Document gDRY8Z1y9nJo4ExDgnobGjrVV

CHEMSTAR NEWS [ H ( U I C A I Sill I U Ml 0 I f C H M I A I A D VO C A [ 1 AM H [ S i A N C H A I S I II I [ A Volume 3, No. June 1991 THE LONG HAUL: NEW TRANSPORTA ION RULES ROLL IN We think we can, we think we temational p;ackaging system. In converting to the international can, we know we can . . . Under the exis ing UJ5. system, system, U.S. manufacturers and CHEMSTAR Panels face chal- packages must meet specific con- shippers of hazardous materials lenges head on. Currently, struction guide!Jines. HM-181 re- must adopt uniform shipping CHEMSTAR Panels are tackling places "spedfic|aition" packaging descriptions, which will replace the weighty task of meeting new standards with performance ori- the former shipping codes. HM- and different shipping 181 revises the Hazard- requirements issued by -- ----. ous Materials Table of the U.S. Department of 49 CFR 172.102 to in- Transportation overthc past year. Two major DOT rulings addressing j . DOT rulings . addressing the transportation elude the mtornational shipping descriptions. TheTable listsapplicable the transportation of of hazardous materials, HM- classification and iden- hazardous materials, 181 and HM-1 will greatly tification number, label- HM-181 and HM-126C, affecf chgmi cal industry ing, bulk and non-bulk will greatly affect chemical industry ship s'h'ipping practices. * packaging designation for a wide array of haz ping practices. ardous materials. HM-181 The proposed rule, HM-181, pub lished in the Federal Register on December 21,1990, will harmo nize U.S. regulations with the in- ented packaging standards in which packages must pass one or more "performano:e" tests forcertification. When DOT revised the Table, many chemicals were reclassified, and therefore will have substantially different packaging and labeling require ments. Of 200 comments on the IN THIS ISSUE Spedal Thank*-----------------------------------------------3 OECD Wants You, EPA Wants You... To Volunteer........................................................4 MEDTREC--New Prescription for Safety ............. 5 ATSDR Tells What's Up niHHHIIIMWHUHtHMMUtlHHllll 6 EPA Proposes Testing in Bundles ......--......------ 8 SPOTLIGHT: Chlorinated Pool Chemicals................... 11 News Briefs12 People.... ..--......... People to Watch----New to CHEMSTAR Recent Releases Federal Register Notion.... Comments Final Reports____ Upcoming Event.... 13 15 15 16 18 [atiiicai MAiafAtimin Ananaiin ;sai m sum, > #aski111ot, i c mu hz/iimiii fa< m; id n11 CMA 03.1.064 CHEMSTAR NEWS rule, many focused on problems resulting from this reclassifica tion. The Methyl Bromide Panel filed comments on certain aspects of HM-181, among them, the re quired packaging changes. For example, in the ruling, DOT lim ited the cylinder capacity for methyl bromide. The Panel com mented that this limitation is un necessary, unjustified, and incon sistent with how materials ofsimi lar or greater hazard are treated in the rule. Bruce Jacobsen ofOlin, Chairman of the Chlorinated Pool Chemi cals Panel, noted that HM-181 af fects the shippers in additional ways. Forexample, the newpack aging regulations will greatly re duce, or perhaps even eliminate companies' opportunities for ex emption loads. Vendors, rather than chemical producers, likely will have to conduct the package certifications. In order for a company to be in compliance with HM-181, the material packaging, thebill oflad ing, and all shipping must be uni form. In addition, companies not yet in compliance may want to adopt a rotation policy to ensure that the older materials currently stored in depots and terminals have alreadybeen shipped before the regulations are phased in. Another concern ofCMA was that the U.S. public would not have ample time to comment to DOT before it adopts international regulations. DOT stated that it will address this issue in the future. Although HM-181 is not effective until October 1,1991, DOT autho rized compliance on January 1, 1991. However, DOT established several transition periods for meeting certain requirements. The only requirements in effect this year are classification and hazard communication regula tionsapplicable tonewexplosives, infectious substances, and mate rials poisonous by inhalation. Shipperscancontinue to usespeci fication packaging until Octo ber 1, 1996 for all materials ex cept those poisonous by inhala tion. Poisonous Inhalation Mate rialsmusthaveperformance pack ages by October 1, 1993. Manu facturers can continue producing specification packaging until Oc tober 1,1994. Jung 1991 Under HM-126C, shippingpapers must include a 24-hour contact for emergency response informa tion. Many companies have been usingCMA's ChemicalTraimpor tation Emergency Response Cen ter (CHEMTREC) as this contact for some time. CHEMTREC pro vides emergency response infor mation to over 12,000 shippers and carriers. Since HM-126C has been enacted, almost 5,000 com panies have registered with CHEMTREC. CHEMTREC re sources include emergency re sponsepersonnel, chemists, prod uct specialists, medical depart ments, and over one million Ma terial Safety Data Sheets. CHEMTRECalsocoordinates sev eral emergency response mutual aid groups trained t address emergencies involving several specific chemicals. The Hydro gen Fluoride Panel includes pro ducers and distributors who de veloped mutual aid agreements to ensure that expert emergency adviceon transportation incidents is available at all times. The Hy HM-126C drogen Fluoride Mutual Aid Group is made up of teams spe The second important rule, HM126C, addresses emergency responsecommunicationstandards. HM-126C requires that emer gency response information ac company hazardous material shipments. Many companies are using the Emergency Response cifically trained in responding to emergencies involving thischemi cal. The Panel has formed a Mu tual Aid Task Group to discuss and monitoremergency response activities, and a Transportation Task Group to address safe trans portation issues. Guidebook, which was developed by DOT to provide information on necessary first response ac tions for incidents involving hazardousmaterials. TheGuidebook specifically addresses the han dling ofmany CHEMSTARPanel chemicals. The newly reconstituted Vinyl Chloride Panel intends to form a similar Mutual Aid Netw rk un derCHEMTREC TheVinylChlo ride Transportation Network (VCNet) will be comprised of chemical company and for-hire response teams that can provide technical expertiseand assistance 2 CHA 03106 June 1991 during emergencies. Often a shipper's emergency response team is too far from the incident and cannot respond promptly. In such a case, the shipper would call CHEMTREC to request a VCNet member company to re spond at the scene. If another company cannot respond, the shipper, through CHEMTREC, will authorize a designated forhire response company to go to the emergency site. The shipper will reimburse the responding VCNet company or for-hire com pany for expenses. CHEMTREC works in tandem with CHEMNET, the CMA Chemical Mutual Aid Network, which provides shippers with ac cess to more than 250 chemical