Document gaZLM2VoxrXO54083a63KLKVV

, ' K)C.D dR)uo^>6 4 , JWO. NN6. TOX* ^-0 | -------------------------------------------------- ' . (( /i THE JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY '`ft * '1 i 4 i >- VOLUME 20 -- J JANUARY, 1938--DECEMBER, 1938 PUBLISHED EY THE WILLIAMS & WILKINS COMPANY Baltimore, Md. THIS DOCUMENT WAS NOT A RECORD OF PPG INDUSTRIES, INC. DID NOT COME FROM IT'S FILES AND CANNOT BE AUTHENTICATED BY PPG INDUSTRIES, INC. \ nS GC 15227" *l | BB 0007213 184 JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY I>I. tO, j0 Of i .1 u ,., . rr 3 AviVi f i y j1 j r\ Anaesthetired cats were given intra tracheal insufflations of fine bismuth car bonate, bismuth subnitrate and lead glass powders by means of a powder blower in serted through a bronchoscope. Fluoro scopy and roentgenograms demonstrated that in the dry state these radio-opaque minerals were not carried into the terminal air spaces but remained adherent to the walls of bronchi lined with ciliated epithe lium. The process of removal could be readily followed. The column of dust on the mucosal surface moved upward with a spiral motion. Neutral bismuth carbonate was usually completely eliminated in 1 to 4 days, the acid subnitrate was excreted slightly more rapidly and the lead glass had disappeared in from 7 hrs. to 2 days. The reaction of the mineral did not affect the rate of elimination, a result at variance with those of other observers. If the par ticles were suspended in fluid either saline or thin, syrup, they were carried into the terminal alveoli from which they were slowly excreted by the bronchial route over periods of weeks. No evidence of drainage to lymph nodes could be discovered. The authors suggest that inhalation of duat in the dry state might be less dangerous than if it were moist. The presence of suffleient amounts of water might permit the mineral particles to penetrate beyond the protec'tive ciliary epithelium and allow gradual accumulation in the lungs.--L. U. Gardner. Occuratiosa.l cancer in asbestos work- ERS. M. Nordmann. Ztschr. f, Krebs- forseh., col. 47, pp. 288-SOt (1335). The author reports on 2 cases of lung cancer of which he made the pathologicalanatomical examination. He reports like wise on the clinical aspects of Hornig'a case (see following abstract) and on a 55 jt. old man who had worked in asbestos from his 36th to 43rd years. Autopsy showed asbestosis and in the left upper lobe a markedly necrotic, cornified squamous celled epithelioma. The author mentions 4 additional cases of cancer with asbestosis in the literature and one must agree with him that, in view of the small number observed and the very few cases of asbesto sis autopsied (12 cases in Germany), the -< -i; number of cancers found is a very high one.-.t^i Of these 6 cases, the site of the cancer in 5 `2\Vcases was the lower lobes, in five there was a squamous-celled epithelioma. Three of..:.{f the victims were less than 43 yra. old; in .Y~ all, work with asbestos had begun 15-21 yrs. before. After all, the author seems quite right in seeing a causal relation be--~t^' tween asbestosis and lung cancer.--L.'jHK' TiSSy. Clinical considerations on tbs question op industrial cancer or asbesto* WQBEXRR- F. Bomig. Ztschr. f. Krebs- if* Jortch., rol. 47, pp. 81-287 (1933). '''A: A 35 year old woman who worked in an - it'.- asbestos factory from 1919-1923 fell ill of -ikf. asbestosis; in 1937 a sharply defined shadow was seen roentgenologically in the upper left :k,` lobe. This shadow was considered by the. author to be a carcinoma and in. the decision ,.:'a on the case, a causal relation between the* -< presence of asbestosis and the development - U- of carcinoma was accepted. Confirmation :~V-- at autopsy of the diagnosis of lung car- - 1.'. cinoma is presented in a paper by Nordman -*1 (preceding abstract).--L. Teltky. ~:.? Experimental investigation or the - SCHNEEBERG lung cancer QUESTION. . H. R. Dihnsrt. Ztschr. /. Krebsforseh^ ~T.. vol. 47, pp. 209-239 (1938). In a very exact manner, with regard to the pertinent literature, and with careful consideration of all factors, the author reporta on the tumors found in mice kept in the ' -`A *Schneeberg mines. In the experiment were -Vf~ 48 animals of whom 28 died. Of these, 28 : were given careful pathological and anatomical examination; the other two were sent to another Institute for examination of their radioactivity. In 7 animals, tumors were found; in two of them, multiple -Ttumors in various organs. Since the experi- 7V mental animals came from almost tumor- /' free stock, the number of tumors found is a -f high one. In two cases there were true epithelial lung tumors, in two, ulcers of the vi mediastinum, in the other 3 eases there were turaor-like, more or less generalized changes of the lymphatic system. After careful consideration, the author blames the r*- dium content of the minea at disposing tancarogenous facte that further investigation no DUST, SMOKE, FUME! Tu* absorption and otcre arsenate in has. L. T. P. A. Need. U, S. Pub. sol. S3, pp. im-l4S (Juli Ten milligrams of lead an gested daily over a period of of two adult human subjee creta were analyzed daily : Both elements were elimis the greater part appearing a of ingestion.. As was form while nearly all the Pb was feces. No evidence of inj subjects could be f u Btickings. Stutues on tot pate op f ORGANISM. 11. 1. StmL and . F. Stohlnuas. L Kept*., sol. S3, pp. IV. 1938).' Selenium was adminis: rabbits, in both organic a bination, in acute and ch: In acute poisoning, with jected inorganic selenitic absorbed slowly by live eliminated with the ur blood and tissue seleniu: and up to 59% of the urin inorganic form. In s with inorganic selenitic tration, inorganic sele times, but not always, the urine, and a protei was found in all tissues selenium was retained and for a longer peril organic selenium. In with organic selenium, was present iu the tis bination.--Georgs B. I Chemical determixasilica) in debts. Fates. Indust. & wol. 10, p. 388 (July The writers propost