Document gD5g9kZxgpVoG4LazB3aYNpEG

THE REFRACTORIES INSTITUTE 1102 OLIVER PLAZA PITTSBURGH, PA. 132.22 December 20, 1977 To the Official Representatives of each Member Company: Subject: Suspected carcinogens used in refractories operations Attached Is your copy of a composite listing of the initial reports from members of the Safety and Health and Toxic Substances committees of chemical substances currently being used in refractories operations suspected by OSHA of posing a potential occupational carcinogenic risk. This preliminary list Is furnished to you in order that you may check It against chemical substances your company uses, and evaluate what would happen to your operations under proposed OSHA regulations. The presence of a chemical substance on this list does not necessarily mean that it would be automatically classified as a Category I or 11 substance and therefore, subject to the stringent controls outlined in the Federal Register notice discussed In my letter to you dated November 15, 1977. Nor, unfortunately, does the absence of a substance from this list mean that It could not be so classified at some future time. As you can see from looking at the comments on the attached sheets which are summaries of data from NIOSH Publication 77'149, there is consider'* able evidence that many of these chemical substances may, under certain conditions, cause tumors In animals, humans, or both. Such substances are therefore technically classified as suspect carcinogenic or neo plastic agents. These are the substances that apparently are moat likely to he classified Initially as Category I or 11 substances. Please note that the proposed regulations do r.ot distinguish between laboratory or production use of a substance. The same controls would apparently be required In either case, although the number of people affected--and the resulting impact--could, of course, vary greatly. Substances for which comments do not indicate any carcinogenic or neoplastic toxic effects might--for present purposes--be considered of secondary Importance. This is not to say such substances are hot toxic in other ways; indeed, many are quite toxic and already have had exposure standards established. However, by NIOSH's definition, every substance on this list is at least a suspect carcinogen. The crux of our problem is to determine what the impact of possible Category I or 11 classifications for these suspected carcinogens would be on the Industry's operations. If you are using any of these substances classified as having neoplastic or carcinogenic effects and If the impo sition of the strict controls outlined in the attachment to my November A NATIONAL ASSOCIATION TO PROMOTH THH INTERESTS OP MANUFACTURERS AND CONSUMERS OP REFRACTORY PRODUCTS G-00046 2- letter would have a substantially adverse effect to your company, we would like to know about It as quickly as possible so that we can consider using those facts in support of a statement of our position to OSHA. If you have any Information or questions, please call me at your earliest convenience. Sincerely yours. . WlMlam Wialng, Jr. JWW/hm Eric T. cc: Safety and Health Committee Toxic Substances Subcommittee G-00047 G-00048 NIOSH NO AH52500 A152500 AJ07000 AL31500 CA93500 CG3&750 CI6A750 CY11000 DA64750 DV77000 ED*5500 EL64750 FF665O0 i. FGA900Q if. A PRELIMINARY LIST OF CHEMICAL SUBSTANCES LISTED IN NIOSH PUBLICATION 77 - 1^9 REPORTED BY SOME REFRACTORIES PRODUCERS PRIME NAME OF COMPOUND (with alternates mentioned) Acetic Acid, (Ethylenedlnltrllo) Tetra-.Trisodlum Salt Syn: EDTA Trisodlum Salt RANK CODE 0000 Acetic Acid, Lead (2+) Salt Acetic Acid, Nitrllotri- Trisodlum Salt, Honahyrirate Acetone Mil -- 0000 Anthracene(coaltar pitch component) A112 Arsenlous Acid, Monosodium Salt 0000 Asbestos M03 Benzene 7222 Benzene, Nltro 2-Blphenylol, Sodium Salt Syn: Dowicide Boric Acid Syn: Orthoborlc Acid 2-Butanone Syn: Ethyl Methyl Ketone; Ketone, Ethyl Methyl> Ethyl Ketone, Methyl Carbon Disulfide Carbon Tetrachloride 0000 3101 0000 0000 *1313 ____________________________ f.OMMFNTS Status: Currently tested by NCI for carcinogenicity by standard bloassay protocol as of April 1976 Toxic Effects: Carcinogenic Status: Currently tested by NCI for carcinogenicity by standard Bloassay Protocol as of ApriI 1976 Status: Undergoing NCI testing V76 Toxtc Effects: Carcinogenic, Neoplastic Review: Carcinogenic determination: human suspected Toxic Effects: Carcinogenic Review: Carcinogenic determination-human positive Toxic Effects: Carcinogenic, Neoplastic Review: Carcinogenic determination: human suspected Toxic Effects: Neoplastic Status: Undergoing NCI testing V76 Toxic Effects: Carcinogenic, Neoplastic G-00049 A PRELIMINARY LIST OF CHEMICAL SUBSTANCES (continued) FJ57000 FJ59500 GB28500 GB29400 Carbowax 1000 Cellulose, Carboxymethy 1 Ether 0000 Cellulose, Carboxymethyl Ether, Sod 1um Sa11 Syn: Carboxymethylcellulose, sodium salt; sodium carboxymethyl cellulose 4101 Chromate of soda Chromic acid. Chromium (3+) salt (3-2) -- Chromic acid, Dlpotasslum salt 3111 GB29550 GB40250 GB42000 Chromic acid, Olsodlum salt Syn: Chromate of soda Chromlte Chromium 0000 -- 4102 GB64750 Chromium (ill) oxide (2:3) 4102 GBbbbOD GF85750 GG11090 GG28000 1 JH48000 1 r) Chromium (VI) oxide (lt3) Coal tar, aerosol Cobalt (II) nitrate (1:2) Cobalt (2+) oxide 1,3,2-Dloxathlolane 2,2*dloxlde 7202 .... 