Document gb4QXxmdpG7MYJRZa4K66B5LJ

FILE NAME: Sperry Rand (SR) DATE: 1955-1957 DOC#: SR013 DOCUMENT DESCRIPTION: 9 Individual Abstracts from Mellon Institute ! i j C U M in iD S U U tC T avtmoki 6. G. Jacob and H. B oh lig. n uNsUwHi Mini r NFC wus. I n c id e n c e and c h a r a c t e r is t ic s o lu n g c a n c e r in a s b e s t o s w o r k e r s . one. acre.. G e r m a n . *. A rch. Gewerbepath.j 14 --G ew erb eh v F . ! W. 10-28 OAT*' AMT*. IFf.i (195SK I B ull. Hyg. VOL. VO. OATC 30 1080 12/55 T h is is a study of the incidence of lung c a n c e r am ong a sb e sto s w o rk e rs in. D re sd e n . T h e in te r n a tio n a l l i t e r a t u r e i s b a s e d e x c lu s iv e ly o n th e r e s u l t s o a u to p s ie s ; th e in c id e n c e am ong a s b e s to s w o rk e rs a p p e a r s to v a ry b etw een 12 and 17% In D re s d e n , h o w e v e r, f r o m re s e a rc h into c a s e s at the clin ic and am ong a sb e sto s w o rk e rs, it a p p e a rs to be r a r e , i t b e ing e stim a te d th a t only about o n e -fo u rth of th e se w o rk e rs have an effective e x p o su re to the do st. In co o p eratio n w ith the ra d io lo g ic a l and ra d iu m in stitu te s the a u th o rs rev iew ed th e c a se s of asb e sto sis rep o rte d sihee the m iddle of the 1930s. T h ese num bered 339 in a ll stag es; they a r e c la ssifie d acco rd in g to -stage and sex . S ilic o sis w as found in eight m a le s. In five fem ales and ten^m ales (4.4% of the to tal) activ e open tu b ercu lo sis w as found. F o u r fa ta l c a se s of lung c a n c e r in a sb e sto s w o rk y ra, w hich o c c u rre d in D resd en up to 1954, a r e ' d e s c rib e d .. A long d isc u ssio n of the lite ra tu re on c a n c e r am ong asb e sto s w o rk e rs in clu d es an exam ination of the c h a ra c te ris tic s of the d ise a se ; these a re no lo n g er convincing evidence of -a h ig h in c id e n c e of c a n c e r in a s b e s t o s i s . In th e f u tu r e , c a s e s o f c a n c e r of th e lu n g in 'a sb e sto sis should not be published individually but should alw ays be co n sid ered in the fra m e w ork of the w hole asb esto s in d u stry in the reg io n . -- Cond. fro m B ull. Hyg. e < l,. 'H & o r irAKMt A-- THACT HANK fON dCNCKM. UM P CMU .UOMWICONtIP m e N UH >D NFC 752 author. H. B a s t s n ie r , H . D e n o lin , A . de C o s t e r , and M E n g ie n t. Tm.c A stu d y ot r e s p ir a t io n in p u lm o n a r y a s b e s t o s is . < OMI6. ner.__ F r e n c h ." A B srvt. n c r e . 1 o A r c h , m a la d ie s ~16 p 4 6 -5 5 3 j 1955' m a . p r o f e s s . -------------- B ull. Hyg. 31 | 544 I 5 /5 6 la o rd e r to te s t th e re s p ira to ry value of lungs affected w ith a s b e s to s is nine c a se s w e re c lo se ly stu d ie d . T he se v e n m e n and two w om en had been exposed to a s b e s to s d u st, 1 ,0 0 0 to Z, 000 p a r t i c l e s p e r c u . m . , f o r 18 to 30 y e a r s . T h e p a tie n ts d is p la y e d d e f in ite u sym ptom s of a sb esto sis w ith troublesom e cough and dyspnea, and all showed x -ra y shadow s b lik e ground g la ss extending o v e r both lungs. No tu b e rc le b acilli w ere found in any c a s e . A ab definite reduction w as found iu v ital capacity, but the m axim um ex p irato ry volum e w as s a tis z factory. B reathing, how ever, w as accelerated by hyperventilation. At re s t breathing w as 7) sufficient and satisfacto ry , hut on exertion dyspnea appeared, varying considerably acco rd ing to the p a th o lo g ic a l le s io n s in the lu n g s. T h e se fu n ctio n al changes w e re in no w ay d if f e r z e n t f ro m (h ose s e e n in o th e r c a s e s of p n e u m o c o n io s is . V a ry in g e m p h y s e m a w