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ACHARLESRIVER COMPANY PATHOLOGY PEER REVIEW REPORT 26-WEEK CAPSULE TOXICI(TAYPFSOT)UIDNYCWYINTOHMAOMLMGOUNSIUMMONPKEERYFSLUOROOCTANOATE `Covance Study Number 6329-231 OBJECTIVE oaAbnjmdeicctthrieovsetcwooopfiactnhipemeaerlresvritehevawitewhwaaodsfattnhoeucnaoslncfthiiesmdsuuaelsneddfrsfoaucmrrtiahlfleircheie(gl1hu0-c5idd7oa2st1ee aainnfidmpao1ls0ss5,i7bsl2ee4,l)ewctatheosd spcaeotrntferodorlmceadan.uismoaTlhsoe,f moriboufnandimialys 105721 and 10724. MATERIALS AND METHODS tThhaet hslaiddeasfnruonmscahledtuilsseudessafcrriofmiceail(a1n0i5m7a2l1sarnodm10G5r7o2u4p)4w,esreelercetveideGwerdouapnd1 caonmimpaalrse,daangdaiannsitmatlhse individual animal data tables prepared by the study pathologist, RESULTS tThheedpeeteerrm-irneavtiieownopaftthholeogciasutsiesoifn maagrriebeumnedinttywfiotrhtthheeGorroiguipna4l caonnicmlaulsi(o1n0s57o2f4)t.heAsstusdtya,teidncblyudtihneg dsettuedryminpeadt.h"ologAilstth,outghhe tcheaurseelatoifontshheipmtoortbruenatdmteyntoifs ithte cGlreaoru,pt 2is aunnliimkaelly(t1h0a5t7t2h1e) mwoarsbunnodt ofstcaltioniocfatlhseigannsi,maalndistahereasuclkt ooff hAiPstFoOlogtirceafitnmdeinntgsbainseadniomnetsherescoelitvairnygoAcPcuFrOreantcseiomfiltahrsansdpehcitgrhuemr dose levels. REPORTED BY: fplomaAfe, ABiCl.etVt.DP.VM. PhD. Review Pathologist ba 3/01 Contributing to the Search for Healthier LivesTM 567 Dunn Circle, Sparks, Nevada 89431 + 775.331.2201 FAX: 775.331.2289 + wwswsierrabiomedical.com