0F| DIAGNOSIS DIAGNOSIS!TO | EXPOSURE! | DIAGNOSIS* 1 DATE OF DEATH |HISTO- | |LOGICAL | ESTIMATED! |CONFIRM-! EXPOSURE |OCCUPATION |ATI0N | LEVEL OTHER CAREER HIGHLIGHTS! OTHER COMMENTS 06.08.84 J 11 11 S4 | 31 | 22 106.08.84 1 Yes 1 High {Worked Information given In letter 09.O8.H4 i ii fregularly from Dr H N Johnson 19.01.84 1 1i |in PVC area 1 1I |In the i tI learly days i iI |vas a i iI J reactor i iI {cleaner ii t - 11953-75. ii t ii 1 1 1I 61 1 20 I 20 128.10.83 1 Yes | High |Normal 1 11 1963-1982\progression 1 11 |from helper 1 11 |to senior 1 t1 (operator, 1 j1 |c leaned 1 11 |reactors, I j1 |stripping i 11 {and t it ii |recovery j 1E lareas as 1 1J (well as 1 1f {charging 1 1J joperator. Thrombo cytopenla and leukopenia since since 1978. Cold treatment for arthritis 1976* Under Dr's care about 6 months before death, had passed standard physical examination 3 months earlier. J Barr letters of 22.10.84 and 21.01.85. March 1984 1 1 65 1 24 1 I i 1 i i 1 1 1 1 t 1 1 i f 1 1 1 1 f 1 1 1! 11 } 23 129.06.84 1 Yes | Low 129.09.60 - Worked t1 | Hay 66 before i I Vinyl 1960 11 1i i1 it High |Fabrication with US |Plant Air (Hay 66 - Force, |Aug 70 United 11 11 |Utility |Resin Wool Dye rs J1 |Operator and 11 |(inc Jul 66 Okanlte if f- Sep 67 11 |Reactor 11 i! | Operator) Low |Sep 70-82 j1 | Monomer 1f 1J {Operator Low | ]982-83 \1 | Ml 1 1 11 |Operat or, J( I1 1f | Ca i emJar | Shop , tint 1 1 |re tiremen t Never in hospital for any chronic or acute medical problems. Death certificate states cause of death cardlo-pulmonary arrest secondary to angiosarcoma of liver. Letter of 15.07.86 from John E Ertel of Pantaaote with letter of 24.02.86 from Dr Auerbach, Pathologist. GENC 008666 1 11 PaKe 31 YUGOSLAVIA ICI CHEMICALS 6 POLYMERS CROUP LIVER Angiosarcoma Cases - (Review Date: t Jan 19B7) VPX/ASL - LANG LOLAS I-S, 12 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH YUGOSLAVIA 05.04.14 Jugo Vlnll 5.11.31 Jugo Vioil 1.06.30 Jugo Vlnll 12 13 15 YEARS OF FIRST VC DATE OF ACE AT EXPOSURE YEARS OF EXPOSURE DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS Split 00.00.53 08.04.73 59 Split 00.00.50 2.07.73 42 23 Split 08.04.73 12.07,73 Yea* 03.09.78 VCH Production SARIC et al paper Env Health Perspective Vol L7. pp 169-192 1976 *In hie letter of 3 Oct 1978* Dr Splrtas of N10SH changed the status of Case 02 to VLM production employee. Dr Splrtas also notified a new Case 03 also a VCM production worker. Rose Kaminski letter of L9 June I960 and I ARC letter of 1 April 1982 GENC 0086*7 APage *2 Incidence of ASL Cases Per Annum TABLE 1 (Review Date - 1 Jan 1987) By date of death 1955 ............................................................................................... 1 60 7 ............................................................................................... 1 8 ............................................................................................... 0 90 1960 ............................................................................................... 0 1 .............................................................................................. 1 21 3 ............................................................................................... 0 4 ........................................................................................................................................... 2 5 ............................................................................................ 0 6 ............................................................................................... 0 7 ............................................................................................... 