2101 4101 see: TQ35000 Status: Undergoing NCI testing 4/76 Toxic Effects: Neoplastic Page 2 See: GB29550 (ARC Review: carcinogenic determination: animal pos1tive Toxic Effects: Neoplastic Toxic Effects: Neoplastic IARC Review; carcinogenic determination: animal suspected IARC Review: Indefinite Toxic Effects: Neoplastic IARC Review: carcinogenic determination: animal posit1ve Toxic Effects: Neoplastic IARC Review: carcinogenic determination: animal suspec ted Toxic Effects: Carcinogenic IARC Review: carcinogenic determination: animal suspected Status: NI0SH candidate subject for hazard review (care 1 nogensis Toxic Effects: Carcinogenic IARC Review: Indefinite Toxic Effects: Neoplastic Toxic Effects: Neoplastic Toxic Effects: Carcinogenic Toxic effects: Neoplastic G-00050 A PRELIMINARY LIST OF CHEMICAL SUBSTANCES (continued) JJ78000 Diphenyl Amine 0000 EDTA Trlsodlum Salt KJ29750 Ethane, 1,1,1-Trichloro Syn: 1,1,l-Trichloroethane 0000 KJ85750 Ethanol, 2-Butoxy Syn: Ethylene Glycol, Monoguty) Ether 0000 KQ63000 Ethyl Alcohol Syn: Ethanol 3112 KV0J500 Ethylene, Chloro-.Polymer Syn. Polyvinyl Chloride 4101 KV36750 Ethylenedlam1ne,N,N1 -DIe thy1 Dlnltroso -- Ethylene Glycol, Monobutyl Ether KX24500 Ethylene Oxide -- LM54250 MNi*7250 Fluorescein, Dlsodlun Salt Hexaroe thy 1 ene te t ram 1 ne 4)01 4101 N074000 N085000 1ron (III) Oxide 1ron (II) Sulfate (1:1) 0000 3101 OM49000 0V45500 OZ50750 Magnetite Mercury Methacryllc Acid, Methyl Ester 3101 4101 4101 , .< Mylar NltrllotrfacetIc Acid .'l r: See: AH52500 Status: Undergoing NCI testing 1*776 Toxic Effects: Carcinogenic Toxic Effects: Neoplastic I ARC Review: Indefinite Toxic Effects: Carcinogenic See: KJ85750 IARC Review: Indefinite Toxic Effects: Neoplastic Toxic Effects: Neoplastic IARC Review: Indefinite Toxic Effects: Neoplastic Toxic Effects: Neoplastic Toxic Effects: Neoplastic Toxic Effects: Carcinogenic See: TQ79000 See AJ01750 Page 3 A PRELIMINARY LIST OF CHEMICAL SUBSTANCES (continued) RA12250 RG22750 RK-43750 SE7I750 SE73500 SF7I750 SJ33250 SM63000 TC95000 TQ33250 TQ35COO TQ79000 TR15800 TR8I000 Nitrous Acid, Sodium Salt 0000 9-0ctadecenolc Acid, (Z) Syn: Oleic Acid 2101 Oleic Acid Olivine 3101 Orthoborlc Acid Petroleum 3121 Petroleum Asphalt Syn: Asphalt (steam refined) -- Phenanthrene (coaltar pitch component)3121 Phenol 3121 Phenol , Pentachloro Syn: Dowlctde G Phosphoric Acid, Trlsodium Salt Polyethylene Polyethylene Glycol Syn: Carbowax Polyethylene Terephythalate film Syn: Mylar Polynuclear Aromatic Hydrocarbons Polystyrene Polyvinyl Alcohol Syn: PVA 3101 0000 A202 3101 -- -- Status: Undergoing NCI testing A/76 Toxic Effects: Neoplastic See: RG22750 Toxic Effects: Neoplastic See: ED<5500 Toxic Effects: Neoplastic Toxic Effects: Neoolastlc Toxic Effects: Neoplastic Toxic Effects: Carcinogenic Status: Undergoing NCI testing A/76 Toxic Effects: Neoplastic Toxic Effects: Carcinogenic Toxic Effects: Neoplastic See WL61*750 Toxic Effects: Carcinogenic G-00051 G-00052 A PRELIMINARY LIST OF CHEMICAL SUBSTANCES (continued) Polyvinyl Chloride PVA Quartz VU2**500 Serpentine 3101 VV73300 Silica, Crystalline-Quartz ------ Syn: Quartz; St I lea Flour (powdered crystalline silica); Silicon Oxide,01-(Sand) Silica Flour (powdered crystalline silica) Silicon Oxide,Dl-(Sand) VW35000 Silver 1*101 VV80500 Sodium Azide Sodium Bisulfate 0000 VZ^7250 Sodium Chloride Sodium Chromate 0000 U|l*i600 Stearic Acid, Methyl Ester 3101 VJL6I750 Styrene Polymer *101 WT1I1100 Sulfuric Acid, Monosodium Salt Syn: Sodium Bisulfate WW50750 Tannic Acid **101 XR22750 , ? XS52500 pi; YR6250Q Titanium Oxide Syn: Titanium Dioxide Tltan I urn Dioxide Toluene Urea 0000 0000 0000 See:KV03500 See: TR8IOOO See: VV7330O Toxic Effects: Neoplastic Toxic Effects: Neoplastic See: VV7330O See: VV73300 Toxic Effects: Neoplastic Status: Undergoing NCI testing U/76 See: WT111100 Status: Undergoing NCI testing V7& See: GB29550 Toxic Effects: Neoplastic Toxic Effects: Neoplastic Patje 5 Toxic Effects: Carcinogenic IARC Review: carcinogenic determination: animal positive Status: Undergoing NCI testing V7& See XR22750 Status; Undergoing NCI testing h/76