Document g2eED03jOQDpjo8vYbK7LkzQQ
:
mteratice Correspondence S00
t C:iHe .E. Freier EA2R01-15 ta JB..DW.. NLiapzpeortledt 223061--11S R.A. Prokop 236-38 FD..AG.. WUebeilblen 220210--1258
subject
FRCat-14T3oxicity Study Request A67821 March 20, 1978
T0: J. E. LONG 220-2E FROM: JON BELISLE -201-1S
sSaumbp-laecsuteof rasterutmoxifcriotmy thsetudryats(rseufrevrievniceng 13th7e-08I9R)DCwe9r0e-daryeceived for analysis of FC-143.
RAT
SURVIVAL
DOSE (ppm) 143 in serum (ppm)
Male
5/5
0
0
Male
5/5
10
21
Male
5/5
30
34
Male
5/5
100
36
Hale
5/5
300
38
Male
5/5
1000
49
Female
5/5
0
Female
5/5
10
Female
5/5
30
Female
4/5
100
Female
4/5
300
Female
5/5
1000
0 not measured
0.15
not measured 0.25 0.65
osraamlpletsoxoifcitwyholsetudbyloo(dreffreormenctehe 85ra3t2s-10s6u5r4v)ivwienrge tahenalIyBzTed28-fdoary FC-143.
RAT
DOSE
143 in whole blood (ppm)
Male
0
0
Male
1000
100
Male
3000
not measured
Female Female Female
not measured
1000
1.5
3000
not measured
G01667
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-2-
.
DISCUSSION
rT ----"n
Garcecautmeurlattehananad rFeetmaalien rFaCt-.143ToatcaonflieivmelthaeppGriofxfiemraetneclyy b1e00tweteinmes
atnhealmyazleed afnodr fteomtaalle,flusoerriunme frcoonmtetnhte. 1000 ppm dosage level was
aT
Male - 1000 ppm Female - 1000 pom
10TAL FLUoORINE (ppmT) 2s
1
A new sampling technique
th nis new teshniques
(not
Only
y5:e0t2Tf3uillsyemo ecnaliSb0re 1aitesd)wanwoalsaseues:eed.s,
dIfetoteesrhdmquiucnlaadtibsoenna.lY7eepipSsufinftiimcmeiisenndtalslhsaatmvapdlluueeesretamoarietnhseihefloirmEietsFeeuddrtthseoerfpl=cehasrisasicczieteersiazdation
fri
pTFaatvoeisdtponDupbtliselcaategsoens stIutpieersievaeni thtehe fsohioitorrpienty StpoutPyessfngouestys Sbeinger's
Proposed study
Grove
NuMBER OF mars
bosace ever
bores
1 2
`
s
.
.
1000 ppm 1000 pom
SGFroouLup E1 1 E-eamtaGttehgse tHermiinatiionBoEfA the l0-dayi study peirieodr, the
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GErionuep1220- Gmaaylse)) Gtrheoupser3u-m wFoeumlatde:be coilected and Ssmitees he
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m wo -- aar
LoTnRSNC
in Belisle
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