Document gELvGa80OwZ7pMxaDOR4L8Bne

DCMITMIM or HEALTH A HVMAN U1V1CU immwh >m **v*a**< Ultfy 4 'WAVUIM* Merck jj, 1*1 *r. Carl lancuckl operations Manager Chrysler Ch<lcal Olvlslon 5437 West Jtfftnonti Trenton, Hlchlfn All 13 Ooar Hr. lancuckl: *he preliminary analysis of rtsuHs from the aedlctl evaluation of the Chrysler Trenton Chemical Plant tnployees has boon complatad. The following report juroarim the tests conducted is veil is prelielnery results of these tests. Hethods of Assastnent The methods employed to essess vorter exposures to asbestos ind subsequent physical changes associated with exposure, included chest x-rayt, pulswntry function tests, a resplratory/neurobehavloral questionnaire and, for Ml chemical products employees, blood samples for lead analysis. Chest x-rays taken, v*r# read by two radiologists (B-ketders) using the International System for Pneumoconioses. When the rioiologlsts disagreed on the extent, size, or location of radiological signs of pneumoconioses, the I-ray was read by a third (0-ketdtr). kesults were reported based upo' agreement by two of the three radiologists. Pulmonary function tests were conducted according to the criteria recoenended by the American Thoracic Society. One-second forced expiratory volume (FCY1) and forced vital capeclty (FVC) ware Matured, and predicted veluet were celculeted using the Knudson equetlona. The questionnaire was derived from the American Thoracic Society's standardised questions for assessing respiratory health. In addition, vortara responded to questions about past work histories, length of employment at the company, smoking history, and specific telf-raported medical conditloni. kesults One hundred teventy-one persons participated In the eedlcel evaluetlon. The pertlclpents included 77f of tho active workforce at this plant. Among the 171 pertlclpents were 39 management personnel and 17 retiree*, fifty-two percent of the workforce was amploytd In friction products, J2t of the vorktr: were amploytd In the chemical division, and Ilf of the workers split their work between friction products and chemical products. PLAINTIFF'S EXHIBIT CHR-268 Pipe 2 *. Carl UK*11 tapteyee chest r.rsys tMw< three perse*if with rUlo)eg*t signs eonslsten lth pneumoconioses. One l-rsy moved Kilters) ia*n rounded opKltlti In the olddle md upper 1 wtftf fields (libestoslt typleelly sppeirt <i Irregultr opecltles <a the olddlt *nd lover lones of the lung). No t-rtyt shoved pleurs) tMckinlng: one of these X*riys shoved pleurs) thickening along the dHohrig* vlth circumscribed plseuis slong the chest nil, and the second r*riy shoved plsuril thickening involvlne the right costophrentc ingle vlth circumscribed pi lours ito#g the chest nil. Abnorva) pu 1*oniry function toots nro recorded for 2t persons. Tvenky tvo porsoAi (US) exhibited ia obstructive pattern (seven of mo* dio ah i possible restrictive sffect), md 5 vorters (3.51) tAond I restrictive pattern. PtrioAt with obstructive elfvty dliim Aon difficulty expelling ilr ripidly. The most comma couto of ia obstructive pit tiro is smoking. PirtoAS with restrictive pittorAs Aivo difficulty filling tholr lungs to cipiclty. Rootrlctlvo pittomo nould bo expected for thooo ixposed to nigh lovolo of dust or fibers such is isbostos. Percont predicted FVC vis good is I neisure of rootrlctlvo pulooriry effect, md fCVl/FYC is i ooisuro of obstructive effect. Afir corroctlAf for age iAd ynokiny, neither percoAt predicted FVC nor FCVI/FVC ns significantly istoclitod with /oirs vork Ia friction products, yeirs of work In cheated) products, or years it Chrysler. Hood leod nop)os collected fro* 2$ Cheolci) plant opintoro shoved m lead level, 43 ug/dl, greeter then 40 ug/dl, Indlcitlng excasslve expos The remaining 27 blood leid levels ringed fro* less thin $ to it ug/dl, vlthif the expected distribution for o populitlon not oceupetlonilly exposed to leid This letter constitutes in interl* report of the oedlcal enelysls to dito. I1 you hove ouestlons About these results, you *iy contact ee it (513) 541-1311. Richard J. wiseo)1 R.5., N.P.H., epidemiologist Medic si Section Hazard evaluations end Technical Assistance Irench Olvlslon of Survolllince, Heiird evaluations end field Studies