industry emergency response teams trained tojmitigate chemi cal spills, leaks, and fires. CHEMNET is activated by ship pers tha t are unal tie to respond to serious hazardou s material emer gencies in a tim jly manner be cause of proximity or availability of resources. Safer transportation is the ulti mate goal of both HM-181 and HM-126C. The challenge for CHEMSTAR Panels, and any shipper, isdevelop ingsmoothand efficient routes lo compliance. CHEMSTAR NEWS Panel members should be come familiar with the major requirements of the new rules and consider the utility ofany joint activities among mem ber companies. Contact your Panel Manager for details. For information on CHEMTRECactivities, allare welcome to contact Henry Sauer at 202/887-1254. For more information onHM-181, contact Michael Heimowitz at202/887-1360. Formorefur ther information on HM126C, contact Alma Howard at 202/887-1263. A. Kosko SPECIAL THANKS THE IMPORTANCE OF LEAVLINNGL ERNIES CHEMSTAR Policy Committee Chairman EarnestW.Deavenport Jr. of Eastman Kodak and ViceChairman Ernest H. Drew of Hoechst Celanese relinquished their positionsonJunel. Bothhad served fortwoyears,duringwhich they approved and oversaw sig nificantchangesinCMA manage ment services. First, theCommit tee inidated arenaming oftlw spe cificchemical special programs to CHEMSTAR P'aneeilss.,and gave the panels increased attention at the CMA Board level Next, at the Committee's requ st CMA mem ber companies designated specific chemical contacts lo aid informa tion flow when panel matters or regulatory issuesdictate a special need. Then, the Committee ap proved and referred to the CMA Board ofDirectors,theadoptionof the Business Council mechanism foraddressingspecial CMAmem ber company business sector or business function interests. The CHEMSTAR service is much changed, for the better, thanks to the efforts ofMessrs. Deavenport and Drew. Weoffermany thanks to them on behalf ofall who work forand withtheAssodation. Their efforts have made a difference for us all. We are glad that they con tinue to serve on the CMA Board of Directors. ... AND REMEMBERING MOMMA After 12 action-packed years, CMA Vice President and TechnicalDirector GeraldineV. Cox has decided to seek new challenges. In announcing her resignation, Geriy stated that "Working for CMA has given me a wealth of veryunique experience in the de velopment and management of science advocacy, public service programs, and issue research -- and I'm eager to use that experi ence in other areas." CMA Presi dent RobertA. Kolai id, inpraising her efforts to build an effective, credible technical nd research organization within the Associa tion, indicated that, "She has suc ceeded inthatmissicmbrilliantly. Under Gerry's ure as the "mother" of ARtheDi- vision has grown a handful ofspecial programs 53chemical panels. These have funded $64 million of so research byuniversities, govi tlabo- ratorie$,and independent research facilities around the world. In addition,Gerryhasaided thebirth of the business councils. In the firstyear, five councils have been established, with memberships ranging from eight to 30 compa nies. The staff and member com panies of CHEMSTAR will miss Gerry's expertise and her ability to crystallize the issues. We wish her great success in all future en deavors. L. Spurlock CHEMSTAR NEWS OECD WANTS YOU, EPA WANTS YOU ... To Volunteer June 1991 CMA is seekingvolunteers to sponsor chemicals for the Organization for Economic Cooperation and Development High Pro duction Volume Existing Chemicals Testing Pro gram. OECD designed the High Pro duction Volume Existing Chemi cals Testing Program to spread the burden of chemical testing among its member countries. Through information collection, evaluation, and testing, the Pro gram will develop an internation ally accepted data base. AScreen ing Data Information Set has al ready been designed for assess ing HPV chemical risks. SIDS tests include screeningstudies for toxicological effects, ecotoxicological effects, and envi ronmental fate and pathways. Although fourteen membercoun tries have agreed to monitor a proportionate share of the test ing, the actual studies will be con ducted by individual chemical manufacturers, except Japan, whose government will conduct the testing. The United States is committed to testing 25% of the chemicals identified by OECD. EPA will serve as the US. moni tor of the data. Many CMA mem OECD EXISTING CHEMICALS TESTING PROGRAM Schedule PHASE a PHASE * ADocaltonot 100 chemicals to Mvidual countries September 1991 ' Requests sent tor existing data on 50chsmtoato September 1991 December 1991 ber companies will participate in the Program (see CHEMSTAR News, Vol. 2, No. 1, March 1990; No. 2, June 1990; No. 3, Septem ber 1991; and VoL 3, No. 1 for background information). Dossiers of existing test data and testing plans for the first phase of the Program were approved in November 1990. CMA member companies have sponsored nine of 53 Phase I chemicals which are now undergoing SIDS testing. The US. quota for the second and third phases is 27 of 100 chemi cals. These chemicals will be allo cated formally in September. Eleven CMA member companies and twoCHEMSTAR Panels have indicated a willingness to test 21 of the latter chemicals tentatively assigned to the US. However, other countries also have solic ited lead responsibility for half of the U.S. requests. Therefore, CMAisseekingseveral more vol unteers to sponsor chemicals for Phases II and III. The overlap willbereconciledata futureOECD meeting. ' Basing data due to OECD * Data reviewed by OECD and SIDS plans proposed ` Dossiera reviewed by member counties and agreement reached on SIDS testing plana January 1992 e May 1992 September 1992 Apt! 1992 Augmf 1992 December 1992 A new schedule evolved from the OECD Extended Steering Group Meeting onExisting Chemicals in Paris on March 21-22. For chemi cals in Phases nand HI, thesched ule will be as shown in the adja cent box. ' SIDS tasting started ' SIDS testing completed December 1992 February 1994 March 1993 June 1994 The HPV chemicals will be tested according to priority categories --Pl,P2,andP3. Organic chemi cals tested in Phase I are in the PI 4 CMA 031 June 1991________________________________ category. In Phases II and III, chemicals may be selected from a reordered P1/P2 list of organic chemicals. Inorganiccompounds will be considered for testing in Phase IV. On May 6-8 in Berlin, the OECD held a meeting of the German/ Swedish Clearing House on Data Availability of Existing Chemi cals. The purpose of this meeting was: to catego rize new HPV chemicals recently submitted by OECD countries; to group the re maining Pi and chemicals to facilitate allocat on of country sponsorships in phases II and III; and, to review the SIDS dossiers of two German 'replacement" chemicals. These tasks were accomplished succ:e|ssfully. ___________ CHEMSTAJt NEWS A list of "W rking Chemicals," compiled from the old and new P1/F2 lists is n w available at CMA. For a copy of the list or information on participating in the voluntary testing program, contact Cecilia Spearing at (202)887-1305. C. Spearing