Document gaz04jQyQBYD9v81YewL6x64Q
^1 Allied. , ^vll Chemical
Allied Chemical Corporation PO Box 1057R Morristown New Jersey 07960
January 12, 1979
Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N.W. Washington, DC 20009
RE: Vinyl Chloride Research Program Continuation of Multi-Component Studies At the University of Louisville
Dear Mr. Clark:
Pursuant to the letter of January 3, 1979, by Dr. J. D. Dougherty of Allied Chemical, on the above subject, please be advised that Allied Chemical sold itSf~Vihyl chloride^ operations in the Baton Rouge area to ICI America and is no longer significantly involved in the EDC/VCM area. While we support in principle the continuation of the research program, we suggest that the request for financial support by better directed to the current manufacturers.
We, of course, will continue in our interest in the research program and would appreciate being kept informed of results at the appropriate time.
Sincerely,
QmH \ Qk/Uj^
JBC:abg
//Joel B. Charm, Director ^Corporate Product Safety
bcc:
J. D. Dougherty W. S. Ferguson
W. C. Fox T. D. Kent J. Plaut H. J. Robinson
AS! 000011681
Industrial Chemicals Division
PO Box 113SR Morristown. New Jersey 07960
January 3, 1979
Mr. A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N,W. Washington, D.C. 20009
Subject: Vinyl Chloride Research Program Continuation of Multi-Component Studies at the University of Louisville
Dear Mr. ^A/Lark;
This is to advise you that Industrial Chemicals Division of Allied Chemical Corporation is no longer involved in the EDC/VCM area and that Mr. Joel B. Charm, Director of Product Safety in Allied's Corporate Office will be the Allied participant on MCA's EDC and VCM Technical Panels.
We are forwarding your letter of December 13 and Ms. Henschel's letter of December 20 to Mr. Charm and ask that you send all future correspondence and reports to him.
Sincerely,
J, D. Dougherty, M.DO Director-Medical Services
cc: T*' Charm/Allied
L. C. Hensche1/MCA
A$I 000011682
ALBERT C CLARK
VICE PRESIDENT TECHNICAL DIRECTOR
MANUFACTURING CHEMISTS ASSOCIATION
1825 CONNECTICUT AVENUE. N.W , WASHINGTON, D.C. 20009
December 13, 1978
TELEPHONE. (202) 328-4240 TELEX 89617 (MCA WSH)
John D. Dougherty, M.D. Director - Medical Services (ICD) Allied Chemical Corporation Industrial Chemicals Division P. O. Box 1139R Morristown, New Jersey 07960
Subject:
Vinyl Chloride Research Program - Continuation of Multi-Component Studies at the University of Louisville
Dear Dr. Dougherty:
The Technical Panel on Vinyl Chloride Research recommends continuation of the multi-component research program being conducted by Dr. C. Tamburro at the School of Medicine, University of Louisville. This research has as its objectives the design of methods for early detection, prevention, diagnosis and treatment of those individuals exposed to potentially toxic chemicals with the aim of preventing any serious injury, precancerous lesions, or the development of cancer either on a short or long-term basis. The program is designed to identify, at the earliest possible time, potentially harmful chemicals and to lead to a reduction in their exposure based on objective chemical data. This is the third year of a three-year research program and it is the view of Panel members that if this overall program is to yield optimum results it is important that con tinuity be preserved.
The technical proposal and budget involve three parts:
A. Research Techniques and Methods for Detection and prevention of Carcino genesis in industrial workers
B. Whole Body Autoradiographic Study of Vinyl Chloride
$260,734 $ 13,500
C. Vinyl Chloride Metabolism in Isolated Mammalian Liver Cells TOTAL
$ 13,550 $287,784
ASI 000011683
2- -
Administration costs will be covered by funds remaining from the second year of research.
The technical proposal, sent to your company's Technical Representative on October 4, 1978, contains additional informa tion on the type of research being conducted and a breakdown of costs.
The attached response form lists your company's maximum pro rata share. Should the number of companies participating be greater than anticipated, your company's share will be reduced proportionately.
Work under the second year of research will be completed in February 1979. in an effort toward eliminating the costly interruption of this research, we reguest that you return the attached commitment form by December 22.
Sincerely
cc: Technical Panel
ASI 000011684
MANUFACTURING CHEMISTS ASSOCIATION
VINYL CHLORIDE RESEARCH PROGRAM
Continuation of Multi-Component Studies at the University of Louisville
CompanyAllied Chemical Corporation
Management ContactDr. John D. Dougherty (if other than indicated, please correct)
Technical Panel Member Dr. John D, Dougherty (if other than indicated, please correct)
//
My company hereby commits a maximum of $ 9,268_________ as its pro rata share for support of the subject program presented in A. C. Clark's letter of December 13, 1978. Should the number of sponsors be greater than anticipated, the pro rata share will be reduced proportionately.