a s fo u n d , b u t u*w"v ; n o s p e c i a l s t r a i n w a s th ro w n upon th e h e a r t . -- Cond. from B ull. Hyg. M j OATC FFR o r t r * c w i ___________________________ A M TK A CT BLANK FO R B C N IR A L UBC c o * rro 0 CLAMIflED IUMRBT mtowMttr vntMMn FILK NUMMR ... NFC pz autho* . G. Jacob and H. Bohllg, Pittsburgh, Tirub Roentgenographic com plication* of pulmonary a sb e sto sis. <m<. w a te r m a n . vet* FP, OATS AMTS, M M ., VOL. FT. Fortachr, Gebiete | A m . R ev. Tuberc, 73 202 Rantgenatrahlcn.... _ai 515-525 ..Qc.L.153_____ ________________ AMTRACT.t OATS 5/56 O ver a p erio d of approxim ately fcwoaty y e a rs, 343 c a s e s of a sb e sto sis, 130 la women and 213 In m en, w ere observed in D resden, a cen ter for indnstries using asbestos. The m ost common complications w ers pleural thickening, com pensatory emphysema, and nonspecific peribronchial, peribronchiectatic, and bronchopneumonia inflammation*. Pleural} changes w ere found in 49 p e r cent of toe cases, 5 p e r cent of which had extensive, irre g n - ' la riy shaped calcifications. Active pulmonary tuberculosis was p rssen t in 4 .4 p sr cent of toe cases: bronchogenic cancer was not m ore frequent than in the general population but, when p resen t, w as found relatively often in toe low er lobe. -- Am._Rev^ T uberc. S,BPITTSBURGH, QATK C X A K lH E O i OLAW M P1CD S tlftJ S C T S*U*PO*E OP EKAUCHi a m t h a c t W.AHK r n oew cral u t m uwwip Hxmmm WL* MUMftK* Me Navrafcil, V. Krecek, and L. Cvachova, - * N:r. TFisCsir.sfv. 7 5 2 TlTUli R esu lts o functional resp iratory and circu latory te sts of w orkers exposed i to a sb estos dust over a number of y ea rs. om. gr. C zech.____ v o u ___ PK___ OATS ABITR. RKPS.i VOU. Pracovni Lekarstvi 8 329-33: 1 1956 jBuIl. Hyg. |32 !!1 abstract. Sixty w o rk ers exposed to asb esto s dost w ere classified according to se v e rity of asb esto sts and according to age. They w ere subjected to functional te sts for prolonged expiration and to r v en tilato ry coefficients, and to electro card io g rap h y . In the o v e r SO age group, quite apart from all radiological data, a drop in vital capacity is found, due net m e re ly to age but a lso to em physem a w hich w as detected in 19 patien ts. The ventilation coefficients in the asbestosts-free and early asbestosis groups w ers within norm al lim its. In those with advanced asbestosis there was a distinct drop in the ventilation coefficients, due to fibrosis and associated pathological conditions. The differences in the carbon dioxide ventilation coefficients and in the vital capacity figures w ere on the lim it ot slgnifl- j cance. H ypertrophy of the right h e a rt w as p re se n t in two subjects w ith advanced a sb e sto sis, Cond. from Biitt. Hyg. JksIiihwi FFR furposk , ftK 8M B 6H L . ABSTRACT BLANK FOB SSN C r AL UBC E PUIHWFS SCPCSmtHt EXHIBIT TkMflOVtUJfctfS o a u - z v - 't e C L A in en u u c ct ai ! I ' ihe il-Jw AUTHOR! H. B oh lig and G. Jacob. rru -o v * * M ir NUM BER NFC Ti-n-i, N ew v ie w p o in ts on p u lm o n a r y c a n c e r in a s b e s t o s w o r k e r s . F IU H U M ID 75 3 MEI.LON INPTII'UTK, PlTTflnUIlQIl, PA oma. <?. G e rm a n . *t- D eu t. m e d . W ochschjr. 87, 231 . . . . . _______________ 1___L.23.3. AOSTR. R if * , i !Feb. 17, 'jj?6. J. A m . M ed. A s s n . 