MEDTREC -- NEW PRESCRIPT! >N FOR SAFETY Medical Treatment Emer gency Communications is a new industry initiative designed to improve medi cal emergency response in formation on chemicals and information exchange to key medical and first response pers mrtel. Com munityphysi are notalways familiarwith patii itmanagement involving indus il chemicals, Information of kind, if it ex- ists, is not easilyacj ressibleto these practitioners an is sometimes unclear, inconsisi or out of date. Enter which targets primary care physicians, corporate medical physicians, emergency personnel, and spe cialists in poison information. Poison control centers are seek ing ways to workwith industry to improve handling industrial chemical inquiries. CMA and the American Association of Poison PROTOCOLS FOR Ml iDICAL PLANNING Chemical* on die SA !IA Section304 list Alkaline Corrosive* Adds and Add Mists (Hydrochloric Add) Aliphatic Fuel Distillates (Gasoline) Ammonia Aromatic Hydrocarbon Solvents (Toluene) Arsine Carbon Monoxide Chlorinated Hydrocarbon Solvent* (Trichloroethylene) Cyanide Ethylene Oxide Formaldehyde Halogen Gases (Chlorine) Hydrofluoric Add Hydrogen Peroxide Hydrogen Sulfide Isocyanates (TDD Methemolglobin-indudng Compounds (Aniline) Methyl Bromide Nitriles Nitrogen Oxide* PestiddesOiganophosphates end Carbamate* (Parathion) Phenol Phoegene Phosphine Smoke Inhalation * Protocols In Progress; * Next For Protocol Development; '* Final Draft Soon to be Distributed for Review. CMA 031068 CHEMSJAR NEWS Control Centers are working co operatively to identify training needs and develop a self-admin istered training package formedi cal information response to in dustrial chemical emergencies. The new U.S. DOT Response Communication Standards re quires a 24-hour emergency con tact telephone number on all haz ardous materials shippingpapers. This contact must have knowl edge ofthe material's hazards and emergency response/incident mitigation information, or have access to a person with such knowledge. Many companiesuse CHEMTREC and poison control centers to meet this obligation. MEDTRBC plans to improve the communications network for emergency medical inquiries through existing CHEMTREC channels. Increasing awareness of the con sequences of hazardous material releases has resulted in new emer gency response requirements for hazardous industrial operations. Section304ofthe Emergency Plan ning and Community Right To Know Act of1986(SARA)requires "advice regarding medical atten tion necessary for exposed indi viduals" following a reportable release of an extremely hazard ous substance. The Agency for Toxic Substances and Disease Registry is address ing the need for medical manage ment information on hazardous chemicals. ATSDR contracted June 1991 with DeLima Associates in Cali fornia to produce detailed proto cols for emergency medical man agement of patients adversely af fected by exposure to chemicals. Under this agreement, protocols will be developed to meet medi cal planning requirements for chemicals listedunder Section 304 of SARA Title ID. The first 25 protocols havebeen identified (see box on previous page). Information, training, and com munications are steps to help in dustry and the community pre plan for effective medical emer gency response. These are basic goals of the MEDTREC initiative. For further information, contact Elizabeth Gormley at 20218871194 or Karen Creedon at 202/ 887-1384. K. Creedon ATSDR TELLS WHAT'S UP Under SARA Title I, the Agency for Toxic Substances and Disease Registry is required to develop a list of the most hazardous sub stances found at National Priority List Sites. The Agency is then to reviewtoxicological data on listed chemicals, and develop research programs to collect data needed to perform health assessments at these sites. Development of re search programs is to be coordi nated with EPA and NTP (see CHEMSTAR News, VoL 2, No. 4, December 1990 for background information). SARA required that 100 substances be listed in 1987 and 1988 with an additional 25 substances listed in each of the next 3 years. On April 29, ATSDR held a public meeting to review its progress and discuss plans for fulfilling its statutory obligations. The Agency highlighted the follow ing areas: LISTING ATSDR has listed 250 priority substances. The final list of 25, required under SARA, is sched uled to be published in October 1991. ATSDRplans to reprioritize the list of 275 chemicals at the same time. The ranking criteria, which is a combination of poten tial hazard and exposure, will be published at the end of June. PILOT SUBSTANCES In 1990, ATSDR published an ex ample exercise to identify data needs using fourpilot substances: carbon tetrachloride, chloroethane, isophorone, and phenol. Comments on the pilot exercise raised generic issues on data needs. ATSDR plans to publish replies to these issues. An ex ample carbon tetrachloride docu ment will be available from the Agency for review. Responses to chemical specific issues raised in the pilot exercise will be available through the docket From the exercise, ATSDR estab lished four principles: 1. The decision logic document will be expanded to meet the 6 CMA 031069 June 1991________________________________ needs for a TSCA Section 4 finding. 2. Special test guidelines and ex* pandeddescriptions oftest re quirements will not be pro vided. Rather, ATSDR envi sions using TSCA test guide lines where they exist. For non-TSCA tests, parties inter ested in conducting the tests will submit protocols for re view by ATSDR, EPA, and NTP. 3. ATSDR will not tier exposure testing ahead of health test ing; ATSDR finds both types of testing necessary and of high priority. 4. ATSDR will require tests by the major route of exposure around NPL sites. Toxicokinetic informationwill be used for extrapolation or to change priorities for second ary routes of exposure. used the following principles'. 1. Analytical methods are high priority. Ifmethods are avail able, determination of envi ronmental arid human expo sure levels are high priority. For substances with known toxicity and exposure, bioavailabilitj 'studiesarehigh priority. Similarly, if species differences are significant, physiological based pharmacokinetic mojdelling is high priority. 3. Studies to develop target or gan and dose response infor mation, if not already avail able, are high priority. 