Document gapVvpE21z4JLbqxYOeeaoMJJ

AR g86- 3289 47 . AR226- 3289 DouPwonce114s18 --_ `TRADE SECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 4 of 5 Laboratory Project ID: DuPont-11418 TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (AUG-1998) ~~ AUTHOR: Susan A. MacKenzie, V.M.D., Ph.D., D.AB.T. STUDYCOMPLETEDON: August 1, 2003 PERFORMING LABORATORY: E.L du Pont de Nemours and`Company Haskell Laboratory for Health and EnvironmentalSciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Requesr Noo:(EY Service Cope Noes: (QY TT Rema Company Santized. Doss no contain TSCA Gal 9H-02-5D4a2y5:GavSaugbeehSrtoundiyc iTnoxRiactistywith One-Generaton Reproduction Evaluations --~ Dupont-11418 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS --~ _-- 505 Company Sanitzed. Does not contain TSCA CBI $10.2D5a42y5:GaSvuabcghrSonyie TinoxRiactistyith OneGeneon ReproductionBruatons DuPont-11418 --~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS EXPLANTORY NOTES A Accidentlyevkielnleldy(iinncjluurdeedswahneimnablesipnrgehsaenndtieedd.deaIdn-oirfemoarnidbnuencdrothpastyhfaivnediinngjsumreadytbheemusseeldvetso or make this determination.) LeHpsisittoonpaGytrhao.dloigniTgchael cdhisatnrgiebsutiaorne d(eesxtcernitboefduisasecs,cuuoneridliianntvgerotalolv,tebhmieelinarttme)roairlsp,ihenodtlieocgaAtiecds,cehvwaehrraetcrtyeaesrpc,pordroieps,itrfriiabtuet,iobny eapprroprsiates,ucishaalssofoacsals,igmnueldtiafsocfaoll,lodwisf:f + Minimal: the amount of change present barelyexceedstht which is considered to bewithin a dnooersmanloitlmipgmrietonsde.urcae, atnhylfeusnicotnioinaelasiimlpyaiidremnetnitfi.ed biugtniofficiatntepodtesnetvieariltfyo. The lesionprobably incteased severity. + SLSieemvceirtuee:rdettihseshudeeegolrreesoeiroognfacinshdpayrnsogfmueinnicestnietiotnbhueirstptaoshsescrioebmlipe.lsete as considered possible or great enoughin - + Intensity or extent to expect significant issue or organ dysfunction: Comment: gsradues mminiwmiatlhtmhirnoiumgahlsrelaevdseierosensrsebeperciensoegtntthheeprm[oeogarrspehssoseilvvoeegrinecvaaanlldcehsmaeevrnearctetseleretiseiiocrnstsyobfaellieonsngigotnhase, hey aolvseorisn,dicWahtieltehethiereglative biological significance. Gross observations listing multiple masses for a tissue are distinguished with eters Geab.e d,etc) Neoplasm Designations "B: "M: MBaelniiggnnannetonpeloapslma,spmr,ipmrairmyasriytesite Abbreviations RSeucbocvh == rseucbocvherroynic -- Sio- CompanySanitized. Doesnot conTtSaCAiCBnI 1e.2a54s25G;avSaugbechrSotnidciTnoRxaitctvyithOeGeneration Reproduction Bvaunion --_ supY 542gpmoavlieng(+ aAInnPidPniaRvlOiVdEduDaat0laPRmAOafnTfoiOrkmCgaOilLnIdL_i*i)vsiStdeixun:agl Waanlilmals sAtnuintmaS l RefMCsWiereTsrceoaptimcen&t:Macroscopic Findings 565008 rKBeirrtpmloiesnauarloenGsarDcoaryuipf:i:c1e217eCOv Eo: ia signed off from necropsy DuPont-11415 " - Gross Patholoay Jo MaocrCoscopOiNcEYAbSn,ormLaUlNGiSt,y OHEbAsReTrS,vTeOMdSAKCEHL,ETADLUODMEUNSUCML.E. JESITULNCEEC, IEAOr,rReAaNCiRLAna,RGDS,,SPGILSNACCNAEIDGLNSUTM,CI,OCRMDACN,OEVLRDOVINEB,,ULARPERICTTLUOYIMMT,PAHRMYENSGOSLDNAEINBDSS,RTOIHPCYIMAUSLSEe.Sr,t NE O O E D iNDea,sk,,PBAYREUART(SIH)NYRAWORIIYDTHSGLLAOADPNDTDEISRC,,NETTRREVASECT,KEESR,S,KIENP,IDIPPRVOMSITDASTSE:: SEOR/KNEE JOINT, STERNDN, NOSE Histopathology LIVERA+FLAMTION, SUBMCUTS/CHRONIC, minimal. ~ No Wi"TcHrYoRsOcIoDpiGcLAANbDnormality Observed : --~ on CompanSyaannitizad. Doesnot contTSaCAiCnBI BFo-2D5a42y5G:avSaugbeehSrtounidyiTonxRiactistywithOneGenerationReproduction Evaluations ~~ sroov Su 5425/Smhaolwieng(*anIAinPmdPaiRlvOiVdEduDaat0laPmRAoOfn/oTikrOmgCaiOlLn1dLi*i)vsiStdeixu:naglMaanliemsals Jka Treatment: Animal Ref `Microscopic & Macroscopic Findings 665015 TKSexirplmolisenudarleonSGDaracoyruipf:i:c9e2subch Innal is signed off from necropsy Dupont-11415 Gross Pathology : No Maoecnnroc:scopRBiRIcAPINNEA,YbSn,oSrPmLIUaCNNlEAGCiLSUt,MyC,ORHODEbC,AOsRLeTOrS,NvT,eOdSAKRCEE:HCL,TEUTMAD,LUODMMEUENSSUCEMLN.ET,EJREISJCPULMELUEiRNM.,eH ADAA EtO.,ADLGGRILEGVAaRANNERDDRS,YS,,GPLSAACRNIADATSTH,IYCRMONAIEDNRDVGIELB,AUNLDAPSRI,TULTITMTRAPACHRHYENAOGS,DKLEIA,NBN.SDOTPHPHRYAOMCSUUTSSA.TE, R SEMUtR/KN/LVEAEERSYIIJCNOELI,ENST,,EYEUS(RTSIE)NRANWURMIY,THBLNAOODPSDTEEIRC,NETREVSET.ES, SPIDIDYNIDES. Histopathology LIVERIIANTFLTAYMMCAHTAINOGNE,, SPEURBIAPCOURTTEA/LC,HROmNiIlCd,. minimal. ~ KIDNEYESRRO: NIC PROGRESSIVE NEPHROPATHY, minimal. TEYHE(OSS)`AHTERWMOIOPTRHHRYH,AOGPETR,IECTImNiNAnELiR,mVaElU.N: ILATERAL, mild. PROSTAAGTGERE:GATES, LYMPHOID, minimal. 665015 Continued on the mext page ---- on Comp`apanynySanitSaniit zed. Doesnot contTSaCAiCnBI S25o42y5G:avSaugbeeShruodniyc iTnoRctistwyithOne-GenerationReproductionEvalotions DupontLisi ~ sropy. 5425S/hnoawlieng(+ anAIinPdmPiaRvlOiVdEduDaat0laPmRAofOn/oTirkOmgCaOilLnI dLi)ivsiStdeixun:aglMaanliemsals Suny IO ng/kg Treatment: Animal Ref Microscopic & Macroscopic Findings s65015 Continued from previous page histopathology No MiCCcrSoescoRnp"MiRABc. CCTAHObN,,noSrKMDmEUEaOLSlDEEiETNNtATUyLEMR,MOIUbCSsJCeELLJrYEUvM,NePUdHMS,PNLOEDIEELN,E,UNS,AAOLRIPTAVANA,CRRYEBARGSAL,TANN,DCSH.CSUPMI,NAL SoSBNORRUOnT,Le:AARYRBGGLOLAPYNRMDAP,GHUSTN,OHDYERP,OHIAADRDYIRGNLEA/NNLADAL,RYGILPKAIA,NDRDEMSSTS,,HKIYNRSF,OCEIIMDASUTERIGM/LCIKANNNNAEDELESR.VVJEEO,SIINCT.LES: R STERE NUM, BLBAODNDEERY,ARRTOEWS,TESN,OSEEPIDIDYM 665016 TKEeixrlpmloiesnduarleonGSarDcoaryuipf:i:c9e2subch SAPoAl is signed off from necropsy Gross Pathology Mo MacrosCcO opiIcDNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETADLUODMEUNSUCYL,E, JESJPULNEUEMN., --~ LIA LeEn.. ABBIRAVAMIACANNRR,EDAYSS,S,PGILSCNACENAICDLAUSTM,CI,OCRMDACN,OENLRDOVSINETB,,OUMLAAPRCREIHCT,TLUUYTMMA,PRHYMENOSGDELEAN.NTDE.RTIHCYMULSY,MPH OOPTRRRtKAhLWB/GLGGAILLRACUNLNDEK,,SP,EAYREAU(TRSHI)YNRAWORIIYDTHBGLLAOADPNDTDEISRC,, NETTRREVASECT,HEESA,S,KIENEP.SIODPIPHDRAYOGMSUITSDA.ETSE., SEMUR/KNES JOINT, STERNUM, NOSE 665016 Continued on the next page ---- --~ ons CompaannyySanSiantiitizzetd.DoesnotcontTSaCAiCBnI 1D.2a54y25G:aSvuabgcehSrtondiyciTnoxRiactistywithOneGeneration Reproduction Evlunions Dupont11413 ~ stupy 5425/Smhaolwieng(* aAnIPinmPdaRilvOiVdEduaDaclaPmRAofOn/oTirkOmgCaOilLnI d_Li*i)vsiStdeixu:nagl Maanliemsals stor MRR Animal Ref C kG Treatment: 0 Microscopic & Macroscopic Findings 665016 Continued from previous page Histopathology LIVERNAF:RLTAYMACTHAINOGNE,, PSEURBTAPCOURTTEA/LC,HROmNiInCi,malm.inimal. KIDNEYLSSRO: NIC PROGRESSIVE NEPHROPATHY, minimal onesA:FLAMATION, SUSACUTE/CHRONIC, PERIVASCULAR, minimal. `SPIDIADGYGHRIEDGEASTE:S, LONPHOTD, minimal. Nos I: NFLAMMATION, VONERONASAL ORGAN, minimal. Mo MiOecriOosc,opSiLcDBOATDbAEnLNorGIWm,UCaSlCJiLLEtYEJyM,UPNOHUbSMPsN,LeOEDrEEvIN,eL,dEOSNAA,OLRITPVAAA,NRCYRBERGAALISAN,N,DSC,SCPUIMMNA.ANLDCICOBLOUOLRNAD,R S RA TRAWCOHS ERo,D/S,EOGSELONAPTTNHHEDYA,RMGUUSST,,HYARPDOHRIAEDRNYANGLLKA/NLGDAL,ARNYDNPSEA,,RATSHCYIARTOIICDEMNGIELNRAAVNLED,SV,ESICLES. ~ TRRYIBTLHADDOEPRT,ICTNEESRTVEES,, SFKEIMNU,R/KPNROESETAJTOEI,NT,S STERNUM, BONE MARROW --~ re o CompanySanititized. Doesnotcontain TSCACBI 2r5a42s5;GaSvuabgeehSoundiyciTnoRxiacistywithOne Generation Reproduction Evilsions ~~ soy 5425/Smhaolwei.ng(*anIAinPdmPiaRvlOiVdEduDaaclaPwRAafOnloTirkOmsCaOilLnX_dLi*)ivsiStdeiuxna:gl Maanliem?als stor Animal Ref 0G rreacnent: 0 Microscopic & Macroscopic Findings s65042 ADEcuxcrpiaodtseiunortneiaslGolfrsyoidugoKpnsieild:nlgero-dfedfcaoyvfsr:om1n27ecropsy Poet uron1iese or or Gross Pathology No MaAcrCoscopSiacvAebn,ormLaUNlGiSt,y OHbEAsReTrS,vTeOMdSAKCE:HL,ETADLUODMEUNSCULME,, JESTPLOENEUNR., EBTLERO, TDiETGNNNLGAA:RNREDRYSS,S,GPLISANCCNEAIDCLASUTM,CI,OCRMDACN,OENLRDOVINEB,,ULRAPERICTTLUUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTIHCYMAOLGSEI.SH AA T BGR R, SCAaSDiICk,L,ESP,AFYRBAU(TRSHI)YNRAWORIIYDTHBGLLAOADPNDTDEISRC,, NETTRREVASECT,HEESA,S,KSIBPNSIODPBIRIDOTSMTIADTEES SEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER| F: LAMMATION, SUBACUTE/CHRONIC, minimal. ~ LovesMVAE+CMROORPRHHAAGGEES,, AALLVVEEOLOALRA,R,miFnOCiAmLa,l.minimal. PANCREEAASSJ: OF CELLULAR ALTERATION, BASOPHILIC, minimal. mPAoRnATs`HMYERMOOIRDRHAGGLEA,NDmSil:d. EE(S)wAItsWsIeITNHGN.OEPRTVIECNONTERVPREESENT, UNILATERAL. 665042 Continued on the next page -.-- -- 5 o Companyany SaniSanitzed. DoesnotcontainTSCACBI 1S2o54y25G: rSeubgchSrowndiyciTnoRxiactitwyithOneGenernion Reproduction Bvilions Duvon11s1 rs stom 425 Smhaotweingr(e*aanIAtimnPemdPnaiRtlvO:iVdEduDaat0laPmRAafOno/TirkOmCyaOilLnIdLi+)ivsiSetdxiu:naglMaanliesmals sony AP Animal Ref like T Wiorescopic & Macroscopic Findings or - s6s082 Continued from previous page Histopathology No MiocroD scopiceAARbTn,omSaKlEiLtEyTALObMsUeSrCvLeEd, : SPLEEN, DENGM, `JEJUNUM, AIOLRETQAM,, SCERCAUTYN, OESROESu sohfabh.,GLw,AiNSDTi,WOMEANSTCOEHHDNY,ETR,EODRIUIADOCDGRLLEAYNNWADPL,HGNTLORADNAEDC,SH,EAS,ASLCIIESVASIATOCRIPLYCHEASGGN,ULESAR,NVUDER,SI.NARY a PL, RETES,SKSIPNI,DIDPYRAOISDTSAST,E, FSEEMMUDRN/AXLNEVEEJOINT, STERNUM, BONG MARROW, NOSE ORGANPSARNAOTTHYERXOAIMDINGELDA:NDS 665063 mKEeirrlpmloiesnduarleonGSarDcoaryuipf:i:c1e2r1ecov Doel is signed off from necropsy --~ Gross PathJooloMgaOycrCo: scopOiNcEYAmSn,omLaOlNiGSt,yCOROHDbE,AsReTrS,vTeOWdSAKCE:HL,ETDAULODMEUNSUCMLE,, JSEPJLUENRIY,, DO ALO,E R GITANNGCLRR,aEDYASS,S,GPLSIACNCNBAIDCLASUT,MI,CMACNOENLRDOVINEB,,ULARPREICTTLUUYIMMT,PAHRMYENOSGDELENA,NTDE.RTIHCOULSi.es 465043 Continued on the next page ---- --_ | 5i6Companypany SaSnaniitized. Dossnot containTSCACBI 2905.4D2a5y;GavSaubgcehSrourdiycTinoxRiacthstywithOneGeneradon Regrodotion Evaluations Duron-Lisio -- sont 5425 Smhaolweing(*anAIinPndPaiRlvOiVdEduDaat0laPmRAoOfn/ToikOrmCgaOilLIndL_i*i)vsiStdeiuxna:gl Maanliemsals Son MR o/kg Treatment: Animal Ref `Wioroscopic & Macroscopic Findings 565043 Continued from previous page Gross Pathology : No MaOcroD scopitcaMADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS, NTERRAVEC,HEAS,KINS,SOPREOASGTDAST,S: DESEEEVU/R/CaNEmERtIJCkOLI,ENST,,EYEUS(RTSIE)NRNAURWMYI,THBNLOOAPDSDTEEIRC, TESTES, EPIDIDVNIDES, Histopathology LIVER`ESNAFTLTAYMMCAHTAINOGNE,, Nery CHANGE, MSPEUEDBRIAIACPNUORTTECAL/LECF,HTR,OmNiImnCii,nmiamlma.iln,imal . THYROTTDWPGRTLRAODPH:Y, FOLLICULAR CELL, minimal. 665047 mKEeixrlpmloiesnudarleonGSarDcoaryuipf: i:c9e2subch fs signed off from necropsy Poa) --~ Gross Pathology No MaCEcrRRo.scopGSiaNciEnYA,bSn,oSrPmLIOaNNlAGiLSt,yCORHODEbC,AsORLeDOrS,NvT,eOdMSAKRCEE:HCL,TEUTMAD,LUODMMEUENSSCUSLMNE.I.SRJSLSTCPULNLECeCELr,t TAEEOANRLRDLGTILCVARANERDASYS,,GLSCACBNICDNUSTM,I,CMANENRDVIEB,ULAPRITLUIIMTPAHRYNOGDLEA.ND,TEYMUS. 665047 Continued on the next page ---- : ~~ on Companyny SaniSanitized. DoesnotcontTSaCAiCanl 5205.4Da2y5G:ovSugbeehSrtoundiyciTnoRxaiicistyithOeGeneration Reproduction Evaluations DuPont 11415 Ps srupy 5425/Smhaolwieng(* aAnnPidPmiRavOliVdEduDaat0laPmRgAOfn/oTikrOmgCaOilLnIdiL*)viisSdteuixa:nlgMaanliemsals Sumy O Animal Ref Jka Treatment: icoscopic & Macroscopic Findings TT 665047 Continued from previous page Gross Pathology No MaoTcreomsscop/iGLcLAARNIADNb,Kn,orDmEAaYRElA(iTStH)yYRWOOIbIDTseHGrLvOAePNTdDISC:, URINARY BLADDER, NTETRREVASECT,HEESA,S,KIENEP,SIODPIPHDRAYOGMSUITSDA.ETSE., E SEMUER/KNEVRESIJCOLIENST,, STERNUM, NOSE Histopathology LIVER:EINNFTLTAYMMCAHTAINOGNE,, SPUEBRAIPCOURTTEA/LC,HROmNiInCi,malm.inimal. xIDNEYSSRONIC PROGRESSIVE NEPHROPATHY, minimal. LovesWENORRUAGE, ALVEOLAR, minimal. mensHEMORRHAGE, minimal ADRENA"ALDRGELNAANLDSMED ULLA MISSING. ~ PROSTAAGTGERE:GATES, LYMPHOID, minimal EPIDIDNVGGMRIEDGEASTES, LYMPHOID, minimal NOSE N: PLAMYATION, ORAL MUCOSA, minimal. 665047 Continued on the next page -.-- --~ Co isCompanypanySaniSatniitizzee:d. Does not conTtSaCAiCn8 1o25o425; vSaguSbeoanitiTnoxRyiactistyvithOne eoeraion Reprucion rains Duport11a1s --_ stuoy 5425/Smhaoewi.nsgr(e*satALnmnPieaPaniRatvO:iVdEduDaac0laPnRAafOno/TirkOmCsaOilLn3dLi*)ivsiStdeixu:neglMaanliemsals soy Uv - Animal Ref Ges047 `Microscopic & Macroscopic Findings Gontinued from previous page sistopathJoologMyiEcOroDscopa icNAMbno,rmWaOSlCiJLAtEJy,(NOUbSNPs,LeErEvINeL,dEUNA,ORTPAA,ICRBERAASI,N, CSHPUMINAN.NADLICOBCLOUORLNDA,:R ROO CTH,E RDLOPSavRnAaieeRN,,CNELRNTiVREEApR,CSK,ENXRoI,pPNEI,,ETSUOSISPATEULAUAIRDGYVNUAASRGL,LYAVNGEPDSHL.IAACRLSTTEH,ONSYN.XR/OUBILRADAIRRGNRIALOTRNAYD. EE Fe. pav/KuNERE JOINT, STERNOH, B ass049 rKEBoxirplmolyisenudarleoSnoSGarDscoairyugipnfe:idc9e2sofufbchfrom necropsy Gross PatJhooloMgaT LycIrVoERs,copKo IiDcNEYASb,aneoNrmTAaGlLsit,yCORWODbE,sReTrS,vTOeWdSAKCEHL,ETADLUODMEUNSOCNLNE,F,EJRSISICPULNELOE1NAN,,PH --~ EA A E, 5pCSe, :. RuSAaCCiTIBiINoCsTI,I,RCOWIACNDOENLRDOVIGNEBL,,UANLDARPSERI,CTTLUUTIIMRTE,AAKCRWHYEENROSGS,DELKEAI,NNE.DS,TORTPUHRAAOUGSSUT.SA,TE, T EHRaItNeR . JOxI,N?EYSSETRSEI)RNNAUWRMIY,THBLNAOODPSDTEEIRC, NETREVSET,ES, BPEDIDVAIZES. 465049 Continued on the next PAGE: -- oe o CompapnyanySariSatniizec. DossnotcontinTSCA CBI F5-02D54a2y5:GaSvuabgeetrSoundiyciTnoRxiactitvyith OneGenertionReprodction Balusions Dupont-11418 --_ srupy 5425S/hnaolweing(+anAIiPnmPdaiRlvOiVdEduaDat0lamPRgAOf/noTkirOgmCaOilLnId_Li*)ivsiSetdxiu:naglMaanliemsals sony WIP Animal Ref kg Treatment: Microscopic & Macroscopic Findings rr 565049 Continued from previous page Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. TEYHE(OSS)HENWMP5OILRTARHMHMAAOGTPEIT,OINC,miNnEPiREmRVaIElO.CULAR, UNILATERAL, minimal PROSTAAGTGERE:GATES, LYMPHOID, minimal. No Mie ecrSoe scopSioecLNUANALGb,Sn,oCrOmHRDEaC,AlORLiTOtS,NyT,OMOSAbKRCEsEHCeL,TrEUvTNeAD,dLUOMDMUEESNSCUELMNE,T,ERJEISJPCULNELUEYMNM,,EKFINLOOERURTME,,. SE TReR RRoEe GArS,N.GELRCAVENCEGU,DLMSA,,NPDISNT,AUNIDTTIRASARCYUHLEGAALR,ANLDYE,MSPOPHTHHANYGORUDOSEI,,D GALDARNEDN.AL GLANDS. PHASRTMEISK,/LARINX. TSReVwiSDEWRISNA,L VFEESMIUCRL/EKSN,ESURJOLIWNATR,Y SBLTAEDRDNEURM,, BTSONE MARROW, NOSE ~ 665066 TKEeixrlpmloiesnduarleonGSrDaoacryuipf: i: c1e2r1ecov nimal is signed off from necropsy Gross Pathology No MaocrnoscopRiIcPNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vTeONdSAKCEHL,ETADULODMEUNSGCNL,E, JESJPULNEUSSN,, APHO GBADRGALALNIIAGVNNRA,EDRASYS,S,GPLISACNCNEAIDCLASUT,MCI,OCRMDCNA,OENLRDOVISNEB,,ULARPERICTTLUUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTHIYCMULST.MEH 665064 Continued onEthAe Lnext page ---- : --~ "520- Company'SaniSantiized.Doesnot conTtSaCAiCBnI H25e2r5:avSausbeeShounideiTnoxRiacsitwyithOne GenerationReproduction Eraunion Duroniinie --_~ supY 25425 Smhaolweing(+enIAinPndPaiRlvOiVdEduaDatlaPmRAaOfn/oTirkOmgCaOilLnIdLi*)ivsiStdOiuX:nasgl aalneismals Sr A Animal Ref WLC ng/kg Trestmenc: 0 Microscopic & Macroscopic Findings " 665064 Continued from previous page Gross PatNhoolMogaoycroC scopiicoA,bnorPmAaRlAiTtHyYROWOIbIDsTeHrGLvOAePNTdDISC, NTERRVAEC.KERS,KINE, SFOROTST,ACS B SEMOUR TR/DKNCiEEtbJO,sIN,T,EYEUS(RTSIE)RNNAURMY,BLNAODSDEER, TESTES, SPIDIDYMINES. histopathology LIVEI R:`TeAhaMTyATCHIAONGNE,, SPEURBIAPCOURTTEA/LC,HROmNiIlCd,. minimal Jo Mi"cTHrYoRsOcIoDpiGcLAADbnormality Observed : 665068 mKEeixrlpmloiesnduarleonSGarDcoaryuipf:i:c9e2subch oml is signed off from NeCOPSY BrB Gross Pathology No MaEcrOoCscopaicvsAb,normLaNlCiSt,y OKbEsANeErS,vTeOdMSAKCE:HL,ETADLUOMDUESNCULLE. JSTPLLIC,L EAORRTA, R EBLrAa ANDSS,sGpLSrCACaNIBLDASNT,CI,OCRMDCAN,OENLRDOVINEB,,ULARPERICTTLUUIOMTP,AERMYENOSGDELENA,TNDE:RTIRCONLSN:RM 665068 Continued oOn tEheAnextG page - --_ Toa oo `CompanySanittziezted.DoesnotcontTSaCAiCnBI 2a54s25:GavSaubgcehSrooniyc TinoxRiacittywith One-Generation Regroduction Evaluators Dupont-11413 ~ stony 5425Smhaolweing(+anAIinPdmPiaRvlOiVdEduDaat0laPmRAaOfn/oTirkOmgCaOilLnIdLi*)ivsiStedxiu:nagl Maenliemsals SStnoivenaN l Ref oFkiGcreTsrceoaptimcen&t:Macroscopic Findings " ses068 Gontinued from previous page Gross Pathology No MaOcroDscopic AibD,noPmAaRlAiTtHyYROObIsDerGLvOAePNTdDISC, NTERRAVCEKERS,KINE,SOPPIRAOCSUTSA,TE. T E SEVURR/R KNSEaEwXJnCOiD,tNsT,,PYBUS(RTSIE)NRNAURWMYI,THBLNAODSDEER, TESTES. BPIDIPYMIDES: Histopathology : LIVERNF:TLIAMACTHAINOGNE,, SPUEBRAIPCOURTTEA/LC,HROmNiInCi,malm.inimal. KIDNEYLSS(CONIC PROGRESSIVE NEPHROPATHY, minimal. PMAANNCDRIEBNBAUPSRLLASARCAYLTTYOIMSOPIHNS,,NODFPOELCAASLH,A mild. CELL, MEDULLARY, mild mansesoRaGE, mild. ~ ESOPHMAIGSUSSI:NG PROSTAATGEGRE:GATES, LYMPHOID, minimal. 465068 Continued on the REXT Page + : -- - Company' SaniSanitized. Doesnot conTtSaCAiCnBI S2o5ro4a2y5G:vaSgubeeShroyniciTnoRsaicstywithOeGoranReproduction Baus DuPont 1141 ~~ stoov 5425iSmhaolweinrgr(e*astAIpmnPiedPnniRatvOl:iVdEduDaat0laPpRoAfO/noTkirOmgCaOilLnI dLi+i)vsiStdeiux:nagl Vaanlienals srooy Animal Ref AG ioroscopic & Macroscopic Findings - s6s068 Continued from previous page HistopahoNloonMyiocrCoscopi ic AmoSmDKaUEOLlDEiETtNAyULM,OWUbSsJCeELJrEUv,NeUdMS,PLEIELNE,OM,AORCTEAC,UL,BRACTONL,ON,SPINAL NCRCEOOSTROPDS,eiRwSOEATLOSCDRRHRNGG,MILPGAENRDNTSEC,RVLETW,RAPCPHIENTSAOUK,DIIENT,,APRHSYASARBLRGMILNIAVLNNA/ADLRL,AYRVDGETILSHKAIY,NCRDLOSEI,SD,AGDLUARRNEIDNN.AALRY N E BONEEMD ARROoW,eSseNT.OISCEENPGIRDVIED,MIDES, FEMUR/KNSE JOINT, STERN, ORGANESSopNHOATGUESXAMINED: 665070 rKEBevirplmolAisenudarleoTnoGSarDscoairyug:ipnf:eidc9e2osfufbchfrom necropsy -- Gross PatJhooloNgaOycOzoDscopEicveAb,noSrPmLIUaNNlAGiLSt,yCOROHDEb,AsReTrS,vTeOMdSAKCE:HL,ETADLUODWEUNSCDLNE,, JESJEULNUEME, EBT OORA ERER TGALaAYNSDS,, GLSACCNEIDCASUT,MI,CMCANOENLRDOVINEB,,ULRAPERICTTLUOYIMMT,PAHRMYENOSGDELENA,TNDE.RTIHCOULSM.EH 65070 Continued on the next page --~ : one `Company SSanainizzed. DoesnotconTtSaCAiOnBI 1'19:02-5D4a2y5:GavSaugbcehSrtoundiycTionxRiactistywithOneGenerationReproduction Evaluations ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg aninals sDousep6 504m2g5//mkagleTr(e*atAmPePnRtO:VEDOPmRgO/TkOCgOLI *) Sex: Males Animal Ref Microscopic & Macroscopic Findings 665070 Continued from previous page Dupont-11418 " Gross Pathology : No MaTcNrRoOsTcDopiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS:, PHARYNK/LARYNK, EYE(S) WITH OPTIC NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMUUTRN/AKLNVEEESIJCOLTENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVER:`FATTY CHANGE, INFLAMMATION, MSUEBDAICAUNTEC/LECFHTR,ONImCi,nimmailnimal. KIDNEYASGGR:EGATES, LYMPHOID, minimal. onesH:EMORRHAGE, ALVEOLAR, minimal. SKELEMTIASLSIMNUGS.CLE : SCIATIMCISSNIENRGV.E : ~ PITUIcTyAsRtY, GLmiAlNdD. : THYROIHDYPEGRLTARNODPH:Y, FOLLICULAR CELL, mild. "PARATMHIYSRSOIINDGGLANDS : BYE(S)OPWTIICTHNEOPRTVIECNONTERVPER:ESENT, UNILATERAL. 665070 ContinuePdROoSnT"AATtGhEGeR:EnGeAxTtES,paLgYeMPHO..I.-D, minimal. ~~ ee 21`Company Sanitzed. Doesnotcontain TSCA CBI 1D2a54y25G;avSaugbcehSrowndiyc iTnoxRaitcstywithOne GencraionReproduction Evluaons Dupont11418 ~ stoor 5425/Smhaolwieng(*anAIinPdmPiaRvlOiVdEduDaatlaPmRAafOnosTirkOmCsaOilLnT dLi*i)vsiStdeiuxna:gl Maanliem?als grunt WPCC treatment: 0 Sninal Ref `ieroscopic & Macroscopic Findings - 665070 Continued from previous page Aistopathology NOSE:\PLANMATION, TURBINATES, mild, with squamous metaplasia No MEiCcRrooscoapEricS.AE0bUnNoUrAMmO,NaNTOlADiI,EtL,yEGBNROS,AbAIsLNePT,rAVvNACeSRRdPYEIANG-SAL,LANDCCSOB,RCDU,NM.ANSCTDOOILMBOAUNCL,HA.RRLECiHeRL NDONOR/ELAA,URASYGTA.CLXLA,ENAESDH,REEYNEU(ARSLI)NGALWRAIYNTDHBSL,AODPDTTERIRAC,CHNEETARE,VSET,EESS,OSPKHEIAPNGIUDSI.DYMIDES B SEVORR/KNER JOINT, STERNUM, BONE MARROW ORGANTS ANOTLEKAMMUISNCELDE:, SCIATIC NERVE, PARATHYROID GLANDS 665076 mKEexirplmolisenudarleonSGDaracoruyipf:ic9e2subch So signed off from necropwsey Bon an ~~ Gross Pathology No MaC EcrRosO copiicNNb,AvbSn,oSrPmILaCUNENlAGCiLSUt,MyC,OROHDEbC,AOsRLeTOrS,NTv,OeMdSARKCEE:HCL,TEUTMAD,LUOMDMUEESNSCUELMNE.T,ERJISUCELNpEE.u, OIaeRL,,NGLEARNARDYS,, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,MD.TTMUS. 65076 Continued on the next page ---- --~ oe Company Sanittized.DoesnotconTtSaCAiCnBI 25025a:pSueboSnoiycTnoaxitcistyithOveGenerionReproduction Evaluations Dupo 11418 -- sry 542r5,Spehaotwei.n"tg{r+eaanAtsiPmnmFeaaRnslOty:VidEaaDuta0laPnRagfOn/oTirkOmgCaOilLnId_Li*)ivsiStdeixu:naglMaalneismals ror A TT Animal Ref Microscopic & Macroscopic Findings TT 665076 Continued from previous page Gross athJooloMsarycroEscopicPAAbRnoTrmEIaVNEl(iRSt)yOIOWbIDsTeHrGLvOAePNdTDISC:, NETRRVAEC,HEAS,KINE.SOPPERAOGSUTSA,TE, T E NNsk iawos,J. om, DSRTAiRNNAMR,BLNAODSDEER, TESTES, BFEDIDYMIZES. Histopathology : waves|N\+FRLAACTiIOsN,, SPUEBRNICPOURTTEA/LC,HROmNiInCi,palm.inipal. GEvRs(S)\A+ CWERIOTTPHIAOGPiEToSIw,C, ANLEPVREEVROEILOASRL,ARF,OCAULN,ILAmTiEnRimAaLl,. mininal. srosTAA GATREiGA\TaEnSi, HoT PRESENT, UNILATERAL TXHPHOID, minimal. --_ ROARabBoLAaDrDsERs., LYMPHOID, minimal. Jo HiT EScTroISD sLcopCicORANbenroSRomOSarwKTlEai,LNt,EyWADMoLUEbOSMDsEUEeNSNrTCOvELNeRE,dI,CJ:ESLJTIULNNEEUERMN,,OADDARTEOLE,RENTDAAYLS,,AGLSLPIRAAVANNAZDCRYSHY,.ZAS. CC SVEi,stPaITULITEARHY NGOLDAEN,D,THTIHNYURSO,ID GLAND. 565076 Continued on the next page --_ 556 ComppaanynySanSainitzed.Doesnot conTtSaCAiCBnI 5$02.5De4y2G: SaubcvtSvuoandiycigTnoRxeiacsityithOneGeneruionReprodutionEvalvtions Dupone11418 -- smoot 5425Smhaolwe.ing(*aAnIPinmPdaRilOviVdEduDaaclaPRAOfnToirOnCaOIlLndLi*)ivsidtuianlg animals Sone IG "treatment: 0ma/ka 1 Sex: Males Animal Ref Microscopic & Macroscopic Findings - Ses076 Goneinued from previous page Histopathology : No MiRScoRrnAo:RscAoSRpEOiNTcIDNAAbGLLnAVoNErDSmSIa,ClLiETtSRy,ACOHbTEEsRSe,FrEvSEe,SdOPS:HPAIGDUISD,INIPDAERSI,NLP/ELHAURRI/NKLN,ES 30s, STERNUM, BONE MARROW, NOSE essoe1 KrEeixrlpmloiesnudarleonGSrbsoacryuipfi c1er27ecor Meat So stoned off from necropsy Gross rathology : Yo MaSokcoornonoes,,copAPBiRADcANNICLNRAY,EbSAm,SSo,PmLIaUCNlNBAiGCLSUt)MyC,OROHDEbC,AOsRLeTOrS,NvT,OeMdSAKRCEE:HCL,FEUTNAD,LUODMMEUENSSUCEMLWE,P,ERJEISTCPULNELUEONNK,,EH RAoORnROEykLaDSLRGGTLEVaRAMMRD,SY, GPLSAACRNIADATSTH,IYCRMONAIEDNRDVIGELB,AUNLDAPSRI,TULTYIRMTAPACHRHYENAOG,DLEA,NEDS.OTHPYKMAUGSU,S, rr PSEHETAORRAY/NLRX/LEVAERSYIJNCOXLI,ENST.,EYEUS(RTSIE)RNNAURWMYI,TBHLNAOODSPDTEEIRC, NETREVSET,ES.SKIBNP,IDIPDRYONSITDAETSE,, Histopathology L1veRFIAN: TFTLYAGCIHTAINOGNE,, SPEURBIAPCOURTTEA/LC,HROmNiInCi,malm.inimal 665001 Continued on' the neXt page ---- -- J oe Company Saniized. Doesnotcontain TSCA CBI 9F0-.2D54a2y5G;avaSugbecShruodniyciTnoxRiaciitwyithOne-GeneraionReproduction Evaluations DuPont11418 ~ stooy | Showing anIinndailvidduaatla AfnoirmailndLiivsitdiunagl animals J5c25/male (+ APPROVED PROTOCOL *) ose ceM> WR ( ng/kg Treatment: 0 ma/k I Sex: Males Aninal Ref Microscopic & Macroscopic Findings 665081 Continued from previous page - Histopathology : No MiTcHrYoRsOcIoDpiGcLANADbnormality Observed : 665086 TKeirlmliendalonSDaacryif:ic9e2 AEnxipmoaslureisGrsoiugpne:d osfufbchfrom necropsy Gross Pathology No MaA`LOcIRrVToEAsR,,copKBIiRDcANINEA,YbSn,SoPmLIaUNlNAiGLSt,yCOROHDEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, ANIODLDEREUE,MN,ALSPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMANCEONRLDVOIENB,,ULRAPERICTTLUUYIMWT,EAHRMYENOSGDELEAN,NTDE,RTHIICMULSY,MPH TSPHHEYAMRRIYONNIAGDL/LVGALERASYNIDNC,XL,ESP,EAYREUA(RTSIH)NYARWROIYITDHBGLLAOADPNDTDEISRC,, NTTERSRVSAETC,EHSE,AS,KIENEP,SIODPIPHDRAYOGMSUITSDA,ETSE,, ~ FRMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER`F:ATTY CHANGE, INFLAMMATION, SPEURBIAPCOURTTZA/LC,HROmNiInCi,malminimal. KIDNEY`CSHR+ONIC PROGRESSIVE NEPHROPATHY, minimal. 665086 Continued on the next page ---- ~~ - ons CompanySanitized. Doesnotcontain TSCA CBI $5:02.5D4a2y5G:aSvuabgcehrSoundiyc TinoxRiaciistywithOneGeneraonRegroducion Evalutons --_ stop 5025S/hmaolweing(*aAnIPinPmdaRilOviVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsidtuianlg animals Treatment: 0 mo/kg I Sex: Males Sree WD M /kg Animal Ref Microscopic & Macroscopic Findings 565086. Continued rom previous page Dupont-11418 or Histopathology onesMA+CROPHAGES, ALVEOLAR, FOCAL, minimal. MHAENADRITEBINRU: FYLLIAAHRMRMOLACYTYMITPOORNS,TNSO/DSEEURBYATCHURTOEP/CHHARGOONCIYCT,OSTmSi,nimSaIlN.US, mininal. BTYoE(nSs)`HEW+NIOTRHRMOAGPET,ICmiNnEiRmVaEl.: INPLAMMNTION, PERIOCULAR, UNILATERAL, minimal. OPTIC NERVE NOT PRESENT, UNILATERAL. No MiRScRErOLoVEOAsTNCcA.Ho,LpiEcMDSUUESOANCDbTLEnEENoR,OrIMm,CaSlPLiJLEEtYEJyMNUP,NOHUbMAsN,OOeRDrTEvI,AeL,dEUSMAB:,RLAIIVPNAA,NRCYRSEGPALISAN,NADLSC,ECCOURANDD,,RENCOALLON. SSEOTERAAOiRNTnND.PSH,YPRROOSSTCTDTANTTGELI,ACNDNSSEE,RMVIETN,RAALCPHVIEETASU,IICTLAEESRSOY,PHGALUGARUNISDN,,ARTYPHHAYBRRLYAOIDIVDDEE/RGL,LAARNTTDEN.KS,TES. ~ SETDIDYNIDES, FEWUR/KNES JOINT, STERNUM, BONE MARROW, NOSE ~~ Co om `Company Sanitized. Does not contain TSCA CBI D25a42y5:GaSvuabgeehrSotnuidcyTionxRiactistywithOneGeneration Reproduction Evaluations ~~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuienlg animals Sstooenyci|%p WG54m2g5//kmgaleTr(e*atAmPePnRtO:VEDOPmRaO/TkOgCOLI *) Sex: Males Anival Ret Microscopic & Macroscopic Findings 665098 TKeirlmliendalonSDaacyrif:ic1e27 AEnxipmoaslureisGrsoiugpned: orfefcovfrom necropsy DuPont11418 " Gross Pathology : No MaATOTcRVrTEoARs,,copBEiRIcADINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyOROHDbE,AsReTrS,vTeOMdSAKCE:HL,ETADLUOMDUESNCULME,, JESJPULNEUEMN,, ANTDoERbEEpUN,MA,LS,APGALLNIACVNRAEDRASYS,,GLSACCNEIDCNSUT,MI,CMNCAEONRLDVOIENB,,ULARPERICTTLUUYIMMT,PAHRMYENGOSLDEEAN,NTDE.RTHIYCMULSY,MPH TS`ASEHNMARTRONYLANDLE/VGLLEAASRNIYDCN,LKE,SP,EAYREAU(RTSIH)NYARRWOYIIDTHBGLLAOADPNDTDEISRC,, NETTRERVSAETC,EHSE,AS,KISNEP,SIODPIPHDRAVOGMSUITSDA.ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERIN: FLAMMATION, SUBACUTS/CHRONIC, minimal. ~ No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : --~ : T50- ---- `Company Sanitized. Does not contain TSCA CBI 9H02.5D4a2y5:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont 11418 --_ srupy 5425S/hmoawlieng(*anAIiPnmPdaRilOviVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsitdiuanlg animals ose oO (ng/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 565106 TKeirlmliendalonSDaacryif:ic1e27 AEnxipmoaslureisGrsoigunped: orefcfovf.rom necropsy Gross Pathology : No MaMvOcOEerNtmoTMs,,,copPBKiRIAcADNINCNERA,YEbSAn,SoS,rPmLTUaCNNlEAGCiLSUt,MCy,OROHDEbC,AOsRLeTOrS,NvT,OeWdSAKRCEE:HCL,TEUTMAD,LUODMMEUENSSUCEMLNE,T,ERJEISJCPULNELUEYMNM,,PH TANoADbYRERE,ONIADLSAGGLLLIAAVNNADDR,SY, GPLSAACRNIADATSTH,IYCRMOAINENDRDVIGELB,AUNLDAPSRI,TLUYTIRMTAPACHRHYENAOG,DLEA,NEDS.TOHPYHMAUGSU,S. `TSHEAMRIYNIAOLU/VCEASRIYCNLKE,S,EYEU(RSI)NARWYITHBLAODPDTEIRC, NTEERSVTE,ES,SKIBNP,IDIPDRYOMSITDAETSE., FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIves`I: NFLAMMATION, FATTY CHANGE, MSEUDBIAACNUTEC/LCEFHTR,ONImCi,ld.minimal. ~ FATTY CHANGE, PERIPORTAL, minimal No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed --_ _ oT `Company Sanitized. Doesnotcontain TSCA CBI 50H.25D4a2y5G:avSaugbeeShrodriciTnoRxaitcistyvithOneGenerationReproducion Evaluations --_ sDotroewc|ro 5425 Smhaotwei.ng+aAnIPinPndaRilOviVdEduDaatlaPRAOfnToiOrnCaOilLndLi+)ivsitdiunagl animals ik Treatment: 0 pg/kg 1 Sex: Males Dupon 11418 Animal Ref Microscopic & Macroscopic Findings - 665121 i`KBTcineplraolmseliudnraeolinsSGarDscoairyguinpfe:id:c1eo2r7efcovfrom necropsy - Gross pacholosy No MLavSocoxerRaoonnws,,copSABiARDcNAECIRNYAE,bSAn,SoS,rPmTICOaNBNAlGCLiSUt,MGy,ORHODCEb,OAsRLeTOSr,NTv,OeMSdAKRCEE:HLC,EOTMAD,LUOMDMEUENSSGCEHLN,ET,ERJEISJCPULNELUEYMNM,,EH ATTOoRnRReEOOraIrLS,SASGGLALLTAAVRNNAKDDR,SY,, GPLSEAAYCRNBIAD(ATSSTH,)LYCRWWOINAIETDNRHDVGIELOS,APUNHLDIAPSCRI,TLNUEYTIRMRTVAPAECHR,HYENAOGS,DLKSAI,NNB,DS.OTPHPKYRAMOGUSUSTS.A.TE. SEEnNUsR/EVEESIJCOLIENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDVMIDES. Histopathology ~ LaveRIIN+NFLEABCAHTAINOGNE,, PSEURBIMPCOURTTEA/LC,HROmNiInCi,malm.inimal No Mi"cTrRosOcTopiGcLAADbnormality Observed : -- - [En `CompanySanitized. DoesnotcontTSaOAiGanll 9F-02-5D4a2y5G;avSaugbechSvtouidyc iTnoxRiactistwyithOneGeneration Reproduction Evaluations ~~ stupy 5425/Sphaolwieng(+anAIiPnmPdaRilOvViEddDuaatlaPRAfOnoTirOmCaOilLndLi*)ivsitdiuanlg animals Dose Group :W 0 mg/kg Treatment: 0 ng/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 865130 TKeirlmliendalonSDaacyrif:ic9e2 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Dupo 11418 Gross Pathology No MaA`LOcIRrVToEAsR,,copBKRIiADcINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyOROHDbE,AsReTrS,vTeOMdSAKCE:HL,ETDAULODMEUNSUCML,'E,JESJPULNEUEMN,, ANJODODEREUE,MN,ALSAPGALLNIACVNRAEDRASYS,,GLSACCNEIDCASUT,MI,CMANCEONRLDVOIENB,,ULRAPERICTTULUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,TRHIYCHULSY,MPH T`PSHHEYAMRRINOYAINLKD,/LVGALERASYNIDNC,KL,ESP,AEYRUEA(RTSIH)NYARWROIYITDHBGLLAOADPNDTDEISRC,, NTETRREAVSECT,HESE,AS,KIENPE,ISDOIPPHDRAYOGMSUITSDA.ETSE,, SEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER:`INFLAMMATION, FATTY CHANGE, PSEURBIAPCOURTTEA/LC,HROmNiInCi,malm.inimal. ~ KIDNEY`CSHR:ONIC PROGRESSIVE NEPHROPATHY, minimal. ELYoEN(GSS)`H:EWMIOTRHRHOAGPET,ICANLVEEROVLEAR:, mild. URINARIYNFLBALMAMDADTEIRON:, PERIOCULAR, UNILATERAL, minimal EPIDID`AVGMGIRDEEGSATE:S, `AGGREGATES, LAMPHOID, LYMPHOID, minimal. minimal. 