161 916 16/3C/5 i T h e {olio-wing d is tin g u ish in g f e a tu r e s hav e b een a ttrib u te d to the lung c a n c e r th a t bas been reco g n ized as an occupational d ise a se of asb esto s w o rk e rs: (1) in c re a se d in c i dence; (2) d ev elo p m en t at an e a rly age; (3) d ependence on d u ratio n of ex p o su re to a s b e s to s dust; (4) a laten t p e rio d betw een o n se t of ex p o su re and the a p p e a ra n c e of the c a n c e r: (5) t h e l o c a l i z a t i o n ; (>) t h e h i s t o l o g i c a l s t r u c t u r e ; a n d ( 7 ) t h e m u l t i c e n t r a l o r i g i n . T h e a u t h o r s d is c u s s each of th e se p o in ts, and snow th at th e re is little c le a r e v id en c e to su p p o rt any of i h e .ae a s s u m p t i o n s , w i t h e x c e p t i o n s n o t e d . W o m e n w o r k e r s i n t h e a s b e s t o s i n d u s t r y h a v e lung can cer m o re often, and at an e a rlie r age than do o th er w om en, but the sam e is not tr u e of m e n . M a lig n a n t g ro w th s of th e p l e u r a s e e m to o c c u r m o r e o fte n in a s b e s t o s w o r k e r s than in o th er p e rs o n s. The m u ltic e n tra l developm ent is o b serv ed also in w o rk e rs exposed to co b alt and to c h r o m a te s . T he stu d y of the p a th o g e n e s is is s till in the s ta te of h y p o th e s e s , and the theory of m e c h a n ic a l p ath o g en esis is given m o s t co n sid eratio n . M ic ro tra u m a s and a s b e s to s b o d ie s a r e a lw a y s found in the p u lm o n a ry c a n c e r s of a s b e s to s w o r k e r s , b u t the au th o rs feel that this does cot n e c e s s a rily p ro v e the m e c h a n ic a l theory. T hey cite se v e ra l fa c to rs that speak ag ain st a p u rely m e c h a n ic a l path o g en esis of a sb e sto s c a n c e r, but they co ncede th at the d ev elo p m en t of s o -c a lle d a s b e s to s w a rts p ro v e s the ir rita tin g effect of asb esto s on hum an tissu es. -- Cond. from J, Am. Med. A ssn. I BT* AM IN CD l -v. F P R or toCN- *VWi*OSC A*TRACT C U N * fO R OCNCRAL U9 Z eo trro , 'N X N s ra ru a 'iE, P i t t s b u r g h , P a , ciAMinco Muia FKM.9WMIIP mukdi* riLK MUMMER M-- J s& *uwo, j , F r o st, J. G eorg, and P . F . M oller. NFC J 3 L WL"' A sb esto sis with p leu ral ca lcifica tio n among insulation w o rk ers. onto, s e n .) Danish. Med. B ull. 3 202-204 N ov.'S? j Bull. Hyg. 32 2 W ~ 3 /5 7 In D enm ark only a few person* m anipulate Insulation products Including asbestos, kieselg u h r, m agnesia, g la ss wool, and. rode wool. The f irs t two b a rs boon re g a rd e d as ftbrogenlc to Hie lungs when th e ir dust la inhaled, l a o rd e r to a s c e rta in any occupational r i s k la the w o rk 31 w o rk e rs w ith m o re than 20 years* exposure, of 52 y e a rs av e ra g e age, w ere carefully exam ined clinically and by x -ra y . A bnorm alities w ars found in the s u rp ris ing num ber of 22. A total of nine exhibited fine m ottling Indicative of pulmonary asbestosis. h i 19 patients p leu ral changes w ere seen, which w ere due to adhesions and extensive thicken ing with calcification. The abnorm alities in the pleura w are so w idespread la som e instances aa to obliterate other pathological changes, The calcification is unusual and m ay be ascribed to com bined ex p o su re to c a lciu m and m agnesium in the p reaen ce of ftbrogenlc a sb e sto s d u st. Sam ple an aly ses of the k ieselg o h r in u se did not re v e a l fits p resen ce of alp h a-q u arts. The finding of pronounced b ila te ra l p le u ra l changes in fits p resen t s e rie s definitely points to a a `occupational origin. . . . . Cond. from Bull. Hyg. DATS rXAMIKtO. E F R m jfltipote O r CAWCHi CONTO- Mellon Institute, Pittsburgh, pa II CUMIPID SUfeJin m u o w iN ip NUMIO Z 'f AlTTNOti E . S a r to r e llL . NFC mu. S evere a sb e sto sis with a lv eo -ca p illa ry block syndrom e. omc. ntn., Ita lia n . DATS A B STR . R E P S .i VOL. Med. iavoro 48 358-362 1957 B ull. Hyg. 02 riL K M UM UV 752 969 p e t . *57 The author re p o rts a case of sev ere a sb e sto sis in a m an aged 57 who w as em