Document g2NoX2XYmO1kw0LOZ7vvm0wkV

Ethics Considerations and Status of Resolution Issue Scientific Validity of the Study Benefits to Participants Appropriateness of Compensation to Participants Infonned Consent Confidentiality Cultural Sensitivity Control of Results Benefits to the General Worker Population Expos~d to Benzene Other Benefits March 2, 2001 Resolution Multiple review of protocols by an independent scientific review committee Approval of protocols by US and Chinese Universities' Institutional Review Boards Protocol changes to be approved by scientific review committee US Standards of diagnosis of hematopoietic disease Increased follow-up after treatment Technology transfer for workplace monitoring Early diagnosis of benzene toxicity and removal from workplace Monetary compensation based on standard practice in China Compensation to be based upon level of participation and, to avoid excessive inducement, standard practice in China for similar procedures. Consent forms tailored to type of participation in the study and disease status, e.g., case or control. Forms to be developed with input of Chinese clinicians and bioethicist. Separate password controlled databases for clinical and study-specific research data. Transfer of data between databases requires consent of participant. Questionnaire to determine occupational history and lifestyle information will be developed with input of local Chinese researchers and Chinese bioethicist. Independent Scientific Review Committee will review proposed abstracts of presentations and manuscripts for publication. The investigators will have final control over content and interpretation of published or presented study data. A committee of the central government believes it can use the molecular epidemiology study to justify a lower benzene occupational exposure standard. - Identification of more sensitive biological indicators of exposure to benzene State of the art diagnostic laboratory will remain in Shanghai for future use. Technology transfer from training of local laboratory technicians Possible increase in standards for diagnosis and follow-up care for hematopoietic disease Technology transfer of industrial hygiene monitoring technology & practices SHELL-MCCLURG-051611