Document gDqvyzewNKZbQ9QrgyDjDboGa

THE TRUDEAU FOUNDATION FOR THE CLINICAL AND EXPERIMENTAL STUDY OF PULMONARY DISEASE AT J>RAMAC UKt. H.T. THE SARANAC LABORATORY THE TRUDEAU fOUNDATtON THE TRUOCAU SCHOOL AT TBUDIAU. N T THE DEPARTMENT OF PHYSIOLOGY THE DEPARTMENT OF SIOChcHiStrv THE DEPARTMENT OF AAOICLOGY THE TRUDEAU LAIORATQUY lo-wabor 16, 194* Mr. 9. U Born* Oww Ililac la OX**# Ceapeay Toledo 1, Ohio Osar Mr. 1mi t Boaleood toa vlll find fer** opl*s of & report oo too results of anlaal tyrlwiti vito Stylo duat* Ao 1* ovr curU** to Mr** r--irl--4 briafly aatorlal prooiowly prosoatod, mmr in~ toria report datod Ootobor 30, 1947, nod Mr* gXT*m totalled dlo- i* *ly of aubewpwt daraXo^oat** R all osporiaoata kaw booo ocapletod, to oapoot to proparo a fiaal report tolto rill la- alada dotails of oaafc pfeaa* oo that all data will bo aeallabla la oao plaoo, loom, too oatporiaostal *tady f too offoota of laboTod Kayla daot oa aoraal oaimfoatod aalaala la w flalohod awl aoaolaaiaao acproaaod oa that robjort aro final, ratoor toaa toatatiTo, la too ropart iaavad oaa yoar apo, Maiob dooarlbos too fiadiaf* ia awiaala toot labeled Kayla dust for ported* ap to 30 aaatoa, too followiac taatatlTo aonalaaio* was aadat la ooaooquoaeo of too aaporiaoatal otadioo eito SoiBoa pita to dotoraiao too Malotiool aotirtty of Kayla, it aay bo taatatitoly eeaoladed toot Kaylo aloao falia to proda-- eifmifiooat polaoLaiy daMpo tooa iabalod late too loaf* Serlaf too 30 to 3d Martha period, bowooor, dofiaito ladtaotloa of tiaseo roaatioa appoarod la too limp* of oalaoli labeling Kayla dost oad to*ro- foro, X rotroi to ty, oar toatotiro ormolaataa 4 abovo aoat bo al tered* la all -4--1* oaarifioad aftar aoro tiae 30 aoatoa of exposure to Kayla dart a--d otatabla oridocoo of aaboatoolo baa developed, ahoelac toat Kayla M IMtolatloa id oapabla of prodoaiaf asbaatoais ad aaot bo roparded ao a pataatlally bi--nMiii mterlal. It toroid bo ootad that oiaao neither ailiaoaia aor toe dlfftaa palactry fibrecL* caused by labeled dl*tcu*cu8 earth ai obaar ini, too parti oad dlataMoooaa earth ooapoaoata of toe dust apparently da aat prodaaa toeix typiaal losioao. Za ordor ta proooat aoro laforaatloai oa too subject aabestoeia, eertaia orldoaaa dorlTod tmm aar exporlnontal vert utto aabootoa dost baa boos d*aaaaed* is those findings bar* act yat baa* roloaaod for pablioatloa, I reqoast that, toils a*lap tba aa roqairod ia foreulatlap a aafoty propren, yea regard Umb aa oontfldaatial* OTIS HISTORtCAl ARCHIVES r^'iiCNA;. >.*.^ic'iM Cr naiT-i -`-0 `.*_ CM ARMED rCiiCES INSTITUTE Of PATHOLOGY THE TRUDEAU FOUNDATION FOR THE CLINICAL AND EXPERIMENTAL STUOY OF PULMONARY DISEASE AT SARANAC LAtt C . ** * THE SARANAC LABORATORY TH TRUOEAU FOUNDATION THE TRUDEAU SCHOOU ?tj# 2. Nr. 0. E. Bcwti Owaaa-fLltnols QlsiS* Company at tryoi* u, h . r THE DEPARTMENT of HY5ICLOCV THE DEPARTMENT OF BIOCMCMfSTRY THE DEPARTMENT OF RAQ40L0CY THE TRUOCAU LABORATORY lembtr 16. 1948 The mv series of experiments with r*spact to the influence of Layla o* tuberculous infection irf well under vay end ere pro-- satisfactorily. It ia, of *our3, too aarly to expact significant results on miisfa to b(t even tentative noneinjions. it tills time mj I review briefly the financial nrrangment for conducting toe inwrtlgution with Laylo? The rcsMnb program up tc tali year va# carried oa under e eontract, initiated la 1945, by voica the experiment* would be subsidised with a (rant of (5,000. per year. 4a pointed oat in mj letter of Keren 3, 1944, the contract terminated offioielly