Document gDeX5jEQNgmnQe6ZdKavOy0me
STLCOPCB4042079
136
and Human Disease
PCBs and Human. Disease James et al JOM Voldm'e^S, Number 2, February 1993
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Robert C. James, PhD Harris Busch, MD, PhD Carlo H. Tamburro, MD, MPH Stephen M. Roberts, PhD John D. Schell, PhD Raymond D. Harbison, PhD
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Polychlorinated biphenyls (PCBs) continue to be of great environmental and occupational health interest. This review summarizes the major clinical findings reported in individuals incurring the greatest PCB exposure--those persons working in the manufacture Or repair of electrical capacitors or transformers. The potential target organs addressed in the studies reviewed include the liver, lungs, skin, cardiovascular system, nervous system, certain endocrine systems, the blood/immune system, and the gastrointestinal and. urinary tracts. After careful analysis, the weight .ofevidence suggests the only adverse health effects attributable to high, occupational PCB exposures, are dermal. This review confirms and extends the observations ofothers, ie, that the collective occupational experience with PCB fluids provides no evidence for adverse PCB effects on any other organ systems.
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Is there a medical test to show whether I've been exposed to PCBs? " ;
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There are tests to find out if'PCBsare'in your blood, body fat, and breasti[X>|lHtests are
probably the easiest, safest, and best method for detecting recent exposbresto la^er-ahibunts of
PCBs.
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However, since all people in the industrial countries have some PCBs in their-bodies^these tests can
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BACKGROUND BLOOD OR PLASMA PCB CONCENTRATIONS IN THE . GENERAL POPULATION OF THE UNITED STATES
STUDY
NUMBER OF SUBJECTS
YEAR MEASURED
REPORTED RAN.GE (ppb)
Finklea, et al., 1972
616
1968
0-29
Humphrey, 1976
16 1973
7-42
Humphrey, 1983
29
1973
Less, than 5-41
Baker, et al., 1980
110
1977
6-79
Smith, et al., 1982
22 .
1977 .
15-77
Kreiss, et al., 1982 Smith, et al., 1982
1631 32
)
1977 1977
Less than 1-57 . 2-78
Chase, et al., 1982
19 1979 10-27
Emmett, 1985 Kreiss, .1985 (Drotman, 1981) Kreiss, 1985
54 . ' ", ' 17
;
105
.
1979 1979 1979 '
1-15 2-30
Less than 5
Fait, et al., 1987
56
1979
8.2-24.4
Emmett, et al., 1988a Fait, et al., 1989
56 . 56
1979 1979
0-15 0-15
......
Kreiss, 1985
10
1980
.
1-18
Kreiss, 1985 (Humphrey, 1983)
418
1980
Less than 3-60
Smith, 1983
73
1981
1.3-14.9
Kreiss, 1985 (Reid & Fox, 1983)
138
; FrtzderaW. et al., 1986 WfcPH, >987
. ;
341 ' ; ' 840
1981 ' 1981.
/ 1982
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Krebi, 1985 (Welty, 1983)
: ` kr^r waS'.tCo'ndbo,. 1983)
. .'-v-
! Krebs, 1985 (Welty, 1983)
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; :?990i,>vV:: .
1983 . '1983''.'
59 '
1983
Less than 3-43
1-21
:
. 0.4-154
1-23 ; '
, 2-30 ' ----------- ---r-----:-- , 1-45
Chnstiam. et a1., 1986 Sahl. et al., 1985a,b
17 738
1983 1984
1-20
Less than 1 -37
'
Brainidt-Rauf & Nimafn, 1988 Hosek, 1988
Hartle & Albrecht, 1387
Mdrtensen^ et
1987
.Sfigai & Be^#>\T988,
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16 . .. 32
30 68 -..3
1986 1386 1987 . 1987 - .... , 1987
0.3-22
.
1-9
. 1.1-9.66
Less than 1-24
..2-106. v;;j
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DSW 189781
STLCOPCB4042081
>PCB CONCENTRATIONS IN.