665130 Continued on the next page -... ~~ - Ton Compa"npyanySanSiantiitziezed. Does not con, TtSaCAiCnBI 9205.D4a2y5G;avSaugbecShtrourdiyciTnoRxaitcsitwyith One-Generation Reproduction Evaluations Dupont-11418 --_ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtoospeY Gr&p 054n2g5//kmgaleTr(e*atAmPePnRtO:VED0PmRgO/TkOgCOLI =) Sex: Males Animal Ref G65130 Microscopic & Macroscopic Findings Continued from previous page Histopathology + No Mi`HcErAoRsT,copSiKcELAEbTnAoLrMmUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, `RLSEYTCMOTPMUHAMC,HN,ODMEED,SUOEDNTEHTNYEUWRMUIS,C, LJEYAJMDUPRNHEUNMNA,OLDEGI,LLAENUSMDA,SL,IVPAASNRCCYIRAEGTALISAC,NDNSCE,ERCVUEMM,A,NDICBOLUOLNA,R VPTERISATICUCHILETEAAS,R,YEGTSELOSAPTNHEDASG,,UST,HFYERMPOUHIRAD/RYKNNGKLEA/ENLDAJ,ROYINNPKTA,,RATSSKHTIEYNRR,NOUIMDP,ROGBSLTAOANNTDEES,,MARSREOMWI,NAL Nose 665148 TKeirlmliendalonSaDcaryif: ic9e2 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology ~ No M`aIcVrEoRs,coKpIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JESJPULNEUEMN,, NTOEDUEM,, SAPLANICVRAERAYS,GLACNEDCSU,M, MCAONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTHIYCMULSY,MPH ATDHRYERNOAILD GGLLAANNDD,S, PSACKIAAITHIYCRONIEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LAEDS,OPHAGUS, SSHEAMRIYNNAXL/LVAERSYINCXL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE 665148 Continued on the next page -... --~ - Ton `CompanySanitzed. DoesnotcontainTSCA Cal F-25425; Subchronic Toxiclty 90-Day GavageStudyinRats with One-Generation Reproduction Evaluations Dupont11418 -- Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDouspeyGrofp 054m2g5//nkagleTr(e+atAmPePnRtO:VED0PmRgO/TkOCgOLI *) Sex: Males Animal Ref Microscopic & Macroscopic Findings 665148 Continued from previous page Histopathology LIVERFA: TTY CHANGE, MEDIAN CLEFT, minimal KIDNEYISNFL: AMMATION, SUBACUTE/CHRONIC, minimal TS"CHRONIC PROGRESSIVE NEPHROPATHY, minimal. EYE(S)HEMWOIRTRHHAOGPET,ICmiNnEiRmVaEl.: PROSTOAPTTEIC: NERVE NOT PRESENT, UNILATERAL. `EPIDIADGYGMRIEDGEASTE:S, LYMPHOID, minimal. AGGREGATES, LYMPHOID, minimal. No MiLcUrNGoSs,copHiEcARTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP: LEEN, AORTA, BRAIN, SPINAL CCOOLRODN,, STROEMCATCUHM,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVANACRRYEAGSL,ANDCSE,CUM, ~ MPAINTDUIIETUALRYARGLLAYNMDP,H TNOHDYER,OIADDRGELANNADL, GLPAANRDAST,HYRSOCIIDATIGLCANNDESR,VE, ETYREA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSEK/INL,ARYSNEKM,INAL VESICLES, URINARY BNLoAsDeDER, TESTES, FENUR/KNEE JOINT, STERNUM, BONE MARROW, -- -- 95s Company Sanitized. Does not contain TSCA CBI 9F0-.2D5a4y25G:avSaugbeeShrtoaniyciTnoRxaiicistwyithOne GenerationReproduction Evaluations Dupont 11418 --~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals sDoosepGroWp| : I 054m2g5//kngaleTr(e*atAmPePnRtO:VED0PmRgO/TkOgCOLI *) Sex: Males Animal Ref Microscopic & Macroscopic Findings 565145 TKeirlmliendalonSDaacryi:fic1e27 AEnxipmoaslureisGrsoiugpned: orefcfovf.rom necropsy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS, TPHHAYRRVOIIODU/GLLAARNYDN,K, PEAVREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AKLNVEEESIJCOLTENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, BPIDIDYMIDES, Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal --~ FATTY CHANGX E, YEDIAN CLEFT, minimal. No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : 53% Company Sanitized. DoesnotcontTSaCAiGBnI 9F-02.5D4a2y5G:avSaubgeehSrtoandiyc iTnoxRiactistywithOne.Generation Reproduction Evaluations -- stop | 5425/Smhaotweing(+aAnIpinemdaRilOviVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsitdiunagl animals Soe cle 0 ng/kg Treatment: 0 mg/kg I Sex: Wales Animal Ref Microscopic & Macroscopic Findings s65159 TKEeixrlpmloiesnudarleonGSarDcoaryuipf: i: c1er27ecov Animal is signed off from necropsy DuPont-11418 Gross Pathology No MaMLOcTRrVIEoARs,,copFBiRIcAOINNEA,VbSn,oSrPmILUaNNAlGLiSt,CyORHODEb,AsReTrS,vTOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, ANTODLDEREUE,MN,ALSPAAGLNLICAVRNADERSAY,S,GLSCACENICDMUSTN,I,CMCANOENLRDOVINEB,,ULAPRERICTTLUUYIMWT,PAHRMYENSGODELEAN,NTDE,RTIHCYMULSY,MPH STFERHMYAIRRNOYATNKLD/LVGALERASYNIDNC,KL,ESP,ASYREAU(TRSIH)NYARRWOYIIDTBHLGALODAPNDTDEISRC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRVAONGSIUTDSAE,TSE,, `PEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER`I:NFLAMMATION, SUBACUTE/CHRONIC, minimal. ~ No MTiHcYrRoOsIcoDpiGcLAANbDnormality Observed : --_ - oCompany Sanitized. Doesnotcontain TSCA CBI 02-5D4a2y5G:avSaugbecShvdonyie nToxRiatcstywithOneGeneration Reproduction Evaluations ~~ stSoevey oy 5425 Smhaolweing(+ anAIinPmdPaiRlvOiVdEduDaatla2RAOfnToirOmCaOilLndiL*)viisdtuianlg WL: 10 ma/kg Treatmenc: 10 ma/kg III animals Sex: Males Animal Ref icroscopic & Macroscopic Findings G6ass3 TEkexirplmolisenudarloen SGDaracoruyipf: i: c9e2subch Animal is signed off from necropsy DuPont11418 Gross Pathology No MaRAScvo0ree0ons,,,copPBKiRIAAcDNINCNERA,YEbSAn,SoS,rPmLIUaNCNlEAGCiLSUt,MCy,ORHODEbC,AOsRLeTOrS,NvT,OeMdSARKCEE:HCL,TEUTMAD,LUOWWDUESESCENLN,ET,ERJEISTCPOLNELUEYKNM,,PH TAN`OHDADNRREREY,ORITAXSDL/ALGLGALILRAAVYNNARDDRKS,Y,, GPLESAAVCRNEIAD(ATSSTH,)IYCRWMOIANIETNDRHDVGIELOB,APUNTLDIAPSCRI,TNLUTEYIRRMTVAPAECHR,HYENAOSG,DKLEIA,NNE.DS,OTPPHHROAOUGSSUT,SA,TE, FSEPMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAORYY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIvERF`IA+NTPTLYAGCOHTAINOGNE,, PSEURBIAPCOURTTEA/LC,HROmNiInCi,malm.ild. -- Yo Mi"TcHrEoRsOcIoDpiGcLAANbDnormality Observed : --~ - oe Company Sanitized. Does not contain TSCA CBI H-25425; SubchvonicToxicity 90-Day Gavage Study in Rats with OnGeeneration Reproducion Evaluations DuPont 11418 ~~ Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDotsuen GrPD NII541205/mmga/lkeg (+TrAePaPtRmOeVnEtD: PRO1T0OmCgO/Lkg*) III Sex: Males Aninal Ref Microscopic & Macroscopic Findings 664995 TKeirlmliendalonSDaacyrif: ic5e2 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, HTOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GSLACNIDAST,IC`NMAENRDVIEB,ULPAIRTLUYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDX,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVERIN:FLAMMATION, SUSACUTE/CHRONIC, minimal. --_ FATTY CHANGE, MEDIA CLEFT, minimal. No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed --_ won `CompanySanitized. Doesnotcontain TSCA Cal 9205-4Da2y5G:avSauglebSethoundiyciTnoRxaictistwyith One-Generation ReproductionEvaluations DuPont-11418 _ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dsorsueoy | W1514025/mnga/lekg (*TrAePaPtRmOeVnEtD: PRO1T0OmCOgL/kg*) III Sex: Males Animal Ref Microscopic & Macroscopic Findings 565033 TKeirlmliendalonSDaacryif: ic9e2 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBARNACIRNE,ASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOITUD/LGALRAYNNDX,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINB,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AXLNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology No MiLIcVrEoRs,copTiHcYROAIbnDorGmLaAlNiDty Observed : ~ 565053 TKeirlmliendalonSDaacyrif: ic92e EAnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology : - No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUTMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC`NMAENRDVIEB,ULPAIRTULIYTMAPRHYNOGDLEA,ND,THYMUS, 665053 Continued on the next page -... --~ ET `CompanySanitized. DoesnotcontTSaCAiC8n1 5B0.2D5a4y25G:avSaugbecShvtoundiyciTnoRxiacsitwyithOneGenerationReproduction Evaluations Dupont11418 ~~ Showing anIindniavlidduaatla AfnoirmailndLiivsidtuianlg animals Dsotsoeox | BC 5425/zmaal/ekg (*TArPeaPtRmOeVnEtD: PRO1T0OmCOoL/kg*) III Sex: Males Animal Ref Microscopic & Macroscopic Findings 665053 Continued from previous page Gross atholosy + No MaP`TcHHrAYoRRYsONcIGoD/pLiGALcRAINADNb,Kn,orPmEAYaRElA(iTStH)yYRWOOIbITsDHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, PSEENUIRN/AXLNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, SPIDIDVHIDES, Histopathology LIVERINFLAMMATION, SUBACUTS/CHRONIC, minimal. No Mi"TcHrYoRsOcToDpiGcLAANbDnormality Observed : 465060 TKeirlnliendalonSaDcaryif:ic8e2 AEnxipmaolseisGrsoiugpned: sofufbchfrom necropsy ~~ Gross Pathology No MaA"LOcIRrVToEAsR,,copKSRIiADcINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyOROWDbE,AsReTrS,vTeOMdSAKCE:HL,ETADLUODMEUNSUCML,E, JESJPULNEUEMN,, ANIODLDEREUE,MN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNBIDCASUTN,A,CMANCEONRLDVOIENB,,ULRAPERICTTULUYIMMT,PAHRWYENOSGDELEAN,NTDE,RTIHCUSLY,MPH 665060 Continued on the next page ... -- --_-- . Company Saniized. Doesnot contain TSCA CBI 9205.D4a2y5G;avSaugbeeShtroundiyciTnoRxaitcistwyith Ope-GenerationReproduction Evaluations DuPont 11418 ~~ srupy 5425/Smhaolwieng(+anIAinPmdPaiRlvOiVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsitdiunagl animals TC kg Treatment: 10 mg/kg III Sex: Males Sn Animal Ref Microscopic & Macroscopic Findings 565060 Continued from previous page Gross Pathology No MaSHcSArrRoRYs0NcTKoD/pLiVGAcLERASYNIANDCbK,Ln,EoSrP,mEAYaREUlA(RiTSItH)NyYARWROOIYbITsDHeBGLrLAOvADPeNDTdDEISRC:,,NETTRREVASECT,HEESA,S,KIENSP,SIODPIPHDRAYOGMSUITSAD,TEES,, SSEEMIUNRA/LKNEE JOTNT, STERNUM, NOSE Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. THYRO`IHDYPGELRATNRDOPH:Y, FOLLICULAR CELL, minimal. 665074 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoasulreisGrsoiugpned: sofufbchfron necropsy --_ Gross Pathology No MaO"ScRTrVToEsR,,copBKiRIcADINNEA,YbSn,SoPmLIaUNlNAiGLSt,yCOROHDEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUODMEUNSUCXL,E,JESJPULNEUEMN,, ANTOODEDRUEEM,N,ALSPAAGLNLICAVRNADERSAY,S,GLSACCNEIDCASUT,MI,CMACNOENLRDOVINEB,,ULARPERICTTLUUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTIHCYMULSY,MPH 665074 Continued on the next page -... --_ ToEa EE CormpanyanitSanitized.Doosnot conTtSaCAiC8n1 9205.4D2a5yG:avSaugbcehrSotundiyciTnoRxaitcistwyith One-GenerationReproduction Evaluations Dupont 11418 -- stop 5425/Snhaolweing(*aAnIPinmPdaRilOvViEdduDaatlaPRAOfnToirOmCaOilLndLi*)ivsidtuianlg animals 0 mo/ky Treatment: 10 mg/kg IIT Sex: Males re 21 Animal Ref Microscopic & Macroscopic Findings 565074 Continued from previous page Gross pathology No M"aT`ScHIErARMoROIYsNTNcADKoL/pLiGVALcERASYNIADNCb,KLn,EoSrP,mAEaYRElUA(iRTStIH)NyYARROOWYIbIsDTeHBrGLvLAOAeDPNDdTDEISRC:,,NETTRERVSAETC,EHSE,AS,KIENEP,SIODPPIHRDAOAGSIUTDSAE,TSE,, PEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER IN FLAMMATION, FATTY CHANGE, SMUEBDAICAUNTEC/LCEHFTR,ONImCi,ldminimal. No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed 565080 TKeirlmliendalon SaDcaryif: ic9e2 Exposure Group : subch s -- Animal is signed off from necropsy Gross Pathology No MaIAfOcVRrEToRAs,,copRBiRIcAOINNEA,VbSn,oSrPmLIaUNNlAGLiSt,CyOROHDEb,AsReTrS,TvOeMdSAKCE:HL,ETADLUODMEUNSCULME,, JESJPULNEUEMN,, NAJODDDEREUE,MN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEICDAUSTM,I,CMACNOENLRDOVINEB,,ULARPERICTTLUUYIMMT,PAHRMYENOSGDLEEAN,NTDE,RTIHYCMULSY,MZH 665080 Continued on the next page ..- ~~ Ton Comp`apanynySanitSaniized. Does notcontTSaCAiCnBI 35D52a54y25G:avSaugbechySounsiyTionxRiactistywithOne-GeveraionReproduction Evaluations Dupont11418 ~ sto 542150Smohaolwgeing(*taArnIPeinaPmdtaiRmlvOeiVndEdtuDa:atlaPRAfO1no0TirOsmCaeOil/LnkdLgi*)ivsiIdtIuianlg aninals Sex: Males som inial Ref Hicroscopic & Macroscopic Findings S65080 Continued from previous page Gross PatYhoolMoaacyroascomoPpiiScinniAkDb,,noPmBAaYRlENi(AtSY)yROOWIbIDsTeHrGLvOAePNTdDISC:,NETRRVAEC,HENS,KINS,SOPPIRAOGSUTSA,TE, /B SELMURR/KoMgSTJCOLTENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, BPIDIDYMIDES, Histopatholosy : LIveRINFLAMMATION, SUACUTE/CHRONIC, minimal. No Mi"cTrRosOcTopiGcLAADbnormality Observed : sesi2e rKFEeeixrElpmnloiaesnludarleoinsSGarDscoairyugipn:feid:c9e2o3fufbchfrom necropsy --_ Gross Pathology Yo MaeAcrNno,scOoDpSDiAIAcNoACNREA,YEbSnn,SoS,rPLmIUaCNNlACGiLUStM,yC,OROHDEbC,AsORLeTOrS,NvT,eOWdSARKCEE:HCL,FEUTNAD,LUODMMEUENSSOCEMLNE,T.ERJISEPCLTELEA,NM,P EOREEiaLCGaLaAuNaDSY, GLSACNIDAST,ICMNAEDRIVBEU,LAPRITLUIIDTAAPRHYNOGDLEA,ND.TVHUS, 665126 Continued on the next page -- Sa Companypany SaniStazrieized.DoesntconTaSCiACnBI 9H02-5D4a2y5G:avSaugbecShtroundiyciTnoRxaitcsitwyithOneGeneration Reproduction Evaluations Dupont. 11418 --_ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals sDtouspeyGrp : W5I 42105/mmga/lkeg (+TrAePaPtRmOeVnEtD: PR1O0TOmCgO/Lkg*) III Sex: Males Animal Ret Microscopic & Macroscopic Findings 665128 Continued from previous page Gross Pathology : No Ma`TcHrYoRsOcToDpiGcLANADb,norPAmRaAlTiHtYyROOIbDserGLvAeNdDS, TRACHEA, ESOPHAGUS, `'SPEHNAIRNYANLX/VLEASRIYCILXE,S,EYUE(RSI)NARWYITBHLAODPDTEIRC, NTEREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOTNT, STERNUM, NOSE Histopathology LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No M`iTcHrYoRsOcIoDpiGcLANADbnormality Observed : s65131 ~. TKeirlmliendalon SDaacryif: ic92e AEnxipmoaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology No mLaIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, 665131 Continued on the next page -..- --~ -_-- CompanySanitized. Doesnot containTSCA CBI 2905.4D2a5y;GavSaubgeehvSotnuidcyiTnoxRiactistywithOneGenerationReproduction Evaluations Dupont-11418 ~~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals stDouspeyGAD WI2542150mmagl/ekg(+TrAePaPtRmOeVnEtD: PRO10TOmCgO/Lkg*) III Sex: Males Animal Ref Microscopic & Macroscopic Findings 665131 Continued from previous pege Gross Pathology No MaTcRrRoOsTcDopiGcLANADb,norPmAaRlAiTtHyYROObIsDerGLvAeNdDS:, PHARVNK/LARYNK, EYE(S) WITH OPTIC NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPTDIDYMIDES, Histopathology LIves`INFLAMMATION, SUBACUTE/CHRONIC, minimal. No MTiHcYrRoOsIcoDpiGcLAANbDnormality Observed 665136 TKeirlmliendalonSaDcaryif: ic9e2 AEnxipmoaslureisGrsoigunpe:d sofufbchfrom necropsy --~ Gross Pathology : No Ma`ALcOIRrVToEAsR,,copKBiRIcADINNEA,YbSn,oSrPmLIaUNNlAGiLSt,CyOROHDEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, ANTODLDEREOE,MN,ALSPAAGLNLICAVRNADERSAY,S,GLSACCNEIDCASUTM,I,CMANCOENLRDOVINEB,,ULAPRREICTTLUUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTHIYCMULSY,MPH 665136 Continued on the next page .... ~~ - Toi ComppaannyySanSiatniized. DoesnotcontTSaCAiCnBI `0$-:2D5a42y5G;avaSugbecShruodnyiciTnoxRiactistywith OneGenerationReproduction Evaluators ~ stopy 25425 S/hmoawlieng(+anAIinPmdPaiRlvOiVdEduDaatlaPRAOfnToirOmCaOilLndLi*)ivsitdiunagl animals g/kg Treatment: 10 mg/kg ITT Sex: Males one cD M0 Animal Ref `Microscopic & Macroscopic Findings G65136 Continued from previous page Dupont11418 Gross pathology No MaTPRcHXrARoROsYTcNDoE,p/iLGcALRAYNANDbK,n,orPmAEaYRElA(iTStH)yYROWObIIsTDHeGrLvOAePNTdDISC:,NETRRVAECH,EAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMNUIRN/ALKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LaverI:NFLAMMATION, SUBACUT/CHRONIC, minimal No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed : --~ --~ - . Sa Companypany SanitizeSanitized. Doesnot con, TtSaCAiCnBI 9205.D4e2y5G:avSaugbeeShvtoundiyciTnoRxaitcistywithOneGenerationReproduction Evaluations DuPont 11418 -- Showing anIinndailvidduaatla AfnoirmailndiLviisdtuianlg animals suDopsey0p WY 1504025n/gm/aklge (T+rAePatPmReOnVtE:D PR10O0TOCmOaL/kg*)V Sex: Males Animal Ref icroscopic & Macroscopic Findings 665035 TKeirlmliendalonSaDcaryif:ic9e2 AEnxipmoaslureisGrsoigunped sofufbchfrom necropsy Gross Pathology : No Ma`LcIrVoEsR,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedS:KELETAL WUSCLE, SPLEEN, ATOLRSTOAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIES,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHYARRYONIGD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIIDTHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology LavenIN:FLAMMMTION, SUBACUTE/CHRONIC, minimal. ~ No mi"TcHrYoRsOcIoDpiGcLAANbDnormality Observed : ~ oa8`CompanySanitized. DoesnotconTtSaCAiCnBI 5112D5e4y25G:eSuvbcaShgruodeni TnoRxaitcsitwyith OneGeneration Reproducion Blustions Duponc 11418 -- estotm c oe Showing+"anAIionmedaRilovivdadupaaalPRAOfnToiOrnCaOilLndiLviisdtuianlg anisals M00 ark Treatment: 100 mg/kg V Sex: Wales Saimal Ret Microscopic & Nacroscopie Findings Gesosa EKTexirplmolisenudarleonGsrbaoacuyrpif i: c5es2ubch ee) Te Elonea off from necropsy Gross pathology No MAaEocvRreTonhs,,copBKRIiADcIUNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyOROMDEb,AsNeTSr,TvOeMdSAKCE:HL,STDAULODMEUNSUCML,E, JESIPULNEOEMN,, ANSD0oERbGE,HK,ALSAAGLNLICAVRNAEDRASYS,,GLSACCNBIDCASUT,M,CMNCAEONRLDVOIENB,,ULAPRERICTTULUIIMNT,EANRMYENOSGDLEEAN,NFDE,RTIHCINLSI,CH ISEOREARROTALRAD/LVGAERaSYIbNC,RL,ESA.ERYACETRSII)NNRAORWLYIDTHBLGAOLDAPDNTEDIRSC,, NTTERERVSAETC,EHSE,RS,KIBNPE,ISDOIPPDHRYAONGSIUTDSAE,TSE,, FEN/KugE Jom, STERNUM, NOSE utatopathology LavenINFLATION, SUBACUTE/CHRONIC, mild --_ Yo Mi":DcHrYoRsOcIoDpiGLcANADb.normality Observed : --~ ere e-- ee E-- T p-- ens-- er e sees (Company Sanitized. Does not contain TSCA CBI 1902-5D4a2y5:GavSaugbeehSvtoundiycTionxRiactistywithOneGeneration Reproduction Evaluations Duont-11418 ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDotsuepyGMD NV 5104025n/gm/aklge (T*reAaPtPmReOnVtE:D PR10O0TOnCgO/Lkg*)V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665073 TKeirlmliendalonSaDcaryif: ic92e AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GSLCANIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND.THYMUS, TPSHHEYAMRRIVNONAIXLD/LVGAELRSAYINNDC,EL,ESP,EAYREUA(RTSIH)NYARRWOYIIDTBHLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIBNEP,SIODPIPHDRAYOGMSUITSDA,ETSE., FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology --~ LIVERIN: FLAMMATION, FATTY CHANGE, PSEURBIAPCOURTTEA/LC,HROmNiInCi,malm.inimal. . No Mi`TcHrYoRsOcToDpiGcLAANbDnormality Observed : o50`CompanySanitized. Doesnot contain TSCA Cal 2H90-02-D5D4a2y5S;GoavvSaauggbeeeShSvutoudndiyyciiTnnoRxRaiatctisstwywiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiioonnEEvvaalluuaattiioonnss ~~ stop | Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals 25425/male (+ aveRoveD PROTOCOL *) Dose GxBp V 100 mg/kg Treatment: 100 ng/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings DDuupPoonntt1111441188 665085 KTeirlmliendalonSaDcaryif: ic9e2 ABnxipmoaslureisGsriogunped: osfufbchfrom necropsy Gross Pathology No MaLAIOcVRrEToRAs,,copBKRiIAcDINNEA,YbSn,oSPrLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETADULODMEUNSUCML,E, JESJPULNEUEMN,, NAIODLDEREOE,MN,ALSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMACNOENLRDOVINEB,,ULARPREICTTLUUYIMMT,PAHRMYENGOSLDEEAN,NTDE,RTHIYCMULSY,MPH TPSHEHAMYRIRYNONAIKLD/LGVAELRSAYINVCDNL,KE,S`,EPAYREUA(RTSIH)NYARRWOYIITDHBLGAOLDPADNTEDIRSC,, NTETRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIvERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. --_ FATTY CHANGE, MEDIAN CLEFT, minimal. No MiTcHrYoRsOcIoDpiGcLANADbnormality Observed : --~ : -_-- osi`CompanySanitized. Donotecontsain TSCA CBI 520.5D4a2y5G:aSvuabgcehrSotniycTionrRiactistwyithOve GenerationReprodaction Evaluations PP. supe 5425/Snhaolweing(+aAnIPinPmdRaiOlvViEddDuaatlaPRAOfnToiOrmCaOilLndLi+)ivsidtuianlg animals Dose Group i V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ret Microscopic & Macroscopic Findings 665103 TKeirlmliendalonSDaacryi:fic92e AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology : DuPont-11418 No MaALOIcRVrTEoARs,,copBKRiIAcDINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E, JESJPULNEUEMN,, ANIODLDREEUE,MN,A'LSAPGALLNIACVNRADERSAY,S,GLSACCNICDAUSTM,I,CMNACEONRLDVOIENB,,ULAPRREICTTULUYINMT,PAHRYMNEGOSLDEEAN,NTDE,TRHIYCMULSY,MPH SPTHEHAMYRIRVNONAIXLD/LVGAELRSAYINCNDLK,E,S`,EPYAEUR(ARSTIH)NYARRWOYIITDHBGLLAODAPDNTEDIRSC,, NTETERRVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology -~ LIVERINFLAMMATION, FATTY CHANGE, MSEUDBIACAUNTEC/LECFHTR,ONImCi,ld,minimal. THYROIFDATGTLYACNHDAN:GE, PERIPORTAL, minimal. HYPERTROPHY, FOLLICULAR CELL, minimal. --_ _-- 552 CompanySanitized. Doesnotcontain TSCA CBI 2-2$0D5-4aD2ayy5G;GaavvSaauggbecehSSrvtoaunddiyyciiTnnoRxRaiatctsistwywiitthhOOnnee-GGeenneerraattiioonn RReepprroodduuccttiioonn Evaalluusstiioonnss --~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDotsuepyGr| oup : V5410205/mmga/lkeg (T+reAaPtPmReOnVtE:D PR10O0TOmCgO/Lkg*) V Sex: Males animal Ref Microscopic & Macroscopic Findings DDuuPPoonntt1114141188 ses11s KTielrlmeidnalon SDaacryif: ic92e EAnxipnoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology : " rr No MLaIcVrEoRs,coKpIiDcNEAYbSn,omLaUlNiGtS,y OHEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUAN,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLOYMM,PH ATNDHODRYEER,NOAILDSAGGLLLIAAVNNADDR,SY, G`PLSAACRNIADATSTH,IYCRMONAIENDRDVGIELB,AUNLDAPSRI,TLUTYIRMTAPACHRHYENAOG,DLEA,NEDS,OTPHHYAMGUUSS,, `FPSRHEMANURIRYN/NAKXLN/LEVAEERSYIJNCOXLI,ENST,,BYEUS(TRSEI)RNNAORWHYI,TBHLNAOODSPDTEEIRC, NTEERSVTE,ES,SKIENP,DIPDRYOMSITDAETSE,, Histopathology : LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. No MTiHcYrRoOsIcDopiGcLANADbnormality Observed : --~ -_-- 5CompanySanitized. DoesnotconTtSaCAiCn81 H25425: Subchronic Toxicity 0-DayGavage StudyinRatswithOneGenerationReproduction Evaluations ~~ Showing anIinndailvidduataal AfnoirmailndiLviisdtuianlg animals DsoTsuepYGroup V 1504025m/gn/aklge (T+reAaPtPmReOnVt:ED PR10O0TOmCOgL/kg*) V Sex: Males Dupont-11418 Animal Ref Microscopic & Macroscopic Findings 665122 TKielrlmeidnalonSDaacyrif: ic92e AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GSLACNIDAST,ICMNAENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND.THYMUS. `PTHHAYRRYOIINDX/GLLAARNYDN,X, PEAYREM(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNVEEESIJCOLIENTS,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. --~ FATTY CHANGE, MEDIAN CLEFT, minimal. No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed : --~ _-- ron `Company Sanitized. Does notcontainTSCA CBI $0B-:2D5a4y25G:avSaugbecShrtonyiciTnoRxiscitwyithOne GenerationReproducion Bvalutions -- stony 5425/Sahloew'ing(+aAnIPinPndRaiOlvViEddDuaatlaPROAfTnoOirCmOaLil,ndLi+)ivsidtuianig animals Dose TV 100 ng/kg Treatment: 100 mo/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings Dupo 11418 665137 EKTxieplromlsieundraelonGSrDaoacuyrpif: i: c9s2eubch oT Aninal is signed off from necropsy Gross Pathology : No MAaLOIcRVrTEoARs,,copBKRIiADcINNEA,YtSn,SoPmLIaUNlNAiGLSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETADLUODMEUNSGCNL,E,JESSPULNEOEMN,, ANIODLDREEEU,MN,AL'SPAGALLNTACUNRADERSAY,S,GSLACCNBIDCNSUT,MI,CMANCENORLDVOIENB,,ULAPRREICTKLUUYIMMT,PAHRMYENGOSLDEEAN,NFDE,TRHIYCMULSy,wps SPTHHEAYMRRIYOANILXD/LVGAELRSAYINNCDXL,,ES`,EPYAREUA(RTSIH)NYARWROIYITDHBGLLAODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRWAOMGSIUTDSAE,TSE,, FEVUR/KNEE JOINT, STERNUM, NOSE Histopathology -- verFATTY CHANGE, MEDIAN CLEFT, minimal INFLAMMATION, SUBACUTE/CHRONIC, minimal. No MiTcHYrRoOsIcDopGiLcANADbnormality Observed --~ -_-- 5 00000 CompanySanitized. Does notcontTSaCAiCnBI 20F0--D2Da5a4y2yO5G;eevvSaaugbgecehSSrutosurtdiyyciiTnnoRRxaaitctsistwywiitthhOOGnneeenGeerneartaitioonnRReepprroodduuccttiioonn EBvraalluuasttiioonnss __________ DDuuPpoonnt--1111441188 ~ Showing anIindmiavlidduaatla AfnoirmailndLiivsidtuianlg animals sDtoospe GFup :V 5104025m/gn/aklge (T+reAaPtPmReOnVtE:D PR10O0TOmCgO/Lkg*) V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665143 TKeirlmliendalon SDaacyr:ific5e2 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRANACIRNE,ASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND.THYMJS, `PTHHAYRRYOITND/LGALRAYNNDK,, `PEAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEENMUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAIRMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + --~ LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, mininal No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : 556- `Company Sanitized. Doesnotcontain TSCA CBI 2S05.4D2ay5:GavSaugbeehSuooniyciTnoRxaitcstywith OneGenerationReproduction Evaluations -- soy 5425S/nhaolweing(+aAnIPinPndaRilOvViEddDuaatlaPRAOfnToiOrmCaOilLndLi+)ivsidtuianlg animals Dose Group + V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings DuPont 11418 665155 TKEexirplmolisenudarleonGSrDaoacurypif: i: c52seubch - Animal is signed off from necropsy Gross athology : No MAaLOIcRVrTEoARs!,copBKRIiADcINNEA,YbSn,oSPrLImONaNAlGLiSt,CyORHODEb,AsRsTrS,TvOeMSdAKCE:HL,ETADLUODMEUNSUCML,E,JESIPULNEUEMN., AINDOLDEREUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GSLACCNIEDCASUT,MI,CWNACEONRLDVOIENB,,ULARPRIETILUYINMT,PAHRYMNEGSOLEDAN,NTDE,RTIHCYMULSr,ip: TSPHERYMARIRONVIANXDL/VLGEALSRAIYNCDNL,EE,S`,PEAYREUA(RTSIH)NYARRWOYIITDBHLGALODAPDNTEDIRSC,, NETTRERVSAETC,HHSE,AS,KIENPE,ISDOIPPDHRYAONGSIUTDSAE,TSE,, FEVUR/KNEE JOINT, STERNUM, NOSE Histopathology --_ L1verINFLAMMATION, FATTY CHANGE, MSEUDBIAACNUTCEL/ECFHTR,ONImCi,nimmailn.imal. No M"iTcHrYoROsIcDo.piGcLAANbDnormality Observed -- ---- oT -- Company Sanitzed. Doesnotcontain TSCA CBI 5205-4Da2y5:GavSaugbecShtsoundiyc iTnRoxaisctwyithOneGenerationReproductionEvaluations DuPonc 11415 --~ stooy 5425/Snhaolweing(+aAnIPinPmdaRilOvViEdduDaatlaPRAOfnToiOrmCaOilLndi+L)viisdtuianlg animals Dose Group : VI 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Aninal Ret Microscopic & Macroscopic Findings TT 664995 KTeirlmliendalonSDaacyrif: ic9e2 mm nExipaoslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MAaLOIcRVrTEoARs,,coKBpRIiADcINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSGCMLNE,,JESSPULNEUEMN,, NAIODLDREEUE,MN,AL`PSAAGNLLCIAVRNAEDRASYS,,GLSACCNIEDCASUT,MI,CMNACEONRLDVOIENB,,ULARPERICTTLUUIYMTM,APRHYMNEOGSDLEEAN,NTDE,RTHIYCMULS,ye TPSHEHAMYRIRYNONAIXLD/LVGAELRSAYINCNDL,XE,S`,BPAYREUA(RTSIH)NYARWROIYITDHBLGAOLDAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : --_ LIVERHIYN:PFELRATMRMOAPTHIYO,N, HESPUABTAOCCUETLEL/UCLHARRO,NICC,ENTmRiInLiOmBaUlL.AR, minimal. KIoNEAYGSGREGATES, LYMPHOID, minimal TLovwessIN+ FLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal THYROIHDEMOGRLRAHNADGE:, minimal. PROSTHAYTPEERTROPHY, FOLLICULAR CELL, minimal. 664999 Continued onAGtGhReEGnAeTxEtS,pagLeYMP.H.O.I.D, minimal. -- -_-- 558- Company Sanitized. Doesnotcontain TSCA CBI 102-5D4a2y5G:avSaugbeeShtoundiyciTnoRxaitcistyithOneGeneration Reproduction Evalustions Dupont11418 ~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals DSoTsUeDYGioup : VI5I412050/0malmeg/k(g+ APTPreRaOtVmEeDntP:ROTO1C0O0L0 m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings or 664995 Continued from previous page or Histopathology : URINARAYGGRBELGAADTDEESR, LYMPHOID, minimal. EeIDIADGYGMRIEDGEASTE:S, LYMPHOID, minimal. NOSE I: NFLAMMATION, ORAL MUCOSA, minimal. No MiHEcArRoTs,cop`SiKcELAEbTnAoLrWmUaSlCiLtEy, OSbPsLeErEvNe,d:AORTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H,`MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNCYREGALSA,NDSC,ECUMMA,NDCIOBLUOLNA,X LPYAMRPAHTHNYORDOEI,D AGLDARNEDNSA,L GTLRAANCDHSE,A, SCESIOAPTHIACGUNSE,RVEP,HARPYINTXU/ILTAARRYYNXG,LAND, FEEYEM(USR)/KWNIETEHJOOIPNTTI,C NSETREVREN,N,SKIBNO,NESMEAMRIRNOAWL VESICLES, TESTES, 665002 ~~ TKeirlmliendalonSDaacryif:ic1e27 AEnxipmoaslureisGrsoigunped: orfefcovfrom necropsy Gross Pathology : No MLaIcVrEoRs,copKiIcDNEAYbSn,omLaUlNiGSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GSLACNIDNST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 665002 Continued on the next page .... --_ 55 `Company Sanitized. Donotecontsain TSCA CBI SH0--2D5a4y2G5:avSaugbeehSrtoundiyciTnoxRaitcsitwyithOne.GenerationReproduction Evaluations Dupont11418 ~ sruoy 5425/Smhaolweing(+aAnIPinmPdaRilOvViEdduDaatlaPROAfTnoOirCmOaiLlndi+L)viisdtuianlg animals Dose Group : VI 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665002 Continued from previous page Gross Pathology : No MaTPHcHArYRoRYsOIcINDoKp/iGLLcAARNYADNb,Xn,orPEAmYRaEAl(TiSHt)YyRWOOIIbTDsHeGrOLvPAeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMNUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : LIVERINFLAMMATION, FATTY CHANGE, MSEUDBIAACNUTECL/ECFHTR,ONImCi,nimmailnimal. THYROTFDATGTLYANCDHAN:GE, PERIPORTAL, minimal. HYPERTROPHY, FOLLICULAR CELL, minimal 665007 TKeirlmliendalonSDaacryif: ic1e27 ~ AEnxipmoaslureisGrsiogunped: orefcfovf.rom necropsy Gross Pathology : No MAaLOIcRVrTEoARs],copBKRiIAcDINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyORHODEb,AsReTrS,TvOeMSdAKCE:HL,ETADLUODWEUNSUCML,E,JESJPULNEOEMN,, NAIODLDREEEU,MN,AL"SPAGALLNIACVNRADERSAY,S,GLSACCNIEDCASUT,MI,CMNACEONRLDVOIENB.,ULAPRREICTTLUUYIMMT,PAHRMYENGOSLDEEAN,NTDE,RTIHYCMULSY,MPH 665007 Continued on the next page -... --~ 960 `Company Sanitized. Doesnot contain TSCA CBI $0H--2D5a42y5G:avSaugbecShtruodiyciTnoxRiactistyithOne-GenerationReproduction Evaluations Dupont11418 ~ Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals sDtoosneyGIup : 5VI 412050/0namlge/k(g+ APTPreRaOtVmEeDntP:ROTO1C0O0L0 m*)y/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665007 Continued from previous page Gross Pathology : No MaTcHYrRoOsIcDopGiLcANADb,norPAmRaAlTiHtYyROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, SPHEAWRIYNNAXL/VLEASRIYCNLKE,S,SYEU(RSI)NARWYITHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOHSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology + LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROHIYDPEGRLTARNODPH:Y, FOLLICULAR CELL, mild. 665026 TKeirlmliendalonSDaacyrif: ic52e AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy ~~ Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,omLaUlNiGtS,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GSLACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, 665026 Continued on the next page .. 