Document g8ww8qRpDxVyr7rbeoE6m7K3

APR.15'2002 14:39 2148210977 KAESKE REEVES #5112 P.002/003 MOUNT SINAI SCHOOL OF MEDICINE vJThrCity Uuiutnity o]Nru> Yffk p I p f H tVt^UE *Ht) IMTH ITIICTtKIW TO*K, W-T. tWT Orpin*'** / CmmPitfSHtiirlPT J*ly 31, 1973 Mrs, M*rt Ehreann Ubririan-m^cbargo Research Center library United States Cypsun Compony '" 1000 East Northwest Highway Des Plaines, Illlnele 90016 ' Dear Mrs. Qunsniis. There Is a vest literature reporting result# of Investigations Into the comper#tlve_to;rtcls> of chry.at,lle-'Stoees, ** relatlem to otpex. ?tt'tV9i in summary, '.po significant difference was -found} a 1) 'varieties show important fibrogesic and carcinogenic activity. At your request, *e will provide some of the most pertinent reference*. Insofar as human effects are concerned, it is conceivable that the animal model# do not reflect a difference which night exist among the iffcber varieties; this possible difference 1# the subject of investiga tes in e number of ways. Dr, McDonald considers that.his studies . in the cbrysotlle nines in Quebec have gbon* less lung cancer and mesothelioma thorn other asbestos-exposed group#. Vary worrisoae 1# bis observation that more heavily exposed cbrysotlle ntners bid five times as such lung cancer a# those more lightly exposed(l), This would provide clear evidence of rbe carcinogenic effect of cbrysotlle asbestos, Since Che Individual# concerned bad been exposed only to this fiber variety. Too, review ot x-rny* among these men bos aborvn numerous esses of asbestoaie, demonstrating the flbrogentc effect, la eddltion to nine sod mill employees, studies have slso been uodertaken of factory populations thought to be exposed only to Chrysotlle. This la nor* complicated, since it is difficult to be absolutely sure thsr the populations concerned never h<d sny exposure, however small, to other fiber varieties, One auch study" was reported by Dr. Thor.aa , Maneuso in 1963, and an important concur risk of the population In vestigated arc found(Z). Another study ha been reported at scientific meetings by Dr. Joseph X. Wagoner of me National Institute for Occupa tional Safety and Health, While this ha# not yet appeared In the acien tlflc press, l om sure that you will !jo able to obtain a copy of tbe manuscript from Dr, Wagoner, 4. SCF-ALLF-04680 / APR.15'2002 14:39 2148210977 ij Hr*. Marie Girsitiuj KAE5KE REEVES -2 #51.12 P.003/003 T/'Ji/va Dr, Joaepb wagoner, Acti rig Director Division of Field Studies 4 clinical investigation Rational Institute for Occupational Safety eod Health 600 Main Street Federal Building, Root 7" 033 Cincinnati, WHO 4520:2 la obtaining information oo tbe quaatlwan, advantage may be taken of another set of circumstances, Aaoslte and eroeidolite, the oth er two sojor fibers used Is commerce, are not' itlned la Worth America* end oust be imported, gecord* of these Imports have been kept by tit* Depsroent of Coasserce. We find that only trivial quantities o-f these fibers were imported until the 1940's and of these snail prsounte, crocidolite waa not used In nay insulation materials* although asoalte vs. Therefore* experience of ssbestOA Insulation workers during tbe 1940's sod 19SO's (especially, tbe former) cannot be escribed to other than the oce asbestos fiber that *s isa regular use io insulation materials during tbe 1930's - chrysotile. Since lung caaeer raises, as veil as the occurrence of mesotbelicmwa and deaths of asbestoi*, were demonstrably Increased among these men during the 1640's end 19 50*9, we nay Infer the chrysotlle-assoeiated risk among the8(3-5). Since the problem Is an important one, J expect that mere information will become Available within tbe next several years. 51nc*re2y yours, US:Jlr 1. McDonald* J.c., McDonald, A.D., Gibb*, G.W., Slcmiatyeki, J. sod Rossi ter, C,I, Mortality io tbe charset ile asbestos mines nod mills of Quebec. Arch. Bv*ron. Health. S2(6)j677-686, June 1971. * * s '' ' 2. Mancuso, T.F. and Coulter, E.J. Methodology in industrial bi)tb studies. The cohore approach, sritfa special reference to an asbestos company. Arch. Envijou, Health 5<2>i210-225 (Feb.) 1963. 2, Selikoff, X.J., churg* J, and HnmmoruJ, E.C. Asbestos Exposure and Neoplasia. J.A.M.A, 199:22*26, 1964, 4. Selikoff, r,J. Churg, J, and Kommorsd, E.C. Tbe occurrence of . ,, osbastoaia among insulation workers la the United states, Anns. H.t. Acad. 5cs. 13;.(1): 139-155, Dec. 31, 1968. 5. Selikoff; I.J., Hr.amond, E.C. and CTsurg, j, Asbestos exposure, smoking and neoplosia. J.A.M.A 204( 3)ji06-112, April '1959