Document gDeDKZkx7QopEZyMeJZ5xV9xq
MINUTES of the two-hundred eightieth meeting of the 3oard of Directors of the Chemical Manufacturers Association, Inc. , held at the Gal eria Plaza Hotel, Itouston, Texas,' Tuesday, October 28, 1980, at . p. m.
Directors:
H. Bare lay Morley, Chairman
William G. Simeral, Vice Chairman
Richard C. Ashley
William G. Kay, Jr.
Dexter F. Baker
John Morrisroe
Charles E, Brookes
Paul F. Oreffice
Harry W. Buchanan
L. John Polite, Jr.
Carlyle G. Caldwell
Seymour S. Preston III
Robert S. Dudley
Toy F. Reid
Richard E. Engebrecht
William C. Roher
Louis Fernandez
Robert A. Roland
William J. Ferracone
John P. Sachs
Robert W. Gerwig
Harold A. Sorgenti
Arthur L. Goeschel
Alfred C. Stepan, Jr.
James B. Henderson
Allan J. Tomlinson
Richard J. Hughes
H. Kent Vanderhoef
William B. Jackson
Konrad M. Weis
Leo H. Johnstone
Harriette F. Witmer
Emerson Kampen
Louis G. Zachary
Secretary: General Counsel: Treasurer:
Bruce M. Barackman Edmund B. Frost Gary C. Herrman
By Invitation:
Warren M. Anderson, Union Carbide Corporation Geraldine V. Cox, CMA Richard F. Gold, Stauffer Chemical Company W. E. Kennel, Amoco Chemicals Corporation W, C. Krumrei, The Procter & Gamble Company James N. Sites, CMA William M. Stover, CMA
1. The meeting was called to order by Chairman Morley.
2. APPROVAL OF SEPTEMBER 8, 1980 MINUTES
Minutes of the September 8, 1980 meeting, as distributed, were approved.
CMA 012619
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Table 4.-- A Partial List of 65 Chemicals Designated as ^Priority pollutants
Arsenic Benzene Beryllium Cadmium Carbon tetrachloride Chlordane Chlorinated naphthalenes Chloroform 2-chlorophenol Dichlorobenzenes 2,4-Dimethylphenol 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Fluoranthene Heptachlor Hexachlorobutadiene Hexachlorocyclopentadiene
Lead N i trosamines Pentachlorophenol Selenium Silver Tetrachloroethylene
Thai1ium Trichloroethylene Vinyl Chloride
UJI1 j e5tl
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Table 6. -- Chemicals Having Substantia Carcinogenicity; CAG List
vidence of
2Acetylaminofluorene Acrylonitrile iCAC. IARC) Aflatoxins (FARC) Aldnn (CAG. NCI) 4-Aminbbiphenyl (IARC) Amitrole (IARC) --
Aramite (IARC)
1.2-Dimethylhydrazine (IARC)
Arsenic and Arsenic Compounds (CAG, IARC)
Dimethyl Suifate (IARC)
Asbestos iCAG. IARC)
2.4-Dimtrotoluene (CAG NCI)
Auramme and the manufacture of Auramine (IARC)
1.4- Dioxane (NCI)
Azaserme iIaRC) `
1.2- Diphenylhydrazme (CAG)
Benzie lacndine iIARC) 1
Epichiorohydrtn (CAG> ;
Benziaianthracene (IARC)
Ethylenebisduhiocarbamate (EBDC) (CAG)
Benzene (CAG. IARC)
Ethyleneimine (Aziridine) (IARC) 1
Benzidine (CAG. IARC)
Ethylene Oxide (CAG, IARC)
Benzol a (pyrene (IARC)
Ethylenethiourea (CAG, IARC)
Benzol bifluoranthene (IARC)
Ethyl Methanesulfonate (IARC)
Benzo(j >fluoranthene (IARC) 1
Formaldehyde (CAG)
Beryllium and Beryllium Compounds (CAG, IARC)
Glycidaldehyde (IARC)
N,.N-Bis(2-ChJoroethyl)-2-Naphthylamine (ChlomaphaTine) (IARC) '
Cadmium and Cadmium Compounds (CAG, IARC) Carbon Tetrachloride (CAG, IARC)
Chlorambucil (IARC) ' Chloroalkyl Ethers
HeptachJor (CAG, NCI) Hexachlorobenzene (CAG, IARC) Hexachlorobutadiene (CAG) Hexachlorocyciohexane (HCH)
HCH (CAG)
Bisi 2-chioroethyl(ether (BCEE) (CAG) (IARC) *
HCH (Lindane) (CAG!
