Document g2J1k3o1w3nbx9O5YOwQqx8MV

FILE NAME DuPont DUP DATE 1997 DOC DUP173 DOCUMENT DESCRIPTION Book Excerpt - Wilhelm C. Pioneer of Environmental Carcinogenesis Herausgegeben von Rolf Winau und Beiuy Muller Dietz Medizingeschichte und Gesellschaftskritik Festschrift f^...rGerhard Baader Herausgegeben VO Michael Hubenstorf Hans Lammel Ragnhild M^...nchSabine Schleiermacher Heinz Schmiedebach und Sigrid St^ckel pais Matthiesen Verlag ochen vom um Hem & OP the Bhulbek . OP fgitaalnahme fgitalnahmefgitaalnahme -schichte und Gebakkritik Fischaut vem MicMihchal aMiclhal Hubozkurt Hubozkurt Hubozkurt 19 7 19 7 INHALTSVERZEICHNIS Caclius Aurelianus Ubergang von der Autike zum Mitelalter interdisziplinaren und integrativen integrativen collectivit^' GO Atodikation im 14. Jahrhundert Abanhuismuv Spitalswesen in Wien 101 koning outdor outdor ni_ 156 156 HERMANS HERMAN S M. HERMANNSHERMANNHSERMANNS Sham und die 174 ing in Legalization Abortion 209 S. NADAY Krankenhaw in Ein Narod 1931 - 1930 HURENSTURF iene " SchulScehule der MediangeschichtMeediangeschichte - Max Neuburger essene deutschsprachigedeutschsprachigdeutscehprachige Medizingeschichte 23 PROTOR CHueper CHueper Ploneet of EnvironmentalCaninogenesi Caninogenesi 290 Verantwortung und Verantwortung Verantwortung dizshistorische dizishistorische und philosekritschephilosophiekritsche philosphiekritsche des Pleckfiebers Zweiten Weltkrieg dese XIME XIMEXIME MallerAX STS 306 FRITZ BxMM BxMM Juden Blutkult der asi zur Entwicklung S als VernichungsplanVernichungsplaner VernichungsplanerVernichungsplaner 306 306 Germansionung Polens 430 336 46 { Alchesistesace Aufarbeim Aufarbeim Aufarbeim actindeaden Yee 3c <e<< Ose t'r { Vilhelm C. Boeper Pleocer of Environmental Carcinogenesis Robert N. ProctorProctor or three or four powerful was the most dustrial carcinogeos was producing hefust to study Ancadreas of Tarson praised to 1942 nograph on the topic whole thedrawing -ironmental cancer by cers is traceable to to able yet the role , the National Card 1904 1948 1904 from 19481904 and be paid that led to the 1958 O Organization that the and is therefore that uncontroversal Gguy which of which was true He he and carcinogemcity once sccording to un here are the single single most widely Brary Two groups apparentlyapparently Eike his repeated denunciations pap manuscript divivion divivion a tobacco industry vef vefWilhelm : Klory and Deb Knew About Laury Laury } seek Bhs Mice orth 873 Aae) . : > foeate FERERL e Bu Tet chastened by buy advertisemeni gas cantatas cantatas to the front to be after thewar in 1923 soon and States from Germany included delivering became interested more than30300 scientific scientific the production of syntheticsynthetic synthetic chemi- as now now was explain to how explain explain the infectious agentsand artifacts leading diagnosisdiagnosis First World War when cigarertes cigarertes were suspected thedelayed cancer followed followed by cancers his view view , was the inhalsoon inhalsoon of coal tar formes and au exhaust along with asphalt asphalt dass from 10ade 10ade and laden smoke for chiracy of diseuse civilization contury." contury." HHuueeppeett Huepet though Huepet advocate of view His rather egrious and egregious egregious forms century led for micha w some myopier most notablyhis dismissal wha Hueper always though thot cigaretes from gencral hozards Wilhelm C Tumors and Occupational The 1385-3,390 1385-3,90 campaign's campaign's campaign's cosmotact campaign's cia abaus derandcdaerlandcal pps pps ( somowa Adata Medical and Gewis #ach inick- Gre Gre Gre ty eatively induarial chemicais - and be was noteatively Fischer for example and Joseph of of cancer bas disappeared suggestionsuggestion has apparently would probably be difficult to do so add probablyno for any sound scientific fullowed up by epidemiological 1. Du Pont and Bladder Cancer Heper's buzard at Du Pont'sPont's dye works in Lahoratory the company's Haskell months of unsuccessful Lahoratory of hunting in interested in environmental employment there of the Nazi party or an anti the fatherlandin the in 1917 when warconditions already lamiliar Nueper lamiliar with lugh lugh rates countnes increasedbladder capnrcoedruacing couarry clear invariably published ten or twenty years ThisThis wasclear clear evidence to him that between years the beginning of exposures and the importance ofsuch studied the wed gran vermicides refrigerant pounds carbon glycols and related suivems suivems Teflonand Freon Freon Teflon cojonys HarborDu Pont made tage } In 1924 in China Blueper was assigned acute heart investigate way a number young showed containingcontaining the Europeans's discussthis