561- CompanySanitized. Doesnotcontain TSCA CBI 205-D4a2y5:GaSgubecShvtoundiyciTnoRxiacsitwyith OneGenerationReproduction Evaluations Dupont11418 ~ stony 5425/Snhaolweing(+aAnIPinPmdRaiOlvViEddDuaatlaPRAOfnToiOrmCaOilLndiL*)viisdtuianlg animals Dose GRoup ~WII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665026 Continued rom previous page Tr Gross Pathology : Yo MaTPHcHArYRoRYsOIcINoDKp/iGLcLAARNYADNt,Kn,oPmSAaYRlBAi(TStH)yYRWOOIbITDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEVVUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, SPIDIDVWIDES, Histopathology : L1vERHIYNPFELRATMRMOAPTHIYO,N, `HSEUPBAATCOUCTEEL/LCUHLARRO,NICC,ENTmRiInLdOnBaUlL.AR, minimal. KIowECYHSRO: NIC HEART: PROGRESSIVE NEPHROPATHY, minimal. MANDIBIUNLFALRAMLMAYTMIPOHN,RODSEUBA: CUTE/CHRONIC, minimal. --~ mSERYTHROCYTOSIS/ERVTHROPHAGOCYTOSIS, SINUS, mild. HEMORRHAGE, minimal TPRHOYSRTOAIHTDYEPEGRL+TARNODPH:Y, FOLLICULAR CELL, mild EPIDTAADGGYGGNRRIEEDGGEAASTTEE+SS,, LYWPHOID, LYMPHOID, minimal. minimal. Nos I: NFLAMMATION, TURSINATES, minimal 665026 Continued on the next page .... --~ _--_--m 6 Company Saniized. Does notcontainTSCA CBI H-25425; SubchonicToxicity 2900--DDaayySGaavvaaggeeSStuuoddyyiinnRRaattsswwiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiioonnEvaluatiEovalunatisons DuDuPPoonntt-1111441188 ~ Showing anIinndailvidduaatla AfnoirmailndLiivsidtuianlg animals sDtousoey Group : V2I5I421500m0alneg/k(g+ APTrPeRaOtVmEeDntP:ROTO1C00O0L m*g)/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665026 Continued from previous page Histopathology : No MLiUcNrGoSs,copSiKcELAEbTnAoLrMmUaSlCiLtEy, OSbPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H,`MDEUSOEDNETENRUI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUAMD,RENCAOLLON, G`TLRAANCDHSE,A, SCESIOAPTHIACGUNSE,RVEP,HARPYINTKU/ILTAARRYYNEG,LAND, PARATHYROID GLANDS, BEYLEA(DSD)ER,WITTHESTOEPST,ICFNEEMRUVRE/,KNESKEINJ,OINSTE,MISNTAELRNVUEMS,ICLBEOSN,E UMARRIRNOAWRY 665027 TKeirlmliendalonSDaacyrif: ic92e AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology --~ No MAaLOIcRVrTEoARs!,copKBRIiADcINNEA,YbSn,SoPrImLNUaNAlGLiSt,CyORHODEb,AsReTrS,TvOeMSdAKCE:HL,ETDAULODMEUNSUCMLE,, JESJPULNEUEMN,, NIOLDEEU,M, `SPAALNICVRAERAYS,GLACNEDCSU,M, MACONLDOINB,ULARERCTLUYMM,PHMENOSDEEN,TERTIHCYMULSY,MPH A`TDHRYERNOAILD GGLLAANNDD,S, `PSACRIAATTHIYCRONIEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, `PSHEAMRIYNNAXL/VLEASRIYCNLXE,S,EYEU(RSI)NARWYITBHLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYONSITDAETSE,, FENUR/KNEE JOINT, STERNUM, NOSE 665027 Continued on the next page -_-- 563 Company Sanitized. Doesnotcontain TSCA Cal 1902-5D0a2y5G:aSvuabgcehSrotniyciTnoxRiactistywith OnGeeneration Reproduction Evaluations Dupont11418 ~ stony 25025/Snhaolweing(+aAnIPinPndaRilOvViEddDuaatlaPROAfTnoOirCmOaiLlndi+L)viisdtuianlg animals Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males nial Ref Microscopic & Macroscopic Findings 665027 Continued from previous page " Histopathology LiverDEGENERATION, INFLAMMATION, HSUEBPAACTUOTCEE/LCLHURLOANRI,C,FOCmAiLn,inamlil.d. LossHYPERTROPHY, `HEPATOCELLULAR, CENTRILOBULAR, minimal MANDIBMUALCARRO.PHLAIGNEESA,NOALDVEEOLAR, FOCAL, minimal. ToSNE;ERCYRTOHSRIOSC,YTLOYSMTPSH/OEIRDY,THRmOinPiHmAaGlO.CYTOSIS, SINUS, mild. THYROIHDEMGORLRAHNADGE+, mild. PROSTAHTYEPER+ TROPHY, FOLLICULAR CELL, mild. Nose;AGGREGATES, LYWPHOID, minimal. INFLAMMATION, TURBINATES, mild. --~ Yo MiSHETcAOrRMoTAs,CcHo,pSiKDcEULOAEDbTEnANLoUrMMm,UaSlCJiLEtETy,UNOUbSNPs,LeErEvTNLe,EdGNA:,ORTPAA,NCRBERAASI,N, CBSOPQIMNN,ALCOCLOORWD,, GRLEACNDTS,, TRACHER, `SWCEESISOAEPTNHITACEGRUNISEC,RVLEPY,HMAPRHPYIINTNOU/DIELT,AARRYYSNAXGL,LIAVNADR,Y GSLAARNNDFSH,YRAODZDRENGLAALNDS, BEBOYLENA(DESD)EMRA,RWRIOTTWEHSTOEPST,ICENPEIRDVIED,YMISDKEISN,, FSEEMMUIRN/AXLNEVSESIJCOLIENST,, SUTREIRNNAURMY, ~ FaE `CompanySanitized. Doesnot contain TSCA Gal 25425: Subchronic Toxicity 202--DDaayyGGaavvaaggeeSSttuuddyyiinnRRaattsswwiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiioonn BEvvaalluusattiioonnss _ DDuuPPoonntt.1111441188 ~ sony Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals 5425/male (+ APPROVED PROTOCOL *) Dose Group: VI 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 565031 KTielrlmeindalonSDaacyrif: ic1e27 AEnxipmoaslureisGrsoiugpned: orefcfovf.rom necropsy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JESJPULNEUEMN,, NAIODLDEREQE,NN,AL`SPAGALLNIACVNRADERSAY,S,GSLACCNIEDCASUT,MI,C`NMCAEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRMYENGOSLDEEAN,KTDE,TRHIYCMULSM, P `PTHHAYRRYONIID/LGALRAYNNDK,, `BPYAER(ATSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNVEEESIJCOLINETS,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : --~ LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERTPORTAL, minimal FATTY CHANGE, MEDIAN CLEFT, mild No Mi`TcHrYoRsOcIoDpGiLcANADbnormality Observed : --~ -_-- 6 CompanySanitized. Doesnotcontain TSCA CBI H902-5D4a2y5;GavSaugbechSrtoundiye iTnoxRiactistywithOneGenerationReproduction Evalustions Dupont 11418 ~ Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals DsotsuepyGroup: VI5I421500/0manlge/k(g+ APTrPeRaOtVmEeDntP:ROTO10C0O0L m*g)/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings s65062 KTeirlmliendalonSDaacry:ific1e27 AEnxipmoaslureisGrsoigunped: orfefcovfrom necropsy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, ANIOOLDREETU,AM,, SABPRALANIICVNRA,ERAYSS,GPLIACNNEADCLSU,MC,ORMDAC,ONLDOISNBT,OUMLAARCREHC,TLUYMMD,PUHODMEENNOSUDEEMN,,TERTJHIEYCJMUUNLSUY,MM,PH A`TDHRYERNOAILD GGLLAANNDD,S, `SPACRIAATTHIYCRONIEDRVGEL,ANDPSI,TUTIRTAACRHYERG,LANEDS,OPHAGUS, 'SFPEEHMMAUIRRNY/ANKLKN/VELEEASRIJYCONLIKEN,ST,,EYEUS(TRSEI)RNNAUWRMIY,TBHLNAOODSPDETEIRC, NTEERVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, Histopathology : ~~ LIvERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROHIYDPEGRLTARNODPH:Y, FOLLICULAR CELL, mild --~ --e--e----------_----------------o66--- ------------------------------ Company Sanitized. Does not contain TSCA GBI H902-5D4a2y5:GaSvuabgcehrSotnuidyc TinosRiactistywith One-Generation Reproduction Evaluations Duron 11418 ~ stoy 5425/Smhaolweing(*anAIiPnnPdaRilOvViEddDuaatlaPRAOfnToiOrmCaOilLndiL*)viisdtuianlg animals Dose Group MWII 1000 mg/kg Treatment: 1000 ng/kg VII Sex: Males Animal Ref Nicroscopic & Macroscopic Findings G65067 TKeirlnliendalonSDaacyrif: ic12e7 or AEnxipmoaslureisGrsoiugpned: orfefcovfrom necropsy Gross Pathology No MAaLOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSu,SoPrLIpUNaNAlGLiSc,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETADULODMEUNSUCML,E, JESJPULNEGEMN,, ANIDOLDREEUE,MN,ALSAPGLALINACVNRADERSAY,S,GLSACCNIEDCNSUT,MI,CMACNEONRLDVOIENB,,ULAPRRIETCPLUUYINMT,PAHRYMENGOSLDEEAN,NTDE,RTHIYCMULS,ib TSPEHEMYAIRRNYOAIIVLD/LGVALERASYNIDNC,KL,ES`,SPYAERU(ARSTT)HNYARRWOYIITDBHLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIBNEI,SDOIPPDHRYAONGSIUTDSAE,RSE,, FEVUR/KNEE JOINT, STERNUM, NOSE Histopathology --_ TLHIYVREORITDN+ FGLLAAMNADTION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, FOLLICULAR CELL, minimal. -- tee Company Sanitized. Does notcontain TSCA Cal -- 9F0-D25a4y25G;avSaugbcehSrtoundiyciTnoRxaitcsitwyithOne-GenerationReproduction Evaluations DuPont 11418 ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitduianlg animals Ssrauopy Mo 2542'510/0n0alemg/k(g+ APTrPeRaOtVmEeDntP:ROTO1C0O0L0 m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665082 TKeirlmliendalonSaDcaryif:ic9e2 EAnxipmoaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology : No Ma"MLOcIRrVToEAsR,,copKSBiIRDcANLEANY,bSn,oSrPLmIUaNNAlGLiSt,CyOROHDEb,AsReTrS,TvOeMSdAKCE:HL,ETADLUODMEUNSUCML,E, JESJPULENEUNM,, NATODEDRUEEM,N,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEICDAUSTM,I,CMACNOENLRDOVINEB,,ULRAPERICTTLUUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTIHCYMULSY,MPH T'SPEEHYMARIRONYTANDLR/GVLLEAASRNIYDCN,LK,ESP,EAYREUA(RTSIH)NYRAWORIIYDTHBGLLAOADPNDTDEISRC,, NETTRREVASECT,HEESR,S,KIENPE,ISDOIPPHDRAYOGMSUITSDA,ETSE,, 'BEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : -- LIVERA`YI: PNEFRLTRAOTPIHOYN,, HESPUABTAOCCUETLEL/UCLHARRO,NICC,ENTmRiInLiOmaBlU.LAR, minimal. KIDNEY"ACSGHGRR:OENGIACTEPSR,OGLRYEMSPSHIOVIED,NEPmHiRnOiPmAaTlH.Y, minimal. LowesCy+st, TUBULAR, mild. HEMORRHAGE, ALVEOLAR, minimal. MANDIBLUEULKAORCYLTYOMSPTHS,NODPELA:SA CELL, MEDULLARY, mild. THOUSHEMORRHAGE, minimal 665082 Continued on the next page .... --~ - 96s `Company Sanitized. Doesnot contain TSCA CBI 9H-02-5D4a2y5G: aSgubeehSvotndiyc iTnoRxaitcistywithOne Generation Reproduction Evaluations `DuPont-11418 ~~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals SDToUsDeY.cup WII5421500/0malmeg/k(g* APTPreRaOtVmEeDntP:ROTO1C00O0L n*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665082 Continued from previous page Histopathology : THYROHIYDPEGRLTARNODPH:Y, FOLLICULAR CELI, mild. EPIDI"DAYGMGIRDEEGSATE: S, LYMPHOID, minimal No MiHcErAoRTs,copSiKcELAEbTnAoLrMmUaSlCiLtEy, ObSsPLeErEvNe,d AORTA, BRAIN, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CESCPUIMN,ALCCOOLRODN,, RGELCATNUDMS,, MSECSIEANTTIECRINCERVLEY,MPHPINTOUDIET,ARSYAGLLIAVNADR,Y GPLAARNADTSH,YRAODIRDENGALALNDS, UTEVRREAI(CNSHA)ERAY,WIBLTEAHSDODPOEHPRAT,GIUCST,ENSETRPEVHSEA,,RYNSFXKE/IMNLU,ARR/YKPNNRXEO,SETAJTOEI,NT,SESMTIENRANLUMV,ESIBCOLNEES, MARROW, NOSE 665095 --~ TKeirlmliendalonSaDcaryif: ic1e27 AEnxipmoasulreisGrsoigunped: rofefcovfrom necropsy Gross Pathology : No MaLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETCAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, 665095 Continued on the next page --.- --~ --- 965`Company Sanitized. Doesnot conTtSaCAiCBnI 9F0--25D4a2y5G;avSaugbcehSrtoundiyciTonxRiactistywithOneGenerationReproduction Evaluations Dupon-11418 ~~ soy 5425/Smhaolwieng(+anAIiPnmPdaRilOviVdEduDaatlaPRAOfnToiOrmCaOilLndiL*)viisdtuianlg animals Soo croup TIT 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665095 Continued from previous page Gross Pathology : No Ma"cTrEoRsOcToDpGiLcANADb,norPmAaRlAiTtHyYROOIbDseGrLvAeNdDS:, PHEARYIOR/LARVYK, EYE(S) WITH OPTIC NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AXLNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed 665096 KTeirlmliendalonSDaacyri:fic9e2 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy ~~ Gross Pathology No MaF`LOcIRrVToEAsR,,copBKRiIADcINNEA,YbSn,oSrPmLIaUNNlAGiLSt,yCOROHDbE,RsReTrS,vTOeMdSAKCE:HL,ETADULODMEUNSUCML,E, JESJPULNEUEMN,, ANTODEDRUEEM,N,ALSAPGLALNIACVNRAEDRASYS,,GLSACCNEIDCASUT,MI,CMANCEONRLDVOIENB,,ULRAPERICTTULUIYMTM,PAHRYMNEOGSDLEEAN,NTDE,RTHIYCMULSY,MPH 665096 Continued on the next page --.. --~ - om Company Sanitized. Donotecontsain TSCA C81 0F--2D5a4y2G5vSaugbechSrtourdiyciTnoRxaitcistyithOGneeneration Reproduction Evaluations DuPont. 11418 ~~ Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals DsouspeYGEup VII5421500/0malmeg/k(g* APTrPeRaOtVmEeDntP:ROTO1C00O0L m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665096 Continued from previous page Gross pathology : No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDserGLvAeNdDS:, PHARYNX/LARYNE, EYE(S) WITH OPTIC NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMTUNRA/LK,NVEEESIJCOLIENST,, USRTIERNNAURMY,BLNAODSDEER, TESTES, SPIDIDYMIDES, Histopathology LIVERHIYN:PFELRATMRMOAPTHIYO,N, HESPUNBTAOCCUETLEL/UCLHARRO,NICC,ENTmRiInLiOmBaUlL.AR, minimal. KIDNEY`CSHRONIC PROGRESSIVE NEPHROPATHY, minimal. LowesA:GGREGATES, LYMPHOID, minimal. INFLATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. THOUSHEMORRHAGE, ALVEOLAR, minimal. ~~ THYROHIEDMOGRLRAHNADGE:, minimal. HYPERTROPHY, FOLLICULAR CELL, minimal. | EYE(S)INWFLIATMHMAOTPITOINC,NEPREVRIEOC:ULAR, UNILATERAL, mild URINAARGYGRBELGAADTDEESR, : LYMPHOID, minimal. 665096 Continued on the next page .... --_ FE oI ---- Company Sanitized.Doesnotcontain TSCA CBI 9H0--2D5a4y25G:avSaugbeeShtvoundiyciTnoRxaitcsitywith OneGenerationReproductionEvaluations DuPont-11418 -- Showing anIinmdailvidduaatla AfnorimailndiLviisdtuianlg animals sDroospeyGroup: WI5I42150/0m0alneg/k(g* APTPreRaOtVmEeDntP:ROTO1C0O0L0 m)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665096 Continued from previous page Histopathology No MiHcEArRoTs,copSiKcELAETbAnLorMmUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, R`SETCOTMUAMC,H,MEDSUOEDNETNEURNI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R LPYAMRPAHTHYNORDOEI,D AGLDARNEDNSA,L GTLRAANCDHSE,A, SCEISOAPTHIACGUNSE,RVEP,HARPYINTGU/ILTAARRYYIXG,LAND, FSKEIMNU,R/KPNREOESTAJTOEI,NT,SESWTIENRANLUMV,ESIBCOLNEES,MARTREOSWT,ES,NOSEEPIDIDYMIDES, 665107 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ~~ ATOLREOTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLOYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNDN,K, PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AXLNVEEESIJCOLIENST., SUTREIRNNAORMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, 665107 Continued on the next page -... -- on. Company Sanitized. Donotecontsain TSCA CBI 9H02.5D4a2y5:GavSaubgeehSrtoundiyciTnorRiactistywith One-Generation Reproduction Evaluations DuPont11418 --~ Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals DsotsuepyGMD WWII5421500/0malmeg/k(g* APTPreRaOtVmEeDntP:ROTO1C00O0L m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 565107 Continued from previous page Histopathology LIVERHIYN: PFELRATMRMOAPTIHOYN,, HESPUABTAOCCUETLEL/UCLHARRO,NICC,ENmTiRnIiLOmBaUlL.AR, KIDNEYASGGR:EGATES, LYMPHOID, minimal. `THYROHIYDPEGRLTARNODPH:Y, FOLLICULAR CELL, mild. EVE(S)OPWTIICTHNEOPRTVIECNONTERVPREESENT, UNILATERAL. PROST"AATGEGRE: GATES, LYMPHOID, minimal. EPIDI`DAYGMGIRDEEGSATE:S, LYMPHOID, minimal. minimal No MiCLOUcRNrDGo,Ss,co`SpHTiEOcAMRATAC,bH,noSrDKmUEOaLDlEEiTNtAUyLM,OMUbSsJCeELJrEUv,NeUdMS,P:LEIELNE,UM,AORPTAAN,CREBARSA,IN,CECSUPMI,NAL -- NMCEOARLNVODENI,,BULRPEAICRTTUULIMYT,MAPRHYMENGSOLEDANENT,DE,RITCHPYAMLRUYASMT,PHHYARDNOORIDEDEN,GALLASNGADLLSAI,NVDASRT.YRACSGHLCEAIANA,DTSI,C `ESSEOMPIHNAAGLUSV,ESIPCHLAERSY,NKU/LRAIRNYANRXY, BELYAED(DSE)R,WITTESHTEOSP,TIC NERVE, SKIN, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -- wom `CompanySanitized. Doesnot contain TSCACBI 9205-4D2ay5:GavSaugbeehSrtouidyc iTnoxRiacistywithOne-GenerationReproductionEvalustions DuPont 11418 ~ Showing anIinmdailvidduaatla AfnorimailndLiivsidtuianlg animals sDtouspeyGYSup : 5VI 412050/0malneg/k(g+ APTPreRaOtVmEeDntP:ROTO1C00O0L m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings ses112 KTeirlmliendalonSDaacryif:ic1e27 ASnxipmoaslureisGrsoiugpned: orfefcovfrom necropsy Gross pathology No MaA`LOcIRrVToEAsR,,copBKiRIcADINNEA,YbSn,oSrPLmIUaNNlAGiLSt,yCORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, ANTODEDEREUE,MN,ASLAPGALLNIACVNRADERSAY,S,GLSACCNEIDCASUTM,I,CMANCOENLRDOVINEB,,ULAPRERICTTULUYIMMT,PAHRYMNEOGSDELENA,TDE,RTHIYCMULSY,MPH T`SRSHEYAMRRIYONNTAXDL/LVGAELRSAYINNCDKL,,ESP,EAYREAU(TRSHI)YNRAWORIIYTDBHGLLOAAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : ~ LIVERIN: FLAMMATION, FATTY CHANGE, MSEUDBIAACNUTCEL/ECFHTR,ONImCi,ld.minimal. No MiTcHrYoRsOcIoDpiGcLANADbnormality Observed : -- - om `CompanySanitized.DoesnotcontTSaCAiCBnI 9H02.5D4a2y5G:avSaugbeeSktoundiyciTnonRiaciistwyithOne-Generation Reproduction Evaluations DuPont 11418 ~~ Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals osrsuepy cMBup WBTI542150/0m0almeg/k(g* APTrPeRaOtVmEeDntP:ROTO1C00O0L m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665120 TKeirlmliendalonSaDcaryif:ic9e2 AEnxipmoaslureisGrsiogunped: osfufbchfrom necropsy Gross Pathology KIDNEY`DSIL:ATATION, BILATERAL, PELVIS, LEFT WODERATE RIGHT SEVERE. No MaS`LcPIrIVoNEsRA,cLopCLOUiRNcDG,SA,bnSoTHOrEMAmARaTCl,Hi,tySDKUOEObLDsEETeNArULvMe,MdUSJ:CELJEU,NUMS,PLEIELNE,UM,AORPTAAN,CREBARSA,IN, SGCLCCAIUNAMDT,SI,CCONMLEAORNNVD,EI,BURLEPACIRTTUUMLI,YTMAPMRHEYSGNEOLNDATENE,DR,ICTHTYLHMYYUMRSPO,HIDANODGDLRSAE,NNDA,LSAGLLIAVNADRSY, UE`PYRAEIR(NASAT)RHYYWRIBOLTIAHDDDGOELPRAT,NIDCST,NEESRTTVERESA,,CHEESAKP,IIND,IEDSYOPMPRIHODASEGTUSAS,T,E,FEPMHSAUERRMY/INKNKAN/LELEAVREJYSONIIXCN,LTE,S, STERNUM, NOSE Histopathology : . LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYHSYDRONEPHROSIS, UNILATERAL, mild. THOUSHEMORRHAGE, minimal. THYROIHDYPEGRLTARNODPH:Y, FOLLICULAR CELL, mild. TRACHIENA:FLATION, FOCAL, minimal. 665120 Continued on the next page . -- LO7S 5 ------ CompanySanitized. DoesnotconTtSaCAiCnBI 9F0--25D4a2y5G:avSaugbeeShtoundiyciTnoxRiactistwyith One-GeperaiionReprodicton Evaluations DuPont 11418 ~~ Showing anIinmdailvidduaatla AfnoirnailndiLviisdtuianlg animals sDotsoeoy cep WI2T5421500/0malmeg/k(g+ APTPreRaOtVmEeDntP:ROTO1C0O00L m*)g/kg VII Sex: Males Animal Ref 665120 Microscopic & Macroscopic Findings Continued from previous page Histopathology No Mi'LcOrNoGsS,copHEiAcRTA,bnoSrKmEaLElTiAtLy OWUbSsCeLrEv,edSP: LEEN, AORTA, BRAIN, SPINAL CCOOLRODN,, SRTEOCMTAUCMH,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAGSL,ANDCSE,CUM, MPAINTDUIIBTUALRAYRGLLAYNMDP,H NPOADREA,THAYDRROEINDAGLLAGNLDASN,DS,ESOSPCHIAAGTUISC,NERVE, "SPEHMAIRNYANLX/VLEASRIYCNLKE,S,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYONSITDAETSE,, FEVUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665138 TKeirlmliendalonSDaacryif:ic1e27 AEnxipmoaslureisGrsoiugpned: orefcfovf.rom necropsy Gross Pathology : ~~ No MaLcIVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, NTOLDESU,M, SAPLANICVRAERAYS,GLACNEDCSU,M, MACONLDOINB,ULARERCTLUYMM,PHMENOSDEEN,TERTIHCYWULSY,MPH ATDHRYERNOAILD GGLLAANNDDS,, PSACRIAATTHIYCRONIEDRVGEL,ANDPSI,TUITTRAACRHYEAG,LANBDS,OPHAGUS, SPEHMAIRNYANXL/LVAERSYINCKL,ES,EYUE(RSI)NAWRIYTHBLAODPDTEIRC, NTEERSVTE,ES,SKIBNP,IDIPDRYOMSITDAETSE,, FENUR/KNEE JOINT, STERNUM, NOSE 665138 Continued on the next page .... --_ o6Company Sanitized. DossnotcontTSaCAiCBnI H02-5D4a2y5G;avSaugbeehSrtourdiycTionRxiacistwyithOne-GeoerationReproduction Evabations Dupont 11418 ~ stony 25425mShaolweing(+aAnIPinEndaRilOviVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsitdiunagl animals Dose GYRNP ? VII 1000 mo/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ret Microscopic & Macroscopic Findings G65138 Continued from previous page Histopathology : LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. No MiTcHrYoRsOcToDpiGcLAANbDnormality Observed : 665146 TKeirlmliendalonSDaacyrif:ic1e27 AEnxipmoaslureisGrsoiugpned: orfefcovfrom necropsy Gross pathology : No MHaLOIcRVrTEoARs,,copBKiRIcADINNEA,YbSn,oSrPLmIUaNNlAGiLSt,CyORHODEb,AsReTSr,TvOeMdSAKCEHL,ETADULODMEUNSUCML,E, JESJPULNEUEMN,, --~ ANIDOLDEREUE,MN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUTM,I,CMANCEONRLDVOIENB,,ULRAPERICTTLUUYIMMT,APRHYMNEOGSDLEEAN,NTDE.RTHIYCMULSY,MPH `'TSSHHEYAIRRNOVAINLDX/VGLELASARINVCDNL,KE,SP,EAYREUA(RTSIH)NYARRWOYIIDTHBGLLAODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERFA: TTY CHANGE, MEDIAN CLEFT, minimal 665146 Continued onNEtChReOSnIeSx,t pFOaCgAeL,..m.inimal. --~ . eoeT `Company Sanitized.DossnotcontTSaCAiCBnI 9205-4Da2y5G:avSaugbechSrtoundiyc TinoxRiactitwyithOneGenerationReproduEcvltusitioonns DuPont-11418 ~~ Showing anIinmdiavlidduaatla AfnoirmailndLiivsidtuianlg animals sotuspeyGPup WT542150/0m0almeg/k(g* APTrPeRaOtVmEeDntP:ROTO1C0O00L m*)g/kg VII Sex: Hales Animal Ref Microscopic & Macroscopic Findings 665146 Continued from previous page Histopathology IvesINFLAMMATION, SUBACUTE/CHRONIC, minimal. THYRO`IHDYPGELRATNRDOPH:Y, FOLLICULAR CELL, mild s65152 KTeirlmliendalonSaDcaryif: ic9e2 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology : No MaA`LOcIRrVToEAsR,,copBKiRIcADINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyOROHDbE,AsReTrS,TvOeMSdAKCE:HL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, NTOCDEEQ,M, SAPALNICVRAERAYS,GLACNEDCSU,M, WCAONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTHIYCMULSY,MPH --~ TAPDHHRYAERRNYOANTLKD,/LGGALLRAAVNNNDDKS,,, PESAYCREIA(ATSTH)IYCRWOIINTEDRHVGELO,APNTDIPSCI,TNUETIRRTVAAECR,HYEAGS,LKAINNED,S.OPPHRAOGSUTSA.TE, FSEEMMIUNRA/LK,NVEEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, SPIDIDYMIDES, Histopathology LIVERHIYN: PFELRATMRMOAPTHIYO,N, HESPUABTAOCCUETLEL/UCLHARRO,NICC,ENTmRiInLiOmaBlU.LAR, minimal. 665152 Continued on the next page ... --_ - o`CompanySanitized. Doesnot containTSCA CBI SH02-5D4a2y5G;avSaugbeehSrtoundiyciTnoRxitcsitwyithOne-Generation Reproducion Evaluations Dupont11418 ~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtouspeYimap "WIT542150/0n0almeg/k(g* APTPreRaOtVmEeDntP:ROTO1C00O0L m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings Ges152 Continued from previous page Histopathology : KIDNE"YCSHR+ONIC PROGRESSIVE NEPHROPATHY, minimal. LowesHE+MORRHAGE, ALVEOLAR, minimal. THUSHEM+ORRHAGE, minimal. "THYRO`IHDYPGELRATNRDOPH:Y, FOLLICULAR CELL, mild. EYE(S)INWFILTAMHMAOTPITOINC,NEPREVREI:OCULAR, UNILATERAL, minimal. NOSE I: NFLAMMATION, VOMERONASAL ORGAN, minimal No Mi``HScETrAOoRMsTA,cCHo,pSiKcDEULOAEDbTEnANoLVrMmM,UaSlCiJLEtEJy,UNOUbSMPs,LeErEvINeL,dEUMA,ORTPAA,NCRBERAASI,N,CESCPUIMN,ALCOCLOORND,, RLEYCMTPUHM,NODMEE,SENATDERREINCALLYGLMAPNHDSN,ODES,CINSTAILCIVNAERRYVEG,LANPDIST,UIMTAANRDYIBGLUALNADR, ~ SEBKPAIIRNDN,ITDHYPYMRRIOODSTETDSA,TGEL,AFNEDSMSEU,MRI/TNKRANALECEHVEEJASO,IICNLTEE,SSO,PSHTAEUGRRUNISUNM,A,RYPBHOBALNRAYEDNDKME/ARLR,ARROYTWMEXS,TES, --~ - oCompanySanitized. DoosnotconTtSaCAiC8n1 9H02.5D4a2y5G:avSaugbechSrtoundiyciTnoRraictitwyithOne-GenerationReproduction Evaluations `Dupont11418 ~ Showing anIinmdailvidduaatal AfnoirmailndLiivsitduianlg animals sDorsuepy CT0up# 2WI5I421500/0malneg/k(g* APTPreRaOtVmEeDntP:ROTO1C0O0L0 m*)g/kg VII Sex: Wales Animal Ret Microscopic & Macroscopic Findings 665158 TKeirlmliendalonSDaacyrif: ic1e27 AEnxipmoaslureisGrsoiugpned: orfecfovf.rom necropsy Gross Pathology No Ma`LcIrVoEsR,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JESJPULNEUEMN,, NIODDEEU,M, SAPALNICVRAERAYS,GLACNEDCSU,M,MACONLDOINB,ULRAERCTLUYMW,PHMENOSDEEN,TERTHIYCMULSY,MPH ATPDHHRAYRERYNONAIXLD/LGGALLRAAYNNNDDK,S,, PAESYRCEAI(TASHT)YICRWOIINEDTRHVGELO,APNTDIPSCI,TNUTEIRRTAVAECR,HYEAGS,LKAINNED,S,OPPHRAOGSUTSA.TE, `FSEEMMUIRN/AKLNVEEESIJCOLTENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. -- THYROIFDATTGYLANCHDAN:GE, MEDIAN CLEFT, minimal. "HYPERTROPHY, FOLLICULAR CELL, minimal. --~ -_ . o%0- CompanySanitized. Doesnot conTtSaCAiCnBI F9-02.5D4a2y5G:avSuabgeehrSotnuidcy TinoxRiactistyithOneGenerationReproduction Evaluations DuPont-11418 ~~ srupy 5425/Smhaolwieng(*aAnIPinPmdaRilOviVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsidtuianlg animals ose cup TWIT 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665160 TKeirlmliendalonSDaacryif:ic9e2 AEnxiproaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology No MaISOcVRrEToRAs,,copKSRIiADcINNEA,YbSn,oSrPLmIOaNNlAGiLSt,CyORHODEb,AsReTrS,vTeOMdSAKCE:HL,ETADLUOMDUESNCULME,, JESGPULNEUEMN,, NAIDOLRDEEEUN,MA,LS,SAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUTM,I,CMACNOENLRDOVINEB,,ULARPREICTTULUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTIHYCMULSY,MPH TP`SEHEYAMRIRNOYATILD,/LGVAELRSAYINNCDKL,,ESP,EAYREUA(RTSIH)NYARWROIYITDHBGLLAOADPNDTDEISRC,, NETTRREVASECT,HEESA,S,KIENEP,SIODPIPHDRAYOGMSUITSDA,ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology ~~ LIVERHIYN:PFELRATMRMOAPTHIYO,N, HESPUABTAOCCUETLEL/UCLHARRO,NICC,ENTmRiInLimOaBlU.LAR, minimal KIDNEY`CSHR+ONIC PROGRESSIVE NEPHROPATHY, minimal. LoNGsIN_: FLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. THYROIHDYPEGRLTARDOPH:Y, FOLLICULAR CELL, minimal. PROST"AATGEGRE: GATES, LYMPHOID, mild. 665160 Continued on the next page .. ~~ - ol Company Sanitized.DoesnotconTtSaCAiCBnI 9F0-.2D5a42y5G:avSaugbecShrtouniyciTnoRxaitcistywith OneGenerationReproduction Evaluations Dupont 11418 ~ srupy 5425/Smhaolwieng(*anAIinPmdPiaRvlOiVdEduDaatlaPRAfOnoTirOvCaOilLndLi*)ivsidtuianlg animals 1000 mg/kg VII Sex: Males ro MI, 1000 mg/kg Treatment: Animal Ref Microscopic & Macroscopic Findings 565160 Continued from previous page Histopathology No MiArcSorAuoATsC,cHo,pSiKcDEULOAEDbTEnANoLUrNmM,UaSlCJiLEtEJy,UNOUbSMsP,eLErEvINeL,EdUMA:,ORTPAA,NCRBERAASI,N, CESCPUIMN,ALCOCLOORND,, SLSEYICMTTPOUHTMT,NAORDMYEE,SGELANTNTHDYE,MRUISCP,ALRYAAMDTPRHEHYNRANOOLIDDEG,LGALNASDNASDL,SI,VSATCRRYIAACTGHLIEACAN,DNSE,REVSEMO,PAHNADGIUBSU,LAR VSEHSAIRCYLNEES/,LARUYRNIXN,ARYEYEB(LSA)DDEWRI,THTEOSPTTEISC, NESRPVIED,IDYSMKIIDNE,S,SEFMEIMNUARL/KNEE JOTNT, STERNUM, BONE MARROW, NOSE ses162 KTeirlmliendalonSDaacryif: ic9e2 EAnxipeoaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology : --~ No Ma`ALOcIRrVToEAsR,,copKBRIiADcINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyORHODEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUOWDUESNCULME,, JESJPULNEUEMN,, NASODDDEREUE,MN,ALSAPGLALNIACVNRAEDRASYS,,GLSACCNEIDCASUT,MI,CMANCEONRLDVOIENB,,ULAPRREICTTLUUYIMMT,PAHRMYENOSGDLEEAN,NTDE.RTIHYCMULSY,MPH TDSRHEAYNRRIYONNIAXDL/LVGALERASYNIIDCN,LKE,SP,EAVREUA(RTSIH)NYARWROIYITDHBLGAOLDAPDNTEDIRSC,, NTETRREVASECT,HESE,AS,KIENPE,ISDOIPPHDRAYOGMSUITSDA,ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE 665162 Continued on the next page .... --_ - Ton `CompanySanitized. DoesnotconTtSaCAiCBnI 9H02D54a2y5G:avSaugbechSrtoundiycToRxaitcistwyithOneGenerationReproduction Evaluations Dupont 11418 ~ stoy 5e25/Snhaolwieng(*aAnIPinPmdRaiOlvViEdduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsidtuianlg animals Dose Yop WWII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings sesie2 Continued from previous page Histopathology : LIVERNE+CROSIS, FOCAL, minimal INFLAGREION, SUSACUTE/CARONIC, mild FFHYAAPTTETTRYYTRCCOHHPAAHNNYGG,EE,,HEMPPEENDRTIIOPACONERLTCLALLUE,LFTA,Rm,inmiCimEnaNilTm.RaIlLOBULAR, minimal MANDIBEURLYTAHRROLCYYMTPOHSINSO,D/EERYTHROPHAGOCYTOSIS, SINUS, mild. mowsHE:MORRHAGE, minimal THYROIHDYPEGRLTARNODPHY, FOLLICULAR CELL, minimal. UPRRIONSATARGYAGTRBEELGAADTDEESR, LYMPHOID, mild. EPIDT"DAYGNGIRDEEGSATE:S, LYMPHOID, minimal. ~ woe;`IANGFGLRAEMGMAATTEIS,ON,LYNNPAHSOOILDA,CRmIiMnAiLmaDlU.CT, mild. No Mi`BRKcADrINoNEs,VcSo,p$iPcLIUNNAAGbLSn,oCrORmHDEa,AlRiTtS,TyOMOSAbKCsEHeL,rEvTeADdLUODM:EUNSGCHL,E,JESJPULNEUEMN,, AIOLRETUAM,, GPSLAAANLNCIDRV,EAARSYP,AGRLCAAETNCHDUYSNR,,OICADODLRGOLENAN,NADLSR,EGCLTATUNRMDA,SC,HEMAES,SCEINEASTTOEIPRCHIACNGEURLSVY,EM,PHPNIOTDUEI,TARY 665162 Continued on the next page .... --~ EH CompanySantized. Doesnot contTSaCAiCnBI 9H-02-5D4a2y5G;avSugbeehSrtoundiyciTnoRxaitcistwyithOne-GenerationReproduction Evaluations DuPont.11418 ~ Showing anIinmdailviddautaal AfnoirmailndLiivsitdiunagl animals Dsorsuepy Wi:5412050/0nalmeg/k(g* APTPreRaOtVmEeDntP:ROTO1C0O00L m*)g/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings o 665162 Continued from previous page - Histopathology No MViPEcASrRIoYCsNLcEEo/SpL,iAcRTYAENSbXTn,EoSr,mEYaElF(iEStM)yURWO/IKbTNsHEeErOvPeJOTdIINC:T,NERSVTEE,RNUSMK,IN,SOSNEEMIMANRARLOW, NOSE. ~ ++ Listing Complete *** --~ _-- E Company Sanitized. Does not containTSCA CBI F9-02.5D4a2y5G:avSaugbeeShtroundiyciTnoxRiactistywithOneGenerationReproduction Evaluations DuPont11418 ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals sDorsuepyGroup II 0Mac/eknga1 T(r*eaAtPmPeRnOtV:ED P0RmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665170 TKeirlmliendalonSaDcaryif:ic9e3 EAnxipmoaslureisGrsiogunped: sofufbchfrom necropsy Gross Pathology : No Ma`ALcOIRrVToEAsR,c,opKBiRIcADINNEA,YbSn,SoPmLIaUNlNAiGLSt,yCOROHDEb,AsReTrS,TvOeMdSAKCE:HL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, NATODLDEREUE,MN,ALSAPGALLNIACVNRAEDRASYS,,GSLCACENICDAUSTM,I,CMACNOENLRDOVINEB,,ULARPREICTTULUYIMMT,PAHRMYENOSGDELENA,TDE.RTHIYCMULSY,MPH TGPHLHYAARRNYODNIRD(/FLGEALMRAAYNLNDEK,),, PEOAYVREAA(RTSIH)EYSR,WOIIDTUHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEASU,KRIINNE,ASORPYMHAABMGLMUAASDR.DYER, FEMUR/KNEE JOINT, STERNOM, NOSE Histopathology : ~ LIveRFATTY CHANGE, INFLAMIATION, MSEUDBIAACNOTEC/LECFHTR,ONImCi,ld.minimal. KIDNEYFCSHARTOT: NYICCHAPNRGOEG,RESPSEIRVIEPORNTEAPLH,ROPmAiTnHiYm,al.minimal. LovesH:EMORRHAGE, ALVEOLAR, minimal. PHARYNDEKG/ELNAERRYANTXIO:N, MYOFIBER, mild. SYE(S)OPWTIITCHNEORPTVIECNONTERVPERESENT, BILATERAL. 665174 Continued on the next page .-.