Document gaLEXwRnQzzZN4kmNqQzbmMGQ

March 20, 1984 Weinberg Consulting Group Inc. 2828 Pefinsytvonift Avenue NW, Suite 301 W aahinflion, D.C. 20007 MAR27 (2 0 2 ) 342-6513 Charles Love m, Esquire Bowles, McDavid, Graff & Love Commerce Square, Box 1386 Charleston, WV 25325-1386 Dear Charlie: Enclosed herewith is a copy of the issue paper describing effects of dioxin on the immune and hematopoetic systems. I think this could be of interest to you. The most significant facts are brought out in the conclusions on page one. Hie first of these facts is that there has been shown to be relatively little correspondejice between findings of studies on the the effects oTsrmilainnat^nals^n_m5fS j ^ Second, and clearly re la te d 'tb th ^ frs tris th e fact that most immunosuppressive J ~ ____materials in animals are shown to be immuncteuppressive by virtue of the fact that these cause involution of the thymus gland^T here is no active thymus gland in the adult human. Thus, n predictiohsc effects in humans can be made on the basis of ^ studies which show that materials cause involution of thymus in animals. It is for this reason that it is frequently difficult, if not impossible, to translate from immunosuppressive effects in animals to man. third major point to make is that no one has, as yet, been able to demonstrate the meaning of changes in certain segments of the immune system in man. As is described in this paper, no effects of dioxin on the immune system of humans has been demonstrated. The paper goes on to say, "... in fact, when the data on extensively exposed human populations are considered, no effects on immune response, immediate or delayed, have been observed a t all (excepting one unpublished report)...." The author has studied this extensively and the data to support this conclusion are found in the issue paper. The final point to make is that reviews of all data in animals show that no irreversible effects of administration of dioxin on the immune or erythropoetic systems have been demonstrated. This fact was reported by Dr. Kenneth Sells at a recent meeting of the Veterans Administration Advisory Commission on use of herbicides in Vietnam.I I am not sure about the specific applications of this paper in the case at hand, but I do think that you may find this interesting reading. SUBJECT TO PROTECTIVE ORDER. C23856 Charles Love RI, Esquire March 20, 1984 Page Two Please let me know if we can help or call me if indeed, a further review of the information in this paper would be useful. Very truly yours, WEINBERG CONSULTING GROUP Inc. Myron S. Weinberg, Ph.D. Enclosure cc: Marcia Silcox (w/o end.) David Snively, Esq. (w/o end.) 1--' C23857