oa February 15, 1944, but the investigation would be continued without chares until June because the original experiments were started late. Since s eaeck we* received which took care of the subsidy up to lovamber 15* 1947, there i* due os the old contract the stab of $1,250. for the final quarter of the contract (frees fevember 15, 1947 to February 15* 1944). Ve hare delayed sending an Invoice for the final quarter mtil all work could be finished sad a final report submitted. Following the termination of the experiment la June, it has required several aonth* to do the histological work, study tae tissue section*, collet* the data and prepare the report which accompanies this letter. Me ere including la toe report * trust' review of the new experi ments in which the effect of inhaled Kayla dust am tuberculous in fection ie being studied. Tour purchase artierAk-170 authorising this experiment at $5,000. for cm# year is dated February 3, 1944, but owing to a shortage of anlee is sad other unavoidable delays the actual experi- mamtal work did net- gee wdar way until May. lance we base eemmladed that flMMttJSHfrt fhr thin new pcagwa hasW be imbed f -- ^p \j 1944. IIrfMlWW bfiUhed ia ay iaibar af'Krvft 3, X nggschd a bam- year oeabahKflMb per year, tear letter ef Kareb 31 eekaewledged this but fttfid te saeftia the extra amount of $2,000. involved. lever- thelcea, me have proceeded at the old rate and are endeavoring to abeorb the increased cost from our Foundation reeerve. Xa a few days our accounting department will forward a statement of tne payment# now due ia support of the research program, as follows t Original experiment, begun Jtbraery 15, 1945, at rate of $5*000. auiually For final quarter (Soveuber 15, 1947 to February 15, 1944) $1,250. Hew experiment, begun Kay 1, 1944, at rate of *5,0C0. annually For fir?t quarter (Kay 1, 1948 to August 1, 1948) For second auarter (August 1, 1948 to loveaber 1, 1948) $1,250. $ , .>1.250. 3 750 PLAINTIFF'S EXHIBIT K-84 AFFIDAVIT PLAINTIFFS EXHIBIT K 84 WASHINGTON DISTRICT OF COLUMBIA CeU ____ ) ) ss. ) BEFORE ME, the undersigned Notary Public, personally came and appeared MIKE RHODE, a person of the full age of majority, being of sound mind and body, who, after being first duly sworn by me, did depose and say: I MIKE RHODE, am the custodian of the originals of the docu ments attached hereto as Exhibit A, pages 1 through 1. I hereby certify that the documents attached hereto are true, correct and authentic copies of documents authorized by law to be filed and actually on file with the Armed Forces Institute of Pathology. M LICE RHODE, AFFIANT / SWORN TO AND SUBSCRIBED before me, the undersigned Notary public, oh this the of rl NOTARY PUBLIC My Commission Expires: .....SHEItA R. 8ETASSO__________ NOfARY "PUBLIC DISTRICT OF COlUMStA My Commissi; n Expires November 14, 199! THE TRUDEAU FOUNDATION FOR THE CLINICAL AND EXPERIMENTAL STUDY OF PULMONARY DISEASE AT SARANAC LAKf, N-Y. THE SARANAC LABORATORY THE TRUDEAU FOUNDATION THE TRUDEAU SCHOOL h|* 2. Hr. 0. K, Bwn Place Company AT TRUDEAU, N.Y. THE DEPARTMENT OF PHYSIOLOGY THE DEPARTMENT OF BIOCHEMISTRY THE DEPARTMENT OF RADIOLOGY THE TRUDEAU LABORATORY The aw series of experlmaats with respect to the iafluenss of Kaylo oa tuberculous infection are well wader way sad ere pro gressing satisfactorily. It is, of sours#, too early to expeet significant results oa whisk to has# m tentative conclusions. At this time nay I review briefly the financial arrangment for conducting ths investigation with Kayle? The research