Document gaLJYXB2x43KwKRJbg4X0wjRN

(conocoi ^ - - -- - Interoffice Communication To From Oat* Subject 0. D. Steffey W. D. Broddle August 18, 1982 WORKPLACE HAZARDS OF LABORATORY CHEMICALS, WESTLAKE REFINERY My memorandum of August 5, 1982, to you was a toxicological review of the 1982 annual inventory of laboratory chemicals at the Westlake refinery. On August 13, we discussed this memorandum with Mr. M. Johnston and agreed to send him an outline of the specific health hazards and to suggest appropriate workplace practices. The following are the chemicals and health hazards as discussed above: Chemical Potential Toxic Properties 1. Arsenic compounds 2. Benzene 3. Bruccine compounds 4. Cadmium compounds 5. Chloroform 6. Chromium trioxide 7. Chromates 8. Cobalt compounds 9. Creosote 10. Dichlorobenzene 11. Dichlorobenzene propane Systemic poisons, carcinogens. Carcinogen. Potent stimulant; very toxic {Rat oral LD^, 1 mg/kg.) Kidney toxin, carcinogen. Liver-kidney toxin, carcinogen Carcinogen. Carcinogenic (hexavalent chromium more potent). Systemic toxin, blood disorders. Skin carcinogen. Skin sensitizer. Similar compounds are mutagenic and carcinogenic (i.e., dibromochloro-propane). 12. Dimethyl phenylene diamine and its salts 13. Diphenyl benzidine 14. Formaldehyde 15. Hydrazine salts 16. Lead salts 17. Mercury salts 18. Methanol 19. Methyl isobutyl ketone (MIBK) Mutagens and carcinogens; sensitizers. Mutagens and carcinogens; sensitizers. Mutagens and carcinogens; sensitizers. Irritant, mutagen & carcinogen. Toxic to kidney & nervous system, carcinogenic. Systemic toxin (kidney, gastro intestinal tract). Systemic toxin, blindness. Nerve damage. ' .m; . AiiMM-l. SHE000000143 Chemical Potential Toxic Properties 20. Morpholine Morpholine borane 21. Nickel salts 22. Picric acid 23. Sodium azide 24. Sodium cyanide 25. Sodium diethyl dithiocarbamate 26. Thioacetamide 27. Trichloro-trifluoro ethane 28. Tri-N-butylamine Irritant, systemic toxin, mutagen, carcinogen. Sensitizer, carcinogenic. Skin sensitizer; explosive if not kept moist. Systemic toxin. Very toxic (Rat oral LD5Q, 40 mg/kg. Systemic toxin; Very toxic (Rat oral LD5q,6 mg/kg). Cholinesterase inhibition (causes nerve toxicity). Liver toxin, carcinogen. Analogs are mutagens and carcinogens. Irritant. I understand that you will suggest appropriate workplace practices and send all of this information to M. Johnston. Jo. W, D, Broddle Senior Toxicologist ck cc: J. L. E. L. Riddle DeWhitt, Jr. SHZ000000144