Document gaGKX9BORya9yyygBY8YD8v3a
Copies to:
E. I. du Ponl. de Nemours and Company
Haskell Laboratory for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT NO. 129-68
Material Tested: Ammonium Perfluorononanoate
H. kell No.: 5490
Material Submitted by:
Plastics Department Fluorocarbons Division
Other Code:
ACUTE ORAL TEST
AR226-2747
Procedure: The test material was administered, as a solution in water, by intragastric intubation t male rats in single doses. Survivors were sacrificed 14-19 days later.
Results:
Solution
%
15 10 10 15 10 10
2 2
2
1
1
1
0.1 0.1 0.1 0.1 0.02 0.02 0.02 0.02
Dose mg/kg
2250 1500 1000
670 450 300 187 130
90 60 40 26 17 12
7.7 5.1 3.4 2.3 1.5 1.0
'
Mort ali ty*
D D ' D D D D D S S S S S S S S S S S -
S s -
1 d. 1 d. 3 d. 1 d. 1 d. 6 d. 5 d. 19 d. 14 ri.
14 d. 14 d. 14 d. 14 d. 14 d. 14 d. 14 d. 14 d. 14 d.
14 d. 14 d.
Toxic Signs
Lethal Doses: polvuria, bellv
crawling, pallor, salivation, half-
closed eyes, incoordination, ruffled fur, diarrhea, contxnuous weight loss, emaciation
Nonlethal Doses: pallor, saliva tion, polyuria, chewing-motions, on day of dosing at 26 mg/kg and above; weight loss for 15, 12, and 9 days at 130, 90, and 60 mg/kg,
respectively; slight initial
weight losses at 40 and 26 mg/kg;
no clinical signs observed below
26 mg/kg
Weight W tien Killed (e)
Body
Liver
228 12.10
-
-
184
10.48
185
13.50
143
13.90
178
15.21
177
13.91
277
23.73
365
2b.90
321
25.07
316
19.53
295
20.78
334
17.42
308
14.00
331
15.40
323
14.70
348
15.30
Controls
352-377 15.09-18.89
* D-
( ) d. " Found dead ( ) days after dosing; S -
( ) d. -
Sacrificed ( ) days after dosing.
Camp anySan^-00'*'
Summary; Ammonium perfluorohanoate its Approximate Letl-il Dose (ALD) being
intestinal irritant and to produce heavy
increased li\ -r/body weight ratio is 3.4
is moderately toxic for the male rat when administered 7 mg7kg. Based on clinical signs, the compound appears to
livers. The highest "no-effect" level for this increased li
nig/kg of body weight.
Report by;
Elizabeth Oral Toxico
lenry Chief, Oral T
ENM:HS/jch Date: June 13. 1968
Approved by:
Doesno^0"13
ri
Co^50"^