pragma up to tala year was sarrisd on uader a contract, iaitiatad la 1945* by which ths experiments would ba subaidiaad with a gnat of $5*000. par year, is pointed out la ay latter of March 3* 1949* the contract terminated officially oa February 15* 194$* but the larestigs tioe would ba eontinued without charge until Fana beeawse the original experiments were started late. Sine# a check was reaairad which took care of the subsidy up to lereaber 15* 1947* there is due oa the old eoatraat the earn*. of $1,250. for the final quarter of the contract (from lereaber 15* 1947 to February 1$, 1941). Ye hare delayed sending an inroiee for tae final quarter until all work could be finished and a final report subnitted. Following ths termination of the experiment in June* it ha# required sereral months to do the histological work* study the tissue sections, collate the data and prepare the report which accompanies this latter. Ye are including in toe report a brief review of the new expertmeats in which the effect of inhaled Kaylo dust as tuberculous in fection Is being studied. Tour purchase orderA9-170 authorising this experiment at $5*000. for one year is dated February 3* 1949* but owing to a shortage of animals and other unavoidable delays the actual experl- In a few days eor accounting department will forward a statement of the payments now dun in support of the research program, as follows* Origin^.} mant. begun February 15* 1945* at rata of $5*000. annually For final quarter {loveaber 15, 1947 to February 15, 194$) #1*250* gov experiment, begun May 1* 1949* at rate of #5,000. annually For first quarter (May 1, 1949 to August 1* 194$) for second quarter (August 1, 194$ to loveaber 1* 1949) ,250. $3,750. ntssDf smK IMASDm Ttt KOLOOICtf. iCtTrtlt or uim mm * ta otM^nojsoxs sujk mmm ms! mn * nc SUUtf UWtitCaT UP, nr SB oetows jo, ii s*v*<tt** ift lytfcsr J. fm*U| Xt ft** Mtvstar Si Unri L. fNAtt Swfctfai X* Mtfmtlai vlttt lt&U C. hilt, H, 8. s. fiafca, ** *. AtNr s- arapflacticg Cm yaar os 0Mater 30, 1947, a IstorU r*?rt tu enhslttod, mrU| tti yrofTwi of trkls asisel axporlsosU stth Uylo ew total period of 30 --tti. It mt Mtamrj *t that Um to rasosMsd further eepertmemte twtmltf oortala ptesos of to* probla** The raport doala with tha final ;baaaa of tho axparl loot than is gnsgroom tad vitt tho early boorvatioo* aado is tha mm aortas of *s?*rla*Bto. Tbs orlflaol wprf--t hso so* boos oasylotod tad to* ooeelaslsss trra ora to**4 apes to* results of a fall three years* ixpMr* to a atsoepberls ncpHtlas of laylo 4wt, frosiaso *zpart*M* tost Aen ttat tti* Is to* ra- ?lred period error afcich exyemeeree to a teat of doaitfal bioiGgloal aetlsltgr art bo atlsy* toftr* final ooselaotos are **maM. Ibis axparlsest, is fast, MUtltato* as example of to* lsportosoo of nak protested atady for, as is to bo toon bales, tho flsdinc* t tom years sera atrikisclr Siffarsot tree those at %w aad <ioo hlf yaars tad tho taotatlse onselsoias isoehed at that Um wrt sew ba altered* Thu, at tho tiao of the jrosioao report, tho eeidouoo ladUttod that Kayla eotsd ao as isovt dost is some! rats sad galas* pi|s) multijf eaiy is tho fsnotties of slsoys of tout oolls, sithoat fibrssls. hsasor, it sill bo ahewa bales that Kaylo is e*patie, os prolonged 1 aha latins, af predialm asbostoola Is tho lasts of |*f !Oa fdga, asd that it ahoold bo Haodlod IstostriaXly as a ha- sardoaa dost*. this repost U1 bo praaaotad la fosr oootioso ao follosoi i* fXaol oboorsatloss, dust lahalstios is sens! (also* p4*. to. ftleasealas. C. Caselweiowe, fragroea