- --_ - os CompanypanySaniSanitized. Doesnotcon" tTSaCAiCnBI 9H0--2D54a2y5G:avSaugbeehSonitcTionuxRiactdistwyiythOneGenerationReproduction Evaluations DuPont 11418 ~ howing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals DsotsuepyGIbup': I 0 eFg/akgl T(r*eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOLIT*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 66517 Continued from previous page Histopathology VAGINAEST: RUS STAGE: METESTRUS. No Mi`HcErAoRsT,copSiKcELAEbTnAoLrmMUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, RSETCOTMOANCH,, MEDUSOEDNETNEURNI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDICBOLUOLNA,R LSYIMTPUHITNAORDYE,GLATNHDY,MUST,HYARDOIRDENGALLANGDL,ANDPSA,RATSHCYIRAOTIIDC NGELRAVNED,S, TGRLAACNHDEA(,FEEMASLOEP)A,GUOSV,ARIEEYSE,(S)UTEWRIUTSH,OPUTRIINCARNYERVBEL,ADDSEKRI,N, MAMMARY FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665178 KTeirlmliendalonsDaacyrif: ic93e EAnxipmoaslureisGrsoiugpn:ed sofufbchfrom necropsy --~ Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THOMUS, 665178 Continued on the next page .... --~ 586 CompanySanitized. Doesnot contain TSCA CBI 9502D54a2y5G;avSaugbeeShroonyiciTnoRxitcsitwyithOne-GeneraionReproduction Evalusions Dupont1418 ~~ soDoosetCHIT IT nhWho/akwgli ngT{r+eaaAnItPinmmPdeaRinlOvtiV:dEduDaatle0PROmAfTngoOi/rCmkOagiLl.nIdLIi*)ivsidtuiSeanxlg: anivals Females Aniral Ref Nicroscopic & Macroscopic Findings PE Continued from previous page Gross Pathology Yo Ma"PNcRirAvRoRIsOIcLGoDHp/iGCcLAARNYADNb,En,orFEmAYaAElT(iEStY)yROWOIIbTDsHerGOLvAPeNTdDISC:, NETRRVAEC,HERS,KINE,SOMPHAAMGMUASR.Y CSlEaUnRb/K(NFEEEUAJLOE)T| ,OVASRTIEERSN.ON,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LrveRIFAN+TFTLYADCIHTAINOGNE,, PSEURBIAPCOURTTEA/LC,HROmNiInCi,nalm.inisal. PLeovesCH+RONIC PROGRESSIVE NEPHROPATHY, minimal. ToSFE;mMiOoRRRRAiNAGGEE,, ALVEOLAR, minimal. minimal. ~ Eavec(5m)OPWT+IITCRNEOPRTVIECNONTERVPREES|ENT, UNILATERAL. Tomas smace: ESTRUS. Yo MiHSEcTArORNoTAs,CcHo,pBiXcDSULOEADTbEAnNLoUrMWm,OaSlCJiLEtEJy,UNOUbSMPs,LeErEvLNeE,dONA,ORTPAR,ACRBERAASI,N, CESCPUINN,ALCOCLOORND,, RDTHiEYnCReTOrI,oDvGWaLR,ASNEDNP,TOREERPNIAACRLNLTGIALNYAERNRODTSND,OOGELS,ACNIDNSSTA,ILCITVRNAAERCRYHVEEGA,L,ANPDISSTS,UOIPMTAAAGNRUYDSI.BGLUALNADR, 665170 Continued on the next page --- -- TT `Company Sanitized. Doesno contain TSOA GBI 9F-02.5D4a2y5G:avSaugbesSotnuidcy iTnoxRiactistywithOGneeneration Reproduction Evaluations DuPont 11418 ~ spy fSehmoawling(+anAIiPnmPdaRilOvViEddDautaalPRAOfnToiOrmCaOilLndLi*)ivisdtuianlg animals Dose Group : II 0Wg/kg Treatment: 0 mo/kg IT Sex: Females Animal Ref Microscopic & Macroscopic Findings 665178 Continued from previous page Histopathology No MiG`cLSrHAAoNRsDYcNo(XpF/iLEcAMRAAYLbXEXn,),ormOEYVaEAl(RiSIt)EyS,WObIsTUeHTErRvOUePSTd,IC: UNREIRNVAER,Y BSLKAIND,DERM,AMMARY SEMUR/KNEE JOINT, STERNDM, BONE MARROW, NOSE 665189 TKeirlmliendalonSaDcaryif: ic1e27 AEnxipmoaslureisGrsoiugpned: orfecfovf.rom necropsy Gross Pathology No MaALOIcRVrTEoARs,,copBKiRIAcDINNEA,YbSn,oSrPmILUaNNAlGLiSt,yCOROHDEb,AsReTrS,vTeOMdSAKCE:HL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, NIOLDEEU,M, SAPALNICVRAERAYS,GLACNECDUSM,, MACONLDOINB,ULARRECTLUYMN,PHMENOSDEEN,TERTHIYCMULSY,MPH ~ 'ATSDHHRYAERRROYAINLDX/GGLLLAAARNNYDDN,SK,, PSAECYREIA(ATSTH)IYCRWOIINEDTRHVGELO,APNTDIPSCI,TUNTEIRRTVAAECR,HYEAGS,LKAINNED,S.OPMHAAMGMUASR,Y FGRLMAUNRD/X(NFEEEMAJLOZ)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed -- - 988 Company Sanitized. Does not contain TSCA C81 9102.5D4a2y5G: SaubcvhSrtoanyicigTnoRreiacsityithOneGenerationReproduction Evaluations ~ howing anIinndailvidduaatla AfnoirmailndLiivsidtuianlg anirals stDoosneyGf%up : II 0Mmg/nkagl T(r*eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOL11*) Sex: Females Animal Ref Microscopic & Macroscopic Findings Dupont 11418 665197 ETKxeiprlomlsieundraelonGSarDcoaruyipf:i:c1er27ecov - Animal is signed off from necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYtSo,maLUlNiGtS,y OHEbAsReTr,veSdK:ELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS.PICNEACLOMC,ORDC,OLOSNT,OMARCEHC,IOMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDNST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIKD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/(KFEEEMALJEO)T.HT,OVASRTIEERSN,M,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology --~ s65201 No Mi"TcHrYoRsOcIoDpiGcLANADbnormality Observed TKeirlmliendalonSaDcaryi:fic1e27 nExipnoaslureisGrsoiugpned: orfefcovfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYtSo,mmLaUlNGiSt,y ONEbRsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDTSI,CMANENRDVIES,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, 665201 Continued on the next page -..- --~ . owe Company Sanilized.Doesnotcontain TSCA CBI 9H02D5a42y5G:evSaugbecShtroundiyciTnoRxaicsiwtyithOneGenerationReproduction Evaluations DuPont 11418 ~~ Showing anIinmdailviddautaal AfnoirmailndLiivsitduianlg animals sDtouspeyGWup : II 0 mg/ekmagl T(r+eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOL11*) Sex: Females Animal Ref Microscopic & Macroscopic Findings Ges201 Continued from previous page Gross pathology : No Ma`TcHrYoRsOcIoDpGiLcANADb,norPmAaRlAiTHtYyROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, PHARYNX/LARYNK, GLAND (FEMALE), OEVYAER(IS)ES,WITUHTEROUPST,ICVANGEIRNVAE,, SUKRIINN,ARYMABMLMAADRDYER, FEMUR/KNEE JOINT, STERNOM, NOSE Histopathology No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : 665204 TKeirlmliendalonSaDcaryit:ic1e27 AEnxipmoasluraisGrsoiugpned: orfefcovfrom necropsy Gross Pathology ~ No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJONLOYNM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HERS,KINE,SOPNHAANGMUASR,Y GFLEANNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, 665204 Continued on the next page -. --~ 590. `Company Sanitized. Doesnotcontain TSCA CBI 125425: Subchronic Toxicity 9-Day Gavage Study in Rats withOne-GenerationReproduction Evaluations DuPont-11418 --~ howing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg aninals sDrouspeyGroup: II OWg/ekagl T(r*eaAtPmPeRnOtV:ED P0RmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665204 Continued from previous page Histopathology : No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : s65211 TKeirlmliendalon SDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,omLaUlNiGSt,y OHEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYNM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTAPRHYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNNDK,, `EPYAZR(AST)HYRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPAHAMGMUASR,Y --~ GFELMAUNRD/K(NFEEEMALJEO)T,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. | KIDNE`YASGG:REGATES, LYMPHOID, minimal LovesH:EMORRHAGE, ALVEOLAR, minimal. 665211 Continued on the next page .. -- -- `Company Sanitized. Does not contain TSCA CBI 'H9205-4D2a5y;GavSaugbcehSrtoundiycTionxRicaistywith One-Generation Reproduction Evaluations DuPont 11418 ~ howing anIinmdiavlidduaatla AfnoirmailndiLviisdtuianlg animals sDorseyGroup : IT eO'rWam/kagl T(r*eAatPmPeRnOtV:ED 0PRmOgT/OkCgOL117) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665211 Continued from previous page Histopathology TonesI:NFLAMYATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. PITUICTYASRTY, GmLiAnNiDma:l. EYS(S)OPTWIICTHNEORPTVIECNNOETRVPER:ESENT, BILATERAL. VAGINEAST:RUS STAGE: PROESTRUS. --~ 665221 No MiHEcArRoTs,copSiKcELAEbTnAoLrMmUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, R`SETCOTMUAMC,H,MEDSUOEDNETNEURMI,C LJEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDICBOLUOLNA,R GLLYAMNPDH, NOPDAER,ATTHHYYRWOUISD, GALADNRDESN,ALTRGALCAHNEDAS,, ESSCOIPAHTAIGCUSN,ERVE, THYROID UPTHEARRUYSI,X/LUARRIYNNAKR,Y SBKLIAND,DERM,AMMFAERMYURG/LKANNEDE J(OFIENMTA,LE)S,TERONVUAMR,IESB,ONE MARROW, NOSE TKeirlmliendalonSDaacyrif: ic5e3 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology PITUILTAARRGYE,GLmAiNlDd.: 665221 Continued on the next page -. --~ 992CompanySanitized. Does not conTtSaCAiCnBI '9F0--2D54a2y5G;avSaugbecShruodnyiciTnoxRiactistywithOneGenerationReproduction Evaluations ~~ sropy ehoawling(*anAIinPdmPiaRvlOiVdEduDaatlaPRAOfnToirOmCaOilLndLi*i)vsitdiunagl snimals Dose GiMup : II OWig/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings ses221 Continued from previous page Dupont 11418 Gross pathology No MaHLOcIRrVTEoARs,,copBKRiIADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyOROHDbE,AsReTrS,vTeOMdSAKCEHL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, ANIOLDDEREUE,MN,ALSAPGALLNIACVNRAEDRASYS,,GLSACCNEIDCASUT,MI,CMACNOENLRDOVIENB,,ULATRREHCYTRLUOYMIM,DPHGMLENAOSNDEDEN,,TERTHIYCMULSY,MPH OEPYVAEAR(RASIT)EHSY,WRIOTIUHTDEROGULPSAT,NIDCSV,ANGEIRTNVRAEA,,CHEUSAKR,IINN,AERSYOMPAHBMALMGAAUDRSDY,ERG,LPAHNFADREYMNU(ERF//ELXMAANRLEYEEN),XJ,OINT, STERNUM, NOSE Histopathology Lvs:"HEMORRHAGE, ALVEOLAR, minimal. PARATMHIYSRSOIINDG.GLANDS ~ EYE(S)`OPWTIITCHNEORPTVIECNONTERVPERES:ENT, UNILATERAL. SKIN:DERMATITIS, FOCAL, minimal. VAGINEAS:TRUS STAGE: METESTRUS. 665221 Continued on the next page .... -- --_-- 593 `CompanySanitized. DoesnotcontTSaCAiCnBI F9-02.5D4a2y5G;avSaugbeehSrtoundiycTionxRiactistwyithOneGeneration Reproduction Evaluations DuPont 11418 ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals sDtouspeyPup : II eOWmg/akgl T(reaAtPmPeRnOtV:ED P0RmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings ses221 Continued from previous page Histopathology No MiLIcVrEoRs,copKiIDcNEAYbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TOMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH INLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NMERAVNED,ISUPLIATRUILTYAMRPYHGNLOADNED,, TTHHYYMRUOSI,D AGDLARNEDN,AL TUETRVEAER(CSUH)SE,A,WUIRTEIHSNOAPOHRPATYGIUCBSL,ANDEDRPEVHREA,,RYNFMXAE/MMLMUAARRR/YYKNNKGE,LEAJNODIN(TF,EMASLTEE)R,NUMO,VARBIOENSE, MARROM, NOSE ORGANPSARNAOTTHYREOXIAMDINGELDA:NDS 665225 TKeirlmliendalonSDaacyrif: ic9e3 EAnxipmoaslureisGrsoigunped: sofufbchfrom necropsy ~~ Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICNANENRDVIES,ULAPRITULIYTMAPRHYNGOLDEA,ND,THYMUS, 665225 Continued on the next page .... --~ _-- ois `CompanySanitized. DossnotcontainTSCACBI $2054D2a5y:GaSvuabgeerSoundiciTnoRxaictistwyithOne-Generation Reproduction Evilusions DuPont11418 ~ stov W, Snnvocaw;lingT(r*eaaAnItPinmPndeRainlvOtiV:dEduDaaclaP0RAmOfngToi/OrmkCagOilLn1d1Li*)ivsidtuiSanelxg:anFiemmaallses ron SO Snimal Ref Microscopic & Macroscopic Findings 665225 Contimied Eom previous page Gross rachology : No MaBiEcaryooRsicno(p/FiGLEcLAWARANAYLDbNE,n,),orPmAOEaYRVlEAA(iRTStIH)ZyYSR,WOOIIbDTsUHeTEGrRLvOUAePSNTd,DISC,VNAEGTRIRVNAEAC,,HEASU,KRIINNE,ASROPYMKAABNGLQUAGSDR,DYER, SEMUR/KNER JOINT, STERNUM, NOSE Histopathology sTvEREINN+FFLTAYMMCAHTAINOGNE,, PSEUREIAPCOURTTEA/LC,HROmNiInCi.malm.inimal. . xwEsGsHRONTC PROGRESSIVE NEPHROPATHY, minimal. 2 LesHEMORRHAGE, ALVEOLAR, minimal. BRAIN'AGGREGATES, LYMPHOID, CHOROID PLEXUS, mild. --~ TEYHEO(SS)`OWPeWTNIIOCTRHRNIEAOGRPETV,IECNmiONlETdRVPERE:SENT, UNILATERAL. acm`Bs:trus Stace: sTRUS. Nose:INFLATION, ORAL MUCOSA, minimal. 665225 continued on the neXt Page -.-- -- 55 Company Saniized. Does not contain TSCA CBI H02.5D4a2y5:GaSvuabgcehvSotnuidcyTionsRiactistywithOneGeneration Reproduction Evaluations Dupont-11418 --~ srupy Shmoawling(*anAIiPnmPdaRilvOiVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsitdiunagl animals Treatment: 0 mg/kg IT Sex: Females ose comp TT OMg/kg Aniral Ref Microscopic & Macroscopic Findings 665225 Continued from previous page Histopathology No Mi'RRMceOErcUAoTRAosTCN,cH,o,pSiMKcEDEUSLOAEEDbNTEnTANoELUrRMMmI,UaCSlCJiLLEtYEJyM,UPNHOUbSMNPs,OLeDErEEvI,NLe,EdUSMAA:,OLRITVPAAA,RNCYRSEGPALISAN,NADLSC,CEOCRUMDMA,,NDCIOBLUOLNA,R vHPHYoARRnOYITODNCO/DGLELA,ARNYDNA,KD,REPNAEAYRLEA(TSGH)LYARNWODIISDT,HGLSOAPCNTIDIASCT,ICNTERRNAVECERH,VEEA,S,KIPNIE,TSOUPIMHTAAAMGRMUYASR,YGLAND, GSLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTEBROUNSE, MAURRIRNOAWRY BLADDER, 665228 TKEexirplmolisenudarleonGsrDaoacuyrpif:: ic1e2r7ecov Animal is signed off from necropsy Gross Pathology : --_~ No MavAOceRrnToAs,,copBKiRIcADINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyOROHDEb,AsReTrS,vTOeMdSAK:CEHL,ETADLUODMEUNSUCML,E, JESJPULENEUNM,, AONDBDRUBEM,N,ALSPAAGLNLICAVRNAEDRASYS,,GLSACCNEIDCASUT,MI,CMCANOENLRDOVINEB,,ULARPREICTTULUIOMTM,APRHYMENGOSDLEEAN,NTDE,TRIHCOULSY,MPH TGUALANARRNYODIILD/(LFGAELRMAYANNLDKE,,), POAEVYRAEA(RTSIH)EYSR.WOIIDTUHTEGRLOUAPSNT,DISC,VNAEGTRIRVNAEAC,,HERSU,KRIINNE,ASORMPYHAAMBGMLUAASDR,DYER, FEMUR/KNEE JOINT, STERNUM, NOSE 665228 Continued on the next page .... -- - 99%CompanySanitized. DoesnotcontTSaCAiCBnI 9F-02.5D4a2y5G;avSaugbechSotnuidcy iTnoxRiactistywithOne.Generation Reproduction Evaluations ~ stony Jehconwailng(+anAIiPnmPdaRilOviVdEduDaatlaPRAOfnToiOrmCaOilLndLi*)ivsitdiunagl animals Treatment: 0 ma/kg II Sex: Females Soe MUD TIT Og/kg Animal Ref Microscopic & Macroscopic Findings s65228 Continued from previous page DuPont11418 Histopathology : No MTiHcYrRoOsIcoDpiGcLANADbnormality Observed : 665230 KTeirlmliendalon SaDacyrif: ic93e AEnxipeoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : CERVIXDISCOLORATION, WHITE, FIRM, 4 Mf DIA.. No MaASOcvRreTonAs.,copFBIiRDcANIENA,VbSn,oSrPmLIUaNNlAGiLSt,yCOROHDEb,AsReTrS,vTOeMdSAKCEHL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, NATDOERDEEEUN,MA,LS,ADGLALNIACVNRAEDRASYS,,GLSACCNEIDCASUTM,I,CMANCEONLRDOVINEB,,ULARPERICTTLUUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTIHCYMULSY,MPH --~ SCPAHhYAaRRpVOITGD(/FLGEALMRAAYNLNDE,K),, PEOAYVREAA(RTSIH)EYSR,WOIITUDHTEGLROAUPNSTD,ISC,VANGTEIRRNVAAEC,,HEASU,KRIINNE,ASROPYMHAABIGLGUAGSDR,DYER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERFA: TTY CHANGE, INFLAMMATION, MSEUDBIAACNUTEC/LCEHFRT,QNImCi,ld.minimal. 665230 Continued on the next page .... ~~ -_ 997`Company Sanitized. Doesnotcontain TSCA CBI 9205.4D2a5y;GavSaugbeehSvtoardiycTionxRicaistywith OneGeneration Reproduction Evaluations --_~ Showing anIinndailvidduaatla AfnoirmailndiLviisdtuianlg animals DsotsuepyGROUP RET OMge/rkagl T(r*eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 865230 Continued from previous page DuPon11418 Histopathology LowesI:NFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. PITUITcyAsRtY,GLmiAlNdD. : BYE(S)OIPNWTFIILCTAHMMNAEOTPRITVOIENC,NONETPREVRPEIREO:SCEUNLTA,R,UNUINLIALTAETERRAALL., minimal. VAGINAEST: RUS STAGE: PROESTRUS. URINAMRIYSSBILNAGD.DER : No MiS`KcPIrIDoNNsAEcLYSo,CpOiRcHDE,AARbTnS,ToOrMmSAaKClEHiL,tETyADULOObDMsEUeNSrUCvMLe,Ed, J: ESJPULENEUNM,, AIOLRETUAK,, BPRAANICNR,EAS, SGSLCEAICNAUDT,SI,CCONMLEAORNNVD,EI,BURLTEAHCRYTROL,IADMMPEGLSANENONDDT,EE,RIPTCAHRYLAMYTUMHSPY,HRONIAODDDREGE,LNAANLSDASGL,LIAVNATDRRSYA,CHEA, --_~ SOVCAORPIHEASG,US,UTEBRFUASR,YNKF/ELMAURRY/NXEN,EESJKIONI,NT,MAMSTMEARRNYUMG,LABNODNE(FMEAMRARLOEW),, NOSE ORGAN`USRINNOATRYEXBALMAIDNDEEDR: ~~ - 99% `Company Sanitized. Donotecontsain TSCA CBI 'H9:02.5D4a2y5G:avSaugbeelSotnuidcyiTnoxRiacsitywithOne-Generation Reproduction Evaluations --~ stupy hcmoawling(*an1AinPvdPaiRlvOiVddEuaDetlaPRAOfnToiOrmCaOilLndiL*)viisdtuianlg animals Sr WG vg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings s6s256 TKeirlmliendalon SaDcaryif: ic1e27 AEnxipmoaslureisGrsoiugpned: rofefcovfrom necropsy Dupon-11418 Gross Pathology : No MaLATOcVRrEToRAs,,copKBRIiADcINNEA,YbSn,oSrPmLTUaNNAlGLiSt,CyOROHDbE,AsReTSr,TvOeMdSAKCEHL,ETADLUODMEUNSUCMLE,, JESJPULNEUEMN,, NATODODEREUE,MN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMCNAOENLRDOVINEB,,ULAPRERICTTULUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTHIYCMULSY,MPH RGSHLOAARNIYDADD(KF/GELLMAAARNLYDEN,)X,, PEOAYVREAA(RTSIH)EYSR,WOIITUDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEASU,KRIINNE,ASROYPMHAABMGLUUAASDR,DYER, 'FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed --~ 665260 TKeirlmliendalonSDaacyrif: ic1e27 EAnxipmoaslureisGrsoiugpned: rofefcovfrom necropsy Gross Pathology No MaSATOcVRrEToRAs,,copKRIiADcINNEA,YbSn,oSrPmLIUaNNlAGiLSt,yCOROHDEb,AsReTSr,TvOeMSdAKCEHL,ETADLUODMEUNSUCML,E, JESJPOLNEGEMN,, NAOODODREME,N,ALSAPGALLNIACVNRAEDRASYS,,GLSACCNEICDAUSTN,I,CMANCEONRLDVOIENB,,ULRAPERICTTULUIYMTM,PAHRYMENGOSDLEEAN,NTDE,RTIHCAYULSY,MPH 665260 Continued on the next page ---- ~~ 5% ---- CompanySanitized. DoesnotcontTSaCAiCnBI 9205.4D2ay5G:aSvuabgcehSrtoundiyciTnoRxaictistwy ithOne-Generation Reproduction Evaluations ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals osuspeeGYOMTT II Omgc/eknga T(r+eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665260 Continued from previous page DuPont11418 Gross Pathology : No Ma"TcArYoRsOcToDpiGcLANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, PHARYINO/LARYNK, EYE(S) WITH OPTIC NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y SGLEAVNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed 665271 TKeirlmliendalonSaDcaryif:ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : -- No MaA`LOciRrVToEAsR,,copBKiRIcADINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyOROHDEb,AsReTrS,vTeOMdSAKCE:HL,ETADULODMEUNSUCML,'E, JESJPULNEUEMN,, ANTODODERECE,MN,ASLAPGALLNIACVNRAEDRASYS,,GLSACCNEIDCASUT,MI,CMNCAEONRLDVOIENB,,ULAPRERICTTULUYIMMT,PAHRYMNEOGSDLEEAN,NTDE.RTHIYCMULSY,MPH GTPLAHAYANRRVDONIXD(/FLGEALWRAAYNLDNE,E),, POEAYVREAA(RTSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,KRIINNE,ASORPYMHAABMGLMUAASDR.DYER, 665271 Continued onFEthMeURn/eKxNtEEpaJgOIeNT.,...STERNOM, NOSE --_ TTo00- `CompanySanitized. DoesnotconTtSaCAiCBnI H62D5a42y5;GavSaugbcehSvotndiyc TionxRiactistywith One-Genersion Reproduction Evaluations Dupont-11418 ~~ stupy erwailng(*aAnIPinPmdaRilOviVdEduDaatlaPRAfOnoTirOmCaOilLndLi*)ivsidtuianlg animals /kg Treatment: 0 mg/kg 11 Sex: Females Dose Grow + o Animal Ref Microscopic & Macroscopic Findings 665271 Continued from previous page Histopathology : LIVERIN: FLAWMATION, SUBACUTE/CHRONIC, minimal. zonesH:EMORRHAGE, ALVEOLAR, minimal. TEYoB(SS)`HEWMIOTRHRHOAGPET,ICmNinEiRmVaEl.: OPTIC NERVE NOT PRESENT, UNILATERAL. VAGINA`ES:TRUS STAGE: METESTRUS. . No MiASScPorIuoNpsArcLeo,pCCOOiRLcHDOE,NAA,RbTnS,oTROrEMsCSAaTKCUlEHMiL,,tEyTAMDOLUEbOSDsMEEUeNNSrTUCEvMLReE,Id,CJ:ESLJPYULMENPEUHNM,,NODAIEOL,RETUAMS,,ALBPIRAVANAICRNRY,EAS, CC2EcSUNND,S, SVE. BMYATNUDTITBAURLYARGLALNYDM,PHTNHOYDREO,IDADGLRAENNDA,L GPLAARNADTSH,YROSICIDATGILCANDS, ~ TTGRvYAAR(CN8H:)EEAS,,WITEUHTSEORPOUHPSAT,GIUCSU,RNEIRNPVAHERA,YRYNSBKKLI/ANDL,DAERRDM,NAXM,{PAERMYURG/LXANNEDE J(OFIENMTA,LE), STERNUM, BONE MARROW, NOSE --~ T1001 ------ CompanySanitized. Doesnot conTtSaCAiCnBI 9H0--2D54a2y5;GavSaugbeeShtruordiycToxRiactitywithOne-GenerationReproduction Evaluations ~~ Showing anIinndailvidduaatla AfnoirrailndLiivsidtuianlg animals stDouspeyGRD : IT 0Mg/okmgal T(r+eaAtPmPeRnOtV:ED 0PRmOoT/OkCgOLIT*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665276 KTeirlmliendalon SaDcaryif: ic1e27 AEnxipmoaslureisGrsoiugpne:d rofefcovfrom necropsy `Dupont 11418 Gross Pathology : No MAaLOIcRVrTEoRAs,,copBKiRIcADINNEA,YbSn,oSrPmLIaUNNlAGiLSt,CyOROHDEb,AsReTrS,vTOeMdSAKCEHL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, ANJODDDEREOE,MN,ALSASGLALNIACVNRAEDRASYS,,GLSACCNEICDAUSTN,I,CMANCEONRLDVOIENB,,ULAPRREICTTULUYIMMT,PAHRMYENOSGDELEAN,NTDE,RTHIYCMULSY,MPH GTHLRAAYRNRYDONTKD/(LFGAELRVAYANNLDYE,,), POAEVYRAEAR(TSIH)EYSR,WOIIDTUHTEGRLOUAPSNT,DISC,VANGTEIRRNVAAEC,,HEAUS,RKIINNE,ASROMPYHAAMBGLMUAASDR,DYER, FEMUR/KNEE JOTNT, STERNUM, NOSE sistopathology No MTiHcYroRsOcIoDpiGcLAANbDnormality Observed --~ 665278 KTeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoigunped: sofufbchfrom necropsy Gross Pathology : No MaRLcOIrRVTEoARs,,copBKiRIcADINNEA,YbSn,oSrPmILaUNNlAGLiSt,CyOROHDbE,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, ANTLODEDRUEEM,N,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMANCEONRLDVOIENB,,ULARPERICTTLUUYIMWT,PAHRYMNEOGSDLEEAN,NTDE,TRHIYCMULSY,MPH 665278 Continued on the next page .... --~ - 1002CompanySanitized. Doesnot containTSCA CBI 5102.5D4a2y5:GavSaugbcehSrtoundiyc TinoxRiactistywithOneGeneration Reproduction Evalvtions DuPont 11418 -- howing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals stDooserGIOWp @ IT ONG/ekngal T(r*eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 655278 Continued from previous page o Gross Pathology : No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, HARYN/LARYN, EYE(S) WITH OPTIC NTERRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMAJLOET),HT,OVASRTIEERSN,IM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. mnFAT+ TY CHANGE, PERIPORTAL, minimal. VAGINHAE:MORRHAGE, miniral. ESTRUS STAGE: PROESTRUS. ~~ No MiBKRIcADrINoNEs,YcSo,pSiPcLIUNNAAGbLSn,oCrORmHDEa,AlRiTtS,yTOMOSAbKCsEHeL,rEvTeADdLUODM:EUNSUCML,E, JESJPULNEUEMN,, AIOLREUTMA,, PSAANLCIRVEAARSY, GCLEACNUDNS,, CWOALNODNI,SULREACRTULMY,MPMHESNEODNET,ERIACDRELNYAMLPHGNLOADNED,S, ESPVCAEIR(AASTT)IHCYWRIONETIRHDVEGO,LPATNIPDCIST,NUEIRTTVRAEAR,CYHEGSALK,AINN,DE,SOMPATHMHAYMGRAUORSIY,DGLGPLAHANANDRDY.N(XF/ELWAARLYEN),K, SOTVEARRNIUEMS,, UBTOENREUSM,ARRUORWI,NARNYOSBELADDER, FEMUR/XNEE JOINT, -- "Too Company Sanitized. DoesnotcontainTSCA CBI '9205-4D2ay5G:avSaugbecShrtonyiciTnoRxaitcistwyith One-GenerationReproduction Evaluations Dupont 11418 ~ howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sBrouspeyGroup : II 0'Beg/akgl T(r*eAaPtmPeRnOtV:ED 0PRmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665317 KTeirlmliendalonSDaacyri:fic9e3 AEnxipmoaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology : No MLaIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND,THYMUS, TGPHLHYAARRNYODNIED(/FLGEALMRAAYNLNDEK,),, PEOAYVREAA(RTSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,RKIINNE,ASROPYMHAABMGLMUAASDR,DYER, FRMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVERFA: TTY CHANGE, PERIPORTAL, minimal. ~~ LomGs`H:EMORRHAGE, ALVEOLAR, minimal. SPINAMLISCSOIRNDG.: MANDIEBRUYLTAHRROLCYYMTPOHSTNSO/DEERY:IHROPHAGOCYTOSIS, SINUS, minimal. PARNTMHIYSRSOIINDG.GLANDS : VAGINEAST:RUS STAGE: PROESTRUS. 665317 Continued on the next page -. ~~ Too `CompanySanitized. DoesnotconTtSaCAiCBnI 9102-5D4a2y5G:avSuabgcehrSotnudiyciTonxRiactistwyith One-GeneratonReproductionEvaluations DuPont: 11418 --~ howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDotsuepyOp II 0Mg/fkemgal T(r+eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOLII*) Sex: Females Animal Ref 565317 Microscopic & Macroscopic Pindings Continued fron previous page Histopathology No MiKcIrDNoEsYcSo,picHEAARbTn,ormSaKlEiLtEyTAOLbMsUeSrCvLeEd, : SPLEEN, AORTA, BRAIN, RSETCOTMUAMC,H, MEDSUEODNETNETRMI,C LJEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNCYREGALSA,NDSC,ECUTMH,WMUCSO,LON, AGLDARNEDN,ALTRGALCAHNEDAS,, ESSCOIPAHTAIGCUSN,ERVPEH,ARYPNIKT/ULIATRAYRNYX,GLAND, THYROID EOYVEA(RSI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y BSLKIAND,DERM,AMFMEAMRUYR/GKLNAENED J(OFIENMTA,LE), STERNUM, BONE MARROW, NOSE `ORGA`NSSPINNOATL CEOXRADM,INEPDA:RATHYROID GLANDS 665319 TKeirlmliendalonSDaacryi:fic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy -- Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRTTLUYIMTPAHRYNOGDLEA,ND,THYMUS, 665319 Continued on the next page .... --~ Tos `CompanySanitized.Does not conTtSaCAiCanl 25425; Subchronic 90-Day Gavage Study TinoxRiactistywithOne GenerationReproduction Evaluations DuPont11418 ~ howing anIinmdailvidduaatla AfnoirpailndLiivsidtuianlg animals sDotsey MED IT oOWn/kagl T(r*eaAtPmPeRnOtV:ED PORmOgTO/CkOgLII*) Sex: Females Aninal Ref Microscopic & Macroscopic Findings 665319 Continued from previous page Gross Pathology : No Ma`PTcHHrAYoRRsYOcNIoKD/pLiGAcLRAYNADNb,Yn,orPmEAYaRElA(iTStH)yYROWOIbIDsTeHGrLvOAePNTdDISC:,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN: FLAMMATION, FATTY CHANGE, MSEUDBIAACUNTCEL/ECFHTR,ONImCi,nimmailnimal. MANDIFBAUTLTAYR CLHYAMNPGHE,NODPEERI:PORTAL, minimal. THvN0SHYPERPLASIA, LYMPHOTD, mild. TRACHHEEAMORRHAGE, minimal. ~~ VAGINAINF+ LAMMATION, minimal. ESTRUS STAGE: METESTRUS. No Mi'KcYrOoNsEcVSo,piLcUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M USCLE, SPLEEN, BRAIN, SPINAL CORD, STOMACH, DUODENGN, JEJUNUM, AIOLRETUMA,, PSAANLCIRVEAARSY,GLCAENCDUSM,, CAODLROENN,ALREGCLTAUNMD,S, MESSCEINATTEIRCICNERLVYEM,PHPNIOTDUEI,TARY GLAND, THYROID GLAND, PARATHYROID GLANDS, ESOPAAGUS, 665319 Continued on the next page -... --~ FE T1006 -------- `CompanySanitized.Does not conTtSaCAiCBnI 0H2-5D4a2y5:GaSvuabgcehrSotnuidcy iTnorRiactistywith OneGenerationReproduction Evaluations Dupont11418 r howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals DsouspeyGMUp : II 0Mge/rkagl T(r*eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOLIT*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665319 Continued from previous page Histopathology : No MiPcHrAoRsYcUo/pLiAcRYANbXn,ormEYaEl(iSt)y OWIbTsHerOvPeTdIC: NERVE, SKIN, MAMMARY GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTSBROUNSE, MAURRRIONWA,RYNOBLSAEDDER, 665323 TKeirlmliendalonSDaacyrif: ic12e7 AEnxipmoaslureisGrsoiugpned: orfefcovfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL WUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIECJUNLOYMM,ZH ANODDREE,NAL`SAGLLIAVNADRSY, GSLACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, ~ TPHHAYRRYONIKD/LGALRAYNNDK,, `EPAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAGRUSY, GFLEAMNUDR/K(NFEEEWAJLOEI),NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No Mi`TcHrYoRsOcIoDpiGcLANADbnormality Observed : -- 1007 `Company Sanitized. Does not contain TSCA CBI 9205-4D2ay5:GavSaubgcehSrtourdiyc TinoxRiactistyithOneGeneration Reproduction Evaluations Dupont 11418 --~ howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDrouspeyGroup : IT eO'/akgl T(r*eaAtPmPeRnOtV:ED 0PRmOgT/OkCgOLII*) Sex: Females Animal Ref Microscopic & Macroscopic Findings 665327 TKeirlnliendalon SaDcaryif: ic1e27 AEnxipmoaslureisGrsoiugnped: orfefcovfrom necropsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND,THAMUS, TPHHAYRRYONIXD/LGALRAYNIDN,K, `EPYAREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGYUASR,Y FGLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology No MiTcHrYoRsOcIDopiGcLANADbnormality Observed : --~ . . "i008`CompanySanitzed. Does notconTtSaCAiCBnI H25425; SubehvoieToxicity 90-Day Gavage Study in Rats withOneGenerationReproduction Evaluations Dupont 11418 ~~ howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals DsoosneyGPUp : IV 10 nge/rkalg (T+reAaPtPmReOnVtE:D P1R0OTnOCgO/Lkg*)IV Sex: Females Anizal Ref Microscopic & Macroscopic Findings 665182 TKeirlmliendalon SaDacyr.if: ic93e AEnxipvoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECTONLGYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINXD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HERS,KINE,SOMPHAAGRUSY, GFELMAUNRD/X(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. ~ No Mi`TcHrYoRsOcToDpiGcLAANbDnormality Observed : ~~ - ow CompanySanitized. Does not conTtSaCAiCBnI 0H2-5D4a2y5G;avSaugbechSvtoundiyciTnoRxaitcistwyithOneGeneration ReproductionEvaluations Dupont 11413 PP. Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtouspeyGp IV 10nge/mkagl (T*rAeaPtPmReOnVtE:D P1R0OTmOCgO/Lkg*)IV Sex: Females Animal Ref Microscopic & Macroscopic Findings se5215 TKeirlmliendalon SaDcaryif: ic9e3 EAnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology No MLaIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUUMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHYARRYONIID/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPAHAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology LIVER:INFLAMMATION, SUBACUTS/CHRONIC, mild. No Mi`TcHrYoRsOcIoDpiGcLANADbnormality Observed : --_ TToio-`CompanySanitized. Doesnotcontain TSCA CBI 119205-4Da2y5G:avSaubgcehSrtoundiyc TinoxRiactistwyithOneGeneration Reproduction Evaluations Dupont 11418 ~~ sDtouspe.y Showing anIinmdailvidduaatla AfnoirnailndLiivsitduianlg animals Iv nge/aklg (T*reAaPtPmReOnVtE:D P1R0OTmOgC/OkLg*)IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665236 TKeirlmliendalonSaDcaryif:ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NASLAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULPAIRTULIYTMAPHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRADNDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)T,WT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. --~ FATTY CHANGE, MEDIAN CLEFT, mild. No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : --~ ion CompanySanitized. Doesnotcontain TSCA CBI 02-5D4a2y5G;avSaugbechSvtoundiyc TinoxRiactistywith One-GenersionReproductionEvaluations Dupont-11418 --~ howing anIinmdailvidduaatla AfnoirrailndLiivsitdiunagl animals sDroospeyGI%up IV 10 mgon/aklg (T+reAaPtPmReOnVtE:D PR10OTmOgC/OLkg*)IV Sex: Females Aninal Ref Microscopic & Macroscopic Findings 665239 TKeirlmliendalonSDaacyri:fic9e3 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,D.THYMUS, TPHHYARRYONIXD/LGALRAYNDN,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINB,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed : --~ Tioiz-`CompanySanitized. DossnotconTtSaCAiC8n1 H902.5D4a2y5:GaSvuabgeehvSotnuidcy iTnorRiactistywithOneGeneration Reproduction Evaluations DuPont 11418 ~ ing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDtouspeYGWup : TV 10 mger/aklg (T*reAaPtPmReOnVtE:D P1R0OTnOgC/OkLg*)IV Sex: Females Aninal Ref Microscopic & Macroscopic Findings ses21 TKeirlmliendalonSDaacryif: ic9e3 AEnxipmoaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIECJUNLOYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, TPHHYARRYONIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAIGGUGSR,Y GFLEAMNUDR/K(NFEEEMAJLOEI),NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology LIVERIN: FLAVMATION, SUBACUTE/CHRONIC, minimal. ~~ No Microscopic Abnormality Observed `THYROID GLAND ~~ : IonsCompany Sanitized. Doesnot containTSCA CBI H902-5D4a2y5;GavSaubgcehSrtoundiyc iTnoxRiactistywithOGneneration Reproduction Evaluations Dupont 11418 oy howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg aninals sDtouspeyGPup : IV 19 moe/rkaly (T*rAeaPtPmReOnVtE:D PR10OTmOgC/OkLg*)IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665268 TKeirlmliendalonSDaacyri:fic93e AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC`NMAENRDVIEB,ULPAIRTLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNDN,K, `EPAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEENAJLOEI)N,T,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal ~ No MiTcHrYoRsOcIDopiGcLAANbDnormality Observed : ~ hoi `CompanySanitized.DoesnotcontTSaCAiCnBI 9H02-5D4a2y5G:vaSugbecShvtoundiyciTnoRxaitcsitwyithOne GenerationReproduction Evaluations Dupont-11418 --~ owing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDrouspeyGESup : IV 10mgf/emkagl (T*reAaPtPmReOnVtE:D P1R0OTmOCgO/Lkg*)IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665277 KTeirlmliendalonSDaacryi:fic9e3 EAnxipmoaslureisGrsoigunpe:d osfufbchfrom necropsy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLGYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULPAIRTULIYTMAPHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIID/LGALRAYNND,X, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology ~~ 665308 No MiLIcVrEoRs,copTiHcYRAObInDorGmLaAlNDity Observed : TKeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoigunped: sofufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTWPAHRYNGOLDEA,ND,THYMUS, 665308 Continued on the next page .... "101-s `Company Sanitized. Donotecontsain TSCA CBI 229005D-4Da2ay5y;GGaavSvuaabggceehSrSttouunddiyyciTinonRxRiaacttisstwywiitthhOOnnee-GGeenneerraattioonnRReepprroodduuccttiioonn BErvaabluuaattiioonnss DDuuPpoonnt1t114141188 --~ owing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtoospeyGroup : IV 10 mgfe/mkagl (T+reAaPtPmReOnVtE:D PR10OTmOgC/OLkg*)IV Sex: Femsles Animal Ref Microscopic & Macroscopic Findings 665308 Continued from previous page Gross Pathology No M`aTcHrYoRsOcIoDpiGLcANADb,norPmAaRlAiTtHyYROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAANRDYNK(/FLEAMRAYLNEX),, OEVYAER(IS)ES,WITUHTEROUPST,ICVANGEIRNVAE,, USRKIINN,ARMYAMBLMAADRDYER, FRMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. No MiTcHrYoRsOcIDopiGcLAANbDnormality Observed : 665324 TKeirlmliendalonsDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy ~ Gross Pathology No MLaIcVrEoRs,coKpIiDcNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 665324 Continued on the next page .. -- --e--e-------------------------------------- "lots `CompanySanitized. DoesnotconTtSaCAiCBnI 25425; Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations Dupont-11418 pa Showing anIinmdailvidduaatla AfnorimailndiLviisdtuianlg animals sDtouspeyGroup + Iv 10 mzge/naklg (T+reAaptpmReOnVtE:D PR10OTmOgC/OkLg*)IV Sex: Females Animal Ref 665324 Microscopic & Macroscopic Findings Continued from previous page Gross Pathology No MaTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHYyROObIDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, G"LPHAANRDYN(XF/ELMAARLYEN)K., OEVYAER(IS)ES,WITUHTEROUPST,ICVANGEIRNVAE,, USRKIINN,ARMYABMLMAADRDYER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No MLiIcVrEoRs,coTpHiYcROAbInDorGLmAaNlDity Observed : 665332 TKeirlmliendalonSaDcaryif: ic9e3 EAnxipmoaslureisGrsoigunped: sofufbchfron necropsy Gross Pathology : ~ No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLREUTMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,ZH ANDODREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,IC`NMAENRDVIEB,ULPAIRTULYIMTPAHRYNOGDLEA,ND,THAMUS, PTHHAYRRYOVTNDK/GLLAARNYDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y FGELMAONRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, 665332 Continued on the next page -... --~ Ion- Company Sanitzed. Doesnotcontain TSCA CBI 129504.D2a5y;GavSeugbcehSrtoundiyc TinoxRiactistwyithOnGeeneration Reproduction Evaluations ~~ howing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals stDoosney GPSUp : IV 10 mge/nkalg (*TreAaPtPmReOnVtE:D PR10OTmOgC/OkLg+)IV Sex: Females Aninal Ref Microscopic & Macroscopic Findings 665332 Continued from previous page Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. No MiTcHrYoRsOcIDopiGcLAANbDnormality Observed : Dupons-11418 --~ -- Tios- `Company Sanitized. Doesnotcontain TSCA CBI 20H0-2:5DD4aa2yy5GG;aavvSaauggbeceShSrutodundiyyciiTnnoRRsaaittcsistwwyiitthhOOnnee GGeenneerraattiioonnRReepprroodduuccttiioonnEEvvaalluuaattiioonnss DDuuPPoonntt-111144118 ~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals DsotsuepyGMup : VI 100 fmegm/aklg (+TrAePaPtRmOeVnEtD: PR1O0T0OCmOgL/k*g) VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665170 TKeirlmliendalonSDaacryif: ic93e AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross pathology : No MLaIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,N'ALSAGLLIAVNADRSY, GSLACNIDNST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THWMUS, `PTHHAYRRYOIINDC/GLLAARNYDN,K, 'EPYAREN(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology + LIVERNE:CROSIS, POCAL, wild. TFLAMYATION, SUBACUTE/CHRONIC, minimal. No M`iTcHrYoRsOcIoDpiGcLANADbnormality Observed -- _-- T1009 `Company Sanitized. Doesnotcontain TSCA CBI 9H0D2-5D6ya2y5SG;oavvSaauggbeecSShtruoudndiyycTiionnxRRiaacttisstwwyiitthh OOnnee-GGeenneercaattiioonnRReepprroodduuccttiioonn EvaluationEsvalutions DDuuPPoonntt--1111441188. ' sropy howing anIinmdailvidduaatla AfonrimailndiLviisdtuianlg animals eral (* APPROVED PROTOCOL *) Dose GIup VI 10 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665195 TKeirlmliendalonSDaacryi:fic9e3 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology : No MAaLOIcRVrTEoARs,,coBpKRiIAcDINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETADULODMEUNSUCML,E, JESJPULNEUEMN,, NAIODLDREEEU,MN,ALSAPGLALINACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMACNEONRLDVOIENB,,ULARPREICTTULUIYMTM,APRHYMNEOGSDLEEAN,NTDE,RTHIYCMULSY,MPH `PGTHLHAAYRNRVDONIXD(/FLGEALMRAAYNLNDEK,),, `OEPVAYARERA(TISH)EYSR,WOIITUDHTEGROLUAPSNT,DISC,VNAEGTRIRVNAEAC,,HEASU,KRIINNE,ASROYMPHAABMGLMUAASDR,DYER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, mild. ~ No MiTcHrYoRsOcIDopiGcLAANbDnormality Observed : . _-- I00- `Company Sanitizod. Doesnot conTtSaCAiCBnI 9205.4D2a5y:GavSaugbeetSroundiyciTnoRxaitcsitwyith One-Generstion ReproductionEvlustions DuPone11415 ~ stor Sghouingt+a*nIAinendpairlvoivddeuaDaslesrAofnroiormcaoilLndLi+)ivsitdiunagi animals Dose GoD TUE 10 ma/kg Treatment: 100 ma/ky VI Sex: Females nial Rot Wicroscopic & Macroscopic Findings pen TKEiexlrplmoeisdnuarleonGsrBaoacyurpif i: c93aeubch Animal is signed off from neczopsy Gross zatholoay : No Ma`ALOcIRrVToEAsR,,copKBRiIADcINNEA,YbSn,oSrPmLIIaNNAlGLiSt)CyOROWDbA,sNeErS,TvOeMSdAKCE:HL,ETADLUODMEUNSUCMLE,, JESJPULNEGEMN,, NAIODLDEREUE,MN,ALSAPGALLNIACVNRADERSAY,S,GSLACCNIBDCNSUFN,L,CWNACNEODRLIVOBENU,,LARPRI,ETCLUTYIMT,eAHRYMNEOGSDLEEAN,NTDE,RTHIICMILSi, b PTGELHAAYRNRYDOID(/FLGEALMRAAYNLNDEE),,, PEOAYVREAA(RTSIH)EYSR,WOIITODHTEGRLOUAPSNT.DISC.VANGTEIRRNVAAEC,,HERUS,RKIINNE,ASORPMYHAAMBGLMUAASDR,DYER, PEMUR/KNEE JOINT, STERN, ROSE Histopathology : --_ LavenFIAR:TFTLYAGCAiTInOeN,, MSEUDBAICAUNTEc)LCEHPRTO,NImCi,ld.minimal. No Mi"TcHrYoRsOcIoDpiGcLAANbDnormality Observed -- Torr CompanySaniized. Docsnot conTtSaCAiCanl 'H9205.4Da2y5G;avSaugbecShtroundiyciTnoRxaiciistywith One-GenerationReproductionEvaluations Dupons-11418 ~ Showing enIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDotsuepyGroup : VI 100 emmga/lkg (*TrAePaPtRmOeVnEtD: PRO1T00OCOgL/k*g) VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 565250 TKeirlmliendalonSDaacryif:ic9e3 AEnxipmoaslureisGrsoigunped: sofufbcfhrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIES,ULPAIRTULIYTMAPHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGOLPANTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology + LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. -- No Microscopic Abnormality Observed `THYROID GLAND --~ TomCompany Sanitized. Doesnotcontain TSCA CBI H25425; Subchvonic Toxicity '90-DayGavage StudyinRatswithOne-GenerationReproduction Evaluations DuPont 11418 ~~ owing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDorsoeyGroup : VI 10 megr/aklg (*TrAePaPtRmOeVnEtD: PR1O0T0OCmOLg/k*g) VI Sex: Females Aninal Ref Microscopic & Macroscopic Findings ses251 TKeirlmliendalonSDaacryif:ic9e3 - AEnxipmoaslureisGrsoigunped: sofufbchfrom necropsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GSLACNIDAST,IC`MNAENRDVIEB,ULPAIRTULIYTMAPHRYNOGDLEA,ND.THYMUS, PTHHAYRRYOVTNDX/GLLAARNYDN,X, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNURD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. ~~ No M`iTcHrYoRsOcIoDpiGcLAANbDnormality Observed : 1023 CompanySanitized. DoesnotcontainTSCA CBI 9205-4D2a5y;GavSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations Dupont-11418 ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals stDoosneyGroup VI 10 emmga/lkg (+TrAePaPtRmOeVnEtD: PR1O0T0OCOmLg/k*)g VI Sex: Ferales Animal Ref Microscopic & Macroscopic Findings 665259 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NA'LSAGLLIAVNADRSY, GLSACNIDNST,IC`NMEANRDVIEB,ULPAIRTULIYTMAPRHYNGODLEA,ND,THAMUS, `PTHHAYRRYONIKD/LGALRAYNDN,K, 'PEAYREM(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPNHAAMGGUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTNEROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. -- No Microscopic Abnormality Observed : `THYROID GLAND --~ 1028 CompanySanitized.Does not conTtSaCAiCBnI 9H02-5D4a2y5;GavSaugbcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproduction Evaluations Dupont 11418 ~ howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtousoeyGroup : VI 100 enrga/lkg (*TArPeaPtRmOeVnEtD: PRO1T0O0COmLg/k*)g VI Sex: Females Animal Ret Microscopic & Macroscopic Findings 665295 TKeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHAYRRYOYINDX/GLLAARNYDN,K, `EPAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGYUASR,Y GFELNAUDR/K(NFEEEMAJLOET),NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. --~ No Microscopic Abnormality Observed : THYROTD GLAND --~ 102s Company Sanitized. Doesnot contain TSCA CBI 9205-4D2a5y:GaSvuabgcehsSotnuidcy TinoxRiacsitwyith OneGeneration Reproduction Evaluations DuPont 11418 / _ srupy showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg emal (+ APPROVED PROTOCOL +) animals Dose Group : VX 10 mg/kg Treatment: 100 mg/kg VI Sex: Females Aninal Ref Microscopic & Macroscopic Findings 665300 KreirlmliendalonsaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology No MaLAIOcVRrEToRAs,,copBKRiIAcDINNEA,YbSn,SoPrLImUNaNAlGLiSt,CyORHODEb,AsReTrS,TvOeMdSAKCEHL,ETADULODMEUNSUCML,E, JESJPULNEUEMN,, NAIODLDREEE,N,ALSAPGLALINACVNRADERSAY,S,GSLACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRMYENGOSLDEEAN,NPDE,RTHIYCMULSY,MPH GTPLHHAAYNRRYDONIKD(/FLGEALMRAAYNLNDEK),,, 'OEBVAYARSRA(TISH)EYSR,WOIITUDHTEGROLUAPSNT,DISC,VANGETIRRNVAAEC,,KERSU,KRIINNE,ASROYPMHAABMLGMAUADSRD,YER, FEMUR/KNEE JOINT, STERNOM, NOSE Histopathology LIVERIN+ FLAMMATION, SUBACUTE/CHRONIC, minimal. ~ No MiTcHrYoRsOcIoDpiGcLANADbnormality Observed : --~ _-- Tio `CompanySanitized. DoesnotcontainTSCA CBI H902.5D4a2y5:GaSvuabgcehrSotnuidcy iTnoiRcaittsywith One-GenerationReproduction Evaluations Dupont 11418 ~ Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals stDouspeyGroup + VI 100 fmegm/aklg (=TrAePaPtRmOeVnEtD: PRO1T00OCOmLg/k*)g VI Sex: Females Animal Ref Microscopic & Macroscopic Findings oT 665380 TKeirlmliendalonSDaacyri:fic93e on AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIGD/LGALRAYNDN,K, `PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. --_ No Microscopic Abnormality Observed : `THYROID GLAND -- Tio- `CompanySanitized.Doesnot conTtSaCAiCBnI 9H02D54a2y5G;avSaugbecShrtoundiyciTnoxRiactistwyithOneGenerationReproduction Evaluations DuPont 11418 ~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitduianlg animals DsotsuepyGroup : VI 10 megm/aklg (*TArPeaPtRmOeVnEtD: PR1O0T0OCnOLg/k*)g VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665301 KTeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoigunped: sofufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYOIIXD/LGALRAYNNDK,, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y FGELNAUNRD/K(NFEEEVALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. ~~ No Microscopic Abnormality Observed : `THYROID GLAND Tos Company Sanitized. Donotecontsain TSCA CBI 9F0--2D5a42y5G;avSaugbecShtroundiyciTnoxRiactistywithOneGenerationReproduction Evaluations DuPont. 11418 ~ wing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDotsperGroup : VIII 10o0n0almg/(k*gAPTPrReOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Aninal Ref Microscopic & Macroscopic Findings s65183 KTeirlmliendalonSDaacyrif: ic93e AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULPAIRTULIYTMAPHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNND,K, PEAYREA(TSH)YRWOIIDTHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEANNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. --~ MANDIBFUALTATRY CLHYAMNPGHE,HODPEERI: PORTAL, minimal. ELREVUTKHORCOYCTYOTSIOSS,TS/PLEARSYTMHAROCPELHLA,GOCMYETDOUSLTLSA,RY,SINmUiSn,imamli.nimal. THYROIHDYPEGRLTARNODPH:Y, FOLLICULAR CELL, minimal. EYS(S)OPWTIICTHNEOPRTVIECNNOETRVPERES:ENT, UNILATERAL. VAGINEAST:RUS STAGE: METESTRUS. 665183 Continued on the next page ... T109-`CompanySanitized.DoesnotconTtSaCAiC8nl 9H02-5D4a2y5G;avSaugbechSrtoundiyciTnoRxaitcistwyith One-GenerationReproduction Evaluations Dupont11418 ~ ing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals DsouspeyGROUP VIII 10o0n0almg/(k+gAPPTrReOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665183 Continued from previous page Histopathology : No MiKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMW,PHINLOEDUEM,, PSIATLUIIVTAARRYYGLGALNADNSD,, TPHAYRMAUTSH,YRAODIDRENGLAALNDGSL,ANDTSR,ACHSECAI,ATIECSONPEHRAVGEU,S, GPLHAARNYDINK(/FLEAMRAYLNEK),, OEYVEA(RSI)ES,WIUTTHEROUPST,ICURNEIRNVAER,Y BSKLIAND,DERM,AMMARY FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665200 TKeirlmliendalonSaDcaryif: ic9e3 EAnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross pathology --~ No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE LETAL MUSCLE, SPLEEN, AORTA, ILEUM, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,D.THAMUS, TPHHAYRRYOIINDC/GLLAARNYDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, 665200 Continued on the next page --_ Tos`Company Sanitized. Does not contain TSCA CBI 0H-25D4a2y5G;avSaugbcehSrtoundiyciTnoxRiactistwyithOneGeneration Reproduction Evaluations Dupont-11418 ~ howing anIinmdailvidduaatla AfnoirmailndLiivisdtuianlg animals sDotsoeny GFoup VIII 100e0almg/(k+gAPPTrReOaVtEmDenPtR:OTO1C0O0L0 +)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665200 Continued fron previous page Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNE`YASGG:REGATES, LYMPHOID, minimal. HEARTIN: FLAMMATION, SUBACUTE/CHRONIC, minimal THONDHSEM:ORRHAGE, minimal. VAGINAEST:RUS STAGE: PROESTRUS. No MiLUcNrGoSs,copSiKcELAEbTnAoLrmMUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, SRETCOTMUAMC,H, `MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R L`TYHMYPRHOINDODGEL,ANDA,DREPNAARLATGHLYARNODISD, GLSACNIDAST,ICTRNAECRHVEER,, PEISTOUPIHTAAGRUYS,GLAND, --~ GPLHAARNYDIN(GF/ELMAARLYEN)K,, OEYVEA(RSI)ES,WIUTTHEROUPST,ICUNREIRNVAER,Y BSLKAIND,DERM,AGGRY FEMUR/KNEE JOINT, STERNUM, BONE MARROW. NOSE ~~ _-- T1051 -- `Company Sanitized. Does notcontain TSCA C81 0H2-5D4a2y5:GavSaubgcehSrowrdiyciTnoxRiactistywith OneGenerationReproduction Evaluations DuPont 11418 --~ howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDuospe GoUp : VIII o100r0almg/(k*gAPTPrReOaVtEmDenPtR:OTOC1O0L00*m)g/kg VIII Sex: Females Animal Ret Microscopic & Macroscopic Findings 665209 TKeirlmliendalonSDaacyrif:ic1e27 AEnxipmoaslureisGrsoigunped: rofefcovrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLREOTMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPAIRTULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOIINDK/GLLAARNYDN,K, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No M`iTcHrYoRsOcIoDpGiLcANADbnormality Observed : r 665229 TKeirlmliendalonSaDcaryif: ic1e27 AEnxipmoaslureisGrsoiugpned: orefcfovf.rom necropsy Gross Pathology No wLaIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, 665229 Continued on the next page -..- --~ T1082CompanySanitized. DoesnotcontTSaCAiCnBI 9H02-5D4a2y5G;avSaugbeeShtrourdiyciTnoxRiactistwyithOveGenerationReproduction Evaluations DuPont-11418 --~ howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals DsopseyMp : VIII 10f0e0mamlg/(k*gAPPTRrOeaVtEmDenPtR:OTOC1O0L00)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665229 Continued from previous page Gross pathology : No MaTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAANRDYIG(/FLEAMRAYLNEX),, OEVYAE(RSI)ES,WITUHTEROUPST,ICVANGEIRNVAE,, USKRIINN,ARYMABNLMAADRDYER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology + THYROEICDTGOLPIACNDTH:YMUS TISSUE. 665234 TKeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology + --_ No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/(XFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, 665234 Continued on the next page ... -- Io `Company Sanitized. Doesnot containTSCACBI 9205-4Da2y5;GavSaugbecShtruodiycTionxRiactistwyith One-GenerationReproduction Evaluations Dupont 11418 ~~ howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals DsorsuepyGfoup : VIII'100e0ralmg/(k*gAPTPrReOaVtEmDenPtR:OTOC1O0L00*m)g/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings G65234 Continued from previous page Histopathology LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYCSHRO+ NIC PROGRESSIVE NEPHROPATHY, minimal. TSHEMORRHAGE, minimal. VAGINAEST: RUS STAGE: ESTRUS. No MiLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP: LEEN, AORTA, BRAIN, SPINAL CCMOOALRNODDN,I,BUSLTROAEMRCATCULHMY,,HPMHDEUNSOODEDENENT,UEMR,AIDCRJEELJNYUAWNLPUHMG,LNAONDTEDL,SE,UMS,ASLCIIPVAANATCRIRYCEANGSEL,RAVNEDC,SE,CON, TPRIATCUHIETRA,RYESGOLPANHDA,GUST,HYRPOHIADRYGNLGA/NLDA,RIPXA,RATHYROID GLANDS, EOYVEA(RSI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y BSKLIAND,DERM,AMMFAERMYURG/LKANNEDE J(OFIENVTA,LE), --_ STERNUN, ONE MARROW, NOSE -- T1054 Company Sanitized. Does not contain TSCA CBI 51.02-5D4a2y5G;avSaugbcehSrtoundiyc TinoxRiactistywithOne Generation Reproduction Evaluations Dupont 11418 --~ howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dsotsuepy VIIT00f0emamlg/(k+gAPPTRreOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Aniral Ref Microscopic & Macroscopic Findings 665237 `KTielrlmeidnalonSaDcaryi:fic1e27 AEnxipmoaslureisGrsoigunped: roefcfovf.rom necropsy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND.THYMUS, TPHHAYRRYOIIXD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/X(NFEEENALJEO)I,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology No M`iTcHrYoRsOcIoDpiGcLAANbDnormality Observed : --~ 665202 Terminal Sacrifice EKxiplolseudreonGDraouyp : : 33subch Animal is signed off from necropsy Gross Pathology : No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUVMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, 665242 Continued on the next page --.- ~~ . Iss Company Sanitized. Doesnotcontain TSCA CBI 9H02.5D4a2y5G:avSauglecShtroundiyciTnoRxaitcistywithOne GenerationReproductionEvaluations Dupont 11418 --~ owing anIinmdailvidduaatla AfnoirmailndLiivsitduianlg animals Dsouspey GMup: VIII 10e0m0almg/(k+gAPPTRrOeaVtEmDenPtR:OTOC1O0L00+n)g/kg VIII Sex: Females Animal Ref 665242 Microscopic & Macroscopic Findings Continued from previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlATiHtYyROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAARNYDVN(XF/ELMAARLYEN)X,, OEYVEA(RSI)ES,WIUTTHEROUPST,ICVANGEIRNVAE,, USRKIINN,ARWYABDLAARDDYER, FEMUR/XNEE JOTNT, STERNUM, NOSE Histopathology : `DopMIeSSI:NG. THOSHEMORRHAGE, minimal. THYROHIYDPEGRLTARNODPH+Y, FOLLICULAR CELL, minimal. EYE(S)OPWTIICTHNEORPVTEICNONTERVPERES:ENT, UNILATERAL. vacTAIN:FLAMMATION, PERIOCULAR, UNILATERAL, minimal. --~ ESTRUS STAGE: ESTRUS. No MiLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN. APOARNTCAR,EASB,RAICNE,CUMS,PICNOALLONC,ORDR,ECTSUTMO,MACMHE,SENJTEEJRUNIUCM,LYWIPLEHUMN,ODE, SSCAILAITVIACRYNEGRLVAEN,DS,PIMTAUNITDAIRBYULAGLRANLDY,MPHPANROADTEH,YRAODIDRENGLAALNDGSL,ANDS, T(RFAECMHAELAE,), ESOOVPAHRIAEGSU,S, UTPEHRAURSY,NK/ULRAIRNYANRKY, BLSAKDIDN,ER,MAMFMEAMRUYR/GKLNEAEND 665242 Continued onJOtIhNeT,nexStTERpNaUgMe, ..BONE MARROW, NOSE -- T1036 `Company Sanitized. Doesnotcontain TSCA CBI 5205-4D2ay5:GavSaubgeehSrtoundiyc TinoxRiactistywithOne-GenerationReproductionEvaluations DuPont 11418 --_ wing anIinmdailvidduaatla AfnoirrailndLiivsitduianlg animals sDoosney OWup VIII 10e00alma/(k+gAPPTrReOaVtEmDenPt:ROTOC1O00L0+)mg/kg VIII Sex: Females Aninal Ref Microscopic & Macroscopic Findings s65242 Continued from previous page Histopathology : ORGANDSUONDOETNUMEXAMINED: ses261 KTeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: sofufbchfrom necropsy Gross Pathology : No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UCDMEENSUENN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THAMUS, THHAYRRYONIGD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y ~~ GFLEAMNUDR/K(NFEEEWAJLOEI)N,T,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal EYE(S)OPWTIICTHNOEPRTVIECNONTERVPERES:ENT, UNILATERAL. VAGINEAS:TRUS STAGE: PROESTRUS. 665261 Continued on the next page -... 1037-`Company Sanitized.Doesnot conTtSaCAiC8n1 2905-4D2a5y:GavSaugbeehSrotniyc TnoxRiacistywithOne Generation Reproduction Evalustons Dupont 11418 ~~ howing anIinvdailvidduaatla AfnoirnailndiLviisdtuianlg animals stDoosneyGYoup : VIIT 100o0nalmg/(k+gAPPTRrOeaVtEmDenPtR:OTOC1O0L00+)ng/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings sss261 Continued rom previous page Histopathology : Nose INFLAMMATION, TURSTNATES, minimal. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y SOKbEsLeErTvAeLd M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLOYNM,PHINLOEDUEM,, GSLAALNIDVSA,RYSGCLIANNTDISC,NEWRAVNED,TSPUILTAURILTYANReYifGLNAONDDE,, TTHHYYMRUOSI,D AGLDARNEDN,AL PEVAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOMPAEMAUGAURSY, GPLHAADRVN(KF/ELMAARLIEU),E, OSVTAERRINEOSM,, UBTOENREUSM,ARRUORWTNARY BLADDER, FEMUR/KNEE JOINT, 665275 TKeirlnliendalon SaDcaryif: ic1e27 AEnxipnoaslureisGrsoiugpned: orfefcovfrom necropsy ~~ Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, ATOLRETUAN,, PBRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,FUMD,UODMEENSUEMW,FSRJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDNST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYYDS, 665275 Continued on the next page -... --~ ewCompanySaniized. DoesnotcontTSaCAiCBnI H902-5D4a2y5G;aSvuabgcehrSoundiyc iTnoxRiaciistywithOneGeneration Reproduction Evaluations DuPont 11418 ~ owing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDouspeyGIO : VIII 0o00nalmg/(k*gAPPTrReOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665275 Continued from previous page Gross Pathology : No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAANRDYNX(/FLEAMRAYLNEK),, OEVVEA(RSI)ES,WIUTTHEROUPST,ICVANGEIRNVAE,, USRKIINN,ARYMABMLMAADRDYER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : 665282 TKeirlmliendalonsDaacryif: ic1e27 aEnxipvoaslureisGrsoiugnped: orfefcovfrom necropsy Gross Pathology --~ No MaLcIrVEoRs,copKiIcDNEAVbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTAPRHYNGOLDEA,ND,THYMUS, TPHHYARROYINKD/LGALRAYNDN.K, PAEVREA(TSH)YRWOIITDHGOLAPNTDISC, NTERRAVEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, 665282 Continued on the next page .... --~ 10%`CompanySanitized. Doesnot conTtSaCAiCnBI 9H02-5D4a2y5G:avSaugbeehSvtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations Dupont-11418 ~ howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDmoospey Group : VIII 100e0ramlg/(k*gAPPTRrOeVatEmDenPtR:OTOC1O0L00+)ng/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665282 Continued fron previous page Histopathology No M`iTcHrYoRsOcIoDpiGcLAANbDnormality Observed 665288 TKielrlmeidnalonSDaacyrif: ic1e27 AEnxipmoaslureisGrsoigunped: orfefcovfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC `NMEANRDVIEB,ULPAIRTULYIMTPAHRYNOGDLEA,ND,THAMS, `PTHHAYRRYOIICD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y --~ GFLEAMNUDR/X(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology THYROHIYDPEGRLTARNODPH:Y, FOLLICULAR CELL, minimal --~ . Too`CompanySanitized. DoesnotcontainTSCACBI 9205.4D2a5yG; SaubvcShtouadiyciTgonxRiaectistwyithOne-GeneratonReproduction Evaluations DwPont.ll41s + --_ Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDtoosneyGYoup VIII 100e0ralmg/(k*gAPTPrReOaVtEmDenPtR:OTOC1O0L00+n)g/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665291 TKeirlmliendalonSDaacyrif: ic9e3 EAnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross pathology : No MLaIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC`NMAENRDVIEB,ULPAIRTULIYTMAPRHYNOGDLEA,ND,THYMUS, PTHHAYRRYOIIXD/LGALRAYNDN,K, `PBAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOMPHAADGMUASR,Y GFLEAMNUDR/X(NFEEEMAJLOE)I,NT,OVASRTIEERSN,ON,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. -- KIDNE`YASGG+REGATES, LYMPHOID, minimal LowesH:EMORRHAGE, ALVEOLAR, minimal. PANCRAEGAGSRE:GATES, LYMPHOID, minimal TinsHE:MORRHAGE, minimal. EVE(S)FOLWDI/TRHOSOEPTTTIEC, NERRETVIENA:L, minimal. 