Bisichloromethyl (ether (BCME) (CAG, IARC)
Technical HCH (CAG)
Chloromethvi methyl ether (CMME), technical grade (IARC)
ChJordane (CAG, NCI) Chionnated Ethanes
1.2-Dichloroethane (Ethylene Chloride, Ethylene Dichlonde (EDC)I (CAG. IARC. NCI)
Hexachloroethane (CAG) 1.1.2.2-Tetrachloroethane (CAG) 1.1.2- Trichloroethane (CAG, NCI, IARC) `
Chlorobenzilate (CAG)
Chloroform (CAG, IARC)
Hydrazine (IARC) Indenod,2,3-cd)pyrene <LARC) Iron Dextran (IARC) ' Isosafroie (IARC) Kepone (Chlordecone) (CAG, NCI) Lasiocarptne (IARC, NCI) MeJphalan (IARC) '
Methapynlene (FDA) 4 3- Methyichoianthrene ' 4.4'-MethyIenebis(2-ChJoroanilin) (MOCA) (IARC) Methyl Iodide (CAG. IARC) Methyl Methanesulfonate (IARC)
**
Chromium Compounds, Hexavalent (CAG. IARC)
N-Methyl-N'-nitro-N-nitrosoguanidine (IARC)
Chrysene (IARC) 1 Citrus Red No 2 tTARrit
Coal Tar and Soot (CAG included in IARC'j soots, tars,
and oils designation) Coke oven Emissions 1 Polycyclic Organic Matter (POM))
(CAG) Creosote (CAG) Cycasin (IARC) Cyclophosphamide (IARC) 4
MethylthtouraciJ (IARC) ' Mitomycin C (LARC) 4 Mustard Gas (IARC) 1- Naphthylamine, technical grade (CAG) 2- Naphthylamine (IARC) Nickel and Nickel Compounds (CAG, IARC) Nitrogen Mustard and its hydrochloride (IARC) Nitrogen Mustard N-oxide and its hydrochloride (IARC) 5-Nitro-o-totuidine (NCI)
Daunomycm (IARC) ' DOT (DichlorodiphenyltrichJoroethane) (CAG)
4- Nitroquinoline-i-oxide' Nitrosamines
I
Diallate (CAG) (IARC) Dibenzia.hlacridine (IARC)
N-Nitrosodiethanoiamine (IARC) N-Nitrosodiethylamine (DENA) (CAG. IARC)
Dibenzi a.j lacridine (IARC)
N'Nitrosodimethytamine (DMNA) (CAG, IARC)
Dibenz(a.hianthrace (IARC) 'H-Oibenzo<c.g)carbazole (IARC)
N-NItrosodi-n-butylamine (IARC) N-Nitrosodi-n-propvlamine (IARC)
7H-Dibenzo(e.g)carbazol* (IARC) Dibenzo(a,e)pyren (IARC) Dibenzola.hipyrene (IARC) Dibenzo(a.i(pyrene (IARC)
1.2- Dibromo-J-chlonjpropane (DBCP) (CAG, IARC, NCI) 1.2- Dibromoethane lEthvlene Bromide, Ethylene
Dibromide (EDB)] (NCI, CAG, IARC) 3.2'-Dichlorobenzidine (DCB) (CAG, IARC) Dieldrin (CAG) Diepoxybuune (IARC)