rtperi os aoo aerie# of axperlaosta. M iibiiltotl m. tost laftalstifift U *&Xm* al* brtnoN to toa Iatoria Saport of totobar 3C 1947, vlll wm! tost two fxospa of sons! |iiow pigs nrt plsaod la to* tost roe** os* f*ot*$ ia Fobro- *17 1945 sad to* mirt is iiagmi 1945. toa *siml* nor* aspesad to ttMCftorla orf*sw4s*s of Isylo tort for tlfb* boor* (dlj, fir* sod 00 half toya s rook torafbo^t tba S2|K*iMttt* Dm dart owi*antntdo* aftiab mrlod aaawetot trm Urn to tiro, bs* tfmp4 lift alllies g*rtlsl*a par add* foot of sir oaor tba astir* osar-- of tte oacporlmrit. to dots. 1 brief rniow of tbo cbaarmtlcra dossribod or pogo 4 of da ggrooioos ra- S*rb vlll ronel toot up to thirty matbr too mortis* la jalaao pdfs ms Hasltod to 1ft* iisil illoi of olaapi of aormfis#*** aaatolstsf dost f*rt*lo*, 1* fmr f odjoaaaft sir spuaos. bU* or**lBal mltlwaalastod float soils mm mb* tbm ms so aate* prolifarstio* of tiara* ftlatiaaptra sad flbmals ms itont. 1 ft* madatatobl* ssWstosls bodies maa Ida*tlftadL fit fnml, tft* samaistios of sails of tft* top** doaarlbad sftara sad their grmlataar* u mto omr s fall thro* jr**r parted, uttowt tfto denlefaewt of fibmsl** bos boa* feard 1* UHttasta tftst tbs afoot wpaalUo for tft** la aat *ftU of jarodoeiaf fibroad*. draft afaat* m rar acmsldarad to bo *biolrflrslly iaatrt,* sirro tbo an aollslsr xamUtt* fe*s aot baa* iwi to affart primary ftoot&a* ar raadrtsrra to diraaro. ftPMt% a# ode* oafaaalo asariflaed nbra.uant to thirty raato* la too pre- aaab all bn dm aat aaly too bn laalarr bat also born danloped baa fibrosis of o tgrpo aftsrartorletla of to* majaawa of falraa pdf* to sabostoo* Mr U s rather dlffaa* typo of ftomla tolab fbs*a sbiatty atoot toa aneOl sir toato, mom sa braaahlolat, ft** aftla* toa sir ago*as, ar dawU, of too Isay arise* toa sppaadad phatoitiamgmpbr toa* too adm of toa i*aia tela* di*- la to* actual sir spec*#, <tr airtaii. la tee pr*snt p*ri;**at tte fTMtot partial of o*-4a>t*tte 4m4*f toiB ?arti*ttiJiisa, lQd$<m 1a t& alTOoii tad naiyete Um pariteoueitlelar tepasiticA f hm of lac fifcrous owpeawt. la r*trepwt, it i poaaifcU to it***** ttot tear* is stave teltea** of *ut 1X actiritj' In to* icgioa cf to# faro, chid** tkac i* atoraatariatl* of la* r**ti* to m inert pcrtictLLnto -do&t* -litl* *14*11 l*aw* %. attested to tola &t to* Via* of toc pr#iri*# report Weans* iter* was aa widow of to* tewelopacaat of fibre#!*. to* differ***** tote*** to* *xljr raaotio* to to/i* ate ttot to aateate# .mf to iAterpreted % * MCifioiti.&* of ta* _eioa* fey toe partitelat* *c*pc***t* of to/lo* atedlfica.tl3** of #llico*i* 1* v*ll racegsdate too* laaioa* of teat dlaaaaa teralap fsltewiag lotolatloa of n airte da*t *wtaiBi*g Heart* teg*te*r wito aatarUl* of m laart aateuro, note a* ire* oaid*. It it of iaporteoce to mote teat toil* te* p*rito*a*Aiolar reaction* ob- *arv*d iaeriaiaat# &fl* a* eapabl* of ^rwimiac **testo*i*, ttey axlate to* jte*iM.Iity ttet it mj mm# iilieoii#, sic**, ow? a fall tor** jr**r parted, tter* is 1b a* wia&l aayr foe.*# el aodslxr fiferexJ# etarx*t*rinti of to* ratloe to ;o*rts toteWMC, It **f to *M#4 teat ite aalaala too* as mviSmm of tea tjv* of dlffa** fifered* white tea to** otetmd 1* tel* laber- atorgr to follow iatolatl** of 41*tote***** wrtk tei* 1* regard to todrated mb* telolaai atli*ate, a*J*r o*#tltwat of Uylt, it **y to a*id teat toil* ttor* 1* a* patatte Wife*** a* to it* *fftot to yslanimy tl*m* tote* i* onto mt6mu to too* teat a rarlaty of ailioate*, iMltelAg sea* form* of sdtto sLUUtetea, at* l**rt. It ***** liialy teat to* etleiat