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08/06/2003 WED 09:43 FAX 312 996 1899 UIC LHS CHICAGO @006 MESOTHELIOMA--LIEBEN & PISTAWKA 568 d deal of circumny unanswered tremely low. Not all mesotheliomas were re ported to us hy the hospitals, but, even if we double the incidence, only a minute fraction of the exposed population was affected. tients no history of asbestos exposure could be obtained. References There are precedents for this with beryllium ; material used a generally real- in the brewery, to the writers, ay others, disease which acts in a somewhat similar pattern; occupational diseases, familial con tacts, neighborhood cases plus a very low attack rate, and a long latent period be tween exposure and onset of disease. L Newhousa, MX., and Thompson, H.; Mesothe lioma of the Pleura and Peritoneum Following Ex posure to Asbestos in the London Area, Brit J Induatr Med 22:261-269, 1966. 2. Hourihane, P.O.: The Pathology of Mesotheliomata and an Analysis of Their Association With os may he the for malignant cases described t Another question which arises is why Asbestos Exposure, Thorax 19:268-277, 1964. 8. Selikoff, IX; Churgh, J.; and Hammond, C.: pleural mesotheliomas are so much more Exposure to Asbestos and Mesothelioma, NeOi Eng frequent than peritoneal mesotheliomas. J Med 272:660-663 (March) 1965. t the minimal The most striking finding of this study 4. Wagner, J.C.; Sleggs, C.A.; and Marchand, P.: duration of a was that of the 42 mesotheliomas which Diffuse Pleural Mesothelioma and Asbestos Expo "he occupationworkers or asjertainly many came from a geographical area of approxi mately 30,000 sq mi, six were clustered in and around an insulation plant (Figure). sure in N.W. Cape Province, Brit J Industr Med 17:260-271, 1960. 5. Cauna, D.; Totten, R; and Gross, P.: Asbestos Bodies in Human Lungs at Autopsies, JAMA i those of the These included two insulation manufactur man-373 (May 3) 1963. contacts. Simibeen reported ing workers (Cases 2-0 and 3-0), three C ' Thompson, J.G.; Kaschula, R.O.; and MacDon ald. -XL: Asbestos as a Modem Urban Hazard, 3 neighborhood cases (Cases 2-N, 3-N, and 4- Afr Med J. 37:77-81 (Jan) 1963. leliomas is ex- N) and one family contact (Case 2-F)--the 7. Thompson, J.G.: Asbestos and Urban Dweller, daughter of an insulation worker. read before the Conference on Biological Effects of Asbestos, New York, Oct 19, 1964. Summary 8. Doll, R: Mortality From Lung Cancer in As bestos Workers, Brit J Industr Med 12:81, 1955. Forty-two cases of mesotheliomas report 9. Lieben, J.: Asbestos and Malignancy, Arch En ed from 152 hospitals over a five-year peri viron Health 13:619-621 (Nov) 1966. [Ul od, were studied with regard to exposure to j 10. Sacconi, A., and Coblenz, A.: Endothelioma of asbestos. Survivors or employers, or both, ' the Pleura, With Report of Two Cases, Artier J Clin Path 13:186-207, 1943. were questioned regarding the possibility of 11. Campbell, W.: Pleural Mesothelioma, Amer J asbestos exposure. Ten patients actually Path 26:473-487, I960. worked in asbestos plants; eight lived or worked close to an asbestos industry; three patients were family members of asbestos workers. In ten patients a history of as sumed exposure to asbestos was obtained 12. Weissman, H: Primary Endothelia of the Pleura, Vis Chest 12:562-670, 1946. 13. Lyman, T. (ed.): Metals Handbook: i. Prop erties and Selection of Metals, ed 8, American Socie ty of Metals. 1961, p 6. 14. Modern Chemical Processes, New York: Rein- after prolonged questioning. In 11 other pa-; hold Publishing Co., 1952, vol 2, p 167. tune 'at lent 2-F w le DISCOVERY OF QUININE Many of the drug sources known in ancient times were apparently discovered by acci dent For example, according to an old South American Indian legend, the curative power of cinchona bark (containing quinine) for malaria was discovered by a rick, fe verish Indian lost in the jungle. He quenched his thirst by drinking from a pool of water. From the bitter taste of the water, he recognized that it was tainted with the poison from the quina-quina tree. Although he shared this fictitious belief, he drank deeply so as to bring about a quick death. To his great surprise, he recovered completely. When he returned to his village, he told the store of his cure and thereafter cinchona bark was used as a medicine, for the fever prevalent in that region. The Incas later taught the Spanish conquistadors that malaria could be cured with cinchona extract-- Rossman, R.E.: The History and Significance of Serendipity in Medical Discovery, Trans Coll Physicians Philo 33:104-120 (Oct) 1965. Arch Environ Health--Vol 14, April 1067 m'm n If HB mm