Document gagookdD1V4E0e5QYgBk8byVG
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E. I. du Font de Nemours and Company
Haskell Laboratory for Toxicc-logy and Industrial Medicine
HASKELL LABORATORY REPORT NO. 984-77
Material Tested
Haskell
No.
11,336
Sample Ready
for Testing
9/20/7
Other Codes
Material Submitted Organic Chemicals Departm
AR226-2866
ORAL LD50 TEST
Procedure: The test material, as received, was administered by intragastric intubation to six grou
ChR-CD male rats in single doses. Survivors were sacrificed 14 days later. The LD50 value was ca lity data using the method of D. J. Finney.t
Results:
Dose (mg/kg)
Average Body Weight (g)
Solution
A- cage Dose (ml)
Mortality Ratio
Clinical Signs
32,530**
247
As Received
7.43
10/10
Prostration, weakness, belly-t
posture, labored breathing, a matlon at 32,530 mg/kg.
20.000
241
As Received
4.46
10/10
Prostration, weakness, bellyposture, labored breathing, l chromodacryorrhea, eyes halfwet and stained perineal area
loss at 20,000 mg/kg.
18,350
244
As Received
4.14
8/10
Belly-to-cage posture, prost labored breathing, salivation
chromodacryorrhea, diarrha,
alopecia on neck, opaque spo
thalmic left eye in one rat,
perineal area, stained nose, body, and weight loss at 18,
15,000
249
As Received
3.45
6/10
Prostration, weakness, belly chromodacryorrhea, wet and s
area, stained mouth and nose
loss at 15,000 mg/kg.
r
-
2 -
Results:
Dose
.W^s)
12.500
(continued) Average Body
Weight (<Q 244
11,357
238
Solution
(%)
Average Dose (ml)
As Received 9..82
As Received 2.50
Mortality Ratio 4/10
2/10
Clinical Signs
Prostration, belly-to-cage posture labored breathing, weakness, chromo cryorrhea, lacrimacion, convulsion piloerection, exophthalmos, and we loss at 12,500 ing/kg.
Belly-to-cage posture, prostration weakness, chromodacryorrhea, piloe wet and stained perineal area, st
mouth, nose, body, and around eyes weight loss at 11,357 ing/kg.
Summary: /HIU^Mnas very low toxicity when administered orally to young adult ChR-FD male rat
mg/kg ofBody weight.*
* Composition:
+ Finney, D. J., Probit Analysis. 2nd Ed.,
1952, Cambridge University Press.
** Administered as a divided dose.
*** 957. Confidence Limits:
Lower
Upper
12,091 mg/kg 15,289 ing/kg
Slope 9.38
CMH:scg
Report No. 984-77 ,Date Issued: December 9, 1977
Report by:
Qj/?0 L^ J /1{
Carolyn M Toxicolo
Approved by:
*
^.^
{/' /^^6/U^
A. Micha Chief. Oral Tox
;-i)mpany Sanftead. Does no