Document gDRE1zvjJg7dn1GV8K1bwjDba

little recorded information upon its physiolog ical activity Isophorone is considered to have a low degree of hazard to health by inhalation, even though it has a moderately high degree of toxicity by this route Vapors are quite irritating and have an unpleasant odor to unacchmated humans, so that overex posure is not likely if its warning properties are heeded One report states that a short exposure of unconditioned human volunteers exposed to concentrations of 25 ppm of vapors of isophorone was definitely irritating to the eyes, nose, and throat Isophorone is classi fied as a primary skin irritant--brief contact can cause inflammation Isopropyl alcohol. Inhalation of isopropyl alcohol vapor can produce mild irritation of conjunctiva and mucous membranes of the upper respiratory tract No cases of industrial poisoning have been recorded in the literature Isopropyl alcohol is potentially narcotic In large amounts, it is more toxic and more narcotic than ethyl alcohol, but less so than n-propyl alcohol to animals There is appar ently little or no accumulation in the body Mild irritation of the eyes, nose and throat was induced m human subjects exposed for three or five minutes to 400 ppm of isopropyl alcohol From the viewpoint of comfort these subjects found 200 ppm to be the highest con centration acceptable for an eight-hour ex posure It has been stated that the minimum concentration with identifiable odor of isopro pyl alcohol is 200 ppm Contact of the skin with solutions of iso propyl alcohol can cause solvent irritation type dermatitis Isopropylamine exhibits strong local irritant properties It has good warning properties-- at 5 to 10 ppm, its ammonia-hke odor is defi nite, between 10 and 20 ppm, the odor be comes so strong that nose and throat notation result from short exposures, workers exposed to concentrations between 25 and 50 ppm ex perienced nausea and temporary impairment of vision Repeated exposure of the skin to the liquid and vapors of isopropylamine may result m dermatitis The eyes mav be chron ically irritated by the vapors Employees should be instructed to minimize contact with isopropylamine liquid and vapors as much as possible If work contact with the liquid or vapors is unavoidable, personal protective equipment should be used Isopropylamine is primarily an acute irritant, and is capable of causing bums on contact It is alkaline m nature and causes bums similar to those of strong solutions of ammonia The high volatility, low flash point, and relatively low ignition temperature produce a high potential fire and explosive hazard Isopropyl ether, like the other ethers, forms explosive peroxides upon standing m contact with air Industrial exposure to isopropyl ether is most likely to occur through a direct contact with the skin or eyes due to an acci dental spill, or through an inhalation exposure to low concentrations of the material m the atmosphere Acute exposures to physiolog ically significant concentrations are rare be cause of the flammability associated with such concentrations The primary physiological response to isopropvl ether is that of general anesthesia Even though it is somewhat more toxic than ethyl ether the vapor concentration necessary for this anesthetic effect is much higher than the concentration that causes irritation and unpleasant odors This compound is only slightly irritating to the skin and is capable of producing only minor injury to the eyes It is not absorbed through the skin m harmful amounts L Lead was one of the first industrial ma terials to be recognized as a serious health hazard, and it stall accounts for many cases of disability In industrial work, lead enters the system mainly in the form of dust by inhala tion Lead compounds can produce poisoning when they are swallowed, but absorption from the digestive system is slow and inefficient, so that large doses of most lead compounds are required and poisoning develops slowly In the respiratory system, on the other hand, most lead compounds are absorbed rapidly and completely so that poisoning will develop from much lower doses It is not even neces sary that the compound penetrate deeply into the respiratory system It has been demon strated experimentally that lead compounds 1151