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LOCATION
exposur^ M v
NUMBER.OF : SUBJECTS
YEAR
ARITHMETIC
(GEOMETRIC) MEAN
RANGE
REFERENCE
....... . jwv
' silo;fpffer; , ,y
;>:S$>omlngtc>o, IN . ' . qepacitor.';pfeartt.:, :
IfixJsfefV Fells, NY
qflpaqi.tp^;piB^t, . :'
^0j^:tartNY.
qapaclto^ pint*.-(2)
r^i^^BTOf-naton, in
cpaci toirptartfc
8loc!lr3tqn, IN yf-N^^rngton,. in
qapacltdr plant" qapecitpryptint: /:
i: 3l$Wftatqrn US
prlvate-yirilfty, -
y^iWb&sen. LIS
publ ic liti rt ty. ;
^.BSlttngs, ht
packing bouse; y v
Falls, NY
copacitoh;;pUnt '
> fljgtit ;NY .
capacitor^plNnts; (2)
vjrijtelhfjigtQn, DC
sw I tcftgi'eiif1 vsKop .':
^-^th.trigton, DC
sw i tch[geA(fv:-$hop; > y':
TvWipington, DC
swi tcKgeftryshop'r'y
^vjlfiBhctington, DC
- swi tchgeNyahop y .
yMff^ington, DE
rai Iroe&yry: ;> y
Hatington, DE
' ' railcoadx'K .; `
yiSi^Princisco, CA utftjty yyy; ^
i 'O icet.ur , IL
. PCB cleanup x ' : / ;,
v?''T*etor';- OH
electpt^i; service^
^BiSpi&itick, OA .' e l ectcicif^serylce
^K^Bedford, MA , . , capac ijtotv pfante:.
vw(Jwibnidg Spr i ngs, pa .utiiHrgy^^yyy-
xcf#$$echUset t s " : ; gear plbrn'; . - -"v
-?[FirstbyAmboy, nj
chemfceImplant ;:
;*> PSefeth' Arrtboy, NJ
chemicaVip^ent ; .
y.
utility
/
i in capac i tot plant
>-N*fry&rkt NY -.; .
munictpaUv utility ,
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PC? fncinieration-
149 7
194 290
18 221
5 25 14 17 194
147 37
35 54 37
86 15'. 15 20 16 6
205 5
38 32
18 . 12
10 16 29 45
1977 ' ':y.'y 28 , .5'300
1976 : 98,4 36*286
1976 (393.) 63-2410
1976
.172 7*3076
1977
75.1 16*357
1977 (144) 1-3580
1977 180.8 65-366
1977 , 51 16-298
1977 38 12-76
1979
: 6.4
4-11
1979 1979
(87) .16-500
(502)
...
1979 26.5 1-300
1979 53,7 4.3-253
1979 (9,7) 1-300
1979 (12.2) 1-300
1979
; 35*4 10-312
1979 14.2 10-30
1980 . 43.2 21-70
1981 . ,, 8.9 : 2.5-36
1981 y..y::58 25-127
1982 " - .5.9 <3-25.2
1982 <18;2) 0-424
1983 . '
/ 14 8.2-25.2
1983 14.4 3-97 1983 '6.5
1983 Ml. 7 . <*
1983 9.7 .7-31.1
1984
(27,7)
3-75
1986 3.5 0.3-22.2
1986
>7:8. 2-31
1987
, 102 5-385
Huriphrey<1983>
Levy(1977)
.
Lawton(1985)
.
Fischbein<1979);Wolff(1982)
Baker(1980);McCloskey<1978)
Smfth(1982)
Steele(1986
Smith(1982)
Smith(1982)
Apol(1980)
.
Lawton(1985)
Taylor(1989)
Fait(1989)PC
Fait(1989)FSC
Emmett(1985,1988);Hoseley(1984
Emmet t(1985,1988)Moseley(1984)
Chase(1982) Chase(1982) Pryor(1984)
Boxer(l982) Kominsky(1983)
.
Uilliams(1983) Acquavella(1986) Tirpak(1988) Christiani(1986) Currtfngs(l985) Cummings(1985)
stark(1986)
/.
stehp-Qreen(i986)
Brarkit-Rsuf(1988)
Hose)c(19.88). Singa|(1?88)
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DSW 189782
SUMMARY BLOOD LEVEL RANGES
GENERAL POPULATION ND TO 20 OR 30 ppb
WORKER POPULATIONS UP TO 3500 ppb
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DSW 189783
ANNISTON RESIDENTS ADPH RESULTS
LESS THAN 20 ppb
20-39 ppb
y.
GREATER THAN 40 ppb
TOTAL TESTED
RANGE: NONE DETECTED
DSW 189784
RESULTS ;;U;au
LESS THAN 20 ppb 20-39 ppb GREATER THAN 40 ppb
TOTAL TESTED
# PERSONS 17 6 12 35
RANGE: NONE DETECTED -180 ppb
' * ' / "i~-
DSW 189785
Years in Aroclor
STLCOPCB4042086