N-Niirosome(hvlethylamine tIARC) N-Nitrosomethylvinylamine (IARC) N-Nitroso-N-Ethylurea (NEU) (CAG. IARC) N-Nitroso-N-Methyiurea (NMU), (CAG, IARC) N-Nitroso-N-methylurethane (IARC) N-Nitrosomorpholine (IARC) N-Nitrosonornicotine (IARC) N-Nitrosopiperidine (IARC) N-Nitrosopyrrolidine (IARC)
N-Nitrososarcosine (IARC)
1.2- Diethylhydrazine (IARC)
Pentachloronitrobenzene (PCNB) (CAG)
Diethylstilbestrol (DES) (IARC) 4
Phenacetin (IARC) 1
Dihydrosafrole (IARC)
Polychlorinated Biphenyls (PCSs) (CAG, IARC)
3.3- Dimethoxybenzidine (o-Dianisidine) (IARC) P-Dimethvlaminoazobenzene (IARC) I.12-Dimethylbenz<a)anthracene 1
3.3'-Dimethy|benzidine (o-Tolidine) (IARC) Dimethvlcarbamoyl Chloride (IARC) il-Dimethyihydrazine (IARC)
Pranamide (CAG) 1.2-Propane Sultone (IARC) ,* Propiolactone (IARC)
Propylthiouracil (IARC) * Reserpine (NCI) ' Sacchann (FDA) `
CMA 012621
Safrole (CAG, IARC) Selenium Sulfide (NCI) Streptozotocin (IARC) * 2.3,7,8-Tetrachlorodibenxo-p-dioxin (TCDD) (CAG) Tetrachloroethylene (Perchloroethylene) (CAG, NCI)
Thioacetamide (IARC)Thiourea (IARC) o-Toluidine Hydrochloride (NCI) Toxaphene (CAG. IARC, NCI) Trichloroethylene (CAG, NCI) 2,4,6-Trichlorophenol (NCI) Tris( l-aziridinyl)phosplune sulfide (Thio-TEPA) (IARC,
NCI) Tris(2,3-dibromopropyl)phosphate (IARC, NCI) Trypan Blue, commercial grade (IARC) Uracil Mustard (IARC)
Urethane (IARC) (Ethyl carbamate; ethyl ester of car-
bamic acid) Vinyl Chloride (CAG, IARC)
Vinylidene Chloride (CAG)
' This is not a comprehensive list of all chemicals having substan tial evidence of carcinogenicity. Other chemicals will be added. No attempt has been made to select chemicals based upon ap propriateness for regulation by EPA. The list is intended to be a .oasts for selection by the various program offices according to their specific needs.
1 Well known carcinogen for which no report has been prepared by CAG or IARC.
1 Fungal toxin, not an industrially manufactured product ' Used as a drug. * Evaluated by IARC as not having sufficient evidence of car cinogenicity. ' Used as a foood.