4. Emphasis will be placed on mechanistic, epidemiology, and mitigatib;n of toxicity studies where there is known high toxicity aind exposure. CHEMSTAR NEWS ATSDR will gather "A" priority data needs on the first 38 sub stances, followed by "B" needs, before moving on to substance 39 and beyond. DATA NEEDS A Federal Register notice will be published identifying the "A" priority needs for the 38 sub stances. Companies will have 90 days to volunteer to sponsor the testing,before EPA issues a TSCA Section 4 test rule. Data needs for chemicals not covered under TSCAwillbe subject to an ATSDR research program. ATSDR plans to fund its testing program by an indirectchargeadded to the clean up cost at NFL sites. A Federal Register notice describing cost re covery will bepublished this year. For more information on ATSDR activities, contact Dr. Elizabeth Moran at 202/887-1182. E. Moran Two of the pilot substances, car bon tetrachloride and chloroethane, are among 38 pri ority chemicals selected fordevel opment of a research program. Phenol and isophorone are de ferred since they are not among the top priority chemicals in the new ranking system. RESEARCH PROGRAMS The 38 substances for which re search programs will be devel oped are expected to remain among the top 50 after the reprioritization exercise. Foreach substance, ATSDRassignedadata need priority. "A" is high prior ity, "B" is low priority, and "C" is not a priority at this time. In assigning these priorities, ATSDR 38 SUBSTANCES FOR ATSDR RESEARCH PROGRAM DEVELOPMENT Ancnic Aldrin/DMdrin Beryllium Cuban Tetrachloride OloraMhuc CUemfom Cyanide W>'-DDT. DDE. DDD Di(24thylhciy1)pfathalat* Mercury Methylene Qiloride Nickel PAHe: Acenaphthylene Besuo{a)anihncane Benjo(e)pyrea Banzo(b)flDoraiiihi< Bcnzo<(Ju)perylene Bnio(10fluomnthee* Quyaeoe Dtbenzo<aJi)anihmcene Fluornaothene Fluoren* IndeacK l,2J-cd)pyrene ffranaruhrena Pyrene Polychlorinated Biphenyl Compounds Arador-1260, .1254. -1241. .1242. .1232, -1221, and -1016 Tdradtlorocthylenc Toluene Trichloroethylene Vinyl Chloride Zinc Federal Register Notices on SARA Section 110 Schedule Coet Recovery Regutolbne Reply to Common* on Pilot Exarch* .. .... _ NewCriterietorlWng--------------------- -----Reeeerch Program on 31I Priority Gtentcto New Uet end ReprioritbLd Uet Rewrite of First 25 ToricotogicalPmSee___ June-September 1991 June- September 1991 .June 1991 -AugueMMI ..October 1991 .October 1991 7 CHEMSTAR NEWS EPA PROPOSES TESTING IN BUNDLES June 1991 OnMarch 4, EPApublished anuttusualproposed TSCA Section 4 rule requiring testing of several chemi calsfordevelopmental and reproductive effect end points and neurotoxicity testing (see this Newsletter, FR Notices). Developmental/repro ductive and neurotoxicity testing are proposed tor twelve and ten chemicals,respectively. TheCMA Health and Safety Committee, and several CHEMSTAR Panels, as well as the American Industrial Health Council filed comments on the rule on June 3. CMA and AIHC closely coordinated each step ofdeveloping thecomments. CHEMSTAR Panels that submit ted comments include: Acetone, Alkylphenol and Ethoxylates, Carbon Disulfide, Diisocyanates, Glycol Ethers, Ketones, Oxo Pro cess, Trimellitate Esters, and Toluenediamines. Highlights of these comments are listed in the box on the next page. CMA GENERIC COMMENTS CMA comments endorsed the* concept of the endpoint rule, but recommended that: supportable criteria be devel oped for identifying sub stances for endpoint testing; the basis for selecting indi vidual test substances be fully explained; 9 substances selected only be cause of large production vol ume and exposure potential be screened using the OECD Screening Information Data Set battery before being con sidered for endpoint testing; substances previously tested under TSCA not be added to endpoint rules in the absence of new data or scientific de velopments; and, EPA request exposure and toxicity information from in* dustry before initiating an end-point rulemaking. CMA questioned whether EPA's screeningcriteriaforthe end-point rules will effectively identify high priority candidates for testing. Of particular concern was EPA's ex clusive reliance on the gross indi cators of exposure (such as the size of the affected workplace population and the presence of chemicals in consumer products) to select substances for neurotox icity testing. CMA recommended that EPA give greater weight to the intensity, duration, and fre quency of exposure, since these factors will determine whether substances with neurotoxic po tential pose a significant risk to workers or consumers. Toxicity considerations and exposure fac tors also should play a role in selectingsubstances forneurotox icity testing. Fordevelopmental/reproductive toxicity testing, CMA recom mended that neither structure activity relationship, nor in vitro screening data, nor an uncon firmed TSCASection 8(e) submis sion solely be used as criteria for selecting substances. CMA sug gested using a tiered testing scheme to give EPA the option of requiring screening assays as the first step in evaluating end-point chemicals. In addition, CMA re quested that EPA make final the Agency's policy for exposurebased findings, (as required by the Fifth Circuit Court of Appeals in the cumenecase), before taking final action on neurotoxicity end point testing in this rulemaking. The CMA submission also sug gested that EPA relate exposure scenarios to toxicological concerns as a means of determining an unreasonable health risk before taking final action under TSCA Section 4 (a)(1)(a). CMA urged EPA not to reject pre vious studies that may not meet current test guidelines but are adequate for determining developmental/reproductiveand neu rotoxic risks. Furthermore, CMA commented that EPA should not overlook reported negative effects studies. For substances whichare tightlycontrolledin the workplace because of concern about other endpoints, as CMA pointed out, it is doubtful that additional test ing will change risk assessment and risk management decisions. CMA identified the critical need for EPA to issue its guidelines for neurotoxicity risk assessment be- 9 CMA 0310/1 June 1991______________________ __________ fore the completion of testing un der the proposed end point rule. The guidelines should take into account the importance of dose factors, the difference between primary and secondary neuro toxic effects, and the lesserdegree of concern associated with tran sient and reversible effects. The CMAcomments endorsed the extensive comments filed by AIHC on EPA's proposed neuro toxicity testbattery. CMA pointed out that the Scheduled Controlled Operant Behavior test is of lim ited scientific value for these end points and may not be feasible as an inhalation study. If EPA re tains the SCOB test, adequate laboratory capacity will not be available to permit full compli ance with the neurotoxicity nile under the proposed test sched ule. Finally, the comments reinforced the observation that many large volume chemicals which are sub ject to EPA's proposed rules need a de minimis exemption from ex port notification requirements under TSCA Section 12(b). CMA urged the Agency to require one time exportnotifications forcoun tries to which Section 4 chemicals are shipped. EPA has not yet responded to these comments. Stay tuned for the update! For further information Panel members should contact their Panel Managers. Copies of the general CMA comments may be obtained by contacting Sandra Tirey by telefax at 202/887-1237. H. Shah CHEMSTAJt NEWS TSCA END-POINT RULE HIGHLIGHTS OF CHEMSTAR PANEL COMMENTS ACETONE The Acetone Panel argued that based on existing data (including data overlooked by EPA), the chemical should be excluded from the proposed test rule. EPA ex cluded othersolventsfromdie pro posed rule that [had comparable data. The Panelajsorecommended that EPA review studies on isopropanol, since