1 8 ............................................................................................... 5 9 ............................................................................................... 3 1970 ............................................................................................... 2 1 ........................................................................................... 3 2 ............................................................................................... 5 3 ............................................................................................... 8 4 ............................................................................................... 5 5 ................................................................................................ 11 6 ...............................................................................................11 7 ............................................................................................... 9 8 ................................................................................................ 10 95 1980 ................................................................................................ 10 1 ............................................................................................... 5 2 ................................................. ............................................. 2 3 ................................................................................................ 10 4 ............................................................................................... 7 5 ............................................................................................... 5 6 .............................................................................................^_2 Total 125 N.8. 1 Does not include Italian 01 but does include German 03. 2 The 1977 total includes US case 24 which is a Choiang tosarcoma . 3 The total does not include US 33 and 36, F 15 and G31 and 32 who are alive WPX/ASL2 - LANGIOCASES,8 GEMC 008668 Distribution of ASL Cases by Country TABLE 2 (Review Date - 1 Jan 1987) USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway 36 *** 31 ** *** 2i *** 12 10 5 **** t^ A AAA A 4* 2 2 2 1 Total 130 * Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangiosarcoma; & US 33 and 36, F 15 and G 31 and 32, who are alive. **** Includes one monomer worker. ***** Includes two monomer workers. i.e Western Europe North America Rest of World 76 46 8 WPX/ASL2 - LANGIOCASES,9 Total 130 GENC 00866 * e 3tf Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1987) (a) W Europe Of the 76 cases in W Europe, 65 have occurred in clusters at 11 factories. Of the 31 German cases, 28 have occurred in clusters at 4 factories. ASL Cases Dynamit, Troisdorf, Germany BP, Barry, UK Wacker, Burghausen, Germany Chloe Chimie (Formerly RP), St PCUK, Brignoud, France Kemanord, Sundsvall, Sweden CWH, Mafl, Germany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium Fons, France 12 9 9 8 7 5 4 3 '3 3 2 65 NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 46 cases in N America, 38 have occurred at four factories out of a total of 54 factories:- In N America 42 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston Goodyear, Niagara 14 10 10 4 38 NB: There are 28 pre 1962 PVC plants in N America; 12 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters of 2 cases. WPX/ASL2 - LANGIOCASES,10 UENc oos6?0  TAM,I1', 4A Latency Periods (Years from first Exposure to Diagnosis) (Review Date - 1 Jan 1987) W Europe N America Count ry Belgium France Germany Italy Norway Sweden UK No of Cases 2 21 31 4 1 5 12 76 Total Years 35 545 632 74 22 122 272 1702 Average 17.5 25.95 * 20.38 * 18.5 22 24.5 22.66 * 22.39 W Europe Average Rest of World US Canada 36 910 25.27 * 10 204 20.4 * 46 1114 24.21 N America Average Summary Czechoslovakia Japan Yugoslavia 2 2 4 8 30 15.0 39 19.5 85 21.2 154 19.2 Rest of World Average W Europe 76 1702 22.39 N America 46 1114 24.21 Rest of Wor1d 8 130 1 54 2970 I9 2 22*'8Q4, uWorildj Aj verage 6EMC 0Q8471 * Of the countries with below world average. > i0 cases, France, and USA have an average latency period above world average, Germany, UK and Canada WPX/ASL2 - LANGIOCASES.il DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1987) Belgium 1 1 1 1 1 1 1 Canada 1 Czechoslovakia France Germany Italy Japan 1 Norway i Sweden UK USA Yugoslavia TOTAL 1 1 1 1 1 1 1 1 1 1 I 1 1 0-9 yrs j 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 1 1 1 1 1 11 1 1i 1i 10-14 yrs 1 15-19 yrs i 11 11 1! 1 21 1 1 31 1 11 1 1 1 1 11 i 11 1 41 1 51 1 ! i ii i t r i i i 2i j i i i 12 i i 1 9i i 21 i 1i ii i ii 2i 1 51 1 71 i i i i 33 i i 20-24 yrs i i | 1 1 1 1 1 1 51 f 1 3 10* 2 1 1 1 1 1 1 f ! i i ti i i i 1 1 1 91 i 4i i i 35 i i 1 1 25-29 yrs i 1 1 1 1 21 7 5 1 I 21 4 8 1 1 1 1 28 i 1 1 ! 30-34 yrs 1 1 t 1 1 1 3 2 1 1 1 11 2 5 l 1 1 ( 13 1 1 11 11 ! 1 1 1 Average | 35+ yrs || Total 1 1 Latency J 1 1 ! 1 Period | 11 1 1 11 11 11 2 11 17.5 | 1 1 JI |1 11 10 11 20.4 | 1 f1 1 2 1t 15.0 | 1 11 3 J 21 11 25.95 | j 11 1 1 31 1 1 20.38 | 1 11 1 4 !1 18.5 | 1 1 ii_ii 11 2 11 19.5 | 1 ii I 1 f1 22 | 1 ii 11 5 11 24.5 I 1 11 1 12 11 22.66 | 1 11 5 1 36 1 1 25.27 1 I 1 11 41 1 11 21.2 1 11 11 1 1 11 1 8 1 1 130 11 22.84 | 1 1 11 * Includes G 03 aerosol can filler WPX/ASL2 - LANGIOCASES,12 Gf*JC 0086?2 Page J7 (Review date 1 January 1987) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE | YEAR OF 1 LATENCY PERIOD | FIRST EXPOSURE 1 LATENCY PERIOD (NO OF .YEARS) | ARITHMETIC MEAN 1 | OF LATENCY PERIODS 1 11 11 47 1 1939 1 38* | 1 46 | 1940 1 1 244 = 34.86 1 45 | 1 1 37,21,37,41 |7 1 44 1 2 I 32,38 I 1 43 1 3 1 38,14,32 | 1 1 4 1 28,11,24,20,24,34,39 1 718 = 26.59 1 1 5 1 27,22,28,29 | 27 1 6 1 21,29,31,26,28,15,23,1 1 1 I 1 30,35 I 1 39 1 7 1 29,24,29,28 38 1 8 1 28,24,34 1 I 1 ! 1 9 1 30,26,20 | 521 = 24.80 1 1 1950 s 1 26,22,31,19,23,14,33 | 21 1 1 1 1 19,28,17,28,34,29 | 34 1 2 1 21**,15 I 1 1 33 1 3 1 25,22,23,22,20,31,22,1 1 1 1 32*** | 1 1 4 1 21,21,25,25,21,28***,| 1 I 1 22 | 787 = 22.48 1 I 5 1 22,23,24,14,19,21,27 | 35 1 1 1 27*** 24,28,30*** 1 1 1 6 1 21,12,27*** | 1 29 1 7 1 19,17,15,13,16,28 | 1 28 1 8 1 18,18,15,17,20 ! ! 1 9 1 16,21,25,27 | 490 18.14 1 | 1960 1 13,18,21,25,24 1 27 1 1 1 1 15,16,16,16,19,19,12 | 1 24 1 2 1 13,18,17,12,18,21 | 1 23 1 3 1 16,17,20,21 I 1 1 4 1 16,17 I 180 = 16.36 1 1 5 1 11,19 1 11 1 1 6 1 9,18 19 | 7 1 16 ,! 1 1 1 18 1 8 1 18 1 9 1 13 11 | 31 = 15.5 1 1 1970 1 12 1 VIOLA 1 14 1 2 1 13 1 3 1 1 1 MALTONI 14 | TOTAL 1 1 130 CASES 1 1 GOODRICH I 2971 = 22.85 1 11 1 130 ! * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; F15 and G31 and G32 still alive. WPX/ASL2 - LANGIOCASES,13 6B-SC 008673 TABLE 4D Page (Review date 1 January 1987) LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION ~' MAX POSSIBLE 1 YEAR OF | LATENCY PERIODS IN LATENCY PERIOD 1 FIRST EXPOSURE | WESTERN EUROPE | NORTH AMERICA 11 1 47 I 1939 I ! 