Document ga5ZLEgzZpxK79LyQv140g7ma

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MV 25303 ucc 020686 a 00019225 SCLERODERMA PAGE 1 322C25 8 2 I2 a f2 821122*;S S222C2 3222C3 - Destructive fibrosis [editorial], - Eng - Connect 1 ve Tt *iue/#p*thology ; Oupuytren's Contraeture/etiology - Hunan i rkiseular Qiseeses/pathology - Scleroderma, Systemic/etiology ; Hound Healing - Bn Med J 1977 26 Mari1(6064):792-3 - Graft-venui-host reactions and autoimmune disease [editorial! - Eng - Adolescence ; Autoimmune Dis*as**/**tiology Child > Female - *Gr*ft vs Host Reaction ; Human ; Male - Scleroderma. Systernic/*tiology - Lancet 1979 4 Mar;l(8062):480-1 - BariKI'i VL - [Latent forms of osteomyelitis in children and collagen diseases] - Adolescence ; Arthritis, Rheumatotd/atiology ; Child - Child, preschool i English Abstract ; Human - Os teomyel11is/complicat t ons/dt agnosis - Rheumatic Heart Oiteasc/**Tiology - Scleroderma, System!c/etiology - Khirurgiia (MosR) 1978 DecM123:51-5 - Bouvet JP ; Le Pare JM ; Auquler L - [Metestasi chordoma with extensive cutaneous sclerosis] - Adult ; Case Report i Chordom*/*compllcat ions/pathology ; Human - Male i Neoplasm Metastasis - Scleroderma, Systemic/*etiology/pathology j Skin/pathology - Spinal Neoplasms/wcomplieat ions/pathology - Ann Med Intern* (Paris) 1977 Nov;l28(ll):877-81 - Brows* NL - Natural fibrinolysis. - Eng - F1brinolysis/drug effects i Human - Scleroderma, Circumscribed/etiology ! Thrombophlebitis/etiology - Am Heart J 1978 Apr;95(43:417-9 - Dalai el JA i Hilcock GK - Progressive systemic sclerosis in the elderly. - Eng - There is evidence to suggest that the incidence of progressive systemic sclerosis in the elderly is more common than in younger age groups. As in younger patients, lata onset cases may have minimal skin changes and this can cause difficulty in diagnosis. The case histories of 2 patients are presented to tllustrat* these points. - Aged i Cate Report ; Female ; Human - Raynaud's Disease/complications - Scleroderma, 3ystemic/diagnosts/etiology 222 II UCC 020687 II 00019226 r _.____________ SCLEROOERMA PAGE 2 0 SO - Postgrad Med J 1979 Mar!55<641):192-3 7 AU - Dobihenski't SI TI - [Familial cases of scleroderma! 0 LA - Hue i MH - Adult ; Case Report > Child English Abstract l Female ; Human MH - Scleroderma* Clrcumscribed/etiology/*famillal A genetic 0 MH - Scleroderma* Systemic/atiology/*fami1ial A genetic SO - Vestn Dermatol Venerol 1979 May;(5):40-2 8 AU - Fenyk JR Jr } Smith CM; Harkentln PI ; Krlvit M ;Solti RM AU - Neely JE * Nesbit ME > Ramsay Nk ; Coed a PP > Kersey JH 0 TI - Sclerodermatous graft-versus-host disease limited to an area of measles exanthem. LA - Eng AB - A female patient with severe idiopathic aplastic anaemia received 0r a successful bone-marrow transplant from her HLA-identical mixed-lymphocyte-culture-compatlble* brother. 8 months after transplantation she had localised cutaneous measles. Chronic sclerodermatous changes developed which were indistinguishable from chronic graft-versus-host disease and were limited to the areas of the original exanthem. Interaction between viral infection and minor histocompatibility differences probably resulted in graft-versus-host disease in this patient. FM - Adolescence * Anemia* Aplasttc/therapy MH - Bone Marrow/atransplantation * Case Report i Female MH - Graft vs Host Reaction > Human ; Lymphocytes/Immunology ! Male MH - Measles Virus/Immunology * Measles/*1mmunology MH - Postoperative Complicot1ons/*etiology MH - Scleroderma* System)c/*e11ology ; SKin/immunology MH - Transplantation* Isogeneic > Support* U.S. Gov't* Mon-P.H.S. SO - Lancet 1978 4 Mar!1(80621:472-3 9 AU - Fessel HJ TI - Scleroderma and welding [letter]. LA - Eng W - Adult ; Female ; Human ; Male * Occupational D1seases/*etiology MH - Scleroderma* Systerntc/*et1ology ; Mtaldlng SO - N Engl J Med 1977 30 Juni296(26):l537 10 AU Fries JP TI - The mierovaseular pathogenesis of scleroderma: an hypothesis. LA - Eng MH - Human * Hypertens 1on/complicat t ons/phys1opathology MH - Microcirculatlon/aphysiopathology MH - Scleroderma* Systemic/aetiology/physiopathology SO - Ann Intern Med 1979 Nov*91(5):788-9 II ucc 020688 iY 00019227 3CLER00ERMA PAGE J * 11 AU - Furst 06 5 Clements PJ ; Graze P ; Gal* R Roberts N TI - A syndrom* resembling progressive systemic sclerosis after bon* marrow transplantation. A modal for scleroderma? % LA - Eng AB -Six long tarm survivor* of bona marrow transplant* davalopad a Syndrom* similar to prograssiva systamic sclarosi* (PSS). Cutaneous involvement 16/6), pulmonary disease (6/6). % musculoskeletal involvement (4/6). keratoconjunct1vitis/postt1v* Schirmer's test (6/6), Raynaud's phenomenon (2/6). and renal and cardiac disease (1/6) were similar to finding* in PSS patient*. T and B lymphocyte counts and functions were also similar. This * PSS-lik* syndrom*, including visceral Involvement, after bone marrow transplantation lends support to an immunologie hypothesis of the pathogenesis of progressive systemic sclerosis. W - Antigen-Antibody Complex > B Lymphocytes/Immunology * MH - Bone (1*rrow/*transplantation i Creatinine/urin* MH - Graft vs Host Reaction ; Human > Scleroderma. Systemic/aetiology MH - T Lymphocytes/Immunology MH - Transplantation, Homologous/*adv*rs* effects A MH - Support. U.S. Gov't. P.H.S. SO - Arthritis Rheum 1979 Aug;22(8)!904-10 AA 12 AU - 6alla*ch 6 ; Gloor H ; Schr'oder J A TI - (Clinical aspects of pelvic stenosis syndrome (Schneidar-Fiseher)1 AA AB - Six cases with posthrombotfc obstruction of the pelvic veins are reported. These case reports demonstrate the variability of the A clinical symptomatology. In addition relationships between the postthrombotie obstruction of the pelvic veins end hemorrhoids and varicocele are discussed. Therapeutfcal aspects are reviewed. MH - Adult ; Aged > Bandage* ; Case Report ; English Abstract > Female A MH - Femoral Vain i Hemorrhoids/compllcations ; Human ; Iliac Vein MH - Leg Ulcer/etiology S Male > Middle Age > Pelvis MH - Scleroderma. Clrcumscr1bed/et1ology MH - Sclerosing Solutions/therapeutic us* A MH - Thrombophl*b1t1*/*complieat1ons i Varicocele/etiology MH - Varicose V*1ns/**tiology i Vena Cava. Inferior SO - Hautarzt 1978 Augi29(8>:630-4 A 13 AU Gottwald H TI (Neurologic, neurophysiologic, neuropathologic and psychiatric .aaaacts of scleroderma. (1st. continuation and conclusion)) X A MH - Adolescence i Adult ; Atrophy ; Electroencephalography MH - Epilepsy/etiology ; Face/pathology i Female i Human i Male MH - Mental 01sorders/dlagnosis/atiology > Middle Age MH - Neurologic Manifestations > Peripheral Nerves/pathology A MH - "Scleroderma, Systemic/compltcatlons/etiology/pathology MH - Hounds and Injurtes/compltcations SO - Z Hautkr 1977 1 Apr!S2(7):399-412 ucc 020689 00019228 SCLEROOERMA PAGE 4 14 AU - Gupta 3 > Malaviya AN > Rajagopalan P > Good PA TI - Subpopulattons of Human T lywphocytes. XX. Imbolanea of T call subpopulations in patients with progressive systemic sclerosis. LA - Eng * AG - Peripheral blood lymphocytes from twenty patients with progressive systemic