Document gDQXwX7qB0NE9Qy67eJQG2jjQ

iiuaust 24, 1965 Barnard R. Bredis, Bh.B., Chief Laboratory of Chemical Pharmacology national Heart vn^ritute National Institutes of Health D&thesda, Maryland 20014 ' Bear Doctor .Brocie: ily attention, perhaps not remarkably, has been called by more than one cf my colleagues to -leferen.ee -r27 in the article entitled ;rTcxicology and the Bic-meaical Jciences," Dy yourself ana associates, in Science 143: (No- 3677 for June 18) 154771554, 1365. "27. It is known that . . . 2-ntohthylaxnine and tetraethyl lead are converted to carcinogenic compounds." I would suppose that there is, or should 1-e, tefinitive evidence in support of this statement, since tstr astky ilead `'coupled therein with ?ceta-naphthy famine which has been so thoroughly convicted. However, X am at a loss to put my finger on any evidence, either experimental or clinical, that would render the statement credible. X would knew, certainly, if there had been cases, cf malignancy traceable to this source in man. It is entirely possible that I have missed something in the literature, since I have been pre-occupied with many other matters in recent years. I would appreciate your courtesy if you were to enlighten me on this point. The issue is of much more than academic or scientific interest and importance. ' Cordially yours. HAKsrms Robert A. Kehoe, h .d . N20072