Document gaam01Lkz8y4KeVBRLXg4gqMa
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lFrrom:
To:
6October 2, 1997
/
Mary Paxton....- -) ' ,I. .I/.-..,r
II
Benzene Task Fon:e CBTF) Benzene Basic Research Work Group (BlBRWG)
Update and Action Items from October 1 Meeting
Attached is an updated version of our issues table containing information presented at yesterday's meeting of the BTF and action items agreed upon.
For those of you who were not there yesterday, I need to inform you that 1 will be leaving AI?I att the end of October. It has been a pleasure working with you.
BP-00017755
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lPROJfE<C'f ANIDl IT.QIJE. OIF AIPIT1 r&IENZIENJE 1I'AJM: lB'O~ClE
(October 2, 199'7)
IJl>Jroj~~uilld l!alttnns
Mechanism of Benzene lndur.:ed Leukemia
Richard Irons (Wayne Stillman, David Ross) University of\.(llorndo tS2lXJK ; i.t51:K,
Validalion experiment on CP colony fonning unils successful in showing qualitative au."Uiacy of BBRA predictions.
; Nalwt (lf t\uw "~ tuuetry subgroups. BTF comment~ J coQvt)yed on man:.smpt abour di?gnostrc value ul MPO
aruVlly fnrleukemUI type.
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A.ciOiol!ll [~ll1!1lS
(fuomn Ml/1/fi)
PBIMBP: convey chat oot repon on smokers proJect expected 12197 [dne] I
,clear up contract/grant is.~ue-' fnr 199S
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Stipulauoru for rest of 1997 money:
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0 Slart characterizing metabQiism in B-cells. with
emphasis on biological signifroaoce;
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0 Slaf1 investigation of differences in metaholi&m & sensitivity betw:n non-.uno~ers & smokers;
0 Request quarterly reporu &. encourage publi~:ation.
9130 quarterly report due
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Biologically-Based Risk Assessment (BBRA) Model
Tony Cox Cox Associates ($64K from 1996~ $6{)K for 19?7 beimg processed)
1996-7 projects: 0 Genoroxicity module; 0 Analysis of data from validation experiment
underway; 0 Draft manuscript on validation of BBRA.
(mua~Eillllli trm 711] Encourage (:l.inical validation.
Chuck ROII>S [tcNASAJ: Plan
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1997-8 projects: 0 Prepare for 8l0d pSliticiJllllte in CP BBJRA review WS 0 Convert BBRA from 1-Think to B)(oen 0 Add Irons mecha!iliw for enriclmuem of IProli.Dfaaoog
S)'IDIPOSium at ACOOM for corporate
physicians !IJWI55 mpm~lllDilrty ro
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populallion 10 IBIBRA medel
0 Convert CP model to lmlzene, wid! PBPOC aRd
cytogenetics mooules
0 Do "model Keducti.on'' oo BZ nno<lcl to mW: ils conclusions Dl.lhXimaily romasa.
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Peer-review WS en CP ($17l< available for
Version of BBRA
travel, meeting
expenses. etc.)
Merabotism
$4K ~o each of 3 nongovtmain reviewers; mioiamal expenses for ' other invitees Rogeoe Hende'rson (BiU Bechtold) ITR! (S 126K balance from
11496:
Genotoxicity
Gary Williams (John Whysner)
American Health Foundation ($92K)
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Provide ci.lmputer model and documentation to half dozen
modelers;
TC: Write up CP BBR.~ +convert to
Workshop witl1 Coi, reviewers, anJ other rclevaJtt parties. ExCel to share wl!h otber modelers.
Cox converting BBRA to Bxcd; Rm 1200 reserved 12/ ll(day after SRA meeting s io DC); Availabdity of key reviewers cbecked in late August.
Baldwin audit in August; melhod developmcm ~low, hut
on track;
2-dimensmoal re-establi&hed end of Sept; adjusting valve tcmperaturt r~)r optimal recovery: Generate s~andard curves by mid-OcttJher:
Finalize prot~.x:ol (or exposures Bitposure at -60 ppm Elfposure at- 6 ppi11, with c()mpletion by Ocrober 1997 Contract signed io June. 7n9 Table of DNA adduct studies received. 9/24 Narrative on studies rc~ived (circulated for comparison to Reddy's paper for EPA commert!.l)
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MBP: Make arrangements for 12!11. I
[12/n nnow loo!illtg like nnrobllem roll'
Smeofmaln m-~wmJ qf]y ilo~ll'~
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Monitor progress regularly
(biweekly conference calls)
Judy Baldwin audit in conjunction wilh
CMA BD visit. [dorne alholll.giD uwt (o
pt. of sAlndairdl CU\ta'\ I
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Schedule sue visn to OK prowcol for
animal study (Novem~?)
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MBP: Clarify lbat tlley do i.Jttend to cover more tllan llp results io taSk on DNA
binding of BZ +metabolites; give them
Reddy's paper. [do!MI
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Gino Scarano
n.s)I (S36K ftoml995)
Wf31 Pbase 1drat't due
Review of genotoJtictly liter.uure on benzene (a) Phase I: DNA reactivity and adduct formation
Literarure search for all metaholiaes initiated
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(b) Pilase IT: Mu!ageoicity and clastogeaicity endpoints
Benzene'case study (along with BD and VC) of bow non MBP: Get timelline for work. Will there twnor <hlta couldfshould be used in cancer risk ru;SC$Smena. be wodxshop on case stoo.ies? (>tine]
Benzene team (Mart}rn Smith, Ridn lrons, an<fi RAy Tice) to deliver draft reporn on O<:l. 6, but unlili:ely any of case sDildies will be on schedule. ][LSI wiU sbare &'mft widfu API wi:Den wmpDece and &Jians to Rnolld W~Ofil to wlDicii API representatives WOI!Id 00 mvhed.