38* 46 1 1940 1 1 45 1 1 1 37,41 | 21,37 44 1 21 1 32,38 43 1 3 I 38 I 14,32 1 4 1 28 | 11,24,20,24,34,39 I 5 1 27 | 22,28,29 1 6 | 21,29,31,33 | 26,28,15,23,30,35 39 1 7 1 29 | 24,29,28 38 1 8 | 28,34 1 24 1 9 I 30,26 | 20 1 1950 1 26,22,31 | 19 1 1 1 19,28,34,29, 1 17,28 34 1 2 1 2r** | 15 33 1 3 | 25,22,22,32*** | 23,31 1 4 1 21,21,25,25 | 21,28*** 1 5 t 22,23,24,27***24,281 14,19,21,27 1 | 30*** I 1 6 I 21,12 | 27*** 29 1 7 I 19,17,15,13,28 | 28 1 8 1 18,18 1 15 1 9 | 16,21,25,27, | 1 1960 1 13,18,21,25 1 24 1 1 | 15,16,16,16,19,19 | 12 24 1 2 1 13,18,17,18,21 | 12 23 1 3 1 16,17,21 1 20 1 4 1 16 I 17 1 5 1 11,19 1 I 6 1 9,18 I 19 1 7 1 16 I 18 1 8 1 18 I 1 9 1 13 I 1 VIOLA 1970 t 1 1I 1 2I 1 1 MALTONI 3 1 TOTAL CASES 1 1 76 1 I 46 * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; F15 and G31 and 32 still alive 1 ROW | I 1 1 1 1 1 1 1 1 1 1 1 1 23,14 | 1 1 1 22,20 | 1 22 | 1 1 1 1 16 | 1 17,20 | 1 1 ! 1 1 1 1 1 I 1 1 1 I 1 1 18 1 WPX/ASL2 - LANGIOCASES,14 GENC 008674 TABLE 4E Page 39 (Review date 1 January 1987) PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF CASES AVERAGE LATENCY PERIOD LOUISVILLE 11 I 1940? | USA 11 TROISDORF 11 I 1954 | W GERMANY 1 1 SHAWINIGAN CANADA 1! I 1943 | 1(1941?)| 11 S CHARLESTON I 1939? | USA 11 11 12,14,15,19,19,20,24,27,28,28,28,29,29 31 12,13,16,16,18,19,19,21,23,25,28,29 11,12,14,21,22,23,24,24,26,28 24,30,32,32,34,35,37,38,38,39, 1 1 1 1 1 1 1 1 1 1 1 ! 1 1 14 | 1 1 12 | 1 10 | 1 1 10 | 1 1 23.07 19.91 20.5 33.99 WPX/ASL2 ' LANGIOCASES,15 GENC 008675 Page 40 TABLE 4F (Review date 1 January 1987) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) YEAR OF FIRST | LOUISVILLE | TROISDORF I SHAWINIGAN 1 S CHARLESTON EXPOSURE I USA | W GERMANY | CANADA 1 USA 1939 1 [ 1 38 1940 1 11 11 1 21 1 37 21 1 1 32,38 31 1 14 1 32 4 1 20 1 11,24 1 24,34,39 5 1 28,29,27 I 22 1 61 I 26,28 1 30,35 7 1 29,28 I 24 1 8 i 24 11 9 11 1950 1 19 1! 1 I 29 I 1 2 1 15 11 3 1 31 I 23 1 4 I 28 | 21,25 1 1 5 1 14,19 | 23,28 1 1 61 1 12 1 1 71 1 13 1 1 81 11 91 11 I960 ! 11 11 1 16,16,19,19, 1 12 1 2 I 12 1 18 1 1 WPX/ASL2 - LANGIOCASES,16 GENC- 008676 Page 4l TABLE 4G (Review date 1 January 1987) PLANT BARRY UK | 1 | | l BURGHAUSEN | W GERMANY | ST FONS FRANCE 1 | | BRIGNOUD FRANCE 1 ( | SUNDSVALL SWEDEN 1 } | NIAGARA USA 1 | | 1 SPLIT | YUGOSLAVIA| 1 MARL 1 W GERMANY START-UP 1948 DATE | LATENCY PERIOD OF ASL CASES 1 1 IN SPECIFIC PLANTS(4-9 CASES)| 1 9,17,18,28,31,33,18,19,18 1 1 1933 1 1 17,21,22,25,24,13,21,32,30 1 1 1939 1950 1945 1947 ! 1 21,28,29,37,38,27,41,34 i i i 11,16,18,26,30,25,34 i 1 I 16,19,27,29,31 i i i 15,17,21,23 | | | | 1950 1948 i i 20,20,22,23 i i i 15,16,22,21 | | NO OF CASES 9 1 1 1 1 1 91 1 1 81 1 I 71 1 1 51 1 1 41 1 1 41 1 1 41 AVERAGE PERIOD 21.22 years 22.77 31.88 22.85 24.4 19 21.25 18.5 WPX/ASL2 - LANGI0CASES.17 GENC 008677 Page 42 TABLE 4H (Review date 1 January 1987) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT ~~~~ (4-9 CASES) ~ YEAR OF |BARRY 1BURGHAUSEN| FIRST EXPOSURE I UK | W GERMANY| 1939 1940 1 1 1 1 1 1 11 1 1 2 3 4 5 6 .7 8 9 1950 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 131,33 1 I 28 1 1 1 1 1 1 1 1 1 1 1 21 3 4 5 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 1 1 1 1 1 1 1 1 I 1 18 1 17 1 1 19 19,18 1 118 1 1 1 1 1 125,32 121 122,24,30 1 1 17 1 1 121 1 1 1 1 t 1 1 1 1 13 1 1 1 1 | | | 1 I 1 1 | 1 1 1 1 1 1 1 1 | 1 1 1 1 ST FONSI FRANCE | 1 37,41 38 1 | 1 | 1 29 28,34 1 | 1 | 1 1 1 1 1 1 27 | 21 | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 BRIGNOUDI FRANCE 1 1 1 1 1 1 1 1 1 1 26,30 1 1 1 34 1 1 1 1 1 1 18 16,25 1 1 1 1 1 1 1 1 11 1 1 1 1 1 1 1 1 1 SUNDSVALLI SWEDEN | 1 1 I 1 1 27* 31 29 1 | 1 | 1 1 1 19 | 1 1 1 1 1 1 1 1 1 1 1 1 16 | 1 1 1 1 1 1 1 1 1 NIAGARA 1 USA 1 1 15,23 17 21 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 t 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SPLIT | MARL YUGO-IW GERMANY SLAVIAI' | I 1 I I 1 I 1 1 23* 1 | I 20 22* 1 | 22 | 1 1 1 20 | 1 1 115,16 |21 1 1 1 1 1 1 1 1 1 1 1 *Monomer worker WPX/ASL2 - LANGIOCASES,18 GENC 008678 Page 43 TABLE 5 (Review Date - 1 Jan 1987) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1 1961 2 4 7 8 9 1970 11 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 1986 TOTAL t1 1 1 | Western Europe | North America | Rest of World | Annual Total 1 1 11 1 11 11 !1 11 1 t1 11 1 1 11 11 1 1 1 112 |1 1 l |1 |1 I1 5 2 11 12 1 i t 1 14 11 |1 41 13 16 16 16 17 2 4 3 '2 12 1 1 1 1 1 !5 -1 16 I5 4! 