Document gEaGz7GwrdzO6nQe7bkVoB3E9

June 5*1939 Mr* If* Aj Huth Chief In Poaiologlcal Physiology University of Illinois College of Agriculture Urbana^ Illinois Dear. Mr. Ruth:- /> Please accept ray deepest thahkb/for the trouble you have taken in oonnentlon with the preparation of the apple powder for our exp&paental work* 2 shall certainly he glad to pay ^wt^-^Js necessary for the labor involved, ^ 9l ' ' ' "' With respect to the lead arsenate content, I think it best that we have as little lead and arsenic contamination from this source as id possible, We are not working on the arsenic end of this problem* and for the present, at least, we db not wish to. Moreover we are providing the lead in the form of a soluble salt and I do not wish to add any more than is necessary in the form of normal dietary lead to that which we experimentally provide. Obviously I should not mind having such quantity of lear arsenate as might inadvertently be present on fruit as a normal article of diet* but I should not want any more than is '^necessary. As near as X can make out now, I shall want a sufficient quantity of the apple powder to feed to two experimental subjects over a period of approximately a month. ! have no idea how much apple powder we should fded to obtain results comparable to those described byBr. Shields, but X shall wish to try increasing quantities in Order to study such effects without making the apple powder a large proportion of the total diet of my experimental subjects. It will be necessary In some measure to be guided by the wishes and appetites of the experimental subjects* since X can not exercise quite the same amount of control as might be accomplished experiments with rats. If you have any further suggest lone in the matter, I would be pleased to hear from you, but at present It seems quite satisfactory to me to postpone the matter until the latter part of August or early September* I am With kindest personal regards. Cordially yours. RAKiis Robert A. freSioe, M.D. KE 00085 ! 3