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~X(IOS~re of Pliofdm Cob.ort
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Dennis Paustenbach (PauJ Price) CbemRisk ($12.5K legs/regs)
Update of Pliofllm Cvhl)rt
Otto Woog
Chmese Epidemiology Sltidy
Otto Wong Appl11~d Hral r~ SCiences.. Inc. (S251-;)
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Outline for p~ received. (ChemRisk bas decided to underta.ke a more comprehensive Monte Carlo analysis,
covering expense~ above contrnct atnount themselves.}
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9/16 DP leaving CbemRisk at end '97. but wW be involved ill project through completioo; Prke says they're pcogrwing all right
Wong interested in updating mortility status for 10 years MBP: Do we have access 10 cohort me
smce 1987
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in form with tdenUJiers that could be
1 linked 10 dea!ll certificates;? I
July l'l97 ]NCI puhlil~at!On on NCI study suppuru bellT.ene I RS: Willun 2 weekf'., ct?mple list of
a.~Mxrated wih nr~ll"tasm' orhtr than AM L. hut ~!JIJ no
quesuons ... tht"Jght~ fN CiR ro conv~y hi
nsk estimates QtteMino: (I} accuracy of case dia!Jiosisl !Wong.
(2) bow low benzene exposure estimates; (3) whedler conloupding expooures.
Ask NCI researcher wnext BTF meeting
in e.arly 1998 when Wong has framed
Ptoposal received from Wong and heing processed.
ioiiliu questions.
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Compilation of Be11zene Monitoring . Levels
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DynCorp with oversight by IHTF
Monitor work ofQu I Chen of NYU for HEI to v!ilidate biomarkers in separate Chinese study as potential
challenge to NCI e11:po ests. Rwort ~eived documenting derivation and contents of
database with appendices presenting analyses requested by
lifiF~ acceptability as final version will be dttermlned at
July 15 llTf meeting. Delivery of elcctrOjlic dalabase expected shortly for use by Bl'F members.
AI: Have DynCorp oorrcct text with max<min problem lk. provide IBTF epidemiologists with electronic fonn of OO.tabase for approval.
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JHU WS on Use of IEpi Di!iia in Developllllent of !Public Heallllll Policy Womshop on Benzene
API via PM-RTS ($IOK if IH&PS re~o~s. 10129)
BTF final wishes conveyed to DyntCorp at end of August; final re~JQn expe~d lreginlliilg of Octohu Silt cases studlies imlc;ludle PM NAAQS. 9n9 APII8~iTF endorse-1.
Sim~ to Airlie WS, IFall 1992. Aim for SUIIltiiler 1998.
CIH: feeU Olllt EfA tbout ~illliy
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COfWIIdiOg. ('11l1.7)
B/5: 00 tml!l:ed wim Krewslli; wil!lll cumnt bulllges 1\)riooties coulcln't apo,nsor in nexsyeao, llut repesennallive
wouldl attend.
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MBf: get iilsl of AlP'! ln'ain~ lfacilitors;
tmumwtit vma!erialls from WS.
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European Community
U.S. EPA
AEGw -Priority
Chemicals List U.S. EPA
Re-cvaluat.ron vf potency fauor
J~han Preston ($4.5~) Vijay Redlly t$JK;
Summary prepared for CONCAWE by EBSI delivered to German rapponeur in May 1996. Adapted risk assessment received by EBSI at end of Septtmber 19971 with more attention to animaltox (le~ to epi) and <;oncludiog that "risk reduction needed." EBSI meeting witll Gennan group in midNov.
May 21, 1997, Federal Rtgister notice tbat benzene among 85 chemicals on priority list for determination of acute
exi)Osure g11ideline (AEGL)! fU!U.est for data or other info.
June 30, 19971 f"ederal Regisrer notice of rclt:aSe for external revtew of NCEA 's rl:v1sion of BPA 'g 19&5 Jll)teocy lactor ~requested by Office of Mob1lc Source 10
1nn uncri1n w1!l1 r I\AAm !992. Rxtcmal ReVJcw Par.d
! n~ed (Rob Schnattcr one of ~ix members) met July 16.
RS: provide MBP with diskette ofbealth effects for distribution to BlF. AU: cmnmeots toRS for EBSl's Nov. meeting.
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CH: call Sonawanc for update. MBP. get comment' submnted lo docket.
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U.S. EP~ Easanond report
California I
AP[ submi~~d written comments August 29, with auachmcm~ by Vijay Reddy and Julian Pr~1on on relative seositivity of DNA-adduct rocbnique.s and nQn-linearities associated with genotoruc eodpoims ()tiler than point mutation, res~_cti vely.
9124 N ioadvertantly foWld Mai l!f97 BPA docwnent by Easunond sddressing narureof hemat()Jl()ietic tumors produced ~IY various clas~s of agents (including BZ) + relevance of rodem models lCJ human re:~JPOme. Why not considered in potency rev~w? 1012 Docwnent pUlled from EPA Website.
WSPA requesting review from CARB: OEHA theo makes decision whether to do review
MBP: review? by Irons?
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wP.teon Ole wmlilflon't g~ from 'We!h>J
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9/97 OEIHHA released draft dccwneot oo BZ's (IOtential as
a DART (reproductive and developmeorru (oxicl ooder PrO!;) 6~: recommend listing as repro (bUit 1001 devel) imlicmtes regula~ory level higher tllmn tbmt ~Gr cruucer; WSJ?A willllumdle any resln)n~.
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