it is metabolized almost exclusively to acetone, be fore identifying any data needs The Panel asked the Agency to justify TSCA Sections 4(aXlXa) and 4(aXlXb) findings foracetone. ThePanel stated thatifEPA feels that neurotoxicity testing is nec essary after reviewing aU avail able information, the Agency should adopt a tiered testing ap proach, but notjndude the pro posed Schedule Controlled Oper ant Behavior Test in the final rule. As its rationale, the Panel cited the reasons identified in the CMA and AIHC comments. ALKYLPHEN >L AND ETHOXYLA TheAlkylphenol ndEthoxylates Panel comments that EPA overestimated the po ntial for expo snretododecylpl und. The Panel believes that th data from one species, the rat, i dicates that an adequate margi of safety exists forexposedindivi luals. The Panel recommended th t EPA remove dodecylphenol |m the final end* point rule for d elopmental ef* facts testing. CARBON DISULFIDE The Carbon Disulfide Panel com mented that EPA has failed to make the thresho dfindingundar TSCA Section 4<aXlXAXi), and thus a test rule for developmental and reproductive effect studies of carbon disulfide in not warranted at this time. Thii cited environ mental exposure < lata contain nu merous errors aid are not ad equate for concluding that expo sure to carbon disulfide may present unreasonable reproduc tive and developmental risks to humans. Because the record does not support a finding under Sec tion 4(aXlXAXi) that carbon dis ulfide may present an unreason able risk, EPA's other findings identified in the proposed rule do not apply. If EPA determines that additional testing of carbon disulfide is necessary, the Panel recommended a tiered testing scheme. The Panel noted that the proposed testingfor carbon disul fide does not provide for screen ing assays before full-scale test ing it initiated. GLYCOL ETHERS The Glycol Ethers Panel recom mended that the Agency remove 2-ethoxyethanol from the list of chemicals selected for neurotox icity testing because: (1) EPA greatly overstated the potential forhuman exposure by relyingon inaccurate and outdated data and fay failing to recognize the ex tremelylowworkplace exposures; (2) imminent regulations of 2ethoxy ethanol by OSHA will fur ther reduce the risk of occupa tional exposure and will render the proposed testingprogram un necessary and irrelevant; (3) tox icitydata adequately demonstrate that the chemical poses no risk of neurotoxicity at expected levels ofexposure; and (4) generally, 2ethoxyethanol does not meet EPA's own criteria for inclusion in this test rule. KETONES The Ketones Panel commented that EPA overlooked numerous studies on methyl isobutyl ke tone which address the potential for MIBK to cause neurobehavioral or neurotoxie effects. The studies show that MIBK may cause mild, transient, pharmaco logical effects whichreverse upon cessation ofexposure. Also, data 9 CMA 031072 CHEMSTAR NEWS TSCA End-Point Rule Panel Comm nts (Cont) on MIBK are comparable to the results which would be derived from the proposed neurotoxicity testbattery, (exceptfor the SCOB test, which should not be included in the array of tests proposed). Further, the Panel recommended that EPAjustify its requirements under TSCA Sections 4(aXlXA) or4(aXlXB). OXO PROCESS The Oxo Process Panel commented onproposedtestsforseven chemicals: 2-methylpropanoic acid (isobutyrie acid), 2ethylhexanol, n-amyl acetate, 1butanol, 1-butyl acetate, ethyl acetate, and isobutyl alcohol. The Panel noted that EPA has not sufficiently justified its Section 4 findingsfor any ofthe oxo process chemicals. Furthermore, even with appropriate findings, the Panel believes that not all seven chemicals should be subject to testingrequirements. The Panel also expressed concern about the . scope of testing required under the proposed neurotoxicity test rules. TOLUENEDIAMINES The Toluenediamines Panel commented thatEPA's exposurefindings were based on CMA comments in 1982 and a study by NIOSH in 1980. These are not representative of current employee exposures. Further, be* cause of2,4-toluenediamine suepectedcardnogenieity.producer* and users have adopted various means to limit exposures to the lowest levels possible. The Panel also addressed the issue of genoral population exposure that the Agency had calculated based on 1984 and 1977 data. The 1988 TRI database indicates that re leasesof2,4-toluenediamine to air and water are less than 10% of EPA's estimate. Hie Panel coneluded that, based on the current data, there is no reason to believe that the small releases to air and water result in any significant human exposures. With respect to the health effects finding, the Panel concluded that the studies cited by EPA contain no evidence ofhuman healthrisk in the workplace. ____ TRIMELXJTATE ESTERS The TerephthalicAnd Task Group of the Trimellitate Esters Panel commented that reproductive effacts testingfor terephthalic add is unnecessary based onexposure data. EPA relied on the 1987 Toxic Releases Inventory database to prove that releases to air andwateroccur, ratherthan identifyingexposed populations or es- timating the level, frequency, or duration of possible exposures, EPA had previously concluded that human exposures to terephth&lic add from air or water toleases are quite low beyond fadlity boundaries. The Panel com mented thatEPA's"unreasonable risk* finding was based solely on one study that did not provide any evidence ofdevelopmental or reproductive toxicity atlevelsthat may occur in the general population. Furthermore, EPA omitted additional studies showing that terephthalic acid presents a low riskfor developmental and reproductive toxicity, June 1991 JO CMA 03107 June 1991_________________________________ ture workshops, contact Carol Stack at 202/887-1196. CEFIC AND PE PANEL TEAM UP AGAIN (BERLIN, May 29) Representatives of the Phthalate Esters Panel attended the third annual joint meeting of the Panel with the Technical Committee Plasticizers, a part of the CEFIC Plasticizers Sec tor Group. Panel members gave presentations on their environ mental testing program, recent advocacy efforts with FDA con cerning DEHA in food film. and actions ticward possible Clean Air Act d^listing ofsome phthalates. Pii:rtidpants dis- cussed the im of ATSDR and OECD tes ting programs on phthalates. Regroups also addressed the ARC meeting, to be held in Jiine, which will evaluate mechknistic data on di-2-ethylhexyl phthalate. The groups ph:n to hold the nextjointmeetijigintheU.S.in 1992. Formore information on PhthalateEsters,;, contactMarion Stanley at 2021887-1207. CHEMSTAX NEWS EOIC HIRES CUT (Washington, DC, June 5) The Ethylene Oxide Industry Council signed a contract with the Chemical Industry Institute of Technology to develop a pharma cokinetics model for ethylene ox ide. Theresearch willspana threeyearperiodbeginning in 1991. The study will develop a preliminary rat and mouse model, and ulti mately, a pk-human model. In addition, CUT will determine chemical parameters, reaction rates, and metabolites as needed. For further information, contact Dr. Robert Romano at 202/8871198. PEOPLE THE NEW "C" TEAM The new Chairman of the