Document gLx8xE0v69DwzwLM48J8VzBJ
U.S, DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE
PUBLIC HEALTH SERVICE
SURVEY OF COMPOUNDS WHICH HAVE BEEN TESTED FOR CARCINOGENIC ACTIVITY
Supplement I
By Philippe Shubik The Chicago Medical School Chicago, Illinois
and
Jonathan L, Hartwell National Cancer Institute National Institutes oF Health
Bethesda, Maryland
1957 y'.
I
ucc
032150
r jit Terence
Animal
Strain or typu
Sex Preparation uml done 240. --VINYL CHLORIDE POLYMER
Site and route
-(CHjCHCl^-
Anlmul:; wi Ui luunira
Sunil vat
l*tral 1 on *>T ex |w-i- Ink jiil.
Oppenhalaer et al., 1932
:
43 rats. .
Viatar -
t
-- Film 247. --VINYL PROPIONATE
S.C. CHjCU2COOCH*CH2
Tumors *M
44 alive at 109 d.
Over 22 mos.
Ambrose, 1930a
3 rats 43 rats
Albino Albino
F 0.64$ in the diet F 0.05 - 2.36$
P.0. O
P.0.
O
-- --
392 d. 223 d.
143. --ZINC DIMETHYLMTHIOCARBAMATE
Zn[-8-CS-N(CH3)2l j
Hodge et el., 1952a
Doga 40 rate
-- Rochester
-- USf
5 or 25 mg* por kg. by capsule dally for 1 K.
0.01 - 0.5$ in the diet
P.0. P.0.
0 0
100$ --
1 mo. 1 no.
248. --ZINC ETHYLENE BISDITHIOCARBAKATE 25 (CH2)2{NH-CS-S-)2Zn
Sultb, Jr., et al.. 1933
200 rata
Albion
10F 300 - 10,000 p.p.a. In the diet
P.O.
o>
Sacrificed at various Intervals
30 d.
100 rate
Albino
me 300 - 10,000 p.p.a. In the diet
P.0.
0l*i
)3 died by 52 vks.
2 yrs.
*----------
9 doge
Uongrel
-- 20 - 10,000 p.p.m. In the diet
P.D.
0**
100$
1 yr.
1J* 14 sarcomas, 12 fibrosarcanos, 1 liposarcama, 1 unclassified malignancy. First tutor at 109 days.
at Marketed aa pithone 278. ,<a 10 rats at tbs 10,000 p.p.n. level bed thyroid hyperplasia.
141 9 lung tumors, 1 adrenal tumor, 1 small bcnral tuner, 1 mammary carcinoma and 1 adenocarcinoma of thyroid In 100 treated rats. Considered spontaneous. 2 lung tumors In 20 controls.
242 10,000 p.p.a. Induced thyroid hyperplasia.