newoccupa ional discase made the way so print Du Pon from the outset by the restrictionsDa Poat placed on Resourch projects ware deteamed not by the institute's institute's were ongually disallowed Huperand hisCompany various departments the Du Pont Company provided the funds which colleagues companiesmight modimcaoldical evninformationinformation the prodier Huepor was bothered by the Laboratory was not studies that allowed to carry een n kngtem more tras 1 year or two might reveal much as cancer The only exception was a which dogs given orally to for a period of cause earned him both this acclaim corporate potency - Blueper concluded from that by and viruse of the the company'cs ompany'scompany's substances conduct failure to bag ociably studies the carcinogenic effects ociablcyoncluded chloreprene . He also concluded hydrazine wamiable media secrecy was was often Hueyes cmployees were being appeared whas appeared to be heavy the whether this mught be case and the Modical Cassamiz's f^r 154-155 04 David Admenstration Admensstration {> dima eb kl that they had been adding lead to several batches of include gynthteichis formation Hueper asked his research chiel whether he When Hueper the chief become upsetthat Hug ersecrets manufacturing discovered one of the company's closely to help On another occasion Hucper Works in Salem County New guarded manufacturing manufacturing to visit the company's dete seriously to bow seriously workers vapors and dust The Chambers Works already as thesite notorious and several killat in thecourse ( compound for gasoline ( The manufacture the nickname FuszFusz *Ma in reference to the fact that many ofthe poisoned workers develope hallucinations)Hueper was taken to the plant floor with several collage was surprised to find that the who told him that heand his plant was very clean He nuntioned men had worked might to clean iut p Hueper realized that what he had seon was a stagal performare be asked to see the benzidine operation in a separate , for which had not been forewarned There he found the powdery white bereke platform window sills everywhere everywhere on the road loading the He wrote a memo to Mr. Du Post describng describing experience sills on awor and was never In November again again allowedallowed toto Hueper visit theChamber of January 1938. The excuse efforts of trouble whenhe protested protested credcitredit medical director and Hueper the efforts eforts two of hes Du Pont superiors head of the Haskell Lab - to claim baza experimental demonstration of the naphthylamine bladder concez was informed at the tone that he was contractually work he refused his Du Pont withoutthe company's consent but refused to reault was bounded by company officials for nuch ofthe west of destb company attitudes softened somewtut a 1984 essay by a 1974 cited Bueper's record with thecompany worker worker health and safety le 1974 evidence of its longst^ding Occupational Safety and #5 stration baul adopted national standards to limit occupanwui exposures the final y admiardadmiard and betanaphthylamine sod in 1976 company company company finally admiard tha 2.000 dye workers exposed Michacis 17 Uueger 30 S Nashes Nashes eebor a. Nashes Nashes Nashes Red Ya Co Me teats Py victim tobladder cancer Hueper must have felta certain vindication for loving sounded the alam so early * Occupational Tumors and Allied Diseases In the summer of 1938. Hueper began work on his page magnum opus published in 1941 as Occupational Tumors and dified Diseases The book presents Be first major review of world literature on occupational causes of cancer but theper fora time had difficulty fading a publisher C Thomas of Springfield agreed HiHninois nois finallaygred to to pprintrint the manuscript but only after Husper's new employer Rm Willam R. Wamer agreed to furnish $ 1.000 to offset costs Hueper had worked for Warner since the summer of 1938 and had given freedom to work on sent^>ficprojects of his own choosing Much of his spent preparing his manuscript during which time he also studied the counogenic effects ofsunlight hormones coal t^rarscais asbestos and ionizing " began his book by suggesting that gigantic growth of modern Hueperhad bath turnedturned bath is creators and beneficiaries into victires of a boss of diseases never observed before The stuemical stuemical industry lad syntheuc substances ending ending numbernumber and for ever- lacquers pigments machines motora and machines drugs componuts componunts drugs articles anamerable other articles Metallurgical industries were exposingpeople in arsenic lead niercury and chemical insecticides had had introduced lead arsenic copper and had introduced novel