01 |1 |7 f1 3 1 1 15 21 15 ! 1 12 | 73* ** 44** 1 1 11 15 I3 I2 13 15 318 -1 5 1 1 11 *2 1 11 19 1 1 10 -1 5 - 1 10 -! 5 12 1 10 17 !5 12 8 1 125 | Cumulative | | Total | Key Events 1 11 12 13 t4 16 17 1 12 1 15 1 17 1 20 1 25 1 33 1 38 1 49 i 60 t 69 1 79 1 84 1 94 1 99 i 101 fill 1118 1123 1125 ! 1 | | } | | | | | | | | | 1 ! | | | | | | 1 | | | 1 1 1 1 I 1 1 1 1 | Viola ! ! | Maltoni j Goodrich i 1 1 1 1 1 1 1 1 ! 1 1 I t * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not include US33, and 36, F15, G31 and 32. All still alive. WPX/ASL2 - LANGIOCASES,19 GENC 008679 Page 44 (Review date 1 January 1987) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) I KEY 1 I EVENTS 1 1 | WESTERN EUROPE i | NORTH AMERICA 1 i I REST OF WORLD 1 I 1 1955 16 1 1 Cl 1 1 1 1 17 18 1 C2 1 1 1 19 11 1 1960 11 1 1 | US8 1 12 | C3 1 13 11 i4 1 US5 1 Cz2 15 11 16 11 1 7 1 FI 11 18 | C4 ,C5 ,US4 ,US7 ,US10 1 1 9 1 G1 | US12.US16 1 |Viola 1 1970 I Swl 1 US11 1 1 1 G2 I C6.US2 1 1 IMaltoni 1 |Goodrich 1 2 1 Nl,Sw2,UKl,It2 3 | G3*** 4 | G4.G5.UK3 1 C7 I C8.US1.US3.US23 I C9.US13 1 1 Yl,Y2,Czl ! 1 5 | F2,F3,G6,G7,G8,It3 I 6 I B1,F4,F5,F6 ,F7,Sw3 | US6.US9.US18.US26 I US19.US20.US22, 1 Japl 1 Jap2,Y3 1 7 | F8,F9,G10,G11,G12,Sw4 | C10.US21.US24* 1 1 8 1 F10.F11,G9.G13.G15 1 1 G16.G17 I US27.US28 1 I Y4 1 19 1 1980 11 12 13 14 I F12.F13.UK4,UK5,G18 1 1 I UK6, UK7,G19,Sw5,G20,G21US I US17, US29, US30,US32| | It4,F14,UK8,G22,G23 1 1 1 G26 I US3 1 1 I UK09,It5,Fl7,B2,G24,G25,G30| US35, US34, US38 1 I UK10, FI6, FI8, G27.G29 | US37.US39 1 1 5 1 UK11, UK12,F19,F20,G28 1 1 1 6 ) F21.UK13 1 Total 1 73*** 1 1 j 44*** i 1 18 1 * Cholangiosarcoma ** Aerosol can filler *** Does not include US33 and 36, F15 and G31 and 32. All still alive. WPX/ASL2 - LANGIOCASES,20 GENC 008680 1 Page 45 TABLE 7 (Review date 1 January 1987) ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) KEY | EVENTS | 1 1 | WESTERN EUROPE 1 1 i NORTH AMERICA 1 I REST OF WORLD 1 11 1 1 1 1939 1 I US24* 1 1 40 1 1 1 1 1 |Frl1 ,Frl6 I C3.US27 1 1 21 I 3 | Frl4 | US13, US29 I C2.US19 I 1 1 4 I UK1 1 5 |Sw2 I Cl,C5,US5,US7,US28,US35 I I C4,US3,US9 1 1 6 IFr1,Fr3, Sw4 | C7,C9,US8,US11,US21,US31 1 1 7 I Sw3 | C6,US22,US26 1 1 8 |Fr9, Frl7 I US1 1 1 9 | Fr 12 , Fr4 I US12 1 1 50 1Fr7 ,N1,UK8,UK9 1 US16 1Y2, Cz2 1 1 |Swl,UK5,Fr20,G30 I US10, US32 1 1 2 | G3** I US4 1 1 3 |G15,It3,G26,G31*** I CIO, US37 1Japl,Y1 1 4 |G7,G8,UK4,G19 I US18.US33*** I Y3 1 5 (Gil,G16,G18, Frl5*** I US2,US17,US20,US34 1 1 IG23 ,G28 ,G32*** 1 1 1 6 |FR10.G1 | US36*** 1 1 7 IFr8,G4,It2,G2,UK12 1 1 Czl 1 8 |Fr6 ,B1 I US23 IJap2,Y4 1 9 |Fr2,It4 ,Frl9,Fr21 1 1 1 60 IG5,G13,G25 ,G28 I US39 1 1 1 |G9,G10,G12,G17,G20,G22| C8 1 1 2 |G6,UK6,G21,B2,G29 I US6 1 1 3 |Frl3, UK7,Frl8 I US38 1 1 4 I Sw5 I US30 1 1 5 |Fr5,UK11 1 1 1 6 IUK3, UK10 1 1 1 7 1 It5 1 1 1 8 IUK13 1 1 1 9 I G24 1 i Viola | 70 1 1 1 1 1 1 2 Maltoni | 31 1 1 11 1 1 1 Total|76 I 46 18 11 1 1 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** US33 and 36, Frl5 and G31 and 32 are still alive. WPX/ASL2 - LANGIOCASES,21 GENC 008631 wrX/ASL2 - LANGIOCASES.22 (Revise date 1 January 1987) TABLE 8 WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL GASES (CMITTING GD3 & It.01) | SIART-UPI COUNTRY NAME 1 COMPANY NAME | LOCATION | ASL CASE NUMBER | YEAR OF | YEAR I 1 I 1931 I West Germany |BASF 1 | Indwigshafen 1 1 | 1st Exposure 1 I 1933 llfest Germany IWhcker 11 I 1938 I Italy IMantecatini | Burghausen 