sclerosis (P53) were analysed for the numbers and proportions of B lymphocytes possessing surface 0 immunoglobulin, cells with Fc receptors. T cello and T cells with receptors for IgM (T mui or IgG (T gammal. In patients with PSS. B cells and lymphocytes with Fc receptors were comparable in both numbers and proportions to those of the control group. Circulating T lymphocytes were significantly fewer in the patient 0 group. T mu cells were decreased and T gamma cells increased, resulting in lower T mu/T gamma ratios as compared to controls. This study demonstrates a profound imbalance between T mu and T 0 gamma cells (containing a population of helper or suppressor cells, respectlvely). These results are discussed in relation to immunodeficiencies observed in patients with PSS. MH - Animal > B Lymphocytes ; Female i Human i IgG > Immunity. Cellular HH - Leukocyte Count . Lymphocytes i Male i Rabbits Receptors. Fc 0 MH - Scleroderma. Systernic/etiology/aimmunology MH - T Lymphocytes/aelassifieat ion i Support. U.3. Gov't. P.H.S. SO - Clin Exp Immunol 1979 Nov;38(21:342-7 0 15 AU - Herbal 6 TI - Scleroderma (progressive systemic sclerosis. PSS). pathophysiological, clintcal and pharmacological aspects of the syndrome. LA - Eng AB - Scleroderma is an uncommon complex disease. The onset is slow and the progress is chronic. The main pathophysiological changes <' vary; they affect blood vessels, connective tissue, collagen fibres, cause fibrtn deposition and Inflammatory reactions. There may be early oedema and a wide spectrum of organic involvement. Clinically, all the fibril-containing and connective tissue organs can be attacked In various degrees. The most common organ manifestations are the Raynaud's phenomenon in the arms and hands, vascular fibrosis, stiff and hard facial skin, restriction of Joint movement by pericapsular hardening, calcium deposition and capsular rigidity. In the gastrointestinal tract muscle atrophy, collagen and connective tissue damage are common, especially at the eardie. Malabsorption may occur. IVogressIve pulmonary fibrosis leads to cor pulmonale and respiratory insufficiency. The liver, kidneys and the endocrine glands are. however, seldom Involved. Therapeutic trials have been performed using many different groups of drugs: vasodilatating agents, corticosteroids, drugs found experimentally to Influence connective tissue, thyroxine and a variety of anti-rheumatic agents. In the last decade best short-term ellnlctl rtiuitw have been achieved with penicillamine, some vasodilators, chlorambucil and in recent years with cyclofenil a potent anti-oestrogen, which has marked connective tissue and collagen metabolism (I ucc 020690 * ii 00019229 SCLERODERMA PA6E 5 influencing properties. Good therapeutic effect* without serious sid effects have been achieved. MH - Cyclofeni1/therapeutic use ; Human > Male > Middle Age MH - Penictllomine/therapeutic use MH - Scleroderma, Systemic/drug therepy/etiology/pathology MH - sktn/pathology SO - Acta Med Acad Sci Hung 197S;35(3-9):201-11 16 AU AU TI Hermier M > Mtcolle JP i Betend B Hermier C ; Perrot H Francois R [An |aie of acute diffuse seleroderma in an infant! AB The authors report a case of diffuse seleroderma in a 15 months old infant. Dermatologic (clinical and pathological) findings are quite typical of the disease. On the other hand, in this case some particularities were observed! the age of the infant (second published case beginning before the age of two); the presence of a durable eosinophil fa, the absence of visceral