threas into the example cising unprecedented lovels of dust as lww medical diagnostic tools remgan- scals for preserving preserving and coloring radium- ultraviolet remgan-radium- and rays and new Workersexposed to aromatic com- dafone included pronarprsonars canhor sukara coaltar suckerssuckers dyersdyers explosive workers unlimery micrs makers Curie Comuni is the Conca Nale NR 1997 ya Wahmudon pagjume valcanters pharmaceutualpharmaceutual pharmaceutual exposed to one degre Hueper went ou to exte though preventable andthat the key in most cases soferd process The hand cancers cancers formerly safety by the introduction of copper smelting rash the rash of cancers associatertwith those regions ofarconical beratuses and epithetionis would probably end substances 20 occupsional convers of the prodaar ben largely closing the WalesWales had drepi^ H^per predicted drepi^ KeichensteiKneichensteinla G arsenic Germa did spinners not because the German cufton oil An shit from made pinning spiderne in the United States where apparentlapyarently schwed acid further i England place took ccartiear rtier in temperatures at wah ^ relatively in Germany because the shift from English and Engfish combining tarry soot Dues were often torraously narrow be bol and vertical segments one to cawl through the chumey requiring the chumey seveni diametr chumey were only uches in climbing diameter hence the poxatice " year old for low pounds Geriau therfore therefore easier and safer to clean clean Cancer In other words about the willegies willegies been foundto seance seance a early an after these laws were of the cancer of scrcture of aliguitynoproved noproved equally appafliog occupational houth sectiodes - as die imponsible Anabondo copper mines from the disappear Muntasia Substances Substances such as generations would heve te ; erred late 1937 there were only two states Colorado and by agents physicians were fa more concerned Gronan accent didn't help his case previously he had returned to Gormany to seek Pathaike REEEE gre **** tee BY gts Started Stared Started Started en Fuhbein was replaced as editor and thejournal stopped occupationaland environmental environmental cancer bnzards publishing awk Hucper's Censorship Starr's known book on that American scicoties Transformation Switi of American & war yearsowned owned autonomy This was indeed the pondj^ Research Graus who in 19511951 wro choosing and is met dii ond sees f^ t to dat wore promisingpromising promising The M7 may well until & 1944 for examste It was outside Humper's investigatoris nvestigators coturely not institute experience shows though Hueper receiveda lener front the Federal that he was poder investigation for >> had firmare Ou Pont's medical director derwunced him 4 able to tha rge that was dismissed when Hueper was mer colleague jealous of the declaim declaim Hueper to show had of * wrote to the director the NCI accusing " though this teo was not necessarily necesarily even pro Hueapekirnd of patermilsoc .one could rugerment relaxions . On at least one one occasion raining health Political Politcal pressures also came from the Public Health Service's own Division of instal Hygiene DIH which on several occasions forced Hueper to limit or even in terminats projects involving chemical or nuclear hazards to one instance the DMB director forced Hueper to remove by name from a studyidentifying hazard spcupational spcupational in the chromats inceary the paper evenmally identifyng cancer as an appeared apeared under de sole authorship of Thomas Mancuso then at theOhio Health Department oven been documenting documenting ozard as a consultant for the Mutual Baltimore since another copies of carboncarbon copies 1946. On his prepublication occasion Hueper leamed prepublication papers submitted to the board NCI clearance were being routinely routinely submitted to the DB Punt company company company management for commentary sad appraisal Hueperwas startled by olyanonable what he considered considered evidence of an collision between some members Hea~-n years Service with an induxrial persecusion se pary which had been en- page memo to John R. Shady History of the Institute Hueper Hueper Hueper complained Environmental Environmental chronicling ThTe he Dark and Section as the National him by that pressures hadbeen exerted on the industrial to restrict his travel compensation trials and his public bealth On severalseveral oc asions submited for publication the names of carcinogens carcinogens Scientificpapers up for approval " in Deparment of Labor on matters until he instance resigned Tumors and , fearing " by by and the phically Hooper protested his research but