1 |Acna 104,07,11,15,23,24 157,54,55,53,55,69,60,53 125,31,32 155 11 I 1939 I France |Rhone Poulenc/ |St Fons 1 |Atochem 1 I 1940 |United Kingdom|ICI |Runcorn 103,09,10,11,14 115,16,17 1 146,48,56,41,43, 155,41,48 1 | United Kingdom|ICI IHillhouse 101,04,12 1 1945 |Sweden IKananord ISundsvall(Stockvik) 101,02,03,04,05 |Switzerland ILonza/ICI since|Sins 1 144,54,57 151,45,47,46,64 1 1 11982 1 11 I 1946 I France IRhone-Poulenc IRousillon 101 146 1 1947 | Italy | Montedison I 1948 | United Kingdom|BP Chen/lCI 1 |since 1982 |West Germany lO-H/Huls 1 1949 |Belgian |Solvay I 1950 |France 1 | PCUK/Atochan 1' I Porto Marghera |Barry 1 |thrl IJemeppe IBrignoud 1 102 157 |03,05,06,07,08,09 166,51,62,63,50,50 110,11,13 166,65,68 109,10,26,29 161,61,53,62 101,02 158,62 102,04,05,06,12,19 159,49,65,58,49,59,51 120 1 I France |Rhone-Poulenc |St Auban 107 150 IHolland I Shell IPemis 1 1 | Norway 1 1951 I Italy I 1952 IItaly | Norsk I Montedison | Montedison IHeroya |Brindisi |Temi 101 1 1 150 1 1 1 1953 |Austria |France IHalvic ISolvay IHallein ITavaux 1 108,13,18 1 157,63,63 |Italy ISpain ISolvay |Rio Rodano |Ferrara IHemani 103 1 153 1 |United Kingdom|BIP | Aycliffe 1 1 |West Germany IHoechst I 1954 IWtest Germany IDynamit IGendorf | Troisdorf 118 155 101,02,08,12,16,17 156,57,54,61,55,61, 1 I 1955 ISpain 11 | Monsanto Iberia IMonzon 119,20,21,22,27,30 154,61,62,61,55,51 11 I 1956 ISpain ICaiqsa | Sabinanigo 1 1 1 IHispavlc | Torrelavega 1 1 1 1958 I West Germany ISolvay I 1960 IItaly |S C Ravenna | Eheinberg |Ravenna 1 104 1 159 |Vfest Germany ILonza/ICI since IWaldshut 106,13,28 ,162 60,60 1 11982 1 11 I 1962 I Portugal I 1965 I France |Italy ICires IRhone-Poulenc |Pozz I Oporto IMontlucon IFerrandina 1 121 1 1 159 1 |West Germany IWacker |Cologne 1 1 1 1966 | West Germany IHoechst | Knapsack/ Frankfurt] 105* 160 1 1967 |France |ATO Qiimie |Balan 1 1 ISpain |Greece I 1968 | Belgian |Rio Rodano |Esso Pappas IBadiphil | Miranda de Ebro IDlavata Salonika | Antwerp 1 1 1 1 1 1 I 1969 I United Kingdom|Vinatex |Staveley 1 1 |Italy IRuidanca | Cagliari Sardina 1 1 1 1970 |Italy |SIR IUnited Kingdom |ICI I 1971 I Italy |S C Ravenna |Spain |Hispavic I Porto Torres Sar |Runcorn |Ravenna IMartorell 1 1 1 1 1 1 1 1 I Sweden IKananord | Stenmgsund 1 1 I United Kingdom | BP Chan IBaglan Bay I 1972 I Finland IPekana |Svartback I Holland IDSM |Beek Limburg I 1976 I France |Soc Art D'viny] | ffezingarbe 1 1 1 1 1 1 1 1 I 1977 I Spain | Monsanto Iberia | Tarragona 1 1 * Laboratory worker in Research Department PANSAC, Mira Venice, case not included (It 05), due not kncwing start up date of the Plant. 6ENC 008682 TABLE 9 Page k7 (Review date 1 January 1987) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP 1 COMPANY NAME YEAR 1 I LOCATION 1 I ASL CASE I NUMBER | YEAR OF | 1st EXPOSURE 1939? l*UCC I S Charleston |07,13,19,21,24,|44,42,43,46,39, 1 1 127,28,29,31,35 141,44,42,46.44 1940? i *BFG 1 Louisville 101,02,03,04,05,148,55,45,52,44, 1 1 106.09,16,17,22,162,45,50,55,47, 1 1 126,33,34,37 147,54.55.53 1946? l*UCC 1 Texas City (Partially closed 1977)| 1947 I Goodyear 1 Niagara Falls 108,10,11,20 146,51,46,55 1948 1 Firestone/ 1 Pottstown 112 149 1950 | Occidental 1 Uniroyal 1 | Monsanto 1 1 Painesville 1 (closed 1975) 1 Springfield 1 1 1 132 1 1 1 , |51 I 1952 I Dow 1 (Closed 1975 1 1 Midland (No PVC since c 1975) 1 | I BFG Avon Lake 118 |54 1953 1 BFG 1 Deer Park (Formerly Diamond) | 1954 I General Tire 1 Ashtabula 136 156 1956 1 |(Closed 1984) 1 1 Air Products I Pensacola 1 I Atlantic Refining 1 Brooklyn(Closed late 1960s) 1 1 | 1 Borden 1 Leominster (Closed 1984) | I Conoco 1 Hebronville (Closed 1975) | 1 BFG I Great American 1 Niagara 1 Fitchburg 1 123 1 |58 