si lie*to i* Iigrla weald caTn with teis jewelmm aatperl#***. to**, te* j--ifedijiy *xpr***< by Sector flwtor is Ms early eeaudderatie* of tela profelto, teat i*yla eight prtete* to* p*wo*wl**e*, aateatoaia end aiiiwais, wite te* reawltant safety teaards, to* tow ***tolyr rtsteite, ate wear* ear 4- - tto UtUr eosdltlos ua bo disaaiaaod. fortarr eonaidor- tio* ma\ to gtrm to sabostosio, bowooor. U Laboratory k* rmaUy onsflotad & largo swouot or work with atoto, abiab &u km roportod to aortairn otaar *u?porting aooywaias, tot sot as ywi pobllabto. Tto following 41so--mios of too prebiso lo dr*%a> largoiy from that work, s4 v* would rw- ooot tomt toooo to oooaitorad *onfttoBti*l. It Is folt tost too foUoulsc lsfonmtlos soy to of aid to too Qwwso-Ilitaoi* tomlto dofsrtoost Is fora*1*ting safety parogrw, tolofc oortoisly to sooosoary Is now of too remit# of tots Isyle wporlosW tatastoala, toto to sos tot Miaalt, lo a total*, alovly dowoloplag port- bras to tolar fitoeata* wfcioh to toto ota<o axtasto Crm too oriflaol otto of 1 ooo 11 otlew toto too osrraiatolnf 1smU. too bowstolotor toooltostlao ia appar- astly too to too fltoaoo a*tar* of too alaonl, tryoi 1 --U1 atadloa todiesto toot too tolef onto of aOttos 1* fty aootosioal irritation of Utm * too fiber*, too strsotaro of ttooo fltor*, and too eopobdlity of reposted laoglttaisal dlrL- tos to aolooulax rtratoe, la toportoot to too aatoal ef tattoo, aiooo too olid fltor* of glaoo wool arw sot oapatio of yrsdsoiog too fltreats. Ctosiosl aetle* lo of little or so lsportsaso to oowoloy naotioi, rinoo ohrysotUo raw tarot partieoleto by oatilsg sad wyonUai toto sot laittoto flbarooto* florists laniHyiilsi toto 1*41oatod toot a aiaoda|ly sogllgltao proportion of fltevB* ootootoo lo SSfflodeet to prodooa too otonotorlstlo reaction. Stas, as totolmttos wprtoat was asrrlod oot with btllnrilto aotostoa to tolah as titayt was arnto to altolsato all fltora trm too satarUl. It mo torn* to to togosalbla to trwak *y all of too fltor* to abort oso par oost of too air ooo- pastod toot twuiito of fiber*. Iks otaraotorlrtlo jorltoatocbur flbroaia developed to too osjosod aslsalo aftor forty sastoo. Usui, it ayyosrs toot vary sat11 aaabers of fiber* *r* dnpbl of prodaolng ttbtiWtli', although the dor*!ooaent of th lasiM li 4lfd. the protest npriaut with layle U also u UCM^li of this fot* the i.rrt*at asttar of prafrooslaa of roaetlo* <ft*r expeeara to %ahetot dost ommi boo bowi axtasaiwely lsbofttgatad* Ifc* roaolta iadieate that la eootreat to *llloc*la, ifrora ptofrooaios wttaaM for mm tlao, thm la no sigaifleaat dagM* of iMfwiw ift oxtoot of the looloop. Bathor, tho aiao of the laaiona dooraaaaa la tabootools daa to tho tsodasay of the fibrous tissue to ocatmt after the stlwslaa to its prodaetioa la resowed. Bo lrrltotloo of tisauo W as aobeetea flbor la sypiwtly imM withia few wartln *fUr It sster* the La* W the fsiwtlw of tfes aobeeteels bo^jr* ( ooott* of tts filar by iwwoocrtolalaf sstorts!), with tto roomlt that tho oxietlac flbsaoo tlaooo mlmts, Iho-thor this acotraetloo oaorto a beseflolal or delotorlooe offset m is* fas tloo la ass wter iarrostlgstleu. JsfarbatWjy, tts studies vltk asbestos boro sot u yot oosplotoly olarlfiod tho problaa of ita affaot os asaortstod Irtsmlai Isfootlos. It 07900r* that layle say wart * slightly ssse waked adooioo laflsonoa m tho iafaetioa thsa dooa pan asbestos. Bo dlffarasso aay wlX bo doo to tho jiroaasoo of tho tsoll tonal f pearls Is fsyle ar perhaps to other IwKwIil fusion, CWo purpose of tho studios aasr aalsr say to