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Table 7. -- Alphabetical Index of Chemicals Cited in the .NTP Annual Plan
Acetamide
25
Acetin
25
Acetohexamide 36
2-Acetyl aminofluorene
40
4-Acetyl aminofluorene
40
N-Acetylaminofluorene
40
Acetyl-o-toluidine
25
Acetylsalicyclic acid
36
Acid black
42
Acid orange #3
42
Acid red 25
68
Acrolein
25
Acrylamide
70
Agar agar
42, 55
Agaritine
42
Aldicarb 36, 5, 62
Allyl chloride 51
Allyl isothiocyanate
42
Allyl isovalerate
42
2- Aminoanthraqulnone
36. 51
3- Am1no-9-ethylcarbazo1e hydrochloride 51
3-Amino-a,a,a-tr1fluorotoluene
25
1-Amino-2-methylanthraquinone
51
2- Am1no-4-n1trophenol 42
2-Am1no-5-n1trophenol '
42
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Tris (2,3-dlbromo propyl) phosphate
67
Trls M.3-dlchlorolsopyl) phosphate
67
Tris(2-ethyl hexyl)phosphate
32, 50
Tris(Isopropyl phenyl)phosphate
34 -
o-Trltolyl phosphate
32
p-Tritolyl phosphate
32
z-Tryptophan
38
Urethane
40
Vitamin A
74
Vinyl chloride
65
Vinyl cyclohexane
50
Vinyl cyclohexene dioxide
61
Vinylidene chloride
1, 27, 50, 56, 60
Vinyl toluene
50
Violet 3
50
Wollastonite calcium silicates
34, 59
Witch hazel
50
m-Xylene
32, 73
o-Xylene
32, 73
p-Xylene
32, 73
Xylenes, mixed
59, 72, 73
Xylenesulfonic acid, sodium salt
50, 61
2,6-Xylldlne
61
Yellow #14
50, 56
Zearalenone
50
Z1 ram
50, 56
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CMA. 012624
CM& 0 1 2 6 2 5
H. C. Shah, Ph.D. Director
D* J* Doltaspb.a.
Project Coordinator
A. B. DeAngelo.Ph.D. Program Administrator
1 -"
A. Hoyd, B.A. Secretary
1 J. T. Seawell,B.S. 1 Program Administrator
1" M. De Marco, B.A. Secretary
C. R. Stack, Ph.D. Program Administrator
i; " L. Walton Secretary
--ftllyl Chloride Butylatod Hydroxytoluono
--Epoxy Resins --Glycol Ethers -----Ketones
--Hoh-Matallic Minerals
-"Acrylonitrile "Ethylene Dibromide --Phosgene Safety --Titanium Dioxide
Trichloroethylene
--Benrene --Chlorobensenea --Rubber Additives --Styrene --Vinyl Chloride --Zinc Dialkyl Dithio-
phosphates
--Phthalate Esters
inylidene Chloride
|,
1 riGURB 1. Organisation of Biomedical and Environmental Steels! Programs
1 J. C. Van Born,M.S. 1 Program Administrator
| D. T. Bilal Secretary
*--Fluorocarbons
1
cm 10/8/80
TABLE 8
BICMEDICAL AND ENVIROTMENIAL SPECIAL ERCGRAMS BUDGET*
PROGRAM Acrylonitrile Allyl Chloride Benzene
--
RESEARCH AND
advocacy commitment
$ 728,484 210,600
1,430,444
ADMINISTRATIVE EXPENSES
$ 59,411
13,948
83,526
TOTAL $ 787,895
224,548 1,513,970
Butylated Hydroxytoluene
21,944
25,213
47,157
Chlorobenzenes Epichlorohydrin Epoxy Resins
300,972 . 214,882
-0-
22,334 27,332
9,368
323,306 242,214
9,368
Ethylene Dibromide
10,000
28,836
38,836
Ethylene Dichloride
288,100
59,376
347,479
Glycol Ethers -0- -0- -0-
Ketones Phosgene Phthalate Esters
-0207,912 106,471
10,901 55,035 72,086
10,901 262,947 178,557
Rubber Additives Styrene Titanium Dioxide Trichloroethylene Vinyl Chloride Vinyl idene Chloride Zinc Dialkyl
Dithiophosphates Subtotal Fluorocarbons TOTAL
27,900 708,218
30,725 490,506 1,326,562 729,482
-0-
6,833,202 7,580,453 $14,413,655
5,867 54,934 14,615 77,152 112,958 52,088
a0ei
784,983 509,214 $1,294,197
33,767 763,152
45,340 567,658 1,439,520 781,570
-0-
7,618,185 8,089,667 $15,707,852
aFluorocarbons program from start thru May 30, 1980. All other programs start to September, 1980.
bAPI is co-sponsoring a portion of this research. Its share ($1,587,786) is not shown in this figure. The figure does include $303,388 paid to aitside legal counsel rot shown on the program summary in Appendix A.
48 9/22Z80 CMA 012626