1 Plastics I Hooker 1 (Closed 1983) 1 1 Hicksville (Closed 1980-81) 1 | I Pantasote 1 Passaic(Closed 1984) 39 | 60 1957 I Atlantic Tubing 1 Cranston (Closed 1967) | I Tenneco 1 Flemington NJ 130 159 1958 1960 1 | Keysor Century I BFG I Air Products 1 (Closed 1985) 1 Saugus, Cal 1 Watson, Cal 1 Calvert City 1 I 1 138 1 1 1 |63 1 1 (closed March 1982'- Re-opened October 1983) 1962 1963 | Borden 1 Illiopolis 1 | Tenneco/Occidental 1 Burlington NJ 1 | Conoco/Vista 1 Aberdeen, Miss 1 | Stauffer 1 Long Beach, Cal (Closed 1982) 1 1 1 | 1965 I Conoco **| Assonet, Mass (Closed by Olin 1975, see below) 1 Ethyl 1 Baton Rouge (Closed 1984) | 1966 I Georgia Gulf 1 Delaware City (Formerly Diamond) | |Gen Tire/Pantasote 1 Mt Pleasant W Va |(Closed 1982) I 1 BFG | Stauffer 1 Henry, 111 I 1 1 Delaware City (Sold to Formosa 1983) 1967 1968 | Allied *** 1 Painesville, 0 1 1 ! (sold to Robintech) | Hooker/Occidental 1 Burlington NJ 1 | Firestone 1 Perryville (Closed 1982) 1 | 1 I 1969 1 BFG | Goodyear 1 Pedrickton NJ 1 Plaquemine 1 i 1 1 | Olin **| Assonet, Mass (Closed 1975) (See above) 1971 t (Formerly Conoco) 1 | Conoco/Vista 1 Oklahoma City 1 1 1 1 WPX/ASL2 - LANGIOCASES.23 Continue d GENC 008683 Page 48 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP I YEAR 1 1972 | 1973 | | 1 1 1 1974 1975 1979 1983 1 | | | | | | | | | COMPANY NAME | LOCATION | Nat Starch 1 | Meredosia, 111 1 | Borden | Springfield | Robintech *** | Painesville, 0 I | (sold to Georgia | | Pacific who | | converted to | | polystyrene) | .Atlantic Tubing/ | Cranston RI (Closed Tallyrand Shintech 1 I Freeport, Tex 1 | Certain-teed | Lake Charles | Georgia Pacific I Plaquemine, La | Tenneco/Occidental | Pasadena, Tex | Firestone/ |'\ Plaquemine | Occidental Formosa 11 | Point Comfort, Tex| ASL CASE NUMBER 1982) 1 YEAR OF | 1 1st EXPOSURE | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refers to same plant at Assonet ***Refer to same plant at Painesville. Allied plant never operated again for PVC after it was sold to Robintech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL2 - LANGIOCASES,24 GENC 008684 Page 49 (Review date 1 January 1987) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP | I YEAR 1 1 1 1943 | 1(1941?) 1 1 COMPANY NAME Goodrich 1 LOCATION 1 1 1 Shawinigan 1 1 I ASL CASE | NUMBER 1 101,02,03,04,05 106,07,08,09,10 1 1 YEAR OF 1 1st EXPOSURE 1 144 ,43,41,45,44, 147 ,46,61,46,53 1 1 I 1951 | Monsanto 1 1i 1 La Salle (Closed 1975) 11 1 1 1 1 1 11 1 1957 | Goodrich 1 1 Welland 1 1 1 1 1 1 1966 | Esso 1 1 ! Sarnia 1 1 1 1 I 1 1 1 11 I 1979 | Diamond Shamrock Alb 1 Fort Saskatchewan 1 1 11 1 1 1 WPX/ASL2 - LANGIOCASES,25 GENC 008665 (Review date 1 January 1987) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES |START-UP | COUNTRY NAME I COMPANY NAME 1 YEAR 1 I IPre 1939 (East Germany |State Company 1 1941 |Russia |State Comps | 1950 1 Yugoslavia 1Jugo Vinil I 1951 |Czechoslovakia |State Comps 1 1955 |East Germany |State Comps I 1956 |Rumania I State Comps 1 1957 |Poland I Rumania |State Comps |State Comps 11 ! 1958 |Rumania 1 1959 |Hungary 1 1961 |Rumania I 1963 I Yugoslavia 1 1965 |Bulgaria I 1967 I Poland 1 1969 |Russia I 1970 I Rumania |Russia |State Comps |State Com^s |State Comps I Ohis |State Comps |State Comps |State Comps I State Comps |State Coraps 1 1972 |Yugoslavia |Vinilplastika I 1975 |Czechoslovakia |State Comps |Russia |State Comps 1 1976 1 Yugoslavia 1 Hip I 1977 |Rumania |State Comps | LOCATION 1 |Schopau |Vladimir et al I Split |Novaky IBitterfeldt |Icechim |Osweicim (Dwory) |Tirnaveni |Turda |Risnov IBerente Borsod | Borzesti 1Skopje |Varna |Tarnow | D.1 erj insk |Rimnicu Vilcea |Volgograd |Zadar |Neratovice IKalush Area |Pancevo | Rimnicu Vilcea | ASL CASE | NUMBER 1 I |01,02,03,04 101,02 1 1 1 ! 