ployed for seven y e a rs in a v ery dusty a sb e sto s facto ry . T h re e y e a rs a fte r com m encing w ork the p atien t com plained of dyspnea on e x e rc ise , w ith slig h t sputum , the condition b e cam e p ro g re ssiv e ly w o rse and finally be w as sen t to a san a to riu m as a case of com bined tu b e rc u lo s is and a s b e s to s is w ith a d isa b ility of 507.. A fte r two y e a rs , in sp ite of h is r e s p ira to ry sy m p to m s, h e s ta r te d w o rk a s a g e n e ra l la b o re r, and w as ad m itte d to the a u th o r's clinic th ree y e a rs la te r w ith a re c u rre n c e of c h est sym ptom s. No tu b e rc le b acilli w ere found. X -ra y of the ch est show ed in ten se re tic u la tio n e sp e c ia lly in the m e d io -b a sa l re g io n s, sm a ll zones of fib ro s is in the rig h t a p ic o -c la v ic u la r a re a and thickening of the p le u ra a t the left b ase. T e sts of re s p ira to ry function showed dyspnea on repose and m arkedly so on ex e rc is e , and w hile re s p iro m e try gave only slig h t a lte ra tio n fro m n o rm al, the oxygen s a tu r - a tio n w a s only 907*. T he d iag n o sis of advanced a s b e s to s is w as m ade on account of the "m arked re sp ira to ry insufficiency, absence of tuberculosis, increased erythrocyte sedim entation ra te and hypergam m aglobulinem ia. -- Cond. from B ull. Hyg. BATS CXAM IH CDi PURPOtC O r IK A N C H i ABSTRACT BkANK PO A GENERAL. USE CLABliriKD IUBJKCT riLT NUMBER i ' O i . ___ 753 K. M. Lynch, F . A. M clver, and J. R. Cain. Tirut, P u lm o n a r y tu m o r s in m ic e e x p o s e d to a s b e s t o s d u st. Inbtitutk, FiTTanvmcm, Pa OH1C. REfft.i A rch, Ind. H ealth VQL MR. 15 1207-214 1 OATS ARITR, RErt.i M ar .'5 7 ! 1 VOL. w* 11 A T X <cn M ice of a se le c te d s tr a in (AC F j } w e re exposed to & d u sty a tm o sp h e re c o n tain in g a s b e s to s flo a ts of a type u sed by o th e rs e x p e rim e n ta lly , at 150 to 500 m illio n p a r tic le s p e r c u b ic fo o t. T h e l a r g e s t s in g le e x p e r im e n ta l g ro u p c o n s is te d of .127 a n im a ls k ille d a t 19 'm o n th s a f te r e x p o su re lo r 17 m o n th s. T h is g ro u p w as c o m p a re d w ith 222 c o n tro l a n im a ls . P rim a ry lung tu m o rs w e?_dem onsirated m ic ro sc o p ic a lly in 467. of the d u sted m ic e and in 367< of the c o n tr o ls . M u ltip le p u lm o n a ry tu m o r s w e r e d e m o n s tr a te d in 1&7< of th e d u s te d a n im a ls and in 87. of the c o n tro l a n im a ls . No sig n ific a n t h isto lo g ic o r cytologic d iffe re n c e w as o b se rv e d betw een tu m o rs in the two g ro u p s. No c le a r - c u t p ro o f of m a lig n a n c y w as z found in any of the lung tu m o rs stu d ie d . The au th o rs have been unable to d e m o n stra te any . proof of the c a rc in o g e n icity of a sb e sto s u n d er the conditions of the ex p e rim e n t, but the &j in c re a se d incidence of m ultip le lung tu m o rs in dusted an im a ls m u st be re g a rd e d a s a p o s s i tt b le accen tu atio n by the in halation of a sb e sto s d u st of an ex istin g tendency to develop lung s tu m o rs. F u tu re ex p erim en ts w ith asb esto s should include the use of ia rg e r a n im a ls, p ro b ably m onkevs. The equivocal n atu re of this re p o rt does not an sw er the questions ra is e d by accum ulating clin ical evidence that asb e sto sis is stro n g ly asso ciated w ith, and th erefo re is a p o ssib le cause of, pulm onary carcin o m a m m an. - - A dapted from a u th o rs' su m m ary DATS dUAmHiIHCDi ... " > ___________ f * f R _____________ su rto sC J" ' : ~ o r s c a k c m .________________ abstract >u m i fo r ccheraa. u s e CONT*B.