665291 Continued onINtFheLAnMeMxAtTIOpNa,gePE.R..I.OCULAR, UNILATERAL, minimal. --_ Toe`Company Sanitized. DoesnotcontainTSCA CBI 9205.4D2ay5:GavSaugbcehSrtoundiyc iTnoxRiactistywithOGneeneration Reproduction Evaluations Dupont-11418 ~ howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals DstoosneyGroup : VIII 100o0nalmg/(k*gAPPTRreOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Animal Ket microscopic & Macroscopic rindings 665291 Continued fron previous page Histopathology : sv:DERMATITIS, FOCAL, minimal. VAGINAEST: RUS STAGE: PROESTRUS. No MiHEcArRoTs,copSiKcELEATbAnLomMaUlSiCLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, MSETSOEMANCTHE,RICDUOLDYEMNPUHM,NODJEE,JUNSUAML,IVATRLEYUMG,LANCDESC,UM,MANCODLIOBNU,LARRECLTYUMMP,H TNOHDYER,OIDADGRLEANNADL, GLPAANRDAST,HYRSOCIIDATIGLCANNDESR,VE,TRAPCIHTEURI,TAREYSOPGHLAAGNDU,S, UPRHIANRYANRXY/LBALRAYDNDKE,R,MAPNEMMAURRY/KNGELAENJDOI(NFTE,VALSET)E,RNUOMV,ARIBEOSN,E MUATRERRUOSW,, NOSE 565299 ~~ KTeirlmliendalonSDaacyrif: ic1e27 AEnxipmoaslureisGrsoigunped: orefcfovf.rom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRRACIRNE,ASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, 665299 Continued on the next page -... --~ ToCompanySanitized. DoesnotconTtSaCAiCnBI 9H02.5D4a2y5G:avSaugbceShrtoundiycinToRxaitcistwyithOneGenerationReproduction Evaluations Dupont11418 ~ howing anIinmdailvidduaatla AfnoirnailndiLviisdtuianlg animals sDotsuepyGroup : VIIII00o0nalmg/(k+gAPPTRrOeVatEmDenPtR:OTOC10O0L0*)mg/kg VIII Sex: Females Aninal Ref Microscopic & Macroscopic Findings 665299 Continued from previous page Gross Pathology : No MaTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAANRDYNX(/FLEAMRAYLNEE),, OEVYAER(IS)ES,WITUHTEROUPST,ICVANGEIRNVAE,, SUKRIINN,ARYMAMBLMAADRDYER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Mi`TcHrYoRsOcIoDpiGcLANADbnormality Observed : 665303 TKeirlmliendalonSDaacyrif: ic1e27 AEnxipmoaslureisGrsoiugpned: orefcfovf.rom necropsy Gross Pathology : ~~ No MaLIcVrEoRs,copKIiDcNEAYbSn,orrLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, IALOERUTMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIEJCUNLUYYM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS, `PTHHAYRRYONTKD/LGALRAYNNDK,, `BPYAER(AST)HYRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTNEORUSSE, VAGINA, URINARY BLADDER, 665303 Continued on the next page .... -- T1083 `CompanySanitized. DoesnotconTtSaCAiC8n1 12905.4Da2y5G:avSaugbeehSrtonyiciTonxRiactistwyithOneGenerationReproduction Evaluations DuPont11418 ~ howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals sDrouspey Group : VIII 100o0ralmg/(k+gAPPTrReOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665303 Continued from previous page Histopathology THYROHIYDPEGRLTARNODPH:Y, FOLLICULAR CELL, minimal 665310 TKeirlmliendalonSDaacryif: ic9e3 AEnxipmoaslureisGrsoiugnped: osfufbchfrom necropsy Gross pathology : LIVERDE:FORMITY, RIGHT, LOBE. No MaKIcDrNoEsYcSo,picLONAGbSn,ormHaEAlRiTt,y SOKbEsLeErTvAeLd M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH INLOEDUEM,, --~ GSLAALNIDVSA,RYSGCLIAANTDISC, NMERAVNED,IGUPLIATRUILTYAMRPYHGLNAONDDE,, TTHHYYMRUOSI,D AGLDARNEDN,AL EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESMOPAHMAMGAURSY,GLPAHNADRYN(EF/ELVAARLYEN),K, OSVTAERRINEUSM,, UNTOESREUS, VAGINA, URINARY BLADDER, FEMUR/XNEZ JOINT, Histopathology + LoNGsHEMORRHAGE, ALVEOLAR, minimal 665310 Continued on the next page - --~ "iow `Company Sanitized. Doesnot containTSCA CBI 9H02-5D4a2y5G;avSaugbcehSrtoundiyc Ti oxRiaclistywithOne-GenerationReproduction Evaluations Dupont 11418 ~ howing anIinmdeilviddautaal AfnoirmailndLiivsitdiunagl animals sDtosoe Group : VIII 100e0malmg/(k+gAPPTRreOaVtEmDenPtR:OTOC1O0L00+)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665310 Continued from previous page Histopathology : PANCRAEGAGSRE:GATES, LYMPHOID, minimal. ToSH:EMORRHAGE, minimal. VAGINEAST:RUS STAGE: METESTRUS. No MiLIcVrEoRs,copKiIcDNEAYbSn,ormHEaAlRiTt,y SOKbEsLeErvTeAdL M:USCLE, SPLEEN, AORTA, CBBRCAUIMN,, CSOPLIONNA,L RCOERCDT,UM,STMOMEASCEHN,TERDIUOCDELNYUMMP,H NJOEDJEU,NUMS,ALIIVLEAURMY, NGELRAVNED,S, `PMIATNUDIITBAURLYARGLALNYDM,PHTHNOYDREO,IDADGLRAENNDA,L GPLAARNADTSH,YROSICDIAGTLIACNDS, TEYREA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYSNKKI/NL,ARMYANM,WARY GLAND (FEMALE), OSVTAERRINEUSM,, BUTOENREUSM,ARRUORWI,NANROYSEBLADDER, FEMUR/KNEE JOINT, --_~ 665326 KTeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAVbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSGEMN,TERJIECJUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULPAIRTULIYTMAPHRYNGOLDEA,KD,THYMUS, 665326 Continued on the next page ... -- 1055 CompanySanitized. Doesnot contain TSCACBI H.25425: SubekronicToxicity 90-DayGavage StudyinRats withOneGenerationReproduction Evaluations Dupont 11418 --~ howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dsroospey Group : VIII 100e0nalmg/(k+gAPPTRreOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665326 Continued from previous page Gross Pathology : No MTaHcYrRoOsIcoDpGiLcANADb,norPmAaRlATiHtYyROOIbDserGLvAeNdDS:, TRACHER, ESOPHAGUS, GPLHAANRDYNI(/FLEAMRAYLNE)K,, OEYVEA(RSI)ES,WIUTTHEROUPST,ICVANGEIRNVAE,, USRKIINN,ARMYAMBLMAADRDYER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal LowesI:NFLAMMATION, SUBACUTE/CHRONIC, PERTVASCULAR, minimal. TOSCYST, EPITHELIAL, mild TRACHEHAEMORRHAGE, minimal. BYE(S)AGWGRIETGHATOEPST,ICLNYEMPRHVOEID:, mild. ~~ IONPFTLIACMMNAETRIVOEN,NOPTERPIROECSUELNTA,R, UUNNIILLAATTEERRAALL., minimal. VAGINEAS:TRUS STAGE: ESTRUS. . No MiKIcDrNoEsYcSo,picHEAARbTn,ormSaKlEiLEtTyALObWsUeSrCvLeEd, :SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOOLROD,N, SRTEOCMTAUCMH,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANRCYREAS, GNELRAVNED,S, PMIATNUDIITASRUYLAGRLALNYDM,PHTHNOYDREO,IDADGLRAENNDA,L GPLAARNADTSH,YRSOCIDIATGLIACNDS, 665326 Continued on the next page ... -- Tio%CompanySanitized.DoesnotconTtSaCAiGBnI 292005--4DDa2ayy5G;GaavvSaauggbeecSShutoduidycyiTinnoRrRaiatctisstwwyiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiioonnBEuvaalluuaattiioonnss ____ DDuuPpoonnet-1111441188 --~ towing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtouspeyGroup : VIII 10a0n0alng/(k+gAPTPrReOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665326 Continued from previous page Histopathology No MOiEVScAOrRPoIHsEAcSGo,UpSi,UcTEAPRbHUnASoR,YrNmUKa/RlLIiANtRAyYRNYOXb,BsLeASrDKvDIeENd,R,:MAFMEMMAURRY/KNGLEAENDJOI(NFTE,MALE), STERNUM, BONE MARROW, NOSE 665328 TKeirlmliendalonSDaacyrif: ic12e7 AEnxipmoaslureisGrsoiugpne:d orfecfovf.rom necropsy Gross Pathology : No MLaIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,FA'LSAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPAIRTLUYINTPAHRYNGOLDEA,ND,THYMUS, --_ `PTHHAYRRYOIIXD/LGALRAYNNDX,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology No Mi`TcHrYoRsOcIoDpGiLcAANbDnormality Observed : --~ EToE -- `CompanySanitized. DossnotconTtSaCAiCBnI F9-02-5D4a2y5;GaSvuabgcehrSotnuidcy TinoxRiactistwyithOGneeneration Reproduction Evaluations Dupont 11418 ~ owing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtouspeyGroup : VIII 10o0r0almg/(k+gAPTPrReOaVtEmDenPtR:OTOC1O0L00*)mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665333 TKeirlmliendalonSDaacryif: ic9e3 AEnxipmoaslureisGrsoigunped: osfufbchfrom necropsy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GSLACNIDAST,ICMANENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND,THYMUS, `PTHHAYRRYONICD/LGALRAYNNDK,, `EPYAREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology LowesH:EMORRHAGE, ALVEOLAR, minimal. -- TSH:EMORRHAGE, minimal. EYE(S)INWFLIATMHMAOTPITOINC, NEPREVRIEOC:ULAR, UNILATERAL, minimal. VAGINBASTRUS STAGE: PROESTRUS. NOSE I: NFLAMMATION, TURBINATES, moderate, (gastric vomitus). INFLATION, SINUS, mild, maxillary. 665333 Continued on the next page . --~ -- 10% fi omeany Saitzea. Doss ot contain TSO cel 0H2-5D4a2y5;GavSaubgcehSrtonuidcyTionxRiactistyith One-Generation Reproduction Evaluations DuPonc1415 --~ stupy onoawling(+anAIiPnnPdaRilOvViEddDuaatlaPRAOfnToirOmCaOilLndiL+)viisdtuianlg animals Dose GOup: VIII 1000 ng/kg Treateent: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665333 Continued from previous page Histopathology + 665335 Gross No MiLBIRcVArEIoRNs,,copKSiIPDcINNEAAYLbSn,CoOrRHmDEa,AlRiTSt,TyOMOSAbKCsEHeL,rEvTDeAUdLODM:EUNSUCML,E,JESJPULNEUEMN,, AIOLRETUAM,, SPSCAAINLACTRTVEIAACRSY,NEGRLCVAEENC,DUSM,,PIMTCAOULNIODTNAI,RSYULRGEALCRATNULDMY,,MPMTHEHSYNERODNOETI,EDRIAGCEDARNELDNY,AMLPHGNLOADNDES,, PSKAIRNA,THMYARMOMIADRYGLAGNLDASN,D BLADDER, FEMUR/KNEE TJ(ORFIAENCMTHA,ELAE,)S,TEERSONOVUPAMHR,AIEGSUB,SO,NEUTPEMHRAAURRSYR,IOCWXU/RLIANRAYNRXY, TKeirlmliendalonSaDcaryif:ic1e27 AEnxipmoaslureisGrsoigunped: orfefcovfrom necropsy Pathology : ~ UTERUSDILATATION, HORNS. No MAaLOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,oSrPmILNUaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, ANIDOLDREEUE,MN,ALSAPGLALINACVNRADERSAY,S,GLSACCNEIDCASUT,MI,C`NMCEAONRLDVOIENB,,ULRPAEIRCTTULUIYMTM,APRHYMENGOSLDEEAN,NFDE,RTIHCYMULSY,MPH 665335 Continued on the next page .. --~ _-- "iow: 0 CompanySanitized. DoesnotcontTSaCAiCnBI 9H02-5D4a2y5G;avSaugbechSrtoundiycTionxRiactistywith One-Generaion Reproduction Evaluations. Dupont11418 stupy chenoaw'ing(+aAnIPinPmdRailOvViEddDuaatlaPRAOfnToiOrmCaOilLndLi*)ivisdtuianlg animals Dose GFoup : VIII 1000 ng/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665335 Continued from previous page Gross Pathology : No MTaPHcHYArRRoYOsNIcKoD/pLiGAcLRAYNANDbK,n,orPEmAYaRElA(iTSHt)YyRWOOIIbTDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPJHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,OM,VAGNIONSAE, URINARY BLADDER, Histopathology : vaGINEAST:RUS STAGE: PROESTRUS. No Mi`TcHrYoRsOcIoDpiGcLANADb,norUmTaERlUiSty Observed : 665337 KTielrlmeidnalonSDaacyrif: ic9e3 EAnxipmoaslureisGrsoiugpned: osfufbchfrom necropsy ~~ Gross Pathology : No MAaLOIcRVrTEoARs,,copBKRiIAcDINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyOROHDEb,AsReTrS,TvOeMSdAKCE:HL,ETADLUODMEUNSUCNL,E,JESJPULNEUEMN,, ANIDOLDREEUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNIEDCASUT,MI,C`NMCAEONRLDVOIENB,,ULPRAEIRCTTULUYIMMT,PAHRYMENGOSLDEEAN,NTDE,RTHIYCMULSY,MPH 665337 Continued on the next page .... T10s0- `Company Sanitized.Doesnot conTtSaCAiCnBI 220:-52D4a2y5:GSaavvSaauggbeeeShStotunudidycyiiTnnoRxRaiatctsistvywiitthhOOnnee GGeenneerraattiioonnRReepprroodduuccttiioonnEEvvaalluuaattiioonnss DDuuPpoonntt-1111441188 -- srupy Sehroawling(+aAnIPinmPdaRilOvViEdduDaatlaPROAfTonOriCmOaiLlndL+i)ivisdtuianlg animals Dose GFoup : VIII 1000 ng/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic& Macroscopic Findings 665337 Continued from previous page Gross Pathology : No MaTPcHHrYAoRRsOYcIIoD/pLiGAcLRAYNANDbK,n,orPEmAYaRElA(iTSHt)YyRWOOIIbTDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTNEORUSSE, VAGINA, URINARY SLADDER, Histopathology : LIVER:INFLAMMATION, KIDNEYS SUBACUTE/CHRONIC, minimal. THMAGGREGATES, LYMPHOID, mild. PARATHHYERMOORIRDHAGGLEA,NDSmin: imal. EYE(S)MISWSIITNHG.OPTIC NERVE : ~ VAGINMAOIPSTSIICNGN,ERUVNEILNAOTTERPARLE,SENLTE,NS.BILATERAL. ose E: STRUS STAGE: PROESTRUS. INFLAMMATION, TURBINATES, minimal. 665337 Continued on the next page .. --~ T051- CompanySanitized. Doesnot contain TSCA CBI H25425: SubehronicToxicity 0D-DyayDGoavvaaggeeSSutuuddyyilnnRRaattsswwiitthhOOGnneeenGeerneartaitioonnRReepprroodduuccttiioonnBErvaalluuaattiioonnss DDuupPoonntt1111441188 --~ owing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDrouspey Group :VIII 10o0n0almg/(k*gAPPTrReOdVtEmDenPtR:OTOC1O0L00*m)g/kg VIII Sex: Females Aninal Ref Microscopic & Macroscopic Findings " 665337 Continued from previous page B Histopathology : No MCiLOOcRNrDGo,Ss,co"SpHTiEOAcMRATAC,Hb,nSoKDmUEaOLlDEiETtNAUyLM,MOUbSJsCEeLJrEUv,NeUdMS,P:LEIELNZ,N,AORPTAAN,CREBARSA,IN,CECSUPMI,NAL PCMOIALTNOUDNII,TBAURLRYEACRGTLULAMYN,MDP,HMETNSOHEDYNETR,EORIIADCDGRLELANYNAMDLP,HGTLNRAOANDCDESH,,EAS,SACLEIISAVOTAPIRHCYAGNGUELSRA,VNED,S, UPTHEARRUYSN,K/LUARRIYNNAXR,Y MARROK `BSLKAIDND,EMRA,MMPAERMYUGR/LKANNEED J(OFIENMTA,LE)S,TERONVUAMR,IESB,ONE `ORGA"NPSARNAOTTHYERXOAIMDINGELDA:NDS ~~ ++ Listing Complete *++ --~ --_-- 1052- Company Sanitized. Does not contain TSCA CBI H:25425: Subchronic Toxicity 0-DayGavageStudy in Rat with One-Genersion Reproduction Evaluations --_ DuPont-11418 APPENDIX O INDIVIDUAL ANIMAL MICROSCOPIC OBSERVATIONS LISTING INDIVIDUAL ANIMALS AFFECTED --_ "1953 Gompany Sanitized. Doss not contain TSCA CBI 3 [ET To zzzaaagaan gE Y 3BE=E m ,BgTcaisEEanndd iii,f i MP 8383888888 g Fe BoE i Helo TH ~ [FE HI wy i: i [1 i i: Boob E 23% Wigooo0 3. 8 if i gat --_ 3 ee leone =| ii ii fi illsi ok 2 iid Eth g 0 iE CompanySoca. BoosrotarsinTscAca i [EErLeCs 1 2 i5i 3 i 8 IF7 ipigifB- | -sm BBE sama gggge || Tosi, aE, Ff sm 2 EH 3p iEoT EmEEEacs IH Bob i fei iE if HErl | 1ge ' i 5 |i # | i4 E[13188 io | 1% dF ey ql Cy PoE Lg Bias | EI | i008; HE EE a HE E | gE iEx jE Eiiz} i PE FE Coma Srtn,sestsT5aon0 ~z Z: ERyPo E lpigiER E| 2 igi i=EE | IH 3p (AE jeRe | CF SEEEEEEEEY 3) goo0f ~i gi: | | in iH ig iE :4 qe CEI |i I Lo dFi gd Ai po i Ho if 3] 1 fF ir ogi ih 3i JH diiasy . i iH IZ _24] i iF Ela Company Sanitized. Doesnot contain TSCA CBI ~3 3i7 1F 3772I , 1 L5 L 3gassE caass | 3 EE i dpigiin | |i odie A iio dE ETTE iT g3ep (MBeI kfoBw | 30000 i dBH,i i i3F | gmasesEaz iEio gB izigE gss: i i= ii ~ |B = Hi git: ; 5 x Ji ; if 29% i is fleas | } jag iog |: ;| i1i82 HE i i% aHEe 54 3 | sgd oioe0 YF ME ~4 8] |i ai Cia irf I is FE iii%: rPEgLdE iHlH iF ce isd iEEig CompanySanitized. DoesnotcontTSaCAiCnBI ~i [iSgTi (1%gE8E, i| 52 agggaEsgzsesgeassssd | i3 o(dgiEgifE e - |i Iori, ii ois3l TTT J gmasemesriFil it (Ai el | BSSEESEEEE 3, El 1 ~ ED H gis | 5 A i Hl aglso ii Eitee JiEo| | IiN i ; Fil ifi iPodg ai olf i ; E id L5LsFE i ii[EI (I E5H H ig of8 lr 1BH5 g i PEE ik ~~ 2iz4 : ; : CompanySata.DoorotcontTaCiCnot ~ 3Z| [igSiT 7sE, EE | 5 agsazaes | 2 2E8E88EEE|E 3 iigdigeiiTn i ii TOTTI lL F P EETomed EEEE | iz jai joi iC SSESEESEes i ~ B i go in #0 if | Fi i gl 250 | | |isEeEE ii 148 H{H3 ' qi i | iis ii i ii [EI i i% 8Bsy | |i 8 [iEEg] ggie |i. i : [itE]h z i |B i2F E isi d F 0| L s iP i:dEiE1 iiiEx it a9 ~~] PEE ik 8 CompanySwitz. Dossotc 56hG1 ~ iii HL } 3 EE CT _83eEEEEELE ii T E imigTiEE _L o i {Ei TIs T, Emm aaizeeasiio ipod =i wood i BHey iil L i13fs ~ [Hi i i &: El pe | i i! agsef: ii ii i{addg HE i ii gi ii ii%i Cyi ;PoiE iis ] gf | |: it } i gl a, iPdEGi 3ig: W 3 F J 2 i }i3 s i[Hit] -- 8#49i fo 22 RP iFE CompanySanz. ossnotconanTSCAG1 ~3 Pl 3 [ST 7g8. 1 5 igsassgess | ig) [REE | % gEEEisedy | ogIEHEi Pod, i iogR ij7E7; i gEzsmreEs of $ 3Ep o(EI jel! i ggggssgsseiiiEEf ~ H2,el1 oF } PH 1i3:0 ig 5 IE i] Ii| i; a ii3tHs 18 ; 3 a4 Pf Hi CEE gli i go. EM : a i3f . 8 oH F F| bo 5ii: i% dF gs i a ~ 34 jo. p83 i 8] Compan Siti. tr TSG ~3 y opEisE te | TTi Pode, ii o{szi EEmIaT amamEEas 0 3oa 181 leBiwm f| -- S8E8282828288888E8S8 5I:, EINE PE [8 Bo i i ~ yi TT of 85% 1 } i2l8y 8Z fies | i 5 Et i iH 5a | ii qe38 | ;| 3{5 58 i ii 8 gl: i# Li i jkaiy e gi | EH i i3 I] E it ig g gl oFi ,F iiI:EE of H{Efs if fF i ose iH Fggd iii5 Pg 88 0 Pi Es --~ 2A 28 CompanySante. DossotraTCAG1 ~ % HL LE IST igi 7gE, 1%8E 1 | 5 3 sgeasaaaad ZEgEggoegE | | 18 i i 888855856 | 3i gEaR i ij #0 digit i old 2 iE lanl BoE 2 2 3333852883 iO f 3, (Bie leR. | 2EGEEEEEEEEEEE 2 00 3 ef | iF | HEM gM fiEg i EE Ti i[Iis 13 on ih .g% jgied | i ;i {5% IH EfiL || iitgs # | iz ge i hi iq |# i F4 Y I is . iii:: 531) 0POFoe iirE iiaEl 1 POE id ae iy gd ~3 i150 8 lk 8 CompanySanz. Doessocontain150ACot ~3 g Eo i i[gFi77(gF8E,E || 53 gfeEaEdgsaagssaEaegy | | PoEhET ; Poa { FIEoHR e ELEN mertii i[ p H(8RoRI. 1 25 EgE3E3E3EEEsEeaEaEsY 2| 0 EEE 5 Belo {i iH i ~a : 123 if 3 5 als! | ig geio i ihid mn iH FH ig E j88 Ho Ee i 232] ~ 449 8 ij P [I OE 2 ii3d53g PRE if Company Saiz. Dooro catTSaCiAGnot ~3 iZ3 1I3ST7(RgE,E [1 95 3s5EgadgdmEaEgseiaEd || y opoiE lgiife ETi 3 {Eger i Pohl imme i Apel = 33883888 15, ~ la i : anEH ii a4 Lo i ida Ed1 i i : ~ i23 42) i 18 & iBe --eeee IRE CompanySarid. Doss notconanTGAG1 z F[5I7RE7LgEER, 1 ole 1g 12 i fone iE] f=RE Dor i Rf] 5 gaa: _ E3888 aaiEE | ggEges | # fy i rm = iiseneg8, go BE, 0 ig i 1 iF ~ #ldioFTT {fs iat of 25 | ii it gles | |i i18% He | i i H i:ii a4 : Ed :i gi . iitsy Pooky ih i 5 gg iy dor iF iio, a% EE 8 if --_ 82 2| _---- iad : - + CompanySanitized.Doesnot contain TSCA CBI ~% :z EEE igi (=RE | P odpigEith FOE ie BE3EEEE 3g 0 fs i$ id, fd] 1B ii | i 0 Be ~ dE fl2o5c0s |1 ii [EEE HE ; | iE | {18 3ih 4 iigE : IH iifzs HE i: daii SHE 2 | i. ;8 |i &5 is 3 i32 glHaH Poi Eo i ifs mooF ie io a iff lk i CompanySatz. Doo rtcontainTSCA ~ Zz i{FqT TIEsEEE, | 25 gGaHaEoEn gEngeaaEEgny || igoaigigiifEe | | pP oso er de it Alpek SSRESEE EEE is, no Helo ~ |Jii iat ie i2B1 ?; {ob i HE | | | I i ji I: CB RwEoBo oo pi opPicEED. iiyk : Fa E E go ihn 8 0F if aiif Won iEdye iH iiiE --i --_-- IEE EX] CompanySnitz. ossotc TGAG1 LL ~ iFg)77I8R,E 11 35 BsmEaEamgnEadziayf || yio Pod igigE ifn | T| io OiE ir an Ei 2Ba oe(BlkloBu | 3 BggEEmEazEaEsaInEEiFfE, SgS LI L iii EI | 5 HHEHE ii i18i% H8a i| Pio2g8 if | HE gq: i it 2n o td DjHi : 2o3o ; g |Hl LE ids Boob af iE Hi Fig P #3 -- IF =8 Company Sats. ooerotsana 5AGol ~i i a ig iERE ggggsiEcie | 3oiipEigiiEE|n| _| o FoRH el is Pole vier iz [EL | B8EBEESEEE 5, Ho de 1 Eo i J 13 LE i ~ PFE ig & PE | iH f3 e i| iHst Hof ie Rl qt | giee | |i 5 | o4 i i i] ii fSaEF i iiBos il HE 3 PoE iE id 21i5z3 18% iHHEM gfea - id i 59] ~iE 8 iii CompanySaid.Dosrco ontTaSiAGnOI ~i i ITTTeE, 1 5 fRaaed maaed | 3 jE 2 Ti oigiggiza i 3 IE] REE fig FT i! if go omEEEEE gE lL poh Bf SSSEREL {7 EPRI i ifagd | gis | | {3a41 53 ie Hoo Ei illei: | i n1 4 o ii 8 24 | 23 2% i}i ~ 842 for =8 i| ; Ci ob Pp 1 I i i = E {i8E 88 qm i5iiE3s is ; Ee388 114% i LE BER igi ihe EERE iy EERE [1i3g3;2 iF Comp Sates. Bows contTHaEATnE ~ f 2 PeIiTgTTGeeEe, 1 3 EgaaigisagaEagsEeidE || ioigigife ioe L: y 3 iE] ER i P 3g,p (o L81isfE eim. Si ET EEEGEEm EEEEEEEY G| 3a8 0 i ii 1i2ukg ~ li a a fis | | i$ ! i [A i: gfi15n3 aIe n| o, k Pi HH ct f isdk Ej iidi: gd, id i iq ~ 5i 7 iid Rigd tr EEE CompanySates. Doss ota5AG1 ~i : TFTIRE,R|g agaaiae|e TGo li h BN P 5 Eo ar de,i iBooCly BiEH EE i ~ 5 ise i i ia 3k . gs i i : glegE | } 183 2071 } {8% 585 | | ii HCHed ;i ii% i Lo i gi | Lin . 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Doesnot conTtSaCAiCnBI ~3 Z3 HEH oe | ] pPE g!i o Ponedm, CT 8888888L8E } i ii, I Boo ITE ~ iagg i i ifs i1f2y% 2: dfaegi i| iIEtEe idq:: | | iisd JgHAiiE : |! frog kii fiatyd . i: H 4ob REE or iE laf | ~1al FEE kr TCyE 28 congener ~ RENE FEsgzegaze | i igigind | gggsgssasy od #0 0 i] its 1: a4 i HH ; iH gE 4 5 i2s ad --~ 28 23 0i @F fo: ! iH ig isd i i i% i% DE % i 1i5g5 eet Cc ig: Coma Srtn,ssrtTsSmRGaE ~ 3:3 157 7sE, | 5 aagsianad | Poh To ogi i811 2 i i 3ToOEEEeE TT IiHs i a -- SEH Lo i 0 Fd EH NEiF i{3y3 ie : 48 : ie 1 Co H HgEi [fI ede 1i5t . 3 LE | EY PE a ii: iy #9) f F F v IFE iH CompanySanitized. Doesnot conTtSaCAiC8n1 ~3 3 i{g5i7 7(aRE,E0E|g2 EjGodsgaESsEaEsDe|s 3 EE oigigifE ii oe f i0 g EFmi; oEaEEmmer giof. $ Bon di Hl BF {fs ~ fi|n: i| i3e i ile i; ifigt Bo : ii ge | 132 Li:F.|. |Loei g ildal. KAols i ife iEliaH w2o 32 ~ 329 =8 | 5 i ge | }i iid gis i; iE CompanySarita.Doe ot cont5aAiGnB ~ y IiH SgTi 7(eEfET ,E | DSg sBgiganeEsgaeEaEals|e|| i i do pigiie n |Ly FR IRELEE i ioizl TT ggmEaEEE Ln $ i 0 1 HBiioid ii;i ~ [3 TT i z o| 252 | | 122 3 Agi i i E85if: | ii ied 12% Ii ; iz geFo ; iisis CHiEs :i t . i1a5 A gi i3 iH EH } i E [22 a od in Boo: ig i+ Z| iq ~ H#S4 i 2 ia i&g 18% 15 i 4 8 zg ig |JS ---------------- | ` 28 CompanySls. Doss otconTStOAiGnOI ~3 zz TEo i e | fodEE 3 Ea ilo i 8] TF Tg gzazEeeEas i) i 51. [o2 a. SESBERELE I, Boo 3 ~ Bei HE FiE i H5i8% 1 ii 1543 = Ji i IH 3 i if ji i 2s n ie f | q14o4 gE Lo i a 2 | |if,3 iigfs gL 8 Ltd iH] ig if iE ie ig 59 iE Ei --~ 4 3 `Company Sanitized. Does not contain TSCA CBI y H iIFgTi eEEEE,E| 5 gEaagdasdagasnsatd || f i lpiglERl,| 3 Emm if i Apel gegggesss i% #H0oof iT iH ~ ih i Hl if i Iai i iH ai i 10 Hi qi | Pod RH 225 a4 | 30 33 |i ~~ 24 | ifr f |g cd g io|d EE3g i: . igs i5 01[k5]2 CompanSanaa, DoscontTSCiAGna ~ z {ST TaE, | IFIRELE 3PoigE igiE ie | io ioonE ETOmT Sgagssmer | 2 gggssssg ii i gE idos god SESE 00 1 BGef ig | IiMk ~ FE 13 Baiags | ii 5ily a | gag i IHide [I : ie i 0 4 | Pfoieg Ea Eg 8l fg EPosg i 12 P PFEiE E i. [fF ~ 24 =8 iH it i=H: iH iEtS: IHl3ai i z . CompanySanitized. Doesnot containTSCA CBI ~3 3oERdT paEeli io HEIR ELE Ls 3 gBdoopee EEE 1 ge 0 i ii - EEgeE | iing : 222s | 38g i i 5% i dflsif | ii iiad 4:8 : Hs gi i E i Pi y LE iiiiat s {FI i HF LI iPgfs5 lai. iii] oo 11d 3 | i H 5i3 i| g gi ls ihIM ids ig 4 ii i i00Fiige isi i1g2ds ~ 82 28 CompanySanit. Doss rotonsTSCAG1 ~3 3g3 Eige ) EEaE G2 EEdsiiEgl | HiI oigElgiif!h | ilL I gogs T Emyi; gaaaserEr liis i Sd 2 0, iE Bod i ; Ih 5s 0 iE ii 35 dma] ing , ~ |:E i i238 g gi: | | 5 : 3a | IH &aafi || i| IjaHd 55 : EL i 58 ii ii%i diqe: iP]E i iEhH CofE Pz : ii : i iE i: q3 oo| 8go i 2 iEGH af i=8 i --~ 58A CompanySand. DossnotconanTSCAGB ~i 3 {iSgT} (7FgE.E | | g2 a35gEadggisfeEsdlm|e| yPooElEisioT | P oF =EoyIH i ig [TT {Tg gEIzEeEaE il a HE g 0 s iid1 #2, 0| iEgF i iiq7 ~ [ED He gl 4s | i i - gE i IH afrisi ii i$ | iiiag ax EE } i ied ho Poe i gHiE :i 525 i 3 : Tii , EiB PE oz |ie gi gf q 2 3[hy : IH iEfy {25 LEE i ~4 z fe me een BE 28 CompanySaris.DosntconTtSGiCnB  igiigiEEn | i Fioo gesl Tihf 00 Hod ~ EE of 552 | {1} hi ig 2 is ' 1 3E%E i; 1i3H2 {1s ii i i ir bob Fn g2l | FEisosd Hoof oE1B rdiiiks ~1g3e loiE0 E iE Z8 oman, pte ~ 3 1ig5i7 7i8%%R,E 3i i{giEgiFfne ide 3PoaiE em is {i jek i|g Eg3gggagsagsngaeagle | || |i -- | mmi | 848 S8ESEES 5, Lon ~ fr iF uo if i : 2553 w1[ao JEPo 8 q gl r 0 BF ~a]g =8| or, OF i ii | ii3 i i153 bd | od d- {7 isfy i: [EF op3 i5 iff i) CompanySaad, Doss not contain TSOAOI ~ F32 IigSiT (1RgEfE. || y giE iEsi| Io o iigs IEFEy iT 2 g3EegagggEsEsiiEs|e| od| ly gEaeeeas ilfL dl a i Ty E gBoelo iF IiE] ~ Ja3d i 5123 | HE i 5 Ji ig giii |i ii%ist i a. {a1 : 0 |8 if HF2d {I]Fak iisd 2 ff og% it bg E i EH]E.;1 ii Mo2o i F7I iigt ~83 i iE ER i7g% ik 8 CompanySantos. ossotonanTSCACo ~3 g2 Boo i igi (REE | 3i oE imigiE ie oe 3 ED =RE IE 3 35dgsiEEdl | _f: y it FET EME FL Hg 1 ~ ED gi g Hol #E55R1 |: i153% : 3 ; ik 0 | H HH. | 11 ge qi g: 1222 i235] 0 ~ 24 i i ig i 0 il | iigrk3 i50: :i E ijzE i j432s Pog iE: 128 0 iE 15 | er---------------- EY 28] CompanySans. GomarotonanTSCA HH ~ obi A [FT 738, | 5 fagagea: @@ | ig) REE $8E88288E 8% } 3 ogiiEgifE | 3 igi iaER ig i [EEE la 8883 888888888 io E2 d i] i i [ht [EE gf, 0 1 ~ [FE o| 20 i {22 1H] i2 HlsIg | ii igies ii | 4 FH Po I 0 ge iPor 8 d 5 Fnd Sd fri DE : gSalEF | fPgE og 3 s BSE EIE 1 ie 80 dE : {15 d z f i Eo ca E Eig ~ a33 is E iE 28 CompanySoiled. Dons otstanTSGAG1  igi 13s ggg ggsgggs i io ~ f Hoo= d ga mo qf | [EE gda i| g g JE I H 4orePE o i Hf (fee = 3 fb 2g i i: | i Ih is} | at iER3 4 Eri: :EOE: {Ey IGE ~3 :3 woTE 5 | PoE E TTEC P oaiEiyi i ETE @ iF Boro aid fp hel Rs T HEobi hoEd rE Hi ~ d|gi fi; iigng .2 glad: Ji :i iHEH : i3e8 | ii i iit ge Pg hi oi | iid gil i ig og iif & PEE 5E3 20i g@ iiE : p8 iEsg iy FD oE id ~ 8i FF iE =8 Company Sarid. Doss rotconiain TSCACa ~ 3z2 FE FigTi 7ReE8E |1g2 dGUmEgEeEeEaEnE g@EE||| $ P joyi 5 iEifi.5 | it DoE LL i: (Efe sm { SESEEEEESE --i% ~ = 2 BF in gf | ; iH | 55 HFEHH ii HifLs] 8| i ii i : is ggexo |Poe iigfi gi i fi iPog |: i a 153 i gdoE iE] dE i5 Eig SwoEo i giiaE at iiid; iyo ide I --~ 5592) f 8 Fr+ if iz ; : . CompanySaiced. SoeroconTSCaA GnR! ~ 3 157 Tf | 5 sannadar | 1) (AF 1 BSEESRESEE | T PoOgE iaiEEom i| Po fy Toy Zo iRo 3 181 loEH 5 3535585508 2 gggggeesss 1iz, fp (LC HEEEL Hoo i f#o0 i1 d 3if . r85E% | ii ias : glad | i {5% 25 } iE HE : iis i i ii: FR ! ig ieEo |i Hiiy de h if ;i fan HE i 8 isd SF is i32 2 ~E3gre4 is | iE [H]] ! P foiE ] 2 E iIEk CompanySanitized. Doesnot conTtSaOAiC8n1 ~3 z3 (FT 7e8y 1g Gaaaaaas | 3ojpg EieE ii 2: ib fi i------ ii o Eig TT R gragmreeasif 3i, (H di jemC | 2SEuEEiSEnESiEeES 2 FE 0 iiE i (2id we i F48E% 4 i fe} [iEmEa ~ fi ; i] fied | | 18 1Si:f i 53 i IF | i 52 6 02 !i |P} od 3fiaid tL Poor iH oF Ei 152 4 | , iE g iB H Mo of EigEe, iig ~ $493) fir id8 = (CompanySanitized. DoesnotcontainTSCA CBI ~3 gz IST Tsk | 5 sgRgasies | i{g3i ({3388| g3E8g8g8E8g8e8s8e8 || FRE i iHgIiziEes ;; P i ETo E nyi} figl FT; sEammeeEna iD fp (ioB_" gseesdusisnE 20 1 ~ fB l = Fd EiH ods i 6 EHH i iH HE ; ifs : : ) $d th FqIi | iis: SgEi iis 5OE iiig: : 8 41 ifr d iift Ha ooifiifE iHh --_~ 24 Z8 CamoanySanz. Boss not erinTSCA ~3 3 3 1E 31 RE EE 1 lpinEn SRESRESES|E; : PPoli og TT I33, IisRlD TGemTeTiF EgEsmERmageEl |0 Hoo i ~3 123 : i feBegs i |i iidgy z i qri IH | iEfI l E3V1 0 qe i. ~ 34 =8 ih rl i || | 8 }i H8 iites13 Cifday fed i BF irI 3 iEek is0 iE CompanSeta. oes connTsoAGa ~ Lb 3 IST af |g eRgeaseEn | ig REE SSESEEESEEE | PoE iE oipiziEes ii PoE i i iE i fig TTT; geamaanean i] pv sRERL g Bo fi iHiE i Cod iH ~ di TT gliic | : igi 5 g: [EE i 3| i iH HH 5H6E i| ii%g fi | | ist io | i gi PoE I oT fr i: b2p5 i|| F[II PE 5 AiifEgy; i3 oi 7i L iE E3 i16s8 de iE ik ~ 24 =8] CompanySats. Doesntcontain TSCA CEI ~% 3g2 yo [igT) 77(3E8m | 35 sSEaEiEiSEaEcEedSa|n| iHE H iplaiI fe ify o = Rgl 3, (di TE ECIT R go iEmamE mmmn i) jem i GEEEEESEES 2 fT EEE BBeoon Hiy ~ [Ei {51 5 jgief: | || iiHH old i iis 4gq0 :i IiHf 1 Fd i oFfi iI-.3 1ia3 Wa2 l or8 iirE i ge iiEi I ~ 385 iist im 8 CompanySunt. Gov toniTSCACS! ~3 [FT gfx | 5 sengeaaiEn | IE iE ii {288 i 8838388888 i| i ipizifes i Fogdy------| PoE i Egil EIT; frammgeas lo EN igi j=8 i 3 $EEELREILE 15g id i Ted i] i ids $B, 0 8 8 ~ H i fi i Lh i i] EE i 18% 4alsE i iig Ba i isd i 1 HEL 1 EH HI i PH de Pog i ' ogFs | |i [i IR haoy . gdai ii g EiHt 2 Pid 5 glWMO 0BFfir oge4 iiG ag iis 0 iE ~3& =8 CompanySantis. Gov otcnain SEACB ~3 p oidpiziEes | PoE ER I ELC i 3g,o g(di EjemT| LI Hod idL; y iH 2 gEEiGgEmEaEEnEaEnR i2l iiN Ea | i 8ga 8 | HI Hgle2 i gEll i 2 | i|: L|o 7ig fkx I. ji3r2 fs: igf iH ho iIf 1 2 1 ~ 4i9 i HE i } ! i ff 11 f 8 =i 0 ik Company Sante. Does econT3EAGt ~3 z 3 voi Pi odiplizEirfe |TT,i i iEiTiame | i2 3h, Edi jewh s iFHEgaEEnSERENERE 4 do 13 BoE ~ ET Hi ii g Jr | iH gls3 | i ied ii | Fl |i i 5 8:i i 1: iPi og iF18Hg gr Pi oEi La i . a 3|F gs i i La EB PPEf H ihPEE igs i i3 oiPogfF g Eig sE5S i1%]3 iE 59] fo 2 iE ~ Z&3 CompanySanz. Dosnotcontain TSCAGa ~3 oigG iziEes EEi Poi i EEE "ii} ode TET gamrmarmeoaC ~ i = a Hoo 0 iE iiEs Boo i oli: | ; ie i= i IH Loo on ro | ; oF Poel PE oy 3 i Poff 2 EF Fg iE 0 g5 0 FfF oir:eos.3 0 B8L ik ~i] ei 8 i F : ~3 Z3 I ig) iE 2 ggEEgEEged || o oipize iEe --,i i jie iH Eoigl TF iT; grammeema iD go {28 ~ iHigEegly FEdd ii14ai3 : NELE i ify 3 El:z8 | i jg ii i iit Be Hi Be i ; I] gi | ; i} g4li Pd i ;x IH 8 gi* iEii iik TE EE iE i2y | 0g% 1i2y Zx e isegd ae iis fin ~ iE =8 Company Saad.boesotconTtSCiAGn1 2g 157Te8n | 5833858 RAR i 3 i o fpisd iEe aoiEoTi PonnT : i iE Tim i 2 i3l TF {Tg gr gsreamarn ( Eo dds 0 iE ~ iE a ih 123 re i i ge FEE EH go gi SE i3d i i z ii | i 2s i i 5 ; Es i | i EE i : iB t3 132 IX.R 3 Eig y iifk - iq --_ $3 0 fF ig Ec FE itd Ee -- CompanySaiz. Dos nt containTSGAGH! ~ Poli A IST 7g%y |g EEieaze: | ig] REE 3 GEE SEEEEEEIT | | pide ; i Ese i i 3, 1(ig4i81iT2egms || 532 BSBEEEEnERRSNCEREERREREEREEED Ii2.t fom mmm Eo BEd iit Hoo ~ |8e% | i| ia 2ig% .22 El21 i IEist ; FEE i IEF] igsii | ij i[i5s8 o33i5 | ii [iHiH: 4: | ; let 1 & 4: Fi og | i i(3H% g iif qi 1 0 fi H S4 SE L, I Pe ! iiBi iEii3: 3 Bffiiff i 3Hiidst ~ 3g4d PFE iE 28 Campa Saiz.Dosrco ontTaSAiGn1 ~ {1 FEE H oiHpinige Pot i {Eis gssiesdies |; iE 3, (dD ebm 0 EEEUEESEE E ig EBo oo | g2gg1 i HE Ei ~ fiH:H | ;| qi i! [E$E 0 ii iEH] PE f1a3z8 : iizH] 2 i2 HL 5 ggEe i E i| o iiigf 6Sli i ; i g g FE I . i ge |i 2i |PgE PEE 3 ES iififft:. Hoo i i m Hd oi ri pi g iiefd ~ 2894 | Nt -------- | = Company Sanitzad, Dossnot contain SGA GB ~3 5 Ta iF PFE oTiHIEELEE] i (ETiaRe | oil TET i Hop god || 1, IH sEmaremn ogil BgEsgEs: 8 5g 1 ~ oliilEEi 5 ii i #0 | iiiig : : i ji i%3 $i j i JH kiN Eirgo: PEEEE door gH 1 iL : i IH|g ad iid if --~ 24 ' TT ee Coane. ovenT50nsGo ~3 IiSgT 7g28E8y || iOaEigirfEed fol i (EB Tiem 5 iagmaze@ |s SEESEEEE | i| ii 3i, 8n ) fenC | 2 BgE3E3RigRgRiEdReEs (4,2 BoE B.Ed iI '~ E25L% | i} igiEfs | ii Ad i .: | j i i 3 . i{z5% 2z ii5i:i i33 1 | i HflIego 10 i gli8 - 23 E i i a iz F , i ;Pi og i i i| B8 a HE E i|ifid3 iiFR il g iad ggiingy : 182 iihiEis io ge Fg ~ 88%3) free e128 Z8 GompanySaizad. Doesno containTSCACol ~3 7 3 po [iSgTi i7%gE%E 1i 5 eBggEapnEgEagassea|z| opiziEm i iP Eeo e y,12 odgl TET EEammaEma il H EA oodin iH f |egod 1ia8s ~ |i | 131 qi Bl82o38ga || iii HH1{53%d 183 gE | ifs 38 i i iq | i ii gii i i| iif ig ;f i HS|E i iiE] a8 iisd EE+E IE I 5ifs 9 20 0 Ff ge iiia I 25 i Ha] 2 ------ibe 28 , 3 > - : CompanySntzad. DossrtcontainTSACEI ~i IFFTE7gL8y | 5 zijaaceEs | gEEdEEELL|E i iipEizoifrm ii Po oEgy, i Bog TTT EEammmRmRn OD ~ a ; Bo i jE er Bei 0 CT S8SSVELELE ia Ee i AH i I | gag i iHgii |Pi E ge i il ; Ef gi . ig i i i8 ii i ies TiigiH:i i it IEi]e . 3 i i] ify gMS o1 r 5 Ede 8 ii ~ 24 =| CompanySaas. DosnotarTtachica ~% 2 Boy a IigSiTTRgEEEr 11 gSEE gGuigzEagaERate|s| 3 ETE i luigidEe | | ole, i Eis | i 20g TTT fEgmamEen i2 Ip diem gsagesces 153 i r ji 35 3giE ~~ isgEiE | ii Blass | ] ist | EhIizEy 2< HEY) = iigEe iis fe 9: iffg hii ql } ie . iy . Tgie | iig o: i{iidn a i or i4t F; ibs i : fig fe 1 2 ied 4az9 f| oro i REF IEigEs ~ Z8& [EE ---- ~3 :2 Ei[I REiI1gizHiifes | i Ea ode ToT Bp AL jem BHoooip | Hoo Emma 3 SRCSRISE ii i an Ll 5 ify iiiEt if ~ FT 2 : gles | H3Es |; iiei Ji aH 1 i EE giq 3 |;i |2 HiEiey fka 60 cpl Re qo Ege IEE i S=]F i 32 ji PE E E Ed g iigE E ~MEz 8 fn 12 8 i5E 5 8FEiNsd fg id 58k BgEEEiREii F] 2L4o8g 1E5R. Hk gBEE [[sEfg iiE CompanySanitzd. Dos ntonain TSCAGi ~ 3: yp ld g [3 |Se BHESEEESES | Piopiziflms |i FEE EL 2 0sl FT Eamaarar_iifo EP jai jon | gogeggeses 15g BE i ~ ig : i= eg HaBo 1 g8l:i . ii 8, # B000 7oF ~~ 3 2g i ii | [Hi 3ig 515 ho ih PPEE 8oadd dy ie 1] iE jE: i iid iE a ----a"_$_aly Compa Stetn soaT,oC ~i 323 yo FIiREEL iT P oipliaiiEes | i ETE 2g TET i1 doo lL| i} Emmmmemma il BESESEEEEE if in} ~ li gif 35 | def fii | | 94:% | ie i: GF8 ii H 2 oo Ho 24 ~ 24 8) ii |i ye gd if PE if I iEIi]g . 8 EE PR 2 HH : i iE ` iis 513 ls i i iiEeM . - iigf Tl iE CompanySanites. Gos ntcont5a08iGnt ~3 3 ~ f|n ii i 157 7g%y |g gmrgeraa | BoiiEgg)i iEi(1SREFE| Co 2$8888828888888E8L8s |ii ;ooidgibiEEe iL o foil TEa T; rEmmk eemz am iif iy (A j=88 } $ESHESEE E854 BEo oon ] EiH] dg2yo0 iF } EiRf qi | it sla ; IH EE i ii io i i gi | iPog isd fi oFgo i| ii 2is5. EE ig 8 i 8 | HE] igs igy lo0 f8 iiEfeEe i oiisd #9] iis Ei ~ g2g3 CompanySanitized. Doesnot containTSCA C81 ~ bEpiaiEEeTeT 8 mGaEmEmEmReEmCnEnE PNTiam iT a8 GEmEGEmGEEEaE ,if Poh Tie BSo ob i gel Fo ~ w35id Td : Haag | | aHfi ;i HiE iF ia a iigzs tH (i52 Wo , gElrE o i Pod :i isd {iH JA4gE + a (Ey- ifgooi l do ad Pig ge8 ~ 8Z4 taf iE i i w 128 CompanySantas. Bort amanTSAGOH ~ 52 FISTIN78E%L|ENE5 2angeazes | d7o odpiziEes i PoE i Rim lIHe oil TET EEmmmesn 0D Boog 3 ~ Flia8i FE 55 | 5 LgHiI i JHiM i iHFE Ho ;|! : | | ;| Pi| op| |ir dt EE if iE ~igd i 18 EF #8 ii15]s 8* Hi] IH IE Ii5M i14H3 Ie . 