Document gDgDYXjKzz9GZEM76xx4Ep019

BIOSEARCH. INC. tp.oe. lbeoxph85o9n8 eph:ilade(lp2hi1a5, )penns8yl4v6an.ia441991091 Submitted to: Material: Sample Received: Date of Report: Test: Object of Test: Method of Test: . 33H CCeonmtpearny Ssts.i0lPaul, Minnesota 34 Company - T-1395 December 6, 1575 March 4, 1976 Primary Skin Irritation Study - Rabbits wThoicdhetetrheminseubjtehcet dmeagtreereiaolf miaryriptratoidounc,e wihfenany, aalpbpilnioedratbobitthse. inTthaectteasntd waabsradpeedrfsokrimnedofin oFerddeerraltoHaczlaarsdsoiufsy StuhbisstamnacteesriaLlabeulnidnegr Atchte. aTnhde mtehethosdcoerimnpgloyoefdthien trheesulttesstiwnasg,siemviallauratitoon tShuabtstadnecsecsriabnedd AirntiScelcetsi,onAd1m5i0n0.i4s1tra-tiHoanzaarnddous NEon.for1c8e7,nenPt. 2R7e0g1u9l,ati2o7nsS,eptFeemdberearl 19R7e3g.ister, Vol. 38, wrIaansbbciautrsserdywienarsge osuuctplpilptipheeedd.sotvueAdrygartohweuipdeexofpaerrseiiamx.enatlabOlnienosasmipdele oaf latnhceetansiumaflfsi'ciebnatcklsy corneum but not enter wdaesep abtoradpeednetatratoene thseitestwriatthum the derma to produce bleeding. Tihnetacstk.in oAf0.t5hegnotphoerrtisoindeofwasmataelrlioawledwatso an abraded and an intact skin site on the arpepmlaiiend to same rabbit. aGtnhaeduzeatnrupnaiktmscpheoerfsviotwuhesere maanttihemeranilaspllatwocaeshdolwodrvaeprtpheetdhepastntcurhgeelasyteadirn oauprnleadacse. wThehoreuerwraplaespropioidmnagdaewnadsaftthreeermtosrveeevadetenadtty-attrhweeaosenhodwuerrosef. etxhaTemhietnweDedrn.atiyz-efRoeuardings wamibetrthahdoewdda)toefrw.esrceoreixnagmiwnaesdedmrpyloyaesd.welBlotahssaiftteser (tIrnetaacttmenatnd CO0CB6 + 3M Company = T=1395, Primary Skin Irritation Study. Results: C= onclusion: See Table 1. tBhaesedsubojnectthemaatcecroimaplanwyoiunlgd tnaobtle,be acllbaisnsoifireadbbiatss awiptrhiimnarytheirdreiftianntititoon of (c) the (4) Act-Reference: and requires noSeccatuitoinon1a5r0y0.3 labeling with respect to that section. DKiarrlectL.or Gabriel, V.M.D., Ph.D. 000087 \ Material: TABLE 1 Primary Skin Irritation ET 3H Company = T-1395, as supplied. Erythens and Eschar Formation Intact Skin Intact Skin Abraded skin Abraded skin f(Heonudris)ng |1 f2abbl3c NAusb5er6 2 000000 72 000000 2 000000 72 000000 subtotal Average 000 000 000 00 0.00 Edema Formation Intact skin Intact Skin Abraded skin Roraded Skin 2% 000000 000 2 000000 0.00 2% 000000 000 2 000000 000 subtotal 0.00 Total 0.00 Primary Irritation Score: 0 00088 Material: TABLE 1 Primary Skin Irritation DRY 3M Company - 7-135, as supplied. Erythema and Eschar Formation Intact skin Intact kin Abraded Skin Abraded skin R(eHaoudrisn)g 2% 2 2% 72 1 R2abbi3t 4Numb5er6 000000 000000 000000 000000 Subtotal Average om 0.00 000 000 0.00 Edema Formation Intact Skin Intact skin Abraded Skin Abraded skin 2% 000000 000 2 000000 000 000000 000 7 000000 000 subtotal 0.00 Total 0.00 Primary Irritation Score: 00089