CHEMSTAR Policy Committee is Seymour S. Preston, III of ATOCHEM North America and the new ViceChairman is Peter R. Heinze of BASF. Both members of the CMA Board of Directors were appointed by the Board to serve terms beginning on June 1. They join CMA staff Vice Presi dents Gordon D. Strickland, Gary C Herman and David F. Zoll as members of the Commit tee whose responsibility is over sight of the CHEMSTAR man agement policies. We look for ward to excellent leadership from Messrs. Preston and Heinze. JOHN JUMPS IN, JIM JUMPS OUT The Phthalate Esters Panel wel comes its newest member, John Bankston of Aristech Corpora tion. He replaces James Santary, who served as Pianel Chairman in 1990. Prior to joining Aristech lastyear. Bankston was employed at Mobay Corpjoration for 15 years. His knoivledge of business and regulatory compliance will be an asset t? the Panel. We look forward tc working with John. Bestofluq: to Jim in future endeavors, and many thanks for fine contributions to the PaneL BENTLEYR TIRES Dr. Edward Bentley retired from both Texaco and CMA activities in June. Bentley lias provided ex ceUentcontributiionstoll CHEMSTAR Panels sin:i:e 1979. At the time of his dep|arture, he was Chairman of the Alkanolamines Panel and mem' >er of the Butadiene, Cyclohe:xane, Ethylene Glycol and Ethyj ene Oxide Panels. Ed will be missed by conv pany representatiives and CMA staff alike for his outstanding ac- complishments, industry knowl edge, and cheerful and friendly nature. Best wishes to Ed in his well-deserved retirement! LYNAM LEAVES Dr. Donald Lynam of Ethyl re signed as Chairman of the Brominated Flame Retardant Industry PaneL The Panel thanks Don for his guidance over the past year. Dr. David McAllister of Great Lakes and Dr. Marcia Hardy of Ethyl will serve as Chairman and Vice Chairman, respectively. We look forward to continuing excel lent leadership! GLICKMAN MOVES ON Andy Glickman retired as Chair man of the Environmental Re search Work Group of the Petro leum Additives Panel due to his promotion to CoordinatorofToxic Substances Control of Chevron. 13 CMA 03:1.074 CHEMSTAR NEWS The Panel thanks Andy for his superb leadership over the past four years. Good luck, Andy! DON'T MESS WITH BROWNING Marilyn Browning, CMA Asso ciate GeneralCounseland CHEMSTAR Counsel for four years, re signed from the Association on May 31 to move to Houston, TX. Marilyn was responsible for gen eral legal oversight of all CHEMSTAR Panels and Business Coun cils. She also acted as supervisor of all outside legal counsels re tained by the panels and coun sels. During her tenure, Marilyn developed the extensive contract and agreement formats necessary for safeguarding member com panies entering TSCA Section 4 and F1FRA testing programs. She also represented panelsinnegoti ating a multitudeofcontracts with laboratories, companies and aca demic institutions. Marilyn has joined her husband, also an attor ney, in Houston whereherecently became a member of a law firm. She currently is seeking a posi tion in the Houston area (member companies take note). Many, many thanks to Marilyn for an excellent job, and the best of luck in finding a challenging new po sition. ENTER ONDOCSIN RobertOndocsin (ON-DOSS-IN), CMA Counsel and former Coun sel to the CMA Engineering and Operations Committee and Health and Safety Committee, was appointed on June 1 to re place Marilyn Browning as CHEMSTARCounsel. Like Mari lyn, Bob will be responsible for general legal oversight ofall Pan elsand Business Councils, includ ing legal review of documents, antitrust counseling, contract re viewand management ofretained counsels. Bob has been at CMA since 1989. His focus with the CMA standing committees and their task groups has been on an titrust and general liability coun seling, contract oversight and OSHA regulatory advocacy. Be forecoming to CMA, Bob worked in safety and health management positions at Union Carbide and PPG Industries. He holds B.S. and MS. degrees from the Uni versity of Pittsburgh. Bob is a member of the New York and Connecticut Barsand receivedhis J.D. from Pace University. We look forward to excellent coun seling from Bob! June 1991 NEW PANEL MANAGER Kathleen Roberts joined CMA and theCHEMSTAR Division staff in April 1991. She is responsible for the management of the Hexamethylene Diisocyanate, Ethylene Glycol, Chlorinated Pool Chemi cals, and Fluoroalkenes Panels. Priorto joining CMA, Roberts was a Product Manager with Jellinek, Schwartz, Connolly, and Fresh man, Inc. Previously, she was a Laboratory Technician for Hazelton Laboratories America, conducting inhalation and genetic toxicology research. Kathleen holds a BS in biology from theUniversity ofNorthCaro lina at Chapel Hill. We welcome her and look forward to great management. ANOTHER RISING STAR To celebrate her first anniversary with CMA, Marian Stanley was promoted to Senior Panel Man ager. Marian came to the CHEM STAR Division in May 1990 to manage the Specialty Acrylates/ Methacrylates Panel and the En vironmental and Toxicology Re search Task Groups of the Phthalate Esters Panel. During the past year, she has assumed the man agement responsibility for the full PEPaneland itsothertaskgroups. Marian holds a MBA in Pharma ceutical Studies from Farleigh Dickinson University and a B5. in Chemistry from Pratt Institute Congratulations to Marian on her promotion! 14 CMA 03107 Jum 1991 CHEMSTAR NEWS SPOTLIGHT This is the twenty-second article in a series which highlights the activities of the various CHEMSTAR Panels. The Chlorinated Pool Chemicals Panel formed in 1989 to promote safety in themanufacturing,packaging, transportation, storage, and use of chlorinated oxidizers used for pool water purification. Panel members include produc ers of calcium hypochlorite and chlorinated isocyanurates world* wide. Current members are ATOCHEM North America, Fer tilizers & Chemicals, Monsanto, Nissan Chemical, Nisso America, Olin, PPG, Saskatoon Chemicals, Shikoku Chemical, and 3-V. The Panel Chairman is BruceJacobsen of Olin. EMERGENCY RESPONSE EDUCATION Chlorinated pool chemicals are highly reactive oxidizing agents which canbecome unstableifmis handled, improperly stored or contaminated. In order to edu cate and train firefighters and other emergency response per sonnel, the Panel has produced a bulletin and videotape on proper procedures for storing and han dling of chlorinated pool chemi cals. The videotape addresses the procedures forrespondingtofires involvingchlorinated poolchemi cals and provides information on protectiveequipmentand cleanup procedures. The videotape and the bulletin haveb^en distributed in the U.S., Japan, and Europe. TESTING In response to a proposed reclas sification of oxidizers in NFPA 43A, "Code for Storage of liquid and Solid Oxidizing Materials" the Panel is explori: ig the conduct of small - and large - scale testing on pool chemicals. The testing will assess burn rat s and provide information to users for ware housing and packaging of pool chemicals. Olin is a inductingpreliminary laboratory testing and the Panel will dearie how to pro ceed afterreviewin;; this informa tion. CHLOROFORM