1 1 1 1 1 1 1 1 ! 1 1 1 1 1 1 1 YEAR OF 1 1st Exposure 1 1 153,50,54,48 I 57,50 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,26 GENC 008686 Page 51 (Review date 1 January 1987) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES | START-UP| I YEAR 1 I 1950 | 11 11 1 1951 | I 1952 | 11 I 1951 | 11 11 1 1955 | 1 1956 | 11 1 1957 | 11 I 1960 | 11 1 1964 | I 1966 | I 1967 | 11 I 1968 | 11 1 1970 | I1 11 11 1I 11 11 I 1971 | I 1973 I I 1974 | COMPANY NAME Chisso Corp Kanegafuchl Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahi Glass Toyo Soda 11 I 1975 | Central Kagaku I 1 Toyo Soda 1 1977 | Unknown | LOCATION 1 | Minamata | Osaka | Sakata | Nagoya | Yokkaichi | Kikumoto | Shibukawa ( Kambara | Tckushima | Uozu | Takoaka | Takeo | Nishiki | Naoetsu | Ohmi | Takasago | Chiba | Tokuyama | Tokuyama | Chiba | Mizushima | Tokuyama | Mizushima | Goi (Chiba) | Kashima | Kawasaki | Sakai I Chiba I Kashima | Yokkaichi I Hayatsuki | Sakata | Yokkaishi | Kawasaki | Yokkaichi | Kashima I ASL CASE | NUMBER 1 t 1 I 01, 02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 53, 58 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ! 1 ! 1 1 1 1 ! 1 t 1 1 1 1 WPX/ASL2 - LANGIOCASES,27 GENC 008687 Page 52 (Review date 1 January 1987) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS |START-UP | COMPANY NAME | YEAR 1 I 1953 | Monsanto Mexica | 1954 | Policyd I 1955. | Geon Do Brazil 1 1956 | Elchlor I 1960 | Electrochlor | Viplastic 1 1961 | tndupa 1 1965 |(SOC Paramanga 1(1967 start up | PET Columbiana 1 1966 | Carburo De Col 1 1967 | Plasticos Omega 1 1968 | Primex I 1970 | Policasa | Petro Dow 1 1971 | Polimeros Mex I 1975 | Rico Chemicals 1 1976 | Petroplas I 1977 | Indust Resistoc I 1978 | Huls Brasil | Polychem | Policyd 1 1979 | PET Camacari I LOCATION 1 11 | Lecheria (Mexico) | Mexico City (Mexico) ! 1 | Sao Paulo (Brazil) 1 | Sao Caetano (Brazil) 1 ICapitan Bermudez(Argentina) 1 | Mendoz (Argentina) 1 I Cinco Saltos (Argentina) 1 | Paramonga (Peru) 1 ) h Cartagena (Colombia) 1 1 I Medellin (Colombia) 1 I Mexico 1 I Puebla (Mexico) | Managua (Nicaragua) 1 1 I Conception (Chile) 1 | St Martin Puebla (Mexico) 1 | Guyanilla (Puerto Rico) 1 | EL Tablazo (Venezuela) 1 ] Tlazcala (Mexico) 1 | Cubato (Brazil) 1 I El Salvador 1 | Coatzacoalcos (Mexico) 1 I Camacari Bahia (Brazil) 1 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,28 GEM'- 008688 Page 53 (Review date 1 January 1987) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP YEAR | COMPANY NAME | 1 Mid 1950s | ICI Australia 1 1960s [ B F Goodrich 1 Late 1970s| ICI Australia i i | LOCATION 1 1 | Botany, Sydney ! \\ Melbourne i | Laverton | Melbourne 1 | 1 I | 1 I 1 | 1 1 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,29 GENC 008689 * Page 54 (Review date 1 January 1987) TABLE 15 MIDDLE EASTERN PVG, PRODUCERS START-UP DATES START-UP DATE Sept 1986 COUNTRY NAME Saudi Arabia COMPANY NAME LOCATION National Plastic Company )(Ibn Hayan) |Arabian Petrochemical |Madiant |Al-Jubail |Al-Sinahyah Company I I i! WPX/ASL2 - LANGIOCASE S,30 QENC 008690 Countr 1C1 CHEMICALS & POLYMERS CROUP LIVER Angiosarcoma Cases - (Review Date: l Jan 19..) 1 12 1 i COUNTRY AND 1 NAME OR REFERENCE |INITIALS NO 1 31 1 DATE OF | BIRTH | 4 COMPANY i 5 16 7 1 8 |9 1 10 | 1 1 12 i n i 14 1 15 | l 1 i 1 1 1I i i1 | |YEARS OF i i |HISTO- i i i |FIRST VC DATE OF |ACE AT |EXPOSURE 1 YEARS OF | DATE OF J LOGICAL |ESTIMATED! 1 1 |OTHER 1 1 | i FACTORY |EXPOSURE DIAGNOSIS!DIAGNOSIS|TO |EXPOSURE! DEATH | CONFIRM--1 EXPOSURE j OCCUPATION |CAREER | ii | |DIAGNOSIS! | \ATION |LEVEL |HIGHLIGHTS! WPX/ASL - LANGIOCASbS,t 16 OTHER COMMENTS 1 * t GENC 008691