Document g4YBXBVzG3XVZoydQxQp1XZa

FILE NAME Talc TALC DATE 1972 May 2 DOC TALC066 DOCUMENT DESCRIPTION Letter to Barry Castleman from the FDA DEPARTMENT OF HEALTH EDUCATION PUBLIC HEALTH SERVICE AND WELFARE FOOD AND DRUG ADMINISTRATION WASHINGTON DC 20204 eT May 2 1972 e ener Unmet ie + Mr. Barry Castieman cairn Technical Services Section Division of Air Pollution and Industrial Hygiene Bureau of Environmental Services Baltimore County Department of Health Maryland Avenue and Hillen Road Towson Maryland 21204 Dear Mr. Castleman letter of April 25 1972 and the enclosed material Thank you for your six months various members of the Food and Drug During the past have had a number of conferences with Dr. Selikoff reviewed about Administration staff here and in New York We have collected and hundred papers on asbestos toxicity and one his of the long time ag and also because of a reluctance the dose response Largely because to a potentially toxic substance to allow human exposure of asbestos toxicity are undetermined The industrial be 20 to 40 relationships rather shaky ground however it will tolerance restist o cn an be determined whether it is too high or too low years before tremolite because it is not widely used have does not have talked with In the meantime of injury as does chrysotile I the background proven less hazardous than other forms who feel that tremolite is some experts be settled by argument of asbestos This point can not Bee and Cosmetic Act which governs With regard to cosmetics the Food Drug be shown to contain activities states precisely that products must i.e. OT our before they are subject to action a harmful or deleterious substance before it can a cosmetic is hazardous The FDA must be prepared to prove beg act against it peteES dusted with talc Henderson et al Condoms and diaphragCm.s A.are F. Joslin A. C. Turnbull and K. Griffiths Henderson W. J. 5. ry es Page 2 - Mr. Barry Castleman eT Talc and carcinoma of the ovary and cervix J. Obstet Gynecol Br Commonw 266 - 272 March 1971 were able to demonstrate talc but not en asbestos within malignant tissue Unfortunately they also noted talc particles in normal tissue nO I would very much like to see the results of a survey such as you discuss There may be a problem in that women who do not use talc dusted contraceptives may have been examined with take dusted gloves so that there may be some problem in developing a control group Sincerely yours stare. Jalin Jalin Loude Loude Jalin Jalin M. John M. Gowdy Loude M.D. Loude . Assistant Director for Medical Division of Colors & Cosmetics Office of Product Technology Affairs Technology fn as SLIT een e Rn nee Wo