MEASUREME The Panel will r research in California this erto mea- sure chloroform [eleases from swimming pools, study is in response to the lifomia Air Resources Board's :oncem about chloroform emissiol in the state, and the potential ting of the chemical as a to: air contami- nant. CARBiden swimming pools that are dis ected with chlorine-containin chemicals as sources of indirect chloroform. The Pi luction of $ research program will measure chloroform emissions associated with swim ming pools under various condi tions in order to evaluate the po tential "health risks" to people living nearby. The Research Task Group, chaired by Bonnie Sandel of Olin, currently is developing a test protocol to be submitted to CARB for approval. TRANSPORTATION The Transportation Task Group, chaired by Kenneth Lee ofPPG, is finishing a bulletin which con tains guidelines for transporting calcium hypochlorite and chlori nated isocyanurates. Thebulletin is intended for shippers of pool chemicals and personnel respon sible for in-transit storage, and will include information on perti nent federal transportation regu lations. This bulletin will be pub lished withinthe next few months. Barbara Francis has served as manager of the Panel since its formation, but will be succeeded by Kathleen Roberts in the near future. Kathleen can be reached at 202/887-1146. ll CHEMSTAE NEWS NEWS BRIEFS Juru 1991 CPSC PROPOSES LABELING RULE (Washington, DC, April 17) The Consumer Product Safety Commission issued a proposed rule on labeling requirements for Art Materials and other Products Subject to the Federal Hazardous Substances Act, guidelines forde termining chronic toxicity, and a . supplementaldefinition of"toxic" (see FR Notices, this Newsletter). The proposed rule covers label ing of all consumer products for chronic hazards. Although issued under the Labeling of Hazardous Art Materials Act, the guidelines also will be applied in enforce ment actions under the FHSA. This act regulates hazardous sub stances . . intended, or pack aged in a form suitable, for use in the household or by children." CPSC classifies carcinogenicity, neurotoxicity, reproductive and developmental toxicity as "chronic hazards" that must be identified on product labels. The CMA Health and Safety Commit tee is taking the lead in preparing comments. The CPSC rule will impact sev eralchemical-specificPanels. The Crystalline Silica Panel is work ing with the Product Safety Task Group to develop arguments' against the use of yet another au tomatic trigger. Comments were due in July 1991; however, CMA has been granted a 90-day exten sion, which is still pending Com mission action. For more infor mation, contact Elizabeth Gormley at 202/887-1194 or Claudette Cofta at 202/887-1278. BUTADIENE RESEARCH UNDERWAY (Washington, DC, May 14) The Butadiene Panel initiated a four-year $1.5 million research programaimed at understanding the mechanism of action and spe cies differences in response to 13butadiene. The Panel's goal is to develop data thatmoreaccurately predicts the potential risk to hu mans. TheResearch Program will be conducted at three facilities: The University of Colorado, the University ofNorth Carolina,and the Inhalation Toxicology Re search Institute in Albuquerque, New Mexico. Butadiene is a commodity chemi calusedintheproduction ofpoly mers and synthetic rubber. Re cent carcinogenicity bioassays show that the chemical is a potent carcinogen in the B6C3F1 mouse but a weak carcinogen in the Sprague-Dawley rat The differ ence in carcinogenic susceptibil ity must be understood in order to assess risk to humans. The University of Colorado pro gram will focus on species differ ences in susceptibility to leuke mia/lymphoma associated with chronic exposure of the B6C3F1 mouse to butadiene. Research at the University of North Carolina will examine the ability of buta diene and its metabolites to in duce mutations, and will deter mine molecular events that cause these mutations. The ITRI pro gram will focus on how differ ences in metabolism ofbutadiene in mice, rats, monkeys and hu mans relate to differences in sen sitivity to the carcinogenicity of butadiene. Formore information, contact Butadiene Panel Man ager,Dr. Elizabeth Moran, at 2021 887-1182. PA PANEL HOLDS FIRST WORKSHOP (San Antonio, TX, May 21) The Petroleum Additives Panel sponsored a Product Approval Code of Practice Workshop for those interested in candidate en gine oil performance testing. The 85 registrants included engine test schedulers, formulators, test en gineers, test or approval program administrators, and research su pervisors. The Panel developed the Code of Practice to help en sureconsistency in testing as per formance specifications of engine lubricantadditives are evaluated. The workshop emphasized ele ments of the Code that address test registration procedures and test stand selection. SeveralTaskGroup membersc ntributedto thesuccess ofthe work shop. Henry K. Newhall of OroniteChevron Research and Tech nology presented an overview of the Code of Practice. Richard Ritchie of Amoco Petroleum Ad ditives led the session on test reg istration procedure, and Rick Oliver of Texaco Additive Com pany led the session on test stand selection. In light of the wide interest, the Panel plans to hold additional workshops to introduce the Code to other interested and affected parties. For information on fu ll CMA 03107 June 1991 NEW TO CHEMSTAR CHEMSTAR NEWS ACETONE PANEL The Acetone Task Group formed under the Ketones Panel in early 1990 to address concerns of ac etone manufacturers, processors, and users. In April, Task Group members decided, because of the complexity of issues, to discon tinue the TaskGroup and form an Acetone Panel. Recently, the Ac etone Panel submitted comments to EPA on the proposed TSCA Section 4 end-point rule for neu rotoxicity. In addition, the Panel is preparing a toxicological review to assist the National Sanitation Foundation with evaluating sol vent cements. Currently, the Panel is co-fund ing a research project with the Coordinating Research Council, California Air Resources Board, theSouth Coast AirQuality Man agement District,and theNational Aerosol Association. Under this cooperativeprogram, theUniver sity ofCalifornia at Riverside will conduct studies of atmospheric reactivities of volatile organic compounds, including acetone. The Chairman of the Acetone Panel is Philip Casterton of Shell Chemical Company. Forfurther information on Panel activities, contact Panel Manager Barbara Francis at 202/887-1314. LABORATORY AND RESEARCH chemicalsI COUNCIL Representatives of nine produc ers of laboratory and research chemicals formed a new Business Council under CHEMSTAR. The Laboratory and Research Chemi cals Council willaddressconcerns specific to itssegment ofthechemi cal industry and comment on regulatoryand leg islative propos als affecting its sector. Javid Bashir of Fisher iidentific is the Council Chairman. For more in formation, contact Dr. Elizabeth Moran at 202/8871182. TOLUENEDIAMINES PANEL The Toluenediamines Panel was reactivated in April in response to the TSCASection 4 proposed rule (see FR