Document ganxZxJq6zb7JK57K6zJjxJkq

AR226-2766 FOR D PONT USE ONLY E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 565-81 Octanolc add, pentadecafluoro-, ammonium salt* Study Initiated/Comnleted 6/25/81 - 8/14/81 12 037 * Material Submitted by CR&D Department Haskell Laboratory ^ ACPTE ORAL TOXICITY COMPARISON TEST IN RATS Procedure: The test materials, as suspensions in corn oil, were administered by lntragastrlc intubation in single doses to 9 groups (10 per group) of LSiiT "S' r M S ; ,Ibr" d" <30 r."> Ur JJ ! lal* urviviaS rats were weighed and observed during a 14-day recovery period and then sacrificed. 8 kesults: ! - Dose Wfcg) Average Body Weight (g) H-14,094 Suspension m Average Dose (mL) Mortality Ratio 670 256 480 256 200 250 4.0 4.28 9/10 2.7 4.55 4/10 1.1 4.55 0/10 I 1not contain T S C A C B l Company Sanitired. Does Results; (Cont'd.) Dose Average Body Suspension Average Mortality (mg/kg) Weight (g) (Z) Dose (mL) Ratio H-14,121 670 480 200 H-12,037 260 253 258 4.0 4.36 10/10 2.7 4.49 10/10 1.1 4.69 0/10 *670 258 480 251 200 253 Clinical Signs: 4.0 4.32 10/10 2.7 4.47 6/O 1.1 4.61 0/10 H-14,094 Stained and/or wet perineal area and weight loss at all levels itested. Stained face at 200 and 670 mg/kg. Weakness at 480 and 670 mg/kg. Chromodacryorrhea at: 200 mg/kg. All deaths occurred within 4 days after dosing. H-14,121 Stained and/or set perineal area , stained face and weight loss at all levels tested. Weakness at 480 and 670 mg/kg Lethargy at 670 mg/kg. All deaths occurred within 4 days after dosing. H-12,037 Stained and/or wet perineal area,, stained face and weight loss at all levels tested. Weakness at 480 and 670 mg/kg. Diarrhea at 480 ag/kg. Alopecia at 200 ag/kg All deaths occurred within 4 days after dosing. Summary_____ ___ klCH-14,094),^ (H-14,121) and ammoniumi^peerrfflluuoroocttaainoate (H-12,037) were administered as single oral doses to young adult Crl:CD* male rats. H-14,121 produced more deaths at the middle level tested (480 mg/kg) than the other 2 test materials; however, overall the 3 test materials appear to have similar toxlcitles. The 3 test materials produced similar clinical signs and all deaths occurred within 4 days after dosing. - 2- C cp.'P** .- j: r-c r , 4 * H-14,094 Synonyms H-14,121 Synonyms; Purity: Contaminants: Qj CAS Registry So.: Ammonium perfluorooctanoate o C-8 3 Does not contain TSCAC3I Qompany Sanitized, Report by: Reviewed by: Approved by: LH:jrg:WP:1.8 *Date Issued : September Report No. 565-81 1981 echnician Study Director ection r*z-H, 3C0 fi iir* W (2'-