lesions and of biological abnormal!teis (of auto-immune nature specially), the ev'olution towards athrepsica and death within one year. Thus, because of these particularities, the diagnosis of scleroderma remains questionable and the diagnosis of progeria has been considered. The affection appeared in the course of a hepatitis leaving a hepatic fibrosis without inflammatory signs; no conclusion can be drawn about the relations between the hepatic affection and the fatal dermatologic disease. W Acuta Disease ; Case Report ; Diagnosis, Differential MH English Abstract ; Eosinophils , Female ; Hepatitis/compllcations MH Human ; Infant ; Progeria/diagnosis MH Scleroderma, System)e/dt agnosis/et1ology/apathology SO Ann Dermatol Venereol 1977 Nov;104(11):725-30 17 AU - Horwit* 0 TI - Raynaud's disease and scleroderma (letter! A - Eng MH - Human ; Raynaud's Disease/*complieat ions MH - Scleroderma, System)c/aetiology SO - JAMA 1979 27 Apr!241(17):1794 AU - Karl H alder's and Fischer's oelv MH - Adult ; Case Report ; Memosiderosis/etlology ; Human MH - Inguinal Canal ; Male ; Pelvis/blood supply MH - Scleroderma, Circumscribed/etiology MH - Thrombophleb111s/acompl1 cat 1ons > Varicose Velna/etfology SO - Z Hautkr 1977 1 Aug;52(IS)!821-2 *1 A A A A A II ucc 020691 Jl 00019230 SCLERODERMA PAGE 6 19 AU - Keplan D TI - tSclerodarma--a vascular disease] tA - to* i Mff' - Blood Vasseis/phystopathology ; Human . Intastines/blood supply MH - Kidnay/blood supply > Lung/blood supply MH - ffciscla. Srnoofh/physiopatholcgy MH - Raynaud's Otsaasa/acompltcattons/physiopeThology MH - Scleroderma. Systamie/*etiology ; SKin/blood supply MH - Stomech/blood supply SO - Tar Arkh 197;S0(9).*102-4 20 AU AU Lawley TJ ; Pack 6L i Moutsopoulos HM i Gratwohl AA Daissaroth AB *> TI Sclarpdarmai S| 'ogran-Kka syndrome. and chronic graft-versus-host disaasa. LA Eng AB A patient with acuta myaloganous laukamia traatad with an alloganatc bona marrow transplant davalopad acuta graft-versus-host disaasa manffastad by savara diarrhaa* hepatitisi and a cutanaous aruption. As tha graft-versus-host disaasa progressed to tha chronic phase. tha pattant davalopad marked cutaneous sclerosis and symptoms of xerophthalmia and xerostomia. Biopsy of his indurated skin showed features of both a* graft-varsus-host disaasa and scleroderma. Results of Schirmer's tests, cornaal fluorescent studies, parotid flow-rate tasting, f* and a lip biopsy ware consistent with Sj'ogran's syndroma. Possibly, activated lymphocytes may have a rola in tha pathogenesis of graft-versua-host disaasa. sclaroderma. and 3J "ogren's syndroma. *7 Hi Adult ; Bona Marrow/transplantation ; Casa Report MH Chronic Otsease *Sraft vs Host Reaction ; Human MH Leukemia. Myeloblastie/therapy > Mala MH Scleroderma Ct rcumscr1bed/complieations/et1ology/pathology 9 MH Sj ogren *s Syndrome/*eompltcations/et1ology MH Transplantation. Homologous/adversa effects SO Ann Intern Mad 1977 Dec;B7(6):707-9 9 21 AU - Lebedev DA possible mechanisms in pathogenesis of systemic scleroderma! Mambrana/matabolism ; Collagen/metabolt sm t English Abstract ttf - Human ; Scleroderma. Systamie/*etio 1ogy/metabo 1 (sm SO - Ter Arkh 1977.99<ll):l26-30 <T 22 AU - Mattingly PC i Mowat AS TZ Rapidly progressive scleroderma associated with carcinoma of the oesophagus. LA - Eng AB - A patient with scleroderma of recent onset was found to have a carcinoma of the oesophagus. The rapid progression of tha scleroderma suggested the possibility that it represented a systemic manifestation of malignancy. 