Document gDDdrVZL9OKoboKOdygXLppXQ

3M (;erteral offices 3Vt Center St Paul, N1AT 55144-1000 651'331i10 June 6, 200 5 A~A zz p. 1 7~ ? Ms Rose Allison U S Environmental Protection Anency EPA East Buildin g ~ 1201 Constitution Avenue, N W Washington, DC 20004 Subject.: Perf7uorobutane sulfon.ate study reports associated with PNIN submissions to the US EPA (r-00-1085, P-01-584, P-02-16, P-02-195, P-02-609, P-42-700, P-E12-883, P-02-891, P-02-920, P-03-32, P-03-77, P-04-174, P-04-176, P-04-537) Dear Ms . Allison : This communication contains thrcc compact disks (CD) that incorporate recent updates to perfluorxrbutane sulfonate (PFBS) study reports .. This CD is supercedes previous versions The reason for' re-issue of the CD at this time is the addition of two reports that are new since the last version that the EPA rcceivcd The first addition is the avian reproductive toxicity (OPPIS 850 .2300/ OECD 206) and it is listed as entry #26B The second addition is a lettcr discussing e histopzthology review of'se3ect tissues related to the 90-day oral toxicity (OPPIS 870 .3100 / OECD 408) and it is listed as entry # 9A . On the enclosed CD, you will find : A copy of this covet IeLteT An index to perfluorohutane sulfhnate study reports on physical chemical properties, environmental and mammalian testing with the following organization : Mammalian toxicity testing Ecotoxicity and fnte studies 1lvian toxicity testing Physico-chemical ptoperties, fate testing and supporting analytical methodology A discussion paper summarizing the results frorn the testing conducted to date by 3M on per f7uocoUutanc sul fonat e The four folders contain sanitized copies of the study ieports submitted to the EPA to date as listed in the index 3M will continue to provide infonnation on a regular basis as it becomes a-milable . The CD is for read-only put poses and is not to be modified . 311-5 will maintain a paper copy and the original CD copy of the documents Ilae paper copies will control over the Cl) in the event oWany discrepanc y Please feel fi-ee to contact me with any questions Re ,~ rds , .Jay P . Schul z Regulatory Affairs Specialist Specialty Materials Regulatory Affairs 3M Center Bldg 236-18-1 0 St.. Paul, lYN 55144-1000 p. 2 3M Mammalian Toxicity Testin g 1 . OECD 423-OPPTS 870 .1100, Acute oral toxicity(rat), 132-00 2 2. OECD 402-OPPTS 870 .1200, Acute dermal toxicity (rat), 132-01 0 3. OECD 4040PPTS 870 .2500, Acute dermal irritation (rabbit), 132-004 4. OECD 405-OPPTS 870 .2400, Acute eye irritation (rabbit), 132-00 5 5. OECD 406-OPPTS 870 .2600, Skin sensitization (guinea pig), 132-01 5 6. OECD 471-OPPTS 870 .5100, Bacte rial reverse mutation test (Ames test), 0623-214 0 7. OECD 473-OPPTS 870.5375, In Vitro Mammalian chromosome aberration (CHO cells), 0623,3110 8. OECD 407, Repeat dose oral toxicity (with FOB & histopathology), 132-00 7 8A . OECD 407, Repeated dose oral toxicity (Range Finding study), 132-006 9. OECD 408-OPPTS 870.3100, 90-day oral toxici ty (rodent), 418-026 9A . , Histopathology review of select tissues, 418-02 6 10. OECD 414-OPPTS 870.3700, Prenatal development toxicity (teratology), 418-02 3 10A . OECD 414-OPPTS 870.3700, Prenatal development toxicity (teratology)-Pilot Study, 418-023A 11 . , Pharmacokinetic study in the Cynomolgus Monkey, T-7485 . 1 12 . OECD 416-OPPTS 870.3800, Reproduction and fertili ty e ffects (Two generation reproduction toxicity), 418-021 Ecotoxicity and fate studies 13. OECD 201-OPPTS 850.5400, Algal toxicity-94-Hour toxicity test with the freshwater alga, 454A-12 9 14. OECD 202-OPPTS 850.1010, 48-hour static acute toxici ty test with the Cladoceran (daphnia magna), 15. OECD 211-OPPTS 850.1350, Chronic toxicity test (daphnia magna), 454A-13 0 16. OECD 203-OPPTS 850.1075, 96-Hour static acute toxicity test with the (bluegill), 454A-11 4 17. OECD 203-OPPTS 850.1075, 96-Hour static acute toxicity test with the (fathead minnow), 454A-1 15 18. OECD 305-OPPTS 850 .1730, Fish bioconcentration (bluegill) 19. OPPTS 850.1035, 96 hour Static acute toxicity with (saltwater mysid), 454A-128 20. OECD 106-OPPTS 835 .1220, Adsorption! Desorption, 023-04 8 21 . OPPTS 835 .1110, Activated sludge sorption isotherm (incorporated with OECD 106 ) 22 . OECD 209-OPPTS 850 .6800, Modified activated sludge respiration inhibition test, 454E-102A 454A-118A Avian Toxicity Testin g 23. OECD 205-OPPTS 850.2200, Acute avian toxicity ( Northern Bobwhite), 454-112 24. OECD 205-OPPTS 850.2200, Acute avian toxicity ( Mallard), 454-11 3 25. OECD 205-OPPTS 850.2200, Analysis of fluorochemicals in Bobwhite quail samples, E02-0659 (from study 454-112) 26. OECD 206-OPPTS 850.2300, Pilot chronic avian toxicity (Northern Bobwhite) 454-11 5 26A . OECD 206-OPPTS 850 .2300, Pilot chronic avian toxicity (Northern Bobwhite) and Test Protocol, 454-115 . 26B . OECD 206-OPPTS 850 .2300, Final Avian reproductive toxicity (Northern Bobwhite) 454-116 Physico-chemical properti es, fate testing, analyti cal methodology 27. OECD 105-OPPTS 830 .7840, solubility studies (water methanol, acetone), 4FACT-TCR009 28. OECD 105-OPPTS 830 .7840, water solubility in nanopure water, 454C-1 1 8 29. OECD 104-OPPTS 830 .7950, vapor pressure by spinning rotor gauge, 454C-12 7 30 . , Laboratory incineration study of PFBS and fluorochemical polymers, UDR-TR-2002-000153 31 . TGA in air and helium (Decomp . Onset: 505C (He), 522C (Air) and DS C 32 . Differential Scanning Calorimet ry (DSC) Melting point (273C) 33 . Boiling point (acid form) (200C at 101 kPa) 34 . Discussion of the photoly ti c decomposition of PFBS 35 . Discussion of the hydrolysis of PFB S 36 . Discussion of the determination of Air-Water partition coefficient of PFBS from vapor pressure and water 37 . Analytical method valida ti on for determination of PFBS-K in fish tissues, 454C-1 1 6 38. Analytical method valida ti on for determination of PFBS-K in freshwater, 454C-11 5 39 . Analytical method validation for determination of PFBS-K in saltwater and algal media, 454C-117 40 . Hammett Acidity Function, Literature value (Ho = 13 .2 ) solubility 6/5/05