to olarlfy this ,0013as. c. jSsanMhM^ 1* XaylOp hooosso of ita eastsst of s approotahls asaiwt of fibsona ahvyaetlle, la capable of fraitsolag aaboatoals aad should bo ,2 Xsyle dooo sot pro does silloool* la aalsola. sates tefwo toisf plssst is te* test row. it tte prosat tis* tte first too $rapm tew tea plsgod la tea dost took; tte tMxi is to go la a P----ter 15, 190. Only two slal* of tte first grasp tew tea sssrlfleod so ysrt, after two mte is UM test* ttlsrosoopis oteorwtloes tew sot tea ado, tet is tte grass, tte Isoioa ssw sapor*kXs site thoM is satrol (3) 9m offsot of so--listed 1*7X0 is tea lags a s ssteogast tsterssloss isftettoo. 9irty --tel girl sss pigs ssrt plsood is tea test mm a Msy 12, 190, sod m 12, 190 wrs isfooto* site tte sttawtod teterelo testlU. fits ssials wr* woriilsod st teis Mm far stealpal susl^stis to ostafcLisfc tte i--rt of test lstelod. Cstral sslssls wrs isfootte a tte ss--s teto* **--~* sor* mmMtmi rsoatlj, too sates sftsar Isfootla. Qrossly, teo lssioss Is teo ospsrtesstsl sad oatrol ssials on apsnK tet sgsls sissooospdLo oteorwtloos tew sot tea ssto* tte tsstUs to teto Is teis ospsarlss--t sro of littl# rigriflsast slops tte itswso Is steals oss at g sl--Mgos teo to teo iitelifrta of test of 07 wtaro sro test to te sis--* looowr, it m te ssM test teo osporlsat is pngwasisg say saiSCiCMtteflfc't sot tet --s s--tis&psto ssoo of teo --pliostloss teiok 1st*--farad site teo MtePtettm of teo jjwwiouu asyarisast is rsfsrt to tte offsot of SS7I0 a apscteMtesl tessalflt* tie* 3 - AiNrtu tafcaUtt--, 30 iMil. mat 9m IwMMdi Im mla jiMWwnwi* it j*rt i!m ai ta H* !#% cf mmtmt* Seta H* of lit vail m te tt* Xtfit fit1 *% 3i nn^tj. Sfefte f ttfcm Ham at utrmt tto til *f *1 luitM illi^ m til m li t tijjmtt ultalt* tlla* 41 ft*. 4 * 30 --ONI. UMK fcf*tor f It f Ok* ttoM *0 to HfO* I- wooli ft tnOoftl dm f HOwOrii lM*t( too --rwi Ooto fttooftot fttowtoto to too ri^t f --tor. H#* 5 * 9mm1 f*$M* ptf i'aaf. 2K53S fti< jS*M tlm tw Imdltlit, mm la Xm&tmilmli Wm mVmm ta wo wtlo* H wall *wUtW UaO MWm wH *f ttw OUfc Wat f tW aWmU wf tftdw- iTm|ii*i i inTTit,i fEBHS5 | EXHIBIT j K-84 ifoveaber 16, 1943 Mr. 9. L Bowes Ovens--IHlnt-i* Glass Ccap-rty Tolado 1, Ohio &ar Mr. Bevo* Enclosed yea ulll find thrve copies of a report on the results of animal experiment* with E&ylo dart. A* Is oar custom, wo have somaarlaed brio fly mat*rial ^revlourly pro mated, including oar in terim report datod October 30, 1947, and hare given detailed diaetutaloa only of subsequent developments. Vheu ell experiments here been completed, v expect to prepare a final report which will In clude date11* of eaca phase *o that all data will be available la ooe place. Severer, the exj^ericental study of the effect# of inhaled Eaylo dust on ooml uninfected animals Is sow finished and conclusion* expressed on that subject ere final rather than tentative. In the report lamed one yvr ago, which describe* the findings In animals that Inhaled Eaylo duat for periods up to 30 Months, the following teatstie* conclusion was eadet la consequence of the experimental atodies with coins* pic* to determine the biological activity of Eaylo, it asy be tentatively concluded that Eaylo alone fell* to produce significant pulmonary damage when in haled Into the lung.