Name (signed)
Name (typed)__________________________________________
Title_____ _______
____
Address
Telephone________________________________________________
Z__ /
While appreciating the opportunity presented, my company has decided not to participate in the program.
Please return one signed copy by December 22, A. C. Clark Manufacturing Chemists Association 1825 Connecticut Avenue, N.W. Washington, D.C. 20009
1978
to:
ASI 000011&85
MANUFACTURING CHEMISTS ASSOCIATION
VINYL CHLORIDE RESEARCH PROGRAM
Continuation of Multi-Component Studies at the University of Louisville
CompanyMl Iff CV^cal Corporation
Management ContactDr, John D. Doogherty
(if other than indicated, please correct)
Technical Panel Member Dr. John D. Dougherty
(if other than indicated, please correct)
/__ /
My company hereby commits a maximum of $ 9, 268 as its pro rata share for support of the subject program presented in A. C. Clark's letter of December 13, 1978. Should the number of sponsors be greater than anticipated, the pro rata share will be reduced proportionately.
Name (signed)
Name (typed)
Title_______________
Address
Telephone___________________________________________________
Z__ /
While appreciating the opportunity presented, my company has decided not to participate in the program.
Please return one signed copy by December 22, A. C. Clark Manufacturing chemists Association 1825 Connecticut Avenue, N.W. Washington, D.C. 20009
1978 to:
ASI 000011686
MANUFACTURING CHEMISTS ASSOCIATION
1825 CONNECTICUT AVENUE, N.W., WASHINGTON, D.C. 20009
TELEX 89617 (MCA WSH)
December 20, 1978
To: Ethylene Dichloride Technical Panel
Subject: European Participation in the Metabolism Study
Members:
Enclosed is a copy of my letter to Professor Bartalini dis cussing the problems of finding a European coordinator to keep the participating European companies fully informed, plus assume responsibility for the collection of funds.
Please mark the'attached ballot, approving or disapproving not having European participation if we cannot get a European company to act as a coordinator.
LCHipmt Enclosures
Sincerely,
JU C.
Lucille c. Henschel
Project Manager Ethylene Dichloride
4250
THE WRITER S DIRECT DIAL NUMBER IS (202) 328-
ASI 000011687
Manufacturing Chemists Association
RESEARCH PROGRAM ON ETHYLENE DICHLORIDE METABOLISM STUDY
/ 7 My company concurs with not having European participation
if MCA cannot get a European company to act as coordinator.
/ / My company does not concur with not having European partici pation if MCA cannot get a European company to act as coordinator.
Name (signed)
Name (typed)_
Company_______
Address
i
Telephone,
Please return one copy by January 26, 1979 to: Mrs. Lucille C. Henschel Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009
ASI 000011688 I
Manufacturing Chemists Association
RESEARCH PROGRAM ON ETHYLENE DICHLORIDE METABOLISM STUDY
/ 7 My company concurs with not having European participation if MCA cannot get a European company to act as coordinator.
/--y My company does not concur with not having European partici
pation if MCA cannot get a European company to act as coordinator.
Name (signed)
Name (typed)_
Company_______ i
Address____
Telephone
Please return one copy by January 26, 1979 to: Mrs. Lucille C. Henschel Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D. C. 20009
ASI 000011689
1
i )
MANUFACTURING CHEMISTS ASSOCIATION
1825 CONNECTICUT AVENUE, N.W., WASHINGTON, D.C. 20009
TELEPHONE (202) 328*4200 TELEX. 89617 (MCA W5H)
December 20, 1978
Professor E. Bartalini Diretorre Medicina e Igiene del Lavoro Montedison Via Appiani, 12 20121 Milano, Italy
Dear Professor Bartalini:
During the past two years, MCA has acted as coordinator for the American companies involved in the long-term ethylene dichloride (EDO) inhalation study, while Montedison administers the study. We assumed that during the metabolism study, you would fulfill the same function, as MCA has in the previous study, for the European companies interested in active participation.
If you are unwilling to act as the European coordinator, can you suggest a company that would fulfill this role and give .us an indication of how many companies would be interested in participating in the study. We would also appreciate a list of the other companies, including names of the responsible individuals and addresses.
Thank you for your prompt reply.
Sincerely,
LCH:pmt
Lucille C. Henschel Project Manager Ethylene Dichloride
4250
THE WRITER S DIRECT DIAL NUMBER IS (202) 328-________
ASI 000011690
I From ALBERT C. CLARK
December 13, 1978 Dear Dr. Dougherty:
We are enclosing your proportionate share in case you decide to participate.
ASI 000011691 1