Notices, this Newsletter) requiringmulti-substance testing for developmental and reproduc tive toxicity. The Panel will de velop advocacy positions and the Toxicology Research Task Group will design research on the poten tial effects of 2,4-toluenediamine on health and the environment. Panel membercompanies include Air Products and Chemicals, BASF, IQ Americas, Mobay, and Olin. The Panel Chairman is James LaPrad of BASF. For more information, contact PanelMan ager Cecilia Spearing at 202/8871305. PEOPIM TO WATCH .,. Kudos to Qaude Wolf, Chairman of the Bioddes Panel, who presented smashing testimony to the House Agricu Iture subcom mittee on cos;and time ex penditures fcr the biodde registration process under FIFRA . . . applause for Henry Newh, ill ofOroniteChevron, Richard Ritdde of Amoco and Ride Oliver ofTexaco Adc litive who led excellent sessi<onsatthePetroleum Additives Panel's Product Approval Code of Practice Workshop . . . thumbs up to CHEMSTAR Associate Director Bob Romano who partidpated in a seminar in Austin, TX on Chlorine Dioxide Wa ter Disinfection. Bob ex panded his wealth of knowledge on chlorine di oxide chemistry, analysis, and regulations. We ex pecthe expanded on fajitas too... is CHA 03.1078 CHEMSTAR NEWS RECENT RELEASES - FEDERAL REGISTER NOTICES - Junt 1991 PROPOSED MULTI-SUB STANCE RULE FOR THE TEST ING OF DEVELOPMENTAL AND REPRODUCTIVE TOXIC ITY (56 FR 9092, March 4,1991). 27th REPORT OF THE INTERAGENCYTESTING COM MITTEE (56 FR 9534, Man* 6, 1991). LABELING REQUIREMENTS FOR ART MATERIALS AND OTHER PRODUCTS SUBJECT TO THE FHSA PRESENTING CHRONIC RISK HAZARDS; GUIDELINES FOR DETERMIN ING CHRONIC TOXICITY; SUPPLEMENTAL DEFINITION OF TOXIC' (56FR15672,April 17, 1991). ADVANCE NOTICE OF PRO POSED RULEMAKING FOR AND REQUEST FOR COM MENT AND DATA ON LAND DISPOSAL RESTRICTIONS; PO TENTIAL TREATMENT FOR NEWLY IDENTIFIED AND LISTED WASTES AND CON TAMINATED DEBRIS (56 FR 24444, May 30,1991). COMMENTS Comments to the California Air Comments to EPA on the PRO Resources Board on the DRAFT POSED MULTI-SUBSTANCE TECHNICAL SUPPORT DOCU NEUROTOXICITY TEST RULE MENTFOR 1,3 BUTADIENE (filed (filed by the Acetone Panel, June 3, by the Butadiene Panel, March 21, 1991) 1991) Comments to EPA on the PRO Commentsto theCaliforniaSouth POSED MULTI-SUBSTANCE Coast Air Quality Management TEST RULE FOR DEVELOP District on PROPOSED RULE MENTAL AND REPRODUC 1410 (filed by theHydrogen Fluoride TIVE TOXICITY AND NEURO Panel, March 25,1991) TOXICITY ON DODECYLPHENOL (filed by the Comments to EPA on the Alkylphenol and Ethoxylates Panel, TWENTY-SEVENTH REPORT June 3,1991) OF THE INTERAGENCY TEST ING COMMITTEE (filed by the Comments to EPA on the PRO Phenol Panel, April 1,1991) POSED MULTI-SUBSTANCE TEST RULE FOR DEVELOP Comments to Office of Manage- MENTAL AND REPRODUC ment and Budget on EPA's IN TIVE TOXICITY (filed by the Car FORMATION REQUEST FOR bon Disulfide Pond, June 3,1991) DATA ACQUISITION FOR PES TICIDE REGISTRATION (filed by Comments to EPA on the PRO the Biocides Panel, May 22,1991) POSED MULTI-SUBSTANCE NEUROTOXICITY TEST RULE FOR2-ETHOXYETHANOL (filed by the Glycol Ethers Panel, June 3, 1991) Comments to EPA on the PRO POSED MULTI-SUBSTANCE NEUROTOXICITY TEST RULE (filed by the Ketones Panel, June 3, 1991) Comments to EPA on the PRO POSED MULTI-SUBSTANCE TEST RULE FOR DEVELOP MENTAL AND REPRODUC TIVE TOXICITY (filed by the Oxo Process Panel, June 3,1991) Comments to EPA on the PRO POSED MULTI-SUBSTANCE TEST RULE FOR DEVELOP MENTAL AND REPRODUC TIVE TOXICITY (filed by the Terephthalic Acid Task Group, June 3,1991) Comments to EPA on the PROPOSEDTEST RULE FOR DEVEL OPMENTAL AND REPRODUC TIVE TOXICITY (filed by the Toluenediamines Panel, June 3,1991) is CMA 03107 June 1991 FINAL REPORTS CHEMSTAK NEWS "An Approach to Using the TwoStage Model for Estimating the Carcinogenic Risk of DEHP" (Phthalate Esters Panel, April 17, 1991). "Limited Study of Oral Toxicity of 2-Ethylhexanol in Mice After Administrationbj ' Gavage (Aqueous Emulsion) for Three Months" (Oxo Process Panel .April 23,1991). "Oral Toxidty of 2-Ethylhexanol in Rats After Administration by Gavage (Aqueous Emulsion) for Eleven Days (Nine Applications)" (Oxo Process Panel, April 23,1991). "Aquatic Toxicity of Phthalate Esters" (Phthalate Esters Panel, April 18,1991). "Oral Toxicity of 2-Ethylhexanol in Rats After Administration by Gavage (Aqueous Emulsion) for Three Months" (OxoProcess Panel, April 23,1991). "Limited Study of Oral Toxidty of 2-Ethylhexanol in Rats After AdministrationbyGavage (Aque ous Emulsion) for Three Months" (Oxo Process Panel, April 23,2992). "Oral Toxicity of 2-Ethylhexanol in Mice After Administration by Gavage for Eleven Days (Nine Applications; Solution in Com Oil)" (Oxo Process Panel, April 23, 1991). "Oral Toxicity of 2-Ethylhexanol in Mice After Administration by Gavage (Aqueous Emulsion) for Three Months" (OxoProcessPanel, April 23,1991). 'Toxicity of 2-Enhylhexanol in Rats After Administration of Mi croencapsulated I Material Via the Diet for Eleven Days" (Oxo Pro cess Panel, April 2 1,1991). 'Toxidty of 2-EI hylhexanol in Mice After AdmirisitrationofMicroencapsulated Material Via the ,Diet for Eleven Eays" (Oxo Pro- cess Panel, April 21 1 1991). "Oral Toxidty of ll-Ethylhexanol in Mice After AcUninisitration by Gavage for Elevitin Days (Nine Applications; Sa ution in Propylene Glycol)' (Oxo Process, April 23,1991). "Oral Toxidty of 2-Ethylhexanol in Rats After Administration by Gavage for Eleven Days (Nine Applications; Solution in PropyleneGlycol)" (OxoProcessPanel, April 23,1991). "Oral Toxidty of 2-Ethylhexanol in Mice After Administration by Gavage (Aqueous Emulsion) for Eleven Days (Nine Applications)" (Oxo Process, April 23,1991). "In-Vivo Percutaneous Absorp tion of 14C-DEHP Plastidzed Polyvinyl Chloride Film in Male Fischer 344 Rats" (Phthalate Esters Panel, May 1,1991). "ChronicToxidtyofNonylphenol to the Mysid, Mysidopsis bahia" (Alkytphenol and Ethoxylates Panel, May 21,1991). "Early Life Stage Toxicity of Nonylphenol to the Fathead Min now, Pimephates promelas" (Alkylphenol and Ethoxylates Panel, May 21,1991). 17 CMA 031080 CHEMSTAR NEWS Jutu 1991 r "............................. .......................................................... ........ ............ .... > UPCOMING EVENT The 20th Annual Conference of the North American Association for Environmental Education will be held in St Paul, Minne sota from September 27 - October 2,1991. The Conference is entitled, "Confronting Environmental Challenges in a Changing World." Theconferencewill include work shops, presentations, symposia, and field study trips focusing on current environ mental issues. For more information on the conference, contact Lori Mann of NAAEE at 415/342-9378. ^ CHEMSTAJtNEWSispublishadquaiteilyasaiervkeof OwChemical MaiuibcturcnAaaodation, Chemical Setffandad Tedmkal Advocacy and Research Division. N special pmmissionislequiradtoquoteor reproducefrom thispublication. Credit isapprobated when reproducing abides. Correspondencemaybesentta CHEVfSTAR NEWS,2501 M Street NW, Washington, DC 20037; Telephone 202/ 887-1337; Fax202/887-1237. Amy Kotin, Editor IS CMA 03108