* During the %} to soothe period, however, definite ladle- tlan of tissue reaetlan appeared in the ltanr* mt enlnaln Inhaling Saylo dost and tharefore, I regret to say, oer tentative conclusion anoted above east be al tered. In qj.1 aninale sacrificed after wore than JO month* of expo-are to Eaylo duet unmistakable evi^attce of aebeetoel* has developed, showing that Xarlo on <>"i|Voa 1* 'capable qf producing astoatoals and must to ngrttd JU 1 PCtectlaLly-hasa^lou* material. It should to acted that Place neitKr llTco.ia nor the diffuse pnlmrrnaryHbrocis caused by inhaled dlatc^ae-eu* earth was observed, the quart* end diatom*eecu* earth ooapeaento of the dust Apparently do not produce their typical lesions. In order to prosent acre information on the subject astoetoaie, certain widenee derived fron our experimental weik with asbestos dust hao been diefused. As these finding* have net yet been released for publication, I role*t that, while using then a* required in formulating a safety program, 7oq regard then confidential. Pag* 2. Mr. 0. E. Bowes Owns-Illinola Glass Coua.-rr Boretsbor 16. 1943 The new evriea of experiments with niyMt te the influence of LayLo oa tuberculous infection are wall under way and are pro-- grossing satisfactorily. It is, of course* toe eerly to ozpoot significant results oa which to base tm tentative conclusions* At this timo any I review briefly the fiaeaeial imnpoit for ecoduatlng the investigation vita laylot ihe rsaocrah program op to tills 7*r via carried on under eontract, initiated is 1945* lay which the experiment# would bo subsidised with o great of C5,COO. par y.ax. As pointed out is sj lattor cf Maren 3, 1948* the contract torsion tad officially cn Jebr-ary 15, 194*, but the inveatig-ties would bo continued without charge until Juno because tas orlgiaal experiaeats woro started late. Since a onook was received union toox ware of to* subsidy up to Koveaber 15* 1947* there is duo os too old centrist the sue. of $1*250* for the final quartos of too seatrust (free Boveaber IS* 1947 to February 15* 1948). Vo bars delayed seeding aa 1avoirs for tae final quarter until all east oeald be flaiabsd aad a flaal report submitted. Following the torminatlea of the eaperiaeat la lues* it tea required several acotaa to do the dittological west* study the tissue Motions, collate the date aad prepare the report waiaa acccsrpaales this latter* We are including la the ro.ert a hr.ef review of the sow eaperl-- aaats in which tee offeet ef labeled Cayle dost oa tuberemleue 1> faction is being studied* Tear peraheas orddl-170 aatherlsiag this xperlaent st $5*000* for cm year la dated February 3* 1941* but owing to a shortage of aniaals aad ether wnswsldahlo delays the actual experi mental work did not got aader eg util Jhy, Bsecc we hare eoaeluied that financial support for this aew psugr^a should be dated frea May 1* 1948, For raaeoae outHeed la ay letter ef March 3* Z suggested a too lbar eontreat at (7*000* par year, laar letter ef March 31 acknowledged this but failed to eonfim the eatra easaat ef $2*000* involved. Severtheleas* we hare proceeded at the eld rate aad are endeavoring to absorb the Increased cost frea our Feuadatlea reeerre. la a few days oar asoogating dopartaaat will forward e etatenant the payxssts new due la sappert ef the resource program* as follows! Orlgiaal begm Febraary 15* 1945* st rate of $5*000* a-maally For flaal quarter (Hovector 15* 1947 to February 1$, 1948) $1*250* lew excerlnent. begun May 1* 1948* at rate of *5*000, For first quarter (May 1* 1948 to August 1* 1948) For second quarter (August 1* 1948 to Bovaeber 1* 1948) . .$1*250. 11 250 $3,750. THE TRUDEAU FO U N D ATIO N POR THE C L IN IC A L A N D E X P E R IM E N TA L STU D Y OP P U LM O N A R Y D ISEASE J9h ma no mo -I x HI m to a> z> > n ta0 73<>0H -1 X -IAi -I*i {