'J 7 020692 00019231 SCLEROOERMA RASE 7 MH - Aged ; Cure I noma, Squamous Cell/*eompl I cat font ; Case Report MH - Esophageal Neoplasm*/*eomplfeat Ions i Female i Human MH - Scleroderma, Systemic/eettology SO - Ann Rheum 01s 1979 Apri38<2):177-8 23 AU - His try CJ > Hagholikar UL ; Deshpande AK i Chi tale SV TI - Primary systemic amyloidosis presenting as scleroderma: (a case report). LA - Eng HH - AmyloIdosIs/*complI cat 1ons/pethology i Case Report HH - Diagnosis, Differential ; Human ; Hale ; Middle Age MH - Scleroderma, Systernic/e11ology SO - J Assoc Physicians India 1978 Mayi26(5):451-2, x 24 AU - Montes LF 5 Gay S 5 Miller EJ ; Fullmer HM TI - Scleroderma. LA - Eng MH - Adult i Case Report i Female ; Human MH - Scleroderma, Circumscr tbed/complI eat Ions/pathology MH - Scleroderma, Systemic/etfology > Skin/pathology SO - J Cutan Pathol 1978 Jun;5(3):l50-1 25 AU - Penny R TI - Scleroderma: pathogenic factors and current management. LA - Eng AB - The aetiology of scleroderma remains unknown. Pathogenetic mechanisms may originate from vascular, collagen or immune abnormalities. These are reviewed and the current management although in the main unsatisfactory may alleviate a number of the distressing symptoms. MH - Blood Vessels/pathology/physiopathology ; Blood Viscosity MH - Collagen/metabolism i Human ; Microcirculation i Review MH - Scleroderma, Systemic/*etiology/1mmunology/pethology physiopathology/therepy ; Skin/metaboltsm/pathology SO - Aust HZ J Med 1978:8 Suppl 1:143-8 26 AU - Rassokhina PR ; Lebedev DA ; Panasiuk AP i Srozdova MD AU - Iakovleva 61 TI - [Current state of the problem of pathogenesis of systemic scleroderma! MH - Acute Disease ; Cell Membrane/metabolism ; Chronic Disease. MH - Collagen/biosynthesis ; English Abstract i Epinephrine/metabolism MH - Human Microscopy, Electron i MorepInephr1ne/metabol1sm tfl - Receptors, Adrenergle/metabolism i Scleroderma, Systemic/*etiology MH - Skin/pathology/ultrastructure SO - Ter Arkh 1979:31(7):ll4- II 00019232 SCLERODERMA PAGE a 27 AU - Richter H i Justus J TI - [Sclerodermiform paraneoplas11c syndrom* during a kidney core I noma] lerodermi formous alterations of th* skin or* doscrlbod os paroneoplasia In different malignant tumours. By an own observation sclerodermiformous alterations of th* skin are described for th* first time as poroneoplasmia in a female patient aged 60 with nephrous carcinoma. The cutaneous efflorescence* receded after elimination of th* tumour. - case Report ; English Abstract > Female i Human - Kidney H*oplasms/compl1eatton*/paThology/surg*ry i Middle Age MH - Postoperative Complications/radiotherapy MM - Selerod*rma> Syitemic/*etiology/pathology SO - Z Gesamt* Inn Med 1970 15 Mar;33(6>*'193-5 28 AU - Sahl MJ TI - Koebner phenomenon! morphoaai and viral exanthems [letter] LA - Eng MH - case Report ; Chiekenpox/*eompl1cations ; Child MH - Exanthema/acomplications i Female i Graft vs Host Reaction ; Human MH - Sclerodermai Ctrcumscribed/*et1ology SO - Lancet 1978 15 Apr;1<8068>:832 29 AU - Sandhofer M i Frit* J i Altmann H TI - [Sclerodermai an ageing process? I. Clinical and Immunological aspects (author's Trensl)] eroderma with Its different manifestations Is mainly a disease of connective tissue and of vascular system. Next Th* alteration to ccllageni which is demonstrable in lesions by decrease of embryonal* collagen type lilt there arc also humoral and cellular phenomena of autoimmunity. In more than 70Z of our patients u* found antinuclear antibodies! and in most of themi we found with