Document gDDLzjJ6LYa4pVjb1B3ep3DKG
AR226-2S20 j
E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT NO. 11-64
gante Chemicals Department, Jackson Laboratory
Haskell No.: 3662 Other Codes:
ACOTE ORAL TEST r" elv ei- by 8tOTach tub* * " *i u *- - u * *
Results:
Dose* fag/kel
11,000 1,500 5,000 2,250
Mortalitv** S - 15 d. S - 15 d. S - 14 d. S - 14 d.
Toxic Siftne Slight initial weight loss
Weiaht When Killed Bodv fami Liver fami
345 23.2 334 18.9 314 15.3 305 15.7
Liver Wt. Body Wt
6.7 5.7 4.9 5.1
ALS
> 11,000 mg/kg
* Based on active ingredient
----
** S - ( ) d. = Sacrificed ( ) ^ a y ^ a f t e ^ d o s ^ g
TEN-DOSE SUBACUTE ORAL TEST
test niatetlal, as received, was administered daily by stomach tube to each of six young adult ChR-CD male
aaerifHTM!! * 8 a week for one oc two weeks. Where animals survived, groups of three test rats, along with controls, were
sacrificed four hours and 14 days after the last treatment.
6
'
contain TSCACBl Sanfced. Does not Comps"'/
Results:
Dose* (mg/kg/day)
5,000
- 2-
Mortality 6/6
Toxic Signs
Death after 3-5 doses, weight loss, diarrhea, discoloration of perineal area.
4 hours after 10th ,dose
Control Test
2,250
0/6 First Week: slight weight loss
13.9 29.8
Second Week: slightly depressed rate of
16.6 35.2
weight gain. Recovery Period: none;
17.4 30.2
weight gain parallel
that of controls
* Based on active ingredient,
14 days after
10th dose control Teat
16.8 16.6 18.6
24.2 25.0 23.9
*.iver wt/Bodv w t X io n
4 hours after
14 days after
10th dose
Control Test
Control Teat
4.5 11.5 5.0 11.6 5. 11.8
4.4 6.1 4.3 6.9 4.3 6.8
Summary:
"Thele crompo,unde pAropdupceidj xainm itn^creSatshe ai^n St-hs*MijA.L- D,,1^.1 *eTi.n t^erS ^cnSanH ifif,iU^0U^m^g/^kg^ o^f ^boBdyMweIiLgSht!, ^basTed* on a rcatilvet oixnlgcrlet ydienotr, th dosed at 7,500 mg/kg. lncrea8e ln the liver weiht of the animal dosed at 11,000 mg/kg, and possibly in the^nimal
day, all died after haviny^^r-^'i^^^'!6 otal toxicity. When administered to each of six rats at a dose of 5,000 mg/kg/
terminal lung damage: in addition thaJlr^f0- ^ ^ dSe8, Tw of the animal8 examined histologically showed kidney and
the digestive tract in a extremely heavyi^ers ^
in the form o a f i m core that wasnot^aasing along admtoi*tered *> t s at a dose of 2,250 m g / k g / d a y j M n p ^ t u c e d
sacrificed after a 14-day recovery roeriod M i ^ n n ^
dfSC' " lth evidence of some recovery v-hen tfil animals were
enlarged nuclei which had nrcminentPmielnftlM1crBCOPlcally the heavy livers contained some enlarged liver cells and
V . . ,h<,,.
i ^ S S r o i T e g f ^ v " w n / l *ttih " 1<'" Chr0" tln " " r i* 1- " *
< **"-
Sawfe Cotnp0^
T S C A cSl oicontai
Because of the effect o to <eteralne . --- a.*. level a? a . U -- *
3-
f.h_ ,,
.
"
HS/hjd Oate: February 3. 1964
Approved by:
D. B. Hood Chief, Toxicology Section
. a - 03snol containt s c a c b ^ Sanitizsa. >--a Comps")?
