Document g2zOQ0K558666bj52OOQ2n1nG

Industrial Hygiene Digest INDUSTRIAL HEALTH NEWS LITERATURE ABSTRACT? ARMED MEDICAL forces ENGINEERING ^ 27 j$55 CHEMICAL \ ^fdical LIuRARy TOXICOLOGICAL LEGAL.. decision* end trends JANUARY, 1955 (Vol. 19, No. 1) INDUSTRIAL HYGIENE FOUNDATION MELLON INSTITUTE 4400 FIFTH AVENUE PITTSBURGH 13, PA. r PLAINTIFF'S >| EXHIBIT i* jjj&a / / / 955 p,iiTstrlal- Hygiene Digest January, 1955 Animal Experiments on the Effect of Amorphous Colloidal and Crystalline Silicic Acid. J. R, Ruttner, W. Willy, and A. Baumann. Schweiz, Z. allgem. Pathol, u. Bakteriol. 17, 352-363 (1954). German. jnfceraysi,a rhe ation nal body, he i Id \ 90 esials tlfi- it. ii Doses of 5 mg. or more of amorphous colloidal silicic acid were toxic to mice in the peritoneal test. Quartz, in equal doses, was nontoxic; on prolonged administration, however, it stimulated the fibroblasts. The .difference in biological activity appears to be due to the structural and physicochemical properties of quartz. The theory is rejected which holds a soluble form of silicic acid responsible for silicosis. -- Chem. Absts. A Case of Silicotic Stone Spitting, E, W, Baader. Arch. Gewerbepathol. Gewerbehyg. 13, 58-72 (1954). The paper describes in detail a case of the rare disease, broncholithiasis in a stonemason. After 15 years of work with sandstone, at the age of 53 he was found to have silicosis. A number of examiners gave discordant opinions on the degree of silicosis. Temporarily he suffered from bronchiectasis with high temperatures. During, this time and intermittently later he coughed out stones which could be identified as siLicotic fibrous tissue indurated with, hydroxy-apatite and calcium carbonate. The stones ranged in weight from 5 to 150 mg. Their appearance, structure, and composition are described in detail. Two similar cases of broncholithiases, also accurring among stonemasons, were found in the literature. The patient felt better after each episode of cough ing and generally improved in health during the two years of observation. Thus the coughing of the silicotic tissue must be considered a kind of self-healing of the lung. No trace of tuberculosis or histoplasmosis could be found. -- Cond. from Bull. Hyg. 91 Asbestosis. Queries and Minor Notes, J. Am. Med. Assn, 156, 1546 (Dec. 18, 1954). * 5?0 . 69, s ust 3yg. t l 92 ti i A 50-year-old man worked at covering pipe with asbestos insulation from 1940 to 1945. The question is the possibility that pulmonary fibrosis evident on roentgenograms in 1952 was due to asbestosis when the films had been normal in 1949. The answer is that the cause of the fibrosis must be sought among other sources than the 1940-45 occupation. Little evidence exists of progression of asbestosis after cessation of exposure to asbestos fibers. Moreover, exposure would have had to be much more severe than in the man's occupation in order to produce asbestosis, and it would have manifested itself in the 1949 roentgenogram. Induction, with Surgical Talc and Transplantation of Granulation Tissue in Cheek Pouch of Golden Hamster. G. R. Bernard, D. 1. Patt, and R. G, Desai. , . ).Arch. Ind, Hyg. & Occ. Med. 10 390-396 (Nov. 195 4 Granulation of tissue Was induced in the cheek pouch of the golden hamster by implantation of surgical talc. Autologous and homologous 31.