th* leukocytemigration--inhibition-test cellular immunphenomenons to RNAi collagen and muscle. There is a small connection between ageing and immunological defense and r*p*irt accordingly of immunocytes and fibroblasts. Further more precise characterization of this call-comportfments under the aspect of a premature ageing could bring a new understanding in th* largely f. unknown ettopathogenese of scleroderma. ftt *Aging ; Antinuclear Factors/analysis i Cell Migration Inhibition Itl - Collagen/metabolism i English Abstract ; Female > Human ; Immunity MH - Leukocytes i Middle Age ; RNA/immunology MH - Sclerodermai Circumscribed/phystopathology MH - Sclerodermai Systemtc/*tiology/1mmunology/*phystapathology SO - Aktuel Gerontol 1977 Dec;7(121:695-51 u ucc 020694 00019233 SCLERODERMA PAGE 9 30 AU - Simon M ; Berk'o 6 Schneider I ; Slkl'osl C > K'osz'o F TZ - [Hepato-erythropoietic porphyria manifested by scleroderma and acrosclarosis In a pair of siblings) Wfe-,*, MM MH - Case Report ; Famala Karyotyping ; Liver/pathology i Mala HH - Middla Aga i Porphyria/complicattons/efamflial A ganatic/pathology MH - Scleroderma. Systemic/etiology/afamilfol A ganat1c/pathology tW - SKIn/pathology SO - Orv Hat 11 1977 27 MarillSI13):731-5 -y 31 AU - Simon N i BarK'o 6 i Schnaidar I p- TI - Hapato-arythropoiattc porphyria praianttng a* scleroderma and acrosclerosfs in a sibling pair. LA - Eng AB - Clinical and bioehamieal data ara raportad on a sibling pair with clinical and bioehamieal faaturas of both arythropoiatic <9 protoporphyria and hapatiq cutaneous porphyria. Aftar many yaars of photosansltivlty tha clinical picture rasamblas systemic sclerosis. MH - Casa Raport i Olagnosls, Diffaranttal i eErythropofesis ; Famala ~J MH - Human > Liver/*metabolism > Mala ! Middla Aga MH - Porphyria/*d1agnosis/famtlial A ganatic/matabolism MH - Scleroderma. Systemic/*et1ology SO - Br J Dermatol 1977 Juni96<6>:663-6 ^ 32 AU - Spielvogel RL ; Goltz RH ; Karsay JH TI - Scleroderma-like changes in chronic graft vs host disease. LA - Eng AB - A case of chronic graft vs host disease had scleroderma-like skin changes. Clinical progression uas from poikiloderma to scleroderma, and histopathological changes and results of direct immunofluorescence uera noted. It Is probable that both cell-mediated (T-cell) and humoral (B-cell) mechanisms contribute to tha pathogenesis of tha graft vs host reaction. MH - Adolescence > Bona Marrou/traneplantatton i Casa Report m - Chronic Disease ; Complement 3 > Female > *Graft vs Host Reaction MH - Human i IgA i IgM ; Mala MH - Scleroderma. System I c/e ttology/lmimaiology/Spathology MH - Transplantation. Homologous i Support. U.S. Gov't. P.H.3. SO - Arch Dermatol 1977 Oct U13(10)U424- 33 AU - Sptrer Z ; Ilia B ; Pick IA i Taron M TI - Localized scleroderma following varicella in a three-year-old girl with IgA deficiency. LA - Eng AB - A three-year-old girl with Isolated IgA deficiency developed localized scleroderma immediately after varicella Infection. Physiotherapy uas started without any drug therapy. Only a minimal clinical Improvement was achieved. The connection between IgA deficiency, viral infection and collagen diseases is discussed. iW - Case Report Chiekenpox/eeonplicattons } Child, ft'esehool II uec 020695 if 00019234 SCLERODERMA PAGE 10 MH - Oysgaimneglobultnemia/compli cat t on* ; Female ! Human MH - IgA/*deficiency ; Scleroderma. Circumscribed/*etiology/pathology MH - Skin/paThology SO - Acta Paedtatr Scand 1979 Sap;6S(5):783-5 34 AU - Stechow A TI - [Rola of tryptophan