Document gDdbBy1XmxZmeGgLmLo2LV3yQ

October 3* 1969 Or* A* R* Glasgow Chief of Reference Standards Section Residue Chemistry Branch Division of Pesticides Pood and Drug Admlnletretion Washington, I> C* 20204 Dear Dr* dlasgowt One pound samples of our Aroclors 1254 and 1260 are being forwarded to you and to Hr. Vincent Bedlak at the Atlanta Yaxioologlcal Branch today* Perhaps it will be of interest to sention that in 1962 on# of our consulting: laboratories determined the oral LD50 in rats of Aroclor 1254 to be greater than 10 grams per kilogram when administered undiluted using four groups of mixed sax animals weighing between 200*250 grams and administered at doses of 7*94# 10.0, 12.6, and 15*8 respectively for the Individual groups* The oral L050 was calculated as 11*9 g/kg with limits of 10.47 to 13.45 g/kg. Zn the case of Aroclor 1260, a 50$ solution In corn oil developed data leading to a calculated LD50 of 10.0 g/kg with lower and upper limits of 8.6 and 11.6 g/kg. X have enclosed summaries of recent data wa have received from Industrial Blo-Teet Laboratorita in . Chicago. The summaries indicate the 90-day intarla restate of two year chronic feeding studies to dogs of Aroclor 1254 and 1260. A second enclosure le the summary showing the status of three generation rat reproduction studies on these materials begun in Nay* Vs also have undarway two year oral studies in rats. We added 300 extra aaluale to this study to allow sacrifice of some animals at three months, six months and one year. DSW 018961 STLCOPCB4005505 Dr. A* R. Glasgow October 3, 1969 Pag Two A verbal report on the 90 day sacrifices indloates that there were no measurable effoots as Indicated by the usual parameter*. A written interim report will be received when the raloro pathology has been completed X have taken the liberty of sending a copy of this letter to you to Mr. Sedlak In the Atlanta Branch. We will be interested in learning of the results of your proposed toxicological testing. Sincerely. Elmer P. Wheeler Manager. Environmental Health EPWtJu c.c. b.c. Jack D. Early Vincent Sedlak R. E. Keller W. R. Richard DSN 018962 STLCOPCB4005506