Document gDMdvEmGNQOGE2X3o73pkM2Zq

FOR.PO' FONT USE ONLY AR226-2888 Copies to E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 Study Initiated/Completed 7/15/80 - 7/18/80 Material Submitted by Jackson Laboratory EYE IRRITATION TEST IN RABBITS Procedure: One hundred ing of solid test material was placed into the right conjunctival sac of each of 2 male albino rabbits.** After 20 seconds, 1 treated eye was washed with tap water for 1 minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris and conjunctiva were made with a hand-slit lamp at 1 and 4 hours, and at 1, 2, and 3 days; Fluor-i-strip stain and a biomlcroscope were used at examinations after the day of treatment. Results: Dose Treatment 100 mg Not Washed undiluted test material 100 mg. Washed undiluted test material None Ocular Effects Cornea Iris None None None Conjunctiva Redness: None Swelling;None Discharge:Mild 4 hrs. Redness: Mild 1-4 hrs. Swelling:Slight 1-4 hrs. Discharge:Moderate (Hemastlx +) 1 hr., mild 4 hrs. Company SanSfEzed. Doss not conta'r. TSCA CBI S"n^y:IH^B:aused transient alld conjunctivitis, no corneal effects, and no <^i) iiBen^Ktsd in the eye of a rabbit. An eye dosed with the test material arrpCompCly washed had transient moderate to slight conjunctivitis, no corneal effects, and no Iritis. Both eyes were normal within 1 day. This material Is a mild eye Irritant and should be flushed with copious amounts of water if eye contact occurs. 7Other NameT Report by; Approved by: Q^pGj er^aldPL^. _K^entn_e_dy_______ Chief, Acute Investigations Section PA:jrg Study Director: 0. L. Dashlell Date las^- rl^ in lORfl Report No. 572-80 Company Sanitised. Doss nst csntajn TSCA CB?