metabolism In tha pathogenesis of systemic scleroderma and pseudosclerodarmtc conditional i MH - Adolascanca > Adult ; Aged > Child > Child. Praachool MH - Comparative Study ; Human ; Infant > Intaatinal Absorption MH - Middle Aga > Scleroderma. Syatamic/etIology MH - Sarotonin/metaboltam > Tryptamines/metabollsm MH - Tryptophan/wmatabollsm SO - Przegl Dermatol 1979 Nov-Daci66(6>:727-9 33 AU Stachou A > Jablonska S i Skiendziclewska A TI 5-Hydroxytryptomin* and tryptamina pathway* in scleroderma. LA Eng Levels of 5-hydroxyfndolaacatie acid, indolaacatic acid and total indolaa war* determined in the urine of 23 patients with systemic scleroderma and 7 patients with cutaneous scleroderma, before and after peroral loading with L-tryptophan (0-1 g/kg body weight). Before loading. 3-hydroxyindoleacatie acid levels were normal in nearly all cases of systemic scleroderma as wall as of cutaneous scleroderma! however after loading, in nearly one half of cases there was no normal increase of this metabolite. These results suggest impaired transformation of serotonin into 5-hydroxyindoleaeetie acid. A disproportionately high ratio of total indoles to indoleacetic acid suggests the presence of excess of tryptamina. The results of the study may indicate that r- in scleroderma metabolism of biogenic amines derived from tryptophan is abnormal, probably a* a result of impaired activity of monoamine oxidase. Adolescence > Adult i Aged ; Female ; Human MH Hydroxyindoleacetic Acid/urine i Indoleacetic Acids/urine MH Indoles/urine i Male i Middle Age m Scleroderma. Cfrcumserfbed/ametebolism MH Scleroderma. Systern1e/e11ology/*metabolis* ; S*rotontn/*m*taboltsm X. tw Tryptamines/emetabolism MH Tryptophan/administration dosage/metabolism SO Br J Dermatol 1977 Augi97(2):147-34 36 AU Studnltstn AA . Delektorskivt W . Nikitina MN ; Bragina EE TI - CTubuloretleular structures in endothelial cells In focal scleroderma! CTUd ; Endoplasmic Rettculum/eultrastructure MH Endothel 1 um/ul tras truetur* ( English Abstract ; Hunan it< Mi crotubules/eultras truetura Scleroderma. Systerntc/ettology/"pathology ; SktnAiltrastrueture SO Vestn Dermatol Venerol 1977 Jin)(6>>3-4 'V ucc 020696 II 00019235 SCLERODERMA PAGE 11 37 AU - TomtI M > Nagahama H } Mori I > Homma M ; Tamat S ! Hoioda T TI - [Upper abdominal pain, scleroderma of both sides of tha fingers and tha back of tha hand (gastric radiography)--schizophrenia! (stomach cancar and sclarodarma)] -Adult ; Casa Report ; Female ! Human ; Schizophranfa/complleatlons - Scleroderma, Systamic/atiology/apathology MH - Stomach Naoplasms/complieations/*pathology SO - Nippon Rinsho 1977 Falli35 Suppl 2:3024-5, 3366-7 36 AU - Van Vloten HA i Schaffer E ; Oooren LJ TI - Localized scleroderma-1ika lesions after bone marrow transplantation in man. A ehronie graft versus host reaction. LA - Eng AB - Localized scleroderma-like skin lesions which developed in two children, from 6 to 10 months after successful bone marrow transplantation for aplastic anaemia, showed histopathological features resembling those of scleroderma. This finding, ltke tha animal models described in the literature, provides additional support for the auto-immune nature of scleroderma. MH - Anemia, Aplastic/'therapy ; Bone Marrow/atransplantation MH - Case Report i Child ; *6raft vs Host Reaction i Human i Immunity MH - Male i Scleroderma, Clrcumscribed/e11ology/tmmunology/pathology MH - Transplantation, Homologous i Bone Marrou/*cytology SO - Br J Dermatol 1977 Apr!96(4)i337-41 * END OF OFFLIHE PRINT L If ucc 020697