5|: ied ix CompanySaniized. DoesnotcoTnSaCAiGna ~ 3% :3 | Tori P i poiziEe Es --| i jE jEEs | ig f 3B, io (mHi oeFETT;T8 gEgE EgaBimumE gagaitmR ia4nl BoE BiH i1T ~| f 35: | 5 ia g; gsi | HE Bo 3 qi yi |i | P; oe Lg iis [FE 15 iiH] EN . io, I iE 4 is 15 Wo id. ii Ge iE iE -- Z| 28 CompanSees, vetT5osR0 ; 7 I IiSgTi 7(RgE%E |i 53 egEsEgRdgEacEzEsEa|s iP dpizio fes mei i ETE i} ode TENT EEmmmmaanC i {Efe S gEgessgr i BoE ggeol BiFF ~ aT 1 iEh iat i ge ; fs 38 i iid: J oi i idYo EE Eo #8000 Ff od iibk PSE 28 i CompanySantee. Doe otcontinTSCAG3 ~1 zz de fF hi [S778 | 5 aangaaciea | 3 EEE gl 1%EE | 2 giigssgiag | &Piuizo ifEr | lii 1 EE i 3op g EemT C ggrEaEmEmEasresd iIDf iE B 5 o | :i E[orL] ~ fi|:i| i: iigii qi ; iH aed | i if ii He i | i It gli | i is qHiIrE: |i L i| da ifii% goEff i i iPogik iri 5i1 BoE z5z i| eg gis iDoFE 8 IHH igM ~8ii q 0% iIEfs2 iiey 28 i- : Company Saiz. Dos rotor TSCACa ~ {2 ig) (EE|E 2 ggEeEsgEsl | iiEgiziifeEs ii ;oinliE Le g dal EIo T EEw ammaemmn (0 3f,p i(B!RjEoEEm S| se3 mggsagiagnagsess i14h #20 iy 3 | go iiHa BoP i ~ EsiEi i IhEeE &? J 1 i [i5 qgea i iij: ie | i8 i i fr. gli i a P24 gb, 32m3 E i F i1 h eB Hy1:138 i] 0 fF i: of3 IH iy fF jf Es itd ~az9 PEE ik 4 CompanySanitzd.Dosnotcontain TSCAGo ~3 HOE 1 A iFg) E(EERE Tg3 gEERmddasbaesrt | ipo ipize ife ei iPomjETiEm i{| 3BpolBgD eTnET2 gSEGaEEmGHmEEaE oC 2 #0 gi | ; ii i 1a | i ~ , i8z7dd i| ii iilgy: 85 iClef i1 IH18a os | i ifs qi gg | i I id 6ge iPEed 2i g 8 o, IiH i iiie: a52g3 oP i 0fg Eioiigae2 iisg3t ~ 3#34 {cme espresso BB i# CompanySanit. Gos rtonanTSG01 ~3 pl HE ipipiEes | i EEE lal TET gg iL i} Eman io i ~ AH|Hi TTi iiit i8 ii | 1 Asi | | iis 1H:e | ;| 1i;4 qf | i i [I i gd gi | SHE 2` Ey 3 : i a i 0i , eP3d8 iiggs M 3 1 0 fF igsde iifsfl 49] ~24 EE iF CompanySatz. Dossotc 56 Ct ~3 [31T77(S8E8E | 52 gEEapgdadadzdsaacny || o i ipizd ife eri Poli | i Eee IH i 3. igi (H] TF | feEn | ZE5asfacEnz 1 3 ggagaaageg 7 gEgL AL i Z7Ti $503338882 iiSa wood 3 Wor i ~ of 125278 | |i 11433 5& &5l325e8d |i ii ies | : ii18]2 EH ie | IB i i Po | Hi a2 31 Ee i i i] I] ifs gi iF ga* a, ig OE led nolan iad i: : iih --~ 3 A 28 Womereer someon CompanySamed. Dos otarsichcna ~3 [5778s |g Zageaasan | lg] &RE $EEEEENNE|E oilEeiziiEEes i| Poni fy I Boo lgpTEEITpgEEEmmmmmaR mRay iOED i: [EEE | gEsEdEEsy iy gEd on iii ~ fii: | ia ii i it HE | iis {| | Hi HF. Pog iH gi | PLE lay Sls i 8 ig gel" | [I i: 35 i: 2 iP]B HY idg H2 ooPfF Eilfae iis"l gd ~ z& ifs i: is 2 . (CompanySanitized. Doesnotcont TSaCAiCBnI ~3 ' i 4oigiaLiEeEs HI 1 2ogEpETRFg iT Jp (EL oR Boi | Li gErameemmaifi: B3EEEEERNE 2, fg nn Hi Bi. 5 ~ dg 258 | id i fal ig a: gifgsa i 3i 5 i | H bw i eo | 152 i }i ;j i{3is 0i i 8 XHE]Y I iH g 3 oi , 1 |5 iifdse (2 0 Fd ] ih i 8 i 8 78 ~ i 23 CompanySanitized. Doesnot conTtSaCAiCBnI ~% 3 igi (REF 3 i gdpiziifEe PoET i (BTiEme 8% SESESSSE | ii ls 15 i: EL {= SEES gEed i%y Hor i, PR ~ lh glais | ji | i ol: | { i le i iH is nn is 48 i ix; HE Poy iH i FE i; Pg d 8PoEEH i HHHo iPEEF o[IE ptET LH ; ls EB EE id io 422] iii 7 ise g8Eo OiE LE52 8E%3 E85 siIffs Hh ~ 453] Feeeee RE is CompanySanit. Doss ntconiain TSCAca ~3 z 1ST Toly 1 > 833348z8EE | $P0 oiggiaoiEyeso i Poli, TopEEL Fg ETT EEmmmemema i0f i Lonis iIE ~3 ie i 123 iE] 4 = HE I 88 ii i i 4s ii iish ia . i8 q , iEsE iIsH W 2 oi rgE Ifg;e iisl -- FH fo LEE i322 23 CompanySantee.Doo torTSGAaC1 ~ 2Fi2 podIST Tef | igi REE 5 saagaanaad | S 8888283888 | P ipo iaife lly| i Eee i d23,p 0(EgHiLlToanE|| T8 SgEEaESua8uESam8nESuaEaEEsdEs oD 1[25, #0 5 5 i] | 1i5 fH e oHod iih: . --~ fa8h3se8 | | i} i3igff 22 i3i5 | :i j18&d & Lo bt 25 } HE | | i1f8y% i ge o ;i ijefg cfg1i : iii ff:g Fi EiNc : m i oo PE i ii iifs HF gg itd gd i 1% Ei ~ 34 ER Gampary Sarizd. 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Does not contain TSCA Cal 9H02.5D4a2y5:GavSaubgcehSvtoundiyc TinoRxaitcstywithOne.GenerationReproductionEvaluations DuPont 11418 ~~ INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P; MALE RATS EXPLANATORY NOTES Notes TestDays 1-74 = Premating period Test Days 74-88 = Cohabitation period Abbreviations NR = Not recovered; the given sign was observoend the date that the animal died. --~ --~ Time -- Company Saniized. Doesnot contain TSCA Cal 9F-02.5D4a2y5G;avSaugbecShotnyic iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont-11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY Anos ws oBsERvATION OFBISRESRTVEDDAY OLBaSsEtRDVAEYD 665144 SCOALCORRIEFDICDEIDSCBHYARDGEESIRGINGHTTESTEVED(ASY) 1R11ED 665104 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTESETD DAY 111 65044 `NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 111 665141 `NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 111 665135 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 111 665005 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 112 665075 NSOACRAIBFNIOCREMDALI5TIEDSESIDGENTETCETSETD DAY 112 --_~ 665051 ASLAOCPREICFIIACEDRIBGYHTDEFSRIOGNNT TLEEGS(TS)DAY 112 665040 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 112 665069 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 112 665020 ASLAOCPREICFIIACEDBOBTYH DFERSOINGTNPATWE(SST) DAY 113 665000 `NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTESETD DAY 113 665166 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 113 665012 NSOACARBINPOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 113 % a m2 12m 105 nsw ~~ Tis0Company Sanitized. Donotecontsain TSCA CBI 9H0:-2D5a4y25:GavSaubgeehSrotnuidcyTionxiRcaistywith One-Generaton Reproduction Evaluations DuPont 11418 --~ INDIVIDUAL CLINICAL OBSERVATIONS TN P MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ADL OER onseRvATION OFBISRESRTVEDDAY OLBASSETRVDEADY. 661996 ASLAOCPREICFIICAEDBOBTYH DFERSOINGTNBATWE(SST) DAY 113 664996 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCTEESDT DAY 113 665045 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCETSETD DAY 113 665021 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 113 665087 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 113 665075 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTETSETD DAY 113 " 1m -- --~ Il `Company Sanitized.DoesnotconTtSaCAiCBnI 9H02.5D4a2y5G:avSaubgcehSrtoundiyciTnoxRiactitsywithOGneeneration Reproduction Evaluations DuPont-11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P VALE RATS GROUP: 111-0 DOSE: 10 MG/KG/DAY e TOL e OER omsERvATION 665153 NSOACARNIOFIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 111 665037 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 111 665163 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 111 665001 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 111 665126 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 111 665125 NSoACARBINPOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 112 665017 NSOACARBINPOIRCMEADLIBTYIEDSESIDGENTE7C2TSETD DAY 112 --~ 665071 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTE7C2T0E7D DAY 112 665032 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 112 664997 SNOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 112 665110 SNOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 113 665041 AALLOOPPEECCIIAA BBOOTTHH SACRIICED BY FFRROONNTT1P8A3H((S5)) DESIGN TEST DAY 113 esse NSOACARBINFOIRCMEADLIBTYIEDSESDIEGNTETCETESDT DAY 113 OFBISRESRTVEDDAY OLBASSETRVDEADY. "7 nmmm --_ - The Company Sanitized. Does not contain TSCA CBI 9205.4D2ay5;GavSaugbcehSrtoundiyc iTnoxRiactistywithOGneeneration Reproduction Evaluations DuPont11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P YALE RATS GROUP: III-0 DOSE: 10 MG/KG/DAY mL NOE oBsERvATION GFBISRESRTVEDDAY LOABSSTERVDEADY 665113 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTESETD DAY 113 665056 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 113 665025 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 113 665038 NSOACARBINFOIRCMEADLIBTYIEDSESDIRGTNECTTEESDT DAY 113 665006 KSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 113 665167 KSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 113 665020 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LAEWG((SS)) SACRIFICED BY DESIGN TEST DAY 113 a7 nm2m --~ --~ Thies Company Sanitized. Does not contain TSCA CBI F-25425; Subchronic Toxicity 90-Day Gavage StidnRayts withOne-Generation Reproduction Evaluations Dupont 1418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY DOL NoUBER oBsERvATION OFBISRESRTVEDDAY LOABSSTERVDEADY 665116 SNOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 111 665034 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 111 665051 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 111 665083 N`SOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 111 665124 N`SOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 111 665078 N'SOACARBINPOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 112 665036 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 112 --_~ 665085 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 112 665052 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 112 665004 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTETSETD DAY 112 65140 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 113 665114 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 113 665139 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 113 665111 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 113 --~ Tie Company Sanitzed. Doesnotcontain TSCA C81 0F--2D5a42y5:GavSaubgeehSrtoundiyc iTnoxRiacsitywith One-GenerationReproduction Evaluations DuPont11418 ~ INDIVIDUAL CLIVICAL OBSERVATIONS IN P MALE RATS GROUP: V=0 DOSE: 100 MG/KG/DAY ANAL OBER oBsERvATION OFBISRESRTVEDDAY OLABSSTERVDEADY 665055 ASLAOCPREICFIICAEDLEBFYT DFERSOINGTNLBTSE(SST)DAY 113 G65066 SSAOCRREIFLIECFETDFBRYONDTETS0I8G(NS)TEST DAY 113 665039 SNOACARBINFOIRCMEDALIBTYIEDSESIDGENTECTTEESDT DAY 113 665003 NSOACARBINFOIRCMEDALBITYIEDSESIDGENTSCTTESETD DAY 113 665068 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 113 665147 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENFETCETSETD DAY 113 0 nm 105 108 ~~ Tis `Company Sanitized. Doesnot conTtSaCAiCBnI 9H02-5D4a2y5G:avSaugbechSotnuidcy TinoRraitcistwyith One-Generation Reproduction Evaluations DuPont11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: VIT-0 DOSE: 1000 MG/KG/DAY rp oBsERvATION FOIBRSSETRVEDDAY O1BaSSETRVDEADY. 665050 NFOOUANBDNODREMAADLI1T2I5E7SDDAEYTE8C9TED 665134 SNOACARRIVFOIRCMEADLIBTYIEDSESIDGENTETCBTSEPD DAY 111 665022 A`ALLOOPPEECCIIAA BBOOTTHH FFRROONNTT 1P2A5I(S5)) SACRIFICED BY DESIGN TEST DAY 111 665105 N`SOACARBIVFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 111 665102 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTESETD DAY 111 665161 N`SOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 111 665133 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDP DAY 112 ~ 665157 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 112 665093 N`SOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 112 665059 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTETSETD DAY 112 665123 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 112 665018 SNOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTESETD DAY 113 665065 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 113 7a mmmm --_~ Thise`Company Sanitized. Does not contain TSCA C8l 9H02.5D4s2y5GavSaugbechSrtoundiyciTnoRxaictistywith One-Generaton Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS TN P MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY ANAL NoMBER opsERvATION FOIBRSSETRVDEADY L0A3SSTERDVAEYD 665063 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 113 665030 N`SOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTESETD DAY 113 665057 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 113 665011 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 113 665109 ASLAOCPREICFIIACRDRIBGYHTDREESIAGRNLETSE(SST)DAY 113 661558 NSOACARBINFOIRCMEDALIBTYIEDSESIDGENTECTTEESDT DAY 113 665077 NSOACARBINFOIRCMEDALBITYIEDSESDIEGTNECTTEESDT DAY 113 " 13m ~ --~ Te CompanySaniized. DoesnotcontTSaCAiCnBI H25425: Subekronic Toxicity 90.Day Gavage Study in Rats with One-Generation Reproduction Evaluations --~ DuPont 11418 --~ APPENDIX Q INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P, FEMALE RATS DURING GESTATION --~ -- Tw Company Sanitized. Does not contain TSCA CBI 9H02-5D4a2y5G:avSaugbechSrtoundiyciTnoRxaitcistywithOGneeneration Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA INP; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Notes `This appendix contains data from females with evidenceofcopulation (gestation days 0-21), and from females that did not show evidenceofmating (dayssignswere observed were determined from the initiation of test substance administration(daysaregreaterthan 21). Abbreviation CS = Continuing sign; the given sign was observed onthelast day of the report period. --_ --~ Ti `Company Sanitzed. Doesnotcontain TSCA CBI H25425: Subchronic Toxicity 0-Day Gavage StudyinRaswith One-Generaton Reproduction Evaluations DuPont-11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ADL NONEER oBsERvATION OFBISRESRTVEDDAY OLBaSsEtRDVAEYD 665220 vacmuL pLus 665334 PCaEcRENmoPRODSITPILVUES 65257 ScPaEoRmMsoNnERGDATPILVUEG,S 65175 vacmuw Zu s6s336 seems postTIve esis vsmuL Bue e522 vaomwL PLuo 65307 vaGmuL PLUG ses206 ALvOaPoEmCuILAzABuDOMEN ses289 vacDuL PLUG ~ 665264 VAALGOTPIEACLIAPBLOGTH FRONT LEG(S) sesiss `ScPaEcRmMaoPRODSIPTLIUVGES AALLOOPPEECCIIAA ARIBGDHOTMENREAR 123(5) S65206 vaGTL PLUG ses305 vacmuL eu ses226 vaomwL Lu 665198 `vCaOcLOmRwELD DPILSUCGHARGE RIGHT BYE(S) RED ses209 vaomwwL FLU 65280 vaGDuL L0G o 0 0 8se 8888 0 o 0 o 1o 2o1cs o 0 2 o0 50 11 a21dcss o o 0 o7 7 o o "0 ~~ Tio. `Company Sanitized. Doesnot containTSCA CBI 9H0-2D5a42y5;GaSvuabgeehvSotnuidycTionxRiactistywithOneGeneration Reproduction Evaluations Dupont. 11418 " ZHDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: 11-0 DOSE: 0 MO/XG/DAY nL NoER oBseRvATION 665240 CSPAEGREMBOMPORSDITPILVUEG,S 665200 CSAPGEERBMOAPORSDITPILVUEG,S OFBISRESRTVEDDAY oo 30 LOABSSTERVDEADY o3 --~ ~~ ToT `Company Sanitized.DoesnotconTtSaCAiC8n1 'H9-02-5D4a2y5G:avSaugbcehSrtoundiyc iTnonRiactistywithOneGeneration Reproduction Evaluations DuPont.11418 rm INDIVIDUAL CLINICAL OBSERVATIONS TN P FEVALE RATS DURING GESTATION GROUP: 1v-0 DOSE: 10 MG/KG/DAY ANDOL NREER ossERvATION CFBISRESRTVEDDAY aOBsStERVnEaDy ses212 AvLaOcPmEuCLIAwBoOoTH FRONT AW(S) G6s150 SCPaEcRmMmoPNORSDITPILVUES AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) 65202 ScPaEcRaMBomPRODSITeILVuEs 665187 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LZEAGW((3S)) `SCPAEGREMBOPAORSDITPILVUEGS ALOPECIA ABDOMEN 665205 ScaPcEERBMONPRODSITPILVUEGS 665263 NO ABNORMALITIES DETECTED ~ 665210 ACLAOGPEEBCOIAARDBOPLTUHGSF.RONT LEG(S) Sear POSITIVE 665181 NO ABNORMALITIES DETECTED 665248 SCAeGaEmBOPROSDITPILVUEG.S AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT P1A5W3((S5)) 665293 AALLOOPPEECCIIAA LLEEFFTT RFERAORNTLBLGS(GS()S) AALOGPETCIA$A10B0DOMEN 665329 SCPAEGREMBOAPRODSITPILVUEGS ALOPECIA ABDOMEN 65200 cSaecemrBomPRODSITEIGVES 1o 2o 0o 0o 2216css o o 2211ccss 00 o> 2a 21 cs 0 oo 00 nes o 0 oo 0o 221 0 2a 2 00 o 2 0 - --~ Tia CompanySanitized. Doesnotcontain TSCA Cal H25425: Subchronic Toxicity 90-Day Gavage Study in Rai with One-GenerstionReproductionEvaluations Dupont-11418 r INDIVIDUAL CLINICAL OBSERVATIONS IN ? FEMALE RATS DURING GESTATION GROUP: Iv-0 DOSE: 10 MG/KG/DAY TAL NEE oBsERvATION OFBISRESRTVEDADY LOaBSSTERDVAEYD 65253 AvLaOGPIENCAILAPBLOUTGH FRONT 2AH(S) ALOPECIA BOTH FRONT LEG(5) 65206 vaGHWAL PLUG Ges261 vaomuL PLUG es186 VAGINAL PLUG 665330 ScPaEcRsMoPaORSITpIVuE,s 65208 vAGDNAL PLUG 65204 vAGDWAL PLUG 6es2se ScPaEcReMmoaPmOSpITPILVUEGS 0o 21o 2 o o 0 o 0 0 --~ ~~ os Company Sanitized. Doesnotcontain TSCA CBI 9H02.5D4a2y5:GavSaugbcehSrtoundiyc iTnoxRiactistywithOne.Generation ReproductionEvaluations DuPont. 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN ? FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY mou NuzER omserATION FOBISRESRTVEDDAY OLBASSETRDVAEYD esas vam Bos 65219 ScvaeEnoarmopsTrTuIvVeEs s6s261 vaomAL Pus 65325 vaomAL Pig 65331 vaGmiAL PIG ss217 van BG 65221 vam ene ss2e2 vam pus 65207 ScaeEesoaPRODSITPILVES 65243 AvLaOGPmEACLIA7BOGTH FRONT PAWS) --~ ALOPECIA BOTH FRONT LBG(5) ssi vAGTNAL PUG ass290 SvcEaRcnmoPmoDsTTpIuVvEs 665207 `ACLAOGPEEBCOIAARDBOPTLHUGSFRONT PAM(S) SPERM POSITIVE, 665273 SCAeGeEmBONPROSDITPILVUEGS sos vam me Gsm vaomAL pus o o 05 0 o o o o o o o o o o o 0 oo 18o nu o o0 o0 0 07 o0 0 o o o o ~ Tie `Company Sanitized. Does not contain TSCA CBI H9-02-5D4a2y5;GavSaugbcehSvtoundiyciTnoxRiactistywith One-Generation Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN FEMALE RATS DURING GESTATION GROVE: VI-0 DOSE: 100 MG/KG/DAY ADL ER omssrvaTIoN OFBISRESRTVEDDAY OLBASSETRVDEADY. 665195 cSheoeEmBOPAORSDITPILVUEGS 665314 vALaOoPmEuCLIABLAOBGDOMEN 665316 vaGmwL PLUG e513 cSaPcEERBMoRPRODSITPILVUEGS 00 uo 21o o0 o --~ ~~ Tos Company Sanilized. Does not contain TSCA CBI 25425; SubchroicToxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont. 11418 ~ THDIVIDUM, CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: VIII-O DOSE: 1000 MG/KG/DAY amo mE oBsERvATION OFBISRESTRVEDDAY OLBASSETRVDEADY 665296 c`SaPcEmRBMONAERGDATPILVUEGS ses13 ALvOaPGEmCuILAPRIGGHT FRONT LES(S) 665320 NO ABNORMALITIES DETECTED 665315 vaGDuL 210 65318 VAGINAL BLOG 65279 vaGmWAL PLUG 65220 vaommL mv 65254 vaGDWL PLUG 665205 AVLAOGPIENCAILAPBLOUTGH FRONT PAWS) ses32 vaemuw PLUG ~ 665214 cSaeceammonPRODSIPTILVES AALLOOPPEECCIIAA BBOOTTHH FFRROONMTE BLAEWG((SS)) 65321 cSaecsnmowPORSDITBIVLE,S 65171 vaomuL FLU ess26s seme postTIvE 65169 vaGmuAL PLUG 65191 vALaOGPmEWCAILAPLBOUTGH SRONE LEG(S) ALOPECIA BOTH FRONT BANS) 665231 cSapcesymoAPRODSITBILVES ALOPECIA RIGHT FRONT L8G(S) ses255 vaGDWL PLUG 77 778 2o a0cs o o o o 0 2 o0 77 a21ccss o oo o 0 1oo 2211o 5 00 o0 k aes o -- Te `Company Sanitized. Does not contain TSCA CBI H:25425: Subchonic Toxicity 0-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN ? PEALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY anos EER OBSERVATION FOIBRSSETRVEDDAY 1OaBSSTERDVAEYD 65213 CSaPGEERBMOAPORSDITPILVUEG,S 665280 ScPaEcREMBONMEDGATPILVuEGS 0 778 87 --~ --~ ToT `CompanySanitized. DoesnotconTtSaCAiCBnI H25425: Subchronic Toxicity 90.Day Gavage Study in Rats with One-Generation Reproduction Evaluations --~ Dupont 11418 -- APPENDIX R INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P; FEMALE RATS DURING LACTATION 119% `Company Sanitized. Does not contain TSCA CBI H9205D4a2y5;GavSaugbeehSvtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont 11418 m~ INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA INP, FEMALE RATS DURING LACTATION EXPLANATORY NOTES Notes `This appendix contains data from females that delivered a liter (lactation days 0-21), and from females that did not deliver a litter (days signs were observed were determined from the initiation of test substance administration (days are greater than 21). Test days for all animal fates are determined from the initiation of test substance administration. Abbreviations NR = Not recovered; the given sign was observeond the date that the animal died. -- -- ww -- Company Sanitized. Does not contain TSCA C8 ZF920-:-2DD5sa4yy2G5GaovvSaauggbeceShStrooundyiyc iTinnoRxRaiatctsistwywiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiioonn EEvvaalluuaattiioonnss DDuupPoonntc114141188. ~~ INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: 11-0 DOSE: 0 MI/KG/DAY Anos wz oBsERvATION OFBISRESRTVEDDAY OLBASSETRVDEADY. 665220 SNoACARBIWFOIRCMEADLIBTYIEDSESDIEGTNECTTESETD DAY 118 665334 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 121 665257 NSoACARmIwFIoCmEmDLIBTYIEDSESDIEGTNECTTEESDT DAY 132 665175 SNOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 119 65336 N`SoACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 131 665152 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 119 665232 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 123 --_ 665307 NSoACARBIVFOIRCMEADLIBTYIEDSESDIGENTETCRTSETD DAY 118 665206 ASALCoREICFIIACEDABBDYOMEDNESIGN TEST DAY 120 665264 ASALCORPIEFCIICAEDBOTBHY FDREOSNITGNLETGE(SST) DAY 113 65185 AALLOOPPEECCIIAA ARBIDGOHMTENR.EAR LEG(S) SACRIFICED BY DESIGN TEST DAY 116 65206 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 118 665305 SM0ACARBINFOIRCMEADLIBTYIZDSESIDGENTECTTEESDT DAY 120 2m 2m 0 22amm --~ -_-- T10Company Sanitized. Does not contain TSCA CBI 9H02.5D4a2y5:GavSaugbcehSrtoundiyc iTorRiaclistywith One-GenerationReproductionEvaluations Dupont-11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: 11-0 DOSE: 0 MG/KG/DAY ANAL NoMBER OBSERVATION 665226 SNOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTESETD DAY 119 s65198 NSoACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 116 665209 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNE7C2T5E7D DAY 127 665284 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTESETD DAY 118 65200 SNOACARINFOIMCGELDIBTYIRDSESDIEGTNETCTEESDT DAY 120 665203 3S0ACARIBFNIOCREWDLIBTYIEDSESIDGENTETCETSETD DAY 121 OFBISRESRTVEDDAY OLBaSsEtRVDEADY. . ~~ _--_---- Ti201`Company Sanitized. DoesnotcontainTSCA CBI 25425; Subchroric Toxicity 90-Day Gavage Study in Rats withOne.Generation Reproduction Evaluations DuPont 11418 rm DIDIVIDUAL CLINICAL OBSERVATIONS TN P FEMALE RATS DURING LACTATION GROUP: 1v-0 DOSE: 10 MG/KG/DAY Anas mE oBsERvATION POIBRSSETRVDEADY 1OBaSSETRVDEADY. 665212 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LE2AGH((5S)) SACRIFICED BY DESIGN TEST DAY 123 665160 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT B1A3N3((S5)) SACRIFICED BY DESIGN TEST DAY 119 665292 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 121 665187 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT 1B3A6M((5S)) A`SLAOCPREICFIIACEADBDBOYMEDNESIGN TEST DAY 118 665205 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 121 665263 N`SoACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 120 ~ 66520 A`SLAOCPREICFIIACEBDOTBHY DFERSOINGTNLETGE(SST) DAY 118 65181 NSoACARBIYFOIRCMEADLIBTYIEDSESDIEGTNECTTESETD DAY 118 66528 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LESAG((S5)) FOUND DEAD TEST DAY 112 665293 AALLOOPPEECCIIAA LLEEFFTT RFERAORNTLELOEG((5)S) ASALCORPIEFCIICAEDABBDYOMDEENSIGN TEST DAY 119 663329 ASLAOCPREICFIICAEADBDBOYMEDNESIGN TEST DAY 124 zno 2amm oo 2211mm 00 77 0 2am o 2m 0 77 o a2amm 2m 0 nm oz Company Sanitized. Doesnotcontain TSCA CBI F9-02-5D4a2y5:GavSaugbcehSrtoundiyc TinoxRiactistwyithOne-Generation Reproduction Evalutions Dupont11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN FEMALE RATS DURING LACTATION GROVE: Iv-0 DOSE: 10 MG/KG/DAY ANTAL WOMBER omsERvATION FOIBRSSETRVDEADY OlBaSsEtRVDEADY 65250 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETC2TSETD DAY 121 665253 A`ALLOOPPEECCIIAA BBOOTTHH FFRROONVTF LPEAGM((SS)) SACRIFICED BY DESIGN TEST DAY 121 665206 SoACARImFNIOCREGDLIBTYIEDSESIDGENTETCETSETD DAY 120 665281 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTT2E5D DAY 121 665186 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCTEESDT DAY 121 665330 SAALCORPIEFCIICAEDBOBTYH DFERSOINGTNETAHE(SST)DAY 119 665296 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 121 ~ 665244 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTSTCETSETD DAY 119 665259 NSoACARBINFOIRCMEADLIBTYIEDSESDIEGNTETCETSETD DAY 120 o 222mm 7 2m ~~ 003Company Sanitized. Does notcontain TSCA CBI 9H02-5D4a2y5G:aSvuabgcherSotnuidcyTionxRiaciistywith One-Generation Reproduction Evaluations DuPont11418 ~ TNDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 Mo/KG/DAY Anos woER oBsERvaTION FOBISSETRVEDDAY OLaBsStERVDEaDy 665338 N`SOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 121 665219 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 122 665267 N`SOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 120 66535 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 119 65331 0SACARImFOIRCGELDIBTYIEDSESDIGENTETCETSETD DAY 123 665217 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 118 65227 `NSoACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 120 --_ 65262 WSoACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCETSETD DAY 123 6527 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 122 665243 NSOACARBISFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 120 65312 SNoACARBINFOIRCMEADLIBTYIEDSESDIeGTNECTTEESDT DAY 120 665207 ASLAOCPREICFIIACEDLEFBTY FDREOSNITGNLSTGE(SST)DAY 118 66573 S10ACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTESETD DAY 119 65276 MS0ACARIsFvIoCmEGDwIBTYIEDSESDIEGTNECTTEESD? DAY 119 7 am --~ 204Company Sanitized. Does not contain TSCA CBI H25425; Subchronic Toxicity 90-Day Gavage StudyinRaswithOne-Generation Reproduction Evaluations DuPort-11418 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN ? FEMALE RATS DURING LACTARION GROUP: VI-0 DOSE: 100 Wa/xG/DAY ANTAL MBER oBsERVATION 665272 SNoACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 119 665195 `NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCETSETD DAY 121 665314 `AALLoOPPsECCIIAA BDOETRHBOFDRYO.NT AW(S) `SAALCORPIEFCIICAEDBOBTYH DFERSOINGTN1738G(8S7) DAY 119 665316 SwoACARmIvFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 129 665173 SNoACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 FOIBRSSETRVEDADY aOBsStERDVEaDv 70 221mm 7 2am --_ --_~ _-- 10s `Company Sanitized. Doesnotcontain TSCA CBI 9H.02-5D4a2y5G:avSaugbeekSrtoundiyciTnoRxaitcistywith One-Generation Reproduction Evaluations Dupont 11418 ~~ INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: VIII-D DOSE: 1000 MG/KG/DAY AL oR oBsERvATION 665296 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTESETD DAY 121 665193 ASALCORPIEFCIICAEDRIGBHYTDFERSOINGTN LTSEGS(TS)DAY 121 665320 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 120 665315 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 118 665318 ASALCORPIEFCIICAEDRIGBHYTDHEISNIGDNQUTAERSTTERDSAY 121 65279 `0SACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETESDT DAY 119 665254 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 119 --~ 665205 ASLAOCPREICFIIACEDBOBTYH FDREOSNITGNPATWEISST)DAY 119 665322 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCETSETD DAY 120 65214 AMAALLSOOSPPEECC1IIAA0.BB5OOTTHcHnFFRRLOOENNFTTTB1A8SM5H((OS5U))LDER(S) ASOSRSE L1EFT2'0S0HOCUnLDELRE(F5T)SHOVLDER(S) `SACRIFICED BY DESIGN TEST DAY 121 65321 SKoACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 119 65170 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 119 OFBISRESTRVEDDAY OLBASSETRDVAEYD 0 wu ld 2m nm o0 22mm 211 12m Et 2m ~. --- T1206 `Company Sanitized. Doesnotcontain TSCA CBI 9H0:2D5a4y25G:avSuabgeehrSotnidcTionrRiacistywithOneGeneration Reproduction Evaluations DuPont-11418 ~ NDIVIDUAL CLINICAL OBSERVATIONS TN ? FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 000 YG/KG/DAY MnoL OBER oBsERVATION GFaIsRzSRTvEDdAY LoAsSsTERDvAEYD w= owwwe 665265 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 122 665169 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNEC7T8ESDT DAY 120 Gesisi ASALLAOOCPPREEICCFIIIAACEBBDOOTTBHHY DFFRREOOSNNITTGNLPEATGWE((SSST)) DAY 124 o H2mm 665231 `ASLAOCPREICFIIACERDIBGYHTDEFSRIOGNNT TLEEOS(Ts)DAY 121 0 am 665255 1`S0ACARBINFOIRCMEADLBITYIEDSESDIEGNTETCETSEDT DAY 118 665213 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 119 665200 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 --~ -- - 1207 Company Sanitized. Does not contain TSCA CBI 9F-02.5D4a2y5:GavSaugbeehSotnuidyc TinoxRiactistywith One Generation Reproduction Evaluators --~ DuPont 11418 --~ APPENDIX INDIVIDUAL BODY WEIGHTS OF P; MALE RATS --~ ee ---------- T1208Strasser Company Sanitized. Does not contain TSCA CBI 9102.5D4a2y5G:evSaugbcehrSondi TionRxiactistvyithOne GenerationReproduction Evaluations ~~ INDIVIDUAL BODY WEIGHTS OF P; MALE RATS EXPLANATORY NOTES Notes TestDays 74-88 = Cohabitationperiod Abbreviations FD = FoundDead SD = Sacribfyidecseigdn Dupont11418 -- --_ = --_-- Company Saniized. Does not contain TSCA CBI 90F-.2D5a4y25G;avSaugbeehSotnuidyc iTnoRxaictistwyithOne-Generaion Reproduction Evaluations DuPont 11418 --~ INDIVIDUAL 30DY WEIGHTS (g) OF P MALE RATS e GRovm R: 1s -0 DoSE: 0 MG/KG/DAY owoTaErSsT: 0 " 5 0 se 108 ANH JOEER 8s6e5s110a00 pron $s5r3. T3o3u5s 357:8.56 eS0e12 s59e6e.s0 ssaesas s0.o4s 1sa0s2 sSoOoLlSs sslaelsa e59175.74 33.5 SSDD ((DDAAYY 111111)) SD (DAY 1) 524.2 SD (DA lu) GeGses113451 886633000755 B$5e5s0 G57 seemeos ss eselaas e4s9i9s7 sssmas esesalas ssaersiis7 ssilsloe s62e00e7 s24.6 sspD ((DDAAYY lluuz)) SD (DAY liz) 7017 SD (BAY 112) 886653004901 68853002899 $$i375 4$486 Gseyos 0s3s.o4 sdeeass 01s ssoelol soa7 ssoedzs suis 559068..90 522.6 SSDb ((ODAAYY 111122)) SD (DAY Lu) ssaee6sssoi0rs0zs0 BB$3i28)5 SGSimolsso Ssaires son esszie sme 63s0e0l9o sens dS6s3l1 s;l sspp ((DoAAY 11133)) sp (AY IL) 3s) Geez uses 02s so2s ssl sp (DAY 113) SSe6ag4o9 sGeess002416 3$4290 3% SS1m5a7 Se sseans 0si2o2n ssiasiss ssiiesns ssalss s52a6l0a9 sseseeilns 5000 ssbp sD (((DDDAAAYYY 1133)) 113) 5:79 SD (DAY 113) G68363008779 4Ti3s Sdaelae esi ese ssel4 eeslo sp (DAY 113) ~~ ~ - T10`CompanySanitzed. DoesnotcontTSaCAiCBnI 9F-02.5D4a2y5G:avSaugbechSrtoundiyciTnoRxaictistwyithOne-Geneation ReproductionEvaluations Dupont 11418 ~~ INDIVIDUAL 30DY WEIGHTS (3) OF P YALE RATS o Rove: 111-0 D0e 82: 10 MG/KG/DAY ou Teosa:vs 7 " 5 0 ss 10s ADL OEE 66856105373 ses163 $s554.08 S58 ss1s1.s4 sore sS41s2 sels s$5e8.s8 sso s56e0l.s2 se6iz e56v42.e6 ssae sSbD sb ((DDAAYY 1liDl)) (DAY Il) sSeess1o2061 sseess1o2rs? SS07060 0s 1300.0 assis ssiso. s S031 sssio.ze sys 5535871.33 5:21 SSe7n0o7 S62 ssbD SD ((DDAAYY I1l)i) (DAY 112) G5 dee 03s ssa 521d S192 sb (DAY 112) 886635003721 S56654191907 e$1e3 Si. 0so0r sss Si0s8o sees 4Ss9;55 see. 5s4016i80 sei 5S19L.1 sess sspp ((DDAAYY 111122)) sp (DAY 112) 30255 sie sea sus sas ss1T sp (DAY 113) GG66ss005a81 sse6ss101536 d$5e3d5 D$e4s0 Sasesz4 a1oss sooso gossi eessiis eesasm a62s7L.s1 s62i7. e48s721 6433 SSp o(DAAY Sp (AY 111133)) 113) 52315 Sb (AY 113) sseesso0a3s8 sseess106078 $$5533 3557 smaos Sms seeule8 ed sseaz seas sserss: ees s0si9 s0sls sssppp (oDaAY 11133)) (DAY 113) 00.6 ae. 01.0 S067 52200 534 sb (DAY 113) Ges020 $05 S30 38817 sas sez sees so (av 113) --~ - Ti: Company Sanitized. Doesnotcontain TSCA CBI 9H2-5D4a2y5G:avSaugbecShrtoundiyciTnoRxaitcistwyithOneGenerationReproduction Evaluations Dupo 11418 ~~ INDIVIDUAL B0DY WEIGHTS (5) OF P MALE RATS - rove: v-0 D0SE: 100 MG/KG/DAY on TEoSaTv:s 20 " wu an ss 108 ADL NOHEER ggssss0i3i4e Ges0s1 4$169.23 D5 s46e1.e9 sess dsesrli soi s49s6.o9 soez s50e4w.s5 5097 55911.10 sSpD ((DoAAY 11111)) 526.7 SD (DAY 111) sssess01823d ses078 $Ge52 $78 dGseedases 64032 sie. a49m6s3. ses ssoss e123 5s0i8l.64 SSpp ((DDAAYY 111111)) e138 Sp (oAY 112) 1 de. dee asso 23 ds7.6 Sp (AY 112) sSeess00s3s6 Sse6s00942 $63508 $5008 0si. sid dsems a sea 4sssm0 swe eanrmz sis 469303i7 sSpp ((OARYY 111122)) sme sp (ORY 112) ssseeesssiiiziaeg0 3303900.67 3535 0033.2 3006 0s.s4a sar Ssa35 ses ssaslsi2 574 s55e7l.s3 sspp ((DDAAYY 111133)) sesle sp (DAY 113) sesess0is5i. s6s086 330035.30 915 a52o0e9 0's ssse0als2 so2lo ss:ml;s s1sls 5s349a0z3 sao 5s5s6.s4 Sspp ((DDAAYY 111133)) 53314 sp (DAY 113) as8s65003083 sss0ss $Se1a5r i204 wSe0s5 adsl2 ssaese as23 ssamiss asels ssses s 47003 sseeea.ls sSbD ((DDAAYY 111133)) 4011 SD (DAY 113) 863147 $36 m6 sos sao swe sels so (GAY 113) --~ ~~ -_ Tz. Company Sanitzed. Doesnot conTtSaCAiCnBI 9H-02.5D4a2y5G;avSualgbechSvotnidc iTnoxRiactistyithOneGeneration Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL BODY WEIGHTS (3) OF P YALE RATS - GRovp: VII-0 DOSE: 1000 MG/KG/DAY on measvts: i) " 0 0 ss 108 ADOL NBER sseessn0a5e0 ses0z2 G$7718..3 G23.4 d5e7e.7 426.5 4$786s..9 FD49(D.A5Y 89) 507.4 433.1 43.8 ado 4S21113 sSDD ((ODAAYY 1111D1)) ags655110025 assist iG5e5o5 $250 saosoisa stele ssielsas Se 5s119073 saz sSSa0Ll7sa7 sS530s54s00 SsSDDp (((DDDAAAYYY 11L1DDD)) Ss66ss115373 863093 3S0i6.d4 dss 5s1a4s4 aesls SSasses asa 2se8l.4 ez sme3ls dess 5s4e1z0 a15iz sspp ((DDAAYY 111122)) sb (DAY 112) sseeSs6ssio0a1sss9 3S95e6c57s Ss49e72i08? Ss7o0o ses ss0e3l7s sels 6s0a6zs e069 6S123223 6114 sspp ((DDAAYY 111122)) sp (DAY 113) sSeessoosess. Ses050 3S5e3s2. 3997 Sssses @seo sS0e4a4 305.8 6s1e2.z4 sani s3i.s02 sms 567024.33 SSDD ((DDAAYY 111133)) 537.3 SD (DAY 113) ssegss0os171 ass108 SSriea Ses 5s1e2.r5 sess is9ea4s3 19.3 sseeza sel 6s8n02 631 663192.s8 SSbp ((DDAAYY 111133)) 6047 SD (DAY 113) 8G6645009787 6$5a.4 15413.44 s893l2s ssays 4ss927i8z 550560135 sSoD ((DAAYY m1133)) ~ ~ - 0 Company Sanitized. DoesnotcontTSaCAiCnBI 9H02-5D4a2y5G;avSaubgcehSvtoundiyciTnoxRiacistywith One.Generation Reproduction Evaluations DuPont11418 --~ APPENDIX T INDIVIDUAL BODY WEIGHT GAINS OF P; MALE RATS -- ----------------T-- I ------------e--e-- e `Company Sanitized. Does not contain TSCA CBI 9H02.5D4a2y5:GavSaubgeehSvtoundiyc TnoxRiactistywithOGneneration Reproduction Evaluations DuPont11418 ~ INDIVIDUAL BODY WEIGHT GAINS OF Py MALE RATS EXPLANATORY NOTES Notes Test Days 74-88 = Cohabitation period --~ --~ ------ doneen-- e --S-- peen `Company Santized. Does not contain TSCA CBI H9:-25D4a25y;G: SuabchvSrtounadiyciTgonxRiaectistwyith OneGeneration Reproduction Evaluations DuPont11418 ~~ INDIVIDUAL B0DY WEIGHT GAINS (g) OF 2 MALE RATS Group: 1-0 DoE: 0 MG/KO/DAY oe onoaTrEsST: 70-77 17-84 84-1 91-98 98-105 70-105 ADA EER seSses11e0a Ses0us w7l2 Jes a11aa1 lae0s cos 818s7 ss as1z za 276000 140 sesse1sstas 863005 5S2o Bo 4Ca3s 3a assas oassa wo nals asshh oan a 63 ms 856653007951 863040 f%s2 a3 aEls23a22 ale ed mmlisn wis 9e7n zTiss ed 333 s866s3008259 565000 3a35 5 i6s 2s a3n2s 3s wean ss 3sls 3h 1aa7l1 ie ws wz on wa sa sseess0i1szs GGeeaassss a5e5 103 T8e3 180 heso saz d0n3 ss s7e0 12.4 2mea 55.9 sseessoou2s1 863087 f2e2e 03 1a4s7 83 ssos mls 1200 m3 12513 8s 256465 a6 ses07s 23 Ws wh 7h es ae --_ --~ - T1t6Company Sanitized. Does not contain TSCA CBI 'H9.02.5D4a2y5G:avSaugbeehSrtoundiycTionrRiactistwyith One-Generation Reproduction Evaluations DuPont11418 ~ INDIVIDUAL B0DY WEIGHT GAINS (5) OF P MALE RATS Grove: 111-0 DOSE: 10 UO/KG/DRY ee onoamress: 20-77 7-84 8491 91.88 $8205 70-105 AHL OER 5g6s5s013573 8ae6s010613 Lai a0 2B8U 221 Bwlso sa s1aa az waids 7.6 G2e8e 380 Gen foo els es ma ma 8s6e3s112256 86017 3B3%0 G5 8WE 1a a3a7y se wsah ml aw1r 27 a2wa0a sse6ss003721 8S6e5s1s1?0 3Hse 21 loomoa 120 oa1si3s 21 aa3s es 1a2l3a 11 0 se a Ls ass wn aes sla m2 sSeessoosust sseessoisiss GH2o Toa adaea 27 1Qss a0 aowllas sa eeel as 5213 @3 Wi Gos Tals owls 2a ase asGses00235e 865006 SWees Gis z0e 4s wsins ss aaalleos m2s0 27 s2o1s8 ass 886635012607 25%2 B1s2 alslas 1733 naia eslee -- -- _ Tar `Company Sanitized. Doesnot contain TSCA CBI 9H0--2D5a42y5G;avSaugbcehSvtoundiyc iTnoRxaitcsitwyithOneGenerationReproductionEvaluations DuPont11418 r~ INDIVIDUAL BODY WEIGHT GAINS (g) OF P MALE RATS e Grou:s v-0 D0SE: 100 G/KG/DAY onaTvEsST: Amos wos 8s6e3s013146 58663008531 sesess102784. se5s6003865 sesasess0i0cs0o2s ggsess1i3i5e SS6e3s015151 GG6e3s003696 s8e6s3008083 ses1ar 70-77 71-84 aas1 91-98 98-105 70-105 7G4a eo awsss ase slas as 7e.s8 3s a6zs wo s3l1s 412 3227 27 l2s8 as seae ws aml2z alo waah 1s 2062 sed 0B513 Na 3l7lsa das s2ss os aasl3o 122 6sas 1s 349.s9 am a3e%s 6 aseos dis mslos los auss isle a2l7s 7 22782 28s TGas 32 meia 8 cmaas ms aeess wma dwsoaes samlEi 3Te%d 72 aollsa fils aaeeds wes 11a2 ams wal cas aaasd 28 d3e 7Wsl waiss wwils asslz aBmo --~ --~ - 28 CompanySanitized. Doesnot contain TSCA CBI 9H0L-2D54a2y5G:aSvuabgcehoStnuidcyiTonxRiactistwyith One-Generation Reproduction Evaluations DuPont-11418 ~ TDIVIDUAL 20DY WEIGHT GAINS (g) OF P VALE RATS e Groups : VII-0 DOSE: 1000 MO/KG/DAY onaTvEsST: 70-77 77-84 Be-s1 91-98 98-105 70-105 Nm NER S6e6s5103540 ses02z w9s4 Ts 2302 &a msian a.s als 1-07 3-03 e326 sse6ss110025 sesisi 9533 iwde 3% ms eslns a1n8sa sn 32 a372 si aaslos ws sGe6ss113537 563093 a80 39 aesle WE 1slss min aa2les swlss Tea a aaes ss866es5s10o28e35 7 2335 m833 13 a2l7s wm 1w2s wa essa am0s as os s865s006653 863090 3B0e 350 asll s NE eeo17006 wh asl calws Cols 1l9s0 ae S86e3s0o5171 s6s100 321130 Za z3ee Bs 0 wis wo 1a9l8s mle aslss ale 3s6u2l se Sesiessosrs7 220% aCeas e1z7 nalsss asuns 2o6w8 --~ --~ EC Ti-- n ------ Company Sanitized. Does not contain TSCA CBI H9:02D54a2y5;GavSaugbeehSotnuidcy iTnoxRiactistywithOGneeneration Reproduction Evaluations DuPont 11418 APPENDIX U -- INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING GESTATION --~ ----------------Ti-- . -------------- Company Sanitized. Does not contain TSCA CBI 9H02.5D4a2y5;GavSaugbcehSrtoundiyc iTnoxRitcistywith One-Geperaton Reproduction Evaluations DuPont11418 ~~ INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Abbreviations NP = Nolitter delivered; data excluded from statistical analysis. - = Nobama _-- Tm Company Saniized. Doesnot contain TSCA CBI 9F0--2D5a42y5G:avSaugbecShtroundiyciTnoRxaitcistwyithOne-Generation Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL BODY WEIGHTS (9) OF ? FEMALE RATS DURING GESTATION eGaeove: 11-0 DOSE: 0 MG/KG/DAY aesaTvasTION kl 1 zn Saenarns Anos WEE sSe6523240 S65257 $ale : G2a9e9-l.s1 s3o0l5s - a43n5l.s8 > a 586655137356 sesis2 2Soala 32000 asieslse sis 3s0e.n0 sels 4a2d7d3 ams ssee56ss5223u30s27 32956.s0 32 a3s0l6o1 ara a8o1s ml sdeiaelns dedls sSeessa266d9 Ses1es J3o0e 5 3s 36m1 asi mmlzz awziz aamuile ssl xe 586655230066 ses226 essiiss 20 3302067s 325.2 saslsiss sos a1as9es0ro0o 8G6655210998 ses280 3Z3sa 2001 s1i7e a3 amews 3s aasssils az Ga6655220030 3J0e3s maemza ms2e we2e01 -- --~ " Evidenceofcopulatwiaosn not observed, but animal delivered2iter --- Tim: `Company Sanitzed. Does not contain TSCA CBI 9F0-.25D4a2y5G:aSvuabgeehSrtoandiyciTonxRiactistywith OneGeneration ReproductionEvaluations DuPont-11418 ~~ INDIVIDUAL BODY WEIGHTS (5) OF ? FEMALE RATS DURING GESTATION e Grove:s 1V-0 DosE: 10 MG/KG/DAY cesmaavrsI:on kl 1 2 sAtavtuas nL Wome asssss128102 G6s292 m20l0.s6 3700s s3r0i9.8 ils 3364500 a6 s42i.d7 sold asSessi2s05 Ges263 2a9e2-0s8 3231- 57 638s - gaelees - a gSeesst2e10 ses248 28-.8 a.6 05-.8 sas 326-.4 38.9 4L- 6 500.0 a 886655239239 ses200 3S22027 Jed sailes 37 dseelse ams sasse a assis ssaess22583s ses281 236'as az ea6m0e7ls 291 a3u13s als daennn dsile ss8ess3t3e0s 85294 3B0e00i3 20003 e5ls3 309i eaesles 3587 o3 asis dedz GGe6ss225484 238575017 aeriins amsses asesdee ~~ --~ e-- e ---- = Evidenceofcopulation was not observed, but animal delivered a ier. -_ Tn Company Sanitized. Does notcontain TSCA CBI 9F-02.5D4a2y5G:avSaugbecShtoundiyciTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-11418 ~ INDIVIDUAL B0DY WEIGHTS (3) OF P FEMALE RATS DURING GESTATION e GROUPs : VI-0 DoSE: 100 WO/XG/DAY ceDsAmYaSt:zon o 7 1 zn saemaarns ATRL OBER 8s6e3s231398 ass267 226.5.32 3000 2259.00 sla 238187s0 Isa 3187709 asin aSsess3a3zs Ses217 325c6.e 3063 ssoeae maz a32m5e5 eas ad0ss.ss als sseess226227 s6s247 33237026 333 aseass desl ssoalss asi2 saaoriiloss 8s6e5s321423 ses298 Z30e2 Saas aslese ale sseals aan aaslsies sale x s5e6s5227037 sesa7a 2300000s6 B60 l3ea 07 3en9a als aadaslnd asi7 psreisaendz sesa1a 2Boaas 364 m3:e3a es 22s ars 4a 000 suo sseessa1s6 0200%05 aaa20la amsllso awnnss ~~ ~~ - Ti `Company Sanitized. Doss not contain TSCA CBI 9H0.-2D5a42y5G;avSaugbeeShtruodiyciTnoRxaitcsitwyithOne-GenerstionReproductionEvaluations Dupont-11418 ~ INDIVIDUAL BODY WEIGHTS (g) OF P FEMALE RATS DURING GESTATION Grove: VIII-0 DOSE: 1000 4G/XG/DAY - aDasAmSa:Tion '12 ASamrvos Dol OER 8s56e65s3321299053 28-.7 2 360--.0 402--.9 487--.6 a a ssseeess23i11s98 J3262a21.z29 as2m9s26l.l70 w0327s3 ssWoa0li6ss1 sseesszz254a ses2is 33196%2 20000 wsiiid mii amraesn 32 aaslse a3 we sseess231242 sesa21 ISl1o3 25208 dmaolns ama osaesios 06s saasliea 3ss2 sseess265 sesie 3S3i6as Ise aamsmeeyn daesrss sees dsaues a4 sseseesis22s3s1s 3s70e50l5ss3 seaan 302 3da8eu3ss 4a0usis0 s00l0 seSsesa2i6s0 Jo:rd 322 3%s oas>is a --~ -- *Evidofeconpulcatieon wasnot observed, but animal deliveresd liter. Tis SA ------ `CompanySanitized. Doesnotcontain TSCA CBI 9F-02.5D4a2y5;GavSaugbechSotnuidyciTnoxRiacistywith OneGeneration Reproduction Evaluations ~~ `Dupont-11418 APPENDIX V --~ INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING GESTATION ------------------------------eie--2--6 ------------eeeeeeesieee `Company Sanitized. Does notcontain TSCA CBI 9H025D4a2y5:GavSaubgcehSronyicnToxRiacistywithOneGeneration Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Abbreviations NP == Nolitter delivered; data excluded from statistical analysis. NoData e---------- Tom ----ep---- eeeeen-- eeees Company Sanitized. Does not contain TSCA C8 9H02-5D4a2y5G;avSaugbecShtoundiyciTnoRxiactistwyithOne GenerationReproductionEvaluations Dupont-11418 ~ INDIVIDUAL BODY WEIGHT GAINS (3) OF P FEMALE RATS DURING GESTATION - Rove: 11-0 Dose: 0 we/KG/DAY casEmaatIon 07 um wen em aStamtus ANTAL NOMEER ses6ss232304 sesasT 2209.090 - aa4l - 9mio53 1s6e16 -- a sseess373s6 ses192 31.22 ;oas2 283; Bmaz 412236 esl ass G66653233027 s63246 35922 30 m3i2o9 esleds a13s00os als ml ae aaGeeesssi22s86s91 32333s2 pamsasa amelliss wme3 al we G86653230088 65226 33000033 332 aslsoa ssaza 11332023 me wiz 18300 G6G365129089 free 3a% 32 1m30 1e03s1 1as mls ma 1a G86655224003 228ss 0m0o 7es0o 112010ss --~ ~ *a Evidenceofcopulation was not observed, but animal delivered a er. _ Ts Company Sanitized. Does not contain TSCA CBI 01.-2D54a2y5:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generstion Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL BODY WEIGHT GAINS (5) OF 2 FEMALE RATS DURING GESTATION eee---- aRovp: e1-e0 e D0S2: 10S MG/Ke G/DAY etereee amsDATYaST:ION 07 74 wen om aStmaetns AIHA SOMBER sess65211820 ses292 l2G5o.52 0el2o sa eesis71s8ss wi ees sSe6s5i2e075 se5263 ZTsh S 2w6ss = sesh 113s10 >- a psre5210 ses2a8 2-.0 2.9 320-.46 7=52 10a 122.-8 167.4 a 655866555223992030 a3l6s 2903 ael1s 0s 7saias 1amaie 700 102 s5e8s5228583 Sesan S$2032 als seass wa amos s1sla mi ass G8e6s5138360 Ges294 3a00o5 203 sao2s eeslly a1s4v97s 491 sls 1s2l9 SSeess22s08 2$080 aallss steelss o1a0s5i1s -- * Evidenceofcopulationwasnot observed, but animal delivered3 ier - TS Company Sanitized. Doesnot conTtSaCAiCnBI 012-5D4a2y5G;avSaubgeehSrtoundiyciTnoxRiactitsywithOneGenerationReproduction Evalusions Dupont-11418 ~ INDIVIDUAL 20DY WEIGHT GAINS (5) OF P FEMALE RATS DURING GESTATION Rove: vI-0 DOSE: 100 MG/KG/DAY aDasamsa:TIon 01 7m um on asmaowss ADL OBER sseess231398 s65267 2a9708 398 a18e0 al lsesa aesse ss aaa aassgss65323213571 3220083 27s smel4s 301 lmlys 1a3s00e7 en 12s GeGseszz2672 S6s247 a3021 a2l7as e1z2 1Taa a sels nals oases SG66s23423 G6s298 32I2033 mmll ow w7msa wmine la ule we Sa8e66s55222770a37 2l36:00o5 se394ss3 eelzlo a1ms: sen 13907 8s6e3s1z5752 sesana 2278 3 saowlas sls emaa sas aaiseae sSeesa17s3 233055 asess 0s0el8l 11 el3 --_ Ti30`Company Sanitzed. DoesnotcontTSaCAiCnBI '9H0--25D4a2y5G;avSaugbecShrtoundiycTionxRiactistwyithOne-GeneratonReproduction Evaluations Dupon-11418 ~ TADIVIDUAL BODY WEIGHT GAINS (g) OF P FEMALE RATS DURING GESTATION aRovp: vIII-0 DOSE: 1000 MG/KG/DAY amsDTaatTsI:oN 07 1m em oa Saamrvas ANTAL NOUBER sess6s129936 863320 35-.3 9- 7- 158-.9 =--= a a s8e6s33115e. ses279 33ss aloe amm8l 11m3)2 2s ls 103i 1763 sS6ess225244 ses2a5 220020 21 mslse 3 saiss 138:32 sl 113 ww sseess231242 23021 w20s4 mesais 116as sseessa7z11 3286035 23a5 e7ns 1132204 sseess126695 22900a5 asmlss esen7118902 sseess213911 Ses255 223018 amlas wall s10s61 20 3a an 1902 SSeess221830 3-a w-o 7-s 1-0 a --~ ~~ ------ * Evidence ofcopulation was not observed, but animal deliveread liter. Tl Company Sanitzed.DoesnotcontTSaCAiCnBI 9102-5D4a2y5:GavSaugbcehSrtoundiyc TinoxRiacittywithOneGenerationReproduction Evaluations DuPon-11418 -- APPENDIX W INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING LACTATION ~~ 3 Company Sanitized. Doos not contain TSCA CBI 01.-2D5a42y5:GavSaugbcehSvtoundiyc iTnoxRiactistwyithOneGeneration Reproduction Evalustions DuPont-11418 ~ INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note Test days for animal fates are determined from the initiation of test substance administration. Abbreviations FD = NP = -= FoundDead Notpregnant NoDam --_ ~~ = `Company Sanitized. Does not contain TSCA CBI H9-02-5D4a2y5G:avSaugbeehSrtoundiyciTnoRxiactistwyithOneGenerstionReproduction Evaluations Duponi-11418 ~ TNDIVIDUNL BODY WEIGHTS (g) OF FENALE RATS DURING LACTATION aRovP: 11-0 DoE: 0 MG/KG/DAY LaocaTtasT:Ion o 7 u zn aStvatnus Amos EER asgss23230a Ges2s7 a36s7o3 aammas 2sas ademaed 323 3m ea wl SGs531356 S519 3a0u60s0 3308s4 3a2as 303281s1 Jol san dee sls se8s65233027 ses26 JJeess m0i2e3 aamsss aess Fra aslo ws sel sSeessz2e6s4 sesiss 33=.7 m-s 6-9 367-.6 303 397 aoa 31 we 886633230065 863226 332737 w33i67 ssiszo 3du3i0s 37a mse 3907 3021 8G6635129489 pr 3slss lelea sdeeallss 33:0s8 Ls el a3 3360 886633224003 23806.94 330s94 s3a3a2 3a3ss ~~ -- Ties Company Sanitized. Doesnotcontain TSCA CB 9F-02-5D4a2y5G:avSaugbeclSotnudiyciTnoRxaictistwyithOne:GenerationReproduction Evaluations DuPont.11418 ~ INDIVIDUAL BODY WEIGHTS (g) OF P FENALS RATS DURING LACTATION Group: 1v-0 DOSE: 10 MG/KG/DAY LDacaTyasTION 712 astmatous TAL NoMBER seSs6s211820 sse6ss128972 se6656655222160035 sseess2i4881 886655322993 s8e6s5225930 sse6s5228815 8s6e5s31380s ass6e8ss5222954480 325634 3m10 asmliss s3a1s2 3390739 30:2s7 sallsl m3l%s 333559i38s 3w30mn900s73 3e30llsos 3a33s85s0 339132% 334070.s5 wo3p9aya112 36003 3slso daemeil 3asses7 3ssms 3396630 3o9l9a1 a39357 3alms 3a0s0i0a7 3320s0 3a9s0e5 3a2lss 326230516 330337 s2l3s 3350003 333070331 33s6e27ss sssee 0 3032521 k1 --~ Tse Company Sanitized. Doesnot conTtSaCAiCnBI H25425; Subchronic 90-Dsy Gavage Study TnoxRiactitywithOGnenerationReproduction Evaluations DuPont 11418 ~ INDIVIDUAL S0DY WEIGHTS (3) OF P PENAL RATS DURING LACTATION Rove: V-0 DOSE: 100 MG/KG/DAY LADCTRAST:ION 7 rl EY aSmnanmuos Am OER sseess6ss232136987 2o6l2.e3 35s 2m8s4 aes 3a06o5 30s 2i98z.8 3667 sseessa3a3s1 ses217 2S9e7l0o6 m30z57 3e0e9s3 3s6i1z0 300s dea 308 34001 Sge6ss226227 865207 337535s seesiesn 3sseelzs sdeasz Ca ania ass 369s 8sSe6es5s225348z3 aeslceo eslleo 3de6a6lss 3m52s09 2--- we 8S663s220773 S6s274 3398.21 3e6l1.o6 339s 336600.76 30s 3a ie ss GG6ess129752 G6s314 335720077 eeslios 3sese aeiLs 33s via 3934 3861 SS66313763 3I7i1e mseiaas 3amsa 3ss2l6s --~ --~ ---------- * Data inadvertently not recorded. i236 `Company Sanilized. Does notcontainTSCACBI 9F-02-5D4s2y5G:avSaugbeeShtoundiyciTnoRraictistwyithOne-Generaion Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL B0DY WEIGHTS (3) OF P FENALB RATS DURING LACTATION Rove: VIII-D DOSE: 1000 HG/KG/DAY LacATvasT:Ion '12 mstatnus ANTAL NonEER sseess219963 ses320 a36m60a1 s37m0e1 2ao2s udseos 22 3144 ws 320s ssseeesssaa21t7se9 3I8a4 3s2e60z1 amoess 33003 307 3803 ses 3683 ssseeesss2222a5050 36- 3 3200 36- 3 30s s=a sz 35- a 3291 we ses6ss231202 ses321 33064s1 3350030 aelzd 3312m 2835 298s sis 31211 sessezse1s1 ses1es 3387655 agoss sasllo d4e0i9n0 Jas 3302 0s 3233 sseess129311 s6s255 lmza 3m6a0 4wl7 33a5 36s 3s 38 304 sesses221830 3333 d3e0siss e1is 3366s92 -- --~ iT Company Sanitized. DoesnotcontTSaCAiCnBI 9H-02.5D4a2y5G;avSuabgeehvSotruidcy iTnoxRiactistywithOnGeeneration Reproduction Evaluations --~ Dupont 11418 --~ APPENDIX X INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING LACTATION --~ -- Company Sanitized. Does notcontain TSCA CBI 5102-5D4a2y5G:avSaugbeehSrtoundyiiTnoxRiacsitywithOneGeneration Reproduction Evalutions DuPont 11418 ~~ INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note Test days for animal fates are determined from the initiation of test substance administration. Abbreviations FD = NP = -= FoundDead Notpregnant NoDua --_ ~~ -- Tm `Company Sanitized. Does not contain TSCA CBI `H9-02-5D4a2y5G;avSaugbechSrtoundiyciTonxRiactistwyithOne-GenerationReproduction Evaluations DuPon 1418 ~ INDIVIDUAL BODY WEIGHT GAINS (g) OF 2 FEMALE RATS DURING LACTATION arovp: 11-0 DOSE: 0 MG/KG/DAY LADCATYAST:ION 07 1 wn om astmaTous ATO OBER 68665323240 865257 1612 8 m2 s03a 1a0l8s W004 3 aslo els 8S6633137356 Ges152 1284 11086 tueos a2ssl as 1 ow 2 SG8e66ss5223340287 B7i5s0 a122 8el3s waes 3s 03 az es GSSee6sss122886594 3~s a- 4 c-a 2=s ms 7s els 2 556635320066 S63226 1e0 ss aes ualzs 2s2as Gls a1 le asia Ga6633129089 ar8s0 o1a9si0s 02a7-1a70 8G6e5s2z480e 865203 320s2 lo aslos aa1slss 2s ash 29803s aul --~ \ ~~ 20`CompanySanitized. Does notcontTSaCAiCBnI 9H0--2D5e42y5G:avSaugbechSrtoundiyc iTRoxaiicsitwyithOGneneratioRneproduction Evaluations DuPont11418 ~~ INDIVIDUAL BODY WEIGHT GAINS (5) OF P FRNALE RATS DURING LACTATION Rove: 10-0 DOSE: 10 MG/KG/DAY LDaAcYTSa:TIon 07 rae wen om AStmaotuns DL NOE sseess128102 ag6e5s219827 ga66s5226038 asGGseess2ia1sa01e GGeess239239 8G6655229503 ssess228861 aa6ss3sss32139s046 asGess2a4s0e G4l4s 73 126m33 sl7ss So ais 3a08 1a w3l3d 232 l1e2s 6ms2 o1u80n3 sels wo 20 do5z3 awss asals s1l9s 4360031 wp DeAYs112 200 3s so a0 1e2s9 z6is4-4e7z ma3z.so 2731 e7s20c2s aashs 1af0les27 usollless aTaoo2ss c1u80l07 llss a1l0s aaulss l1o4 --~ ~~ Tat Company Sanitized.DoesnotconTtSaCAiC8n1 9H02-5D4a2y5G;avSaugbecShtoundiyciTnoRnaitcistwyithOneGenerationReproduction Evaluations Dupont-11418 ~ INDIVIDUAL BODY WEIGHT GAINS (5) OF P FRALE RATS DURING LACTATION Grove: v1-0 DOSE: 100 MG/KG/DAY LACaTvAsT:ION 07 7 um om astamtuos ADL oR Ss66ss231398 1a5 1ms1 csoals 2306s S6655322657 2S7i8 a2sss alsss 1n7l6s sge6s5233117 ses221 25852 S70 1e3a1 0nz7 1a9l0s als ml ass sess65226427 B-z o25s 3a6l3e 1o2a3 se8s65321423 202 2sl3s 7 2a 3ulae 8s6e5s220078 2.5 2>13 28=.3 2-s we as8s65227713 1sl8s 13s0 aoslss w1s sseess1a925 2B3I a3le mlhs smlas 6se55331106 ses73 L3l Isoo malls el nls ule wh 30 --_ eee * Data for interval couldnotbecalculated; data inadvertently not recordedfor lactation da0y. Tas Company Saniized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-DayGavageStudyinRatswith One-GenerationReproductionEvaluations DuPont11418 ~ INDIVIDUAL BODY WEIGHT GAINS (g) OF P FEMALE RATS DURING LACTATION Group: vIzI-0 DOSE: 1000 HO/KG/DRY LACTaAvTsI:ON 07 Ta wan em asmanmus AOL NEE seaess2199s6 wsilro aae2 a2 slo a20s2 s8e6s33210s n2r2 230h4 we3ia msho 6s8e5s23715a Sills 2s3s0 s0l2s eas3e sSeessaaszea 2:0 5z 0 aw a 02 8 wo sseessses32a21a2as 2B26Is3 1w52a30 0s6r01o a1laslz sseess137z11 210360 22609 1e3s7 28s1s2 SS66ss126695 21837 1m020 dseo 1al94s sG6ess213911 sslsss e8a7s a100 ness asGses2z1s3s 12000 wsmal m2las 017s Gesze0 als 2h asl od ~~ --~ Te. Company Sanitized. Doesnotcontain TSCA CBI 9H02-5D4a2y5G:avSaugbcehSronticiuTnoRdxaitcyistywith OneGeneration Reproduction Evaluations --~ Dupont 11418 -- APPENDIX Y INDIVIDUAL FOOD CONSUMPTION OF P; FEMALE RATS DURING GESTATION --~ T-- --a Company Sanitized. Does not contain TSCA CBI 2905-4D2a5y:GavSaugbeeShvtoundiye iTnoxRiaciistywith OneGeneration Reproduction Evaluations DuPont 11418 ~ INDIVIDUAL FOOD CONSUMPTION OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Abbreviations NP= Not Pregnant; excluded from statistical analyses. - = NoData ~ a Company Sanitized. Doos notcontain TSCA CBI 9H-02-5D4a2y5G:avSaugbecShtoundiyc TinoRnaictistwyithOneGeneration Reproduction Evaluations Dupont-11418 ~~ TDIVIDUML FOOD CONSUMPTION (g/day) BY P FEMALE FATS DURING GESTATION Rove: 11-0 DOSE: 0 Wo/KG/DAY casamvasn:ton 07 Tu en om astnaorrs ANHAL NBER 66se5s2323a0 565257 0a30 mmas 2m8aa 22741 :-2- a seses5137356 ses192 22.s0 22a.10 2257.6 22402 21 2s 269 253 sesseesss23230d27s 22654 3 285 a30705 2288'1s 208 282 m8 2603 sesses22869a ses18s 225250 a2l6s7 a3m0ss 22112 2805 291 283 ae o 886653230056 s6s225 2m0l4s s28a3 2275.74 22s68 202 248 20 2507 ses6s5i2s0e9 22300008 223082 223s3 2214gs 8se6s224800 f2ils0 2alss 223s1 223a123 865203 20 261 2h 20 --~ --~ * Evidence ofcopulation wasnot observed, but animal delivearlietedr. Tike `Company Saniized. Doesnotcontain TSCA CBI '9H02-5D4a2y5G;avSaugbecShtruodnycTionxRiactistwyith One-GeneratonReproductionEvaluations DuPont 11418 ~ INDIVIDUAL FOOD CONSUMPTION (g/day) BY Py FEMALE RATS DURING GESTATION Grove: 1-0 DOSE: 10 MG/KG/DAY GDesAmTaST:Ion 01 7m wn en astnatuys Anos women sseess128102 215.003 22643 226822 22630s sseessia8s12 22058 22661ss 22s82 a2s6s2 5562562035 2-85 2=33 w-i wze a ssGses211801 ses2a8 a2a-.ss 22-as m2=2a3 a=ls as a 566655239239 22005 2263s 2s1z9 228621 se86s5228503 22693 2297s s2l1a 22a2 sseess226616 030088 aas2s 20022 2n3d5 ss6ee6ss5i32s39s04 2221 22a0 a2lss 22as 02 275 308 281 sesess22as0s 220033 2261s3 22083 22:6200 --_ --_ -- nm ------ * Evidenceofcopulation was not observed, but animal delivered a iter Te Company Saniized.DoesnotcontTSaCAiCBnI 9H02-5D4e2y5G;avSaugbecShrtourdiyciTnoRxaitcistwyith OneGenerationReproductionEvaluations DuPont11418 -- INDIVIDUAL FOOD CONSUMPTION (g/day) BY P, FEMALE RATS DURING GESTATION Rove: VI-0 DOSE: 100 MG/KG/DAY ceDsAmasT:Ion 07 ae wen em sntataus NOL EER 86e6s5231398 21.26 a213 2m1e aalss 886653226s7 2l6s 2 2s a2sas a2l1s7 886655231371 865227 2221 aallss mmaa aall 262 ass ase 218 GG66G5s6s222446732 22'ss a30; 2a07 23608 le 2s slo 248 Ggs6ss321028 865207 2D386 slo 2m6a0 awl a28s0 ass a25s2 2607 w 8s665s227734 Ges272 afilss 2m0a 22037 2a011 32 292 288 210 G6Ga6s5ss313911506 63011 m2a1 m2sa 23060s2 212i m0 2d G6s173 262 21 as 280 --~ ~ Ties Company Sanitized. Donotecontsain TSCA CBI 'H9205-D4a2y5G;avSualgbecShrtoundiycTionxRiactistwyithOneGenerationReproduction Evaluations DuPont-11418 ~ INDIVIDUAL FOOD CONSUMPTION (g/day) BY Py FEMALE RATS DURING GESTATION Rove: vIII-0 DOSE: 1000 MG/KG/DAY Gesatvast:ion 01 74 mem on Satantuas amo woes 666655125938 sesazo 2-.2 6- 2-.4 2-a --= a a assessa3tse s8s275 225.081 a2s6s0 o2asais 22.96 8a mo 21 2s SG665s225244 G63245 225:023 mols 22628 22646 21 261 260 240 w asss6s231242 sesaz1 320s1 aallss a210 22:s20 200 232 oasis 2a pG6r52i6n5 S6s169 230s2 m262s 2211s 2266s1 als ae 2:2 26 GGeess213911 a6s255 2a0l0s6 2255071 226s3 224400 21 wa ws 2s sa6sss228103 2~ m-ls z-o s=ls a ~~ --~ -------- * Evidenceofcopulation was not observed; therefore, no gestation data wire collected. Te Company Sanitized.DoesnotconTtSaCAiCBnI H902-5D4a2y5:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generaion Reproduction Evaluations -- DuPont 11418 --_ APPENDIX Z INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P; MALE RATS 10: Company Sanitized. Doesnot contain TSCA CBI 012-5D4a2y5G;avSaubgcehSotnudiyc iTnoxRiactistywith One-GenerationReproducion Evaluations DuPont 11418 --_ INDIVIDUAL ANTWAL SPERM MOTILITY DATA TN By MALE RATS 0GRmOgU/Pkg/1d-a0y 1G0ROmUgP/k1g1/1d-a0y ANnuismbaelr P_e_Mrocteilnet NAnuimmbaelr PMeortcielnet 666655110400 2] 666655014414 995 66656050153.5 9% 665560570591 6888 666655006490 875 100GRmOgU/PkVg-/0day 666655105337 9886 666655010613 99%7 666655112265 7891 666655007117 794% 666655909372 989 10G0R0OUmPg/VkIgI/-d0ay NAunmibmearl P_eMroctielnet NAnuimmbaelr pMeortcielnet --~ 666655101364 99 665051 9% 666655103242 899 665105 9% 666655102803 9%97 665078 7 666655110621 8I2n 665133 3 666655008356 9717 665092 92 666655105973 9952 665059 8 665004 Ed 665123 82 --~ _-- Ist. CompanySanitzed. DoesnotcontTSaCAiCn8 9H02-5D4a2y5;GavSaubgcehiSotnuidcy TinoxRiacsitywith One-Generation Reproduction Evaluations --_ DuPont-11418 ~~ APPENDIX AA INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Py MALE RATS ~~ TI `Company Sanitized. Does not contain TSCA CBI H-25425: Subehronic Toxicity 90.DuyGavageStudyinRatswithOGneneration ReproductionBalan DuPonc11418 -- INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P, MALE RATS Group 1-0: 0 mg/kg/day ANnuinmbaelr sseessii0aaa e65s014a4l 6e6s5103055 666655009715 666633006450 NToortmaall Abmnaoirlmal AbHneoramdal TaAiblno&rmHaelad PNeorrcmeanlt 119999 00 1o 200 0 0 01 9999..55 0 100.0 210909 00 1o 197 0 3 0o 15090..50 0 9815 210906 00 02 200 0 0 0o 19080..00 0 100.0 198 o 2 0 99.0 GROUP III-0: 10 mg/kg/day NAnuismbaelr NToortmaall AbnToarimlal AbnHoeramdal TaAiblno&rmHaelad PNeorrcmeanlt ~ 6e6s510s337 119934 0 57 665163 200 0 0 00 9976.50 0 100.0 66655010216 219080 00 02 65125 200 0 o o0 19090..00 o 100.0 5660570117 129090 o0 o1 032 199 0 1 o0 19090.050 0 99.5 663997 200 o 100.0 -- --Ti-- s CompanySanitized. Doesnot conTtSaCAiCBnI F-25425: Subchronic 90-DayGavage Study iTnoRniacsitwyithOve-Generation Reproduction Evaluations DuPont11418 --~ INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P; MALE RATS Group V-0: 100 mg/kg/day AMnuismbaelr NToortmaall AbnToarimlal AbnHoeramdal TaAiblno&rmHaelad PNeorrcmeanlt s6e6s5101364 119998 00 12 66655008531 119997 o1 31 6e5s017z8a 210908 oo 02 666633008356 119959 oo 51 66653000942 210908 o 20 00 9999..50 o0 9989.50 0 19090..00 00 9997..55 0 19090..00 GROUP VIT-0: 1000 mg/kg/day aunmibmearl NToortmaall AbnToairlmal AbnHoeramdal TaAiblno&rmHaelad PNeorrcmeanlt 6e5s103242 119969 00 41. 00 9989.50 -- 66653110025 210905 0 o5 00 19070..50 6e5s13l3 119989 0 21 0 9599.05 ees105973 119976 01 23 01 9588.50 6561520539 220000 0 o 00 110000.000 ~~ Ties CompanySanilized. Doesnotcontain TSCA CBI