information officers restuctions such as these the perverted by by Michael R. Surgeon General's grounds that they they worked indirecty to manager to spend kamer kamer insure Battnad an Phe be ted Be sad setcospessara Wneb cespowd hess hu 7 should move devolop vancer No Huepes 306 onve ocupational occupational cancer impensation impensation consequential act investigating from investigating the Wllers of the Colorado plateas Hupper in April of 1988 vare of the fact that Dropean tes of lung cancer His efforts longsufferesduffered from vayi WA papers dealing with radiation had to be evidnce When to Huepersought presentpresent evidence of the mission ARCColorado StateMedical Society the 4FC's Director of Biolog edicine Shields Warren ordered meinect I references in his papetorthe the NCY to the Sonay's presides When word hy nays upWarren again director silently axOPENE lassiture smissal Huepocvetruedatat the The epidemiologicaepidlemiolgical work en occupational but was cancer order came from eneral fiueper was heaxefond from was prohibited allowed to do only experimental work investigations into the camssance of consi search travel west otherwise old Out of Step With the Times rained in 1964 be ww As he later wrote he had " to OSQ mumo mumo 1. BrymbusBrymbus $3 1961.70 1961.70 may prove to be of atom Blame for thisconditon industrial managers dramatic rebirth of bit ernes be bitterness as goverMZIU comprehensive set of strategies strategies to avoid moral and piece or delay em- the lloottoonn were not compensable publicize the problem presong many of thewaxpresong such such activities la an Publichealth authorities were also culpable industry to becaptured industry interests Bemselves ut often not until political pressure had been broughtbrought groupe presu hond pointing medical establishment establishment Hueper of governmentgeovernmente medical reasreasreas of needendeedednededneededneded inquiry inquiry inquiry andand andand in tudy oof fneededbazards posed built radioactive of bazards posed to to bones on the radioactive radioactive dag people living hosphate mines and there were insufficient studies of the risks from retall brome dust and fumes in foundries shops More needed to be se rick ef ects in bout the effects of acid mists manufacture manufacture and chrome chrome operations chromite pigruents used in various industries Stoles migrant laborers pesticides pesticides wnd of the nickel retiners of Ingioia Evidence of a cancer risk anonganong chemical workers tumo romatic amines in rubber factories for exaraplez had been been around for decasiot ybere were the studies of the effects of these substances on dyera paint~ s rinters using colored ^<aks More needed in be known about whether the given to women as contraceptives contraceptives of merepause increase the risk & carcinogens terinecancer and whether cansferred through the placenta carcinogens in the midternal organst to canst cancer tineper compled wuh few important exceptions pubhc had uthontes been study problems such as these Why was the bver laza d laza d animnul discovered only in the 1978 when plastics inplanted plastics had exploring whetherwhebtheer et Lun or other Whybabd ad thesenever show show increased increasiendcreased conversi long ceding irradiated funds toaconscruble number ofyoung subteryis the 95087395098739 Hueper's relentless me ofhis closest friends uncanny lucility ) the NC to check and alarm precision cholarly cholarly especially yebrows yebrows yebrows a National Coansil ndustry stormedstormed in in waving a copy of the sticlewaged in among among the picturespictures of Larold Stewart later recalled the for that life On one vicuska where where scattie in winch Hea scurity outreat batang bermid a pro at fs Bege opp 0 radna tazer publish such appeared flag in the face ofabullw problemproblem Hooper's main problem carrents of ume suspicion could even even wennethwenneth Rudolf Vrchow Vrchow rather staid colleagues The warung rea that he was couc of cancer a the century to the early that chemicals genes o or to perhaps the parely axxumptive radiaton radiaton anadnd other was in his view mums Beeper play an important role in } 1930s s laboremphasi workplace + in the post conservatism theup severoarent boasted that he had a3 peers of flueper did Rosenthal Memorial Award for Advancement Association for the In 1958 be won the Anne Frankel presented to him by the American American Nations United United the Cause and Control ofCamerCamer the World presented the award at a plenary session of the United Nations at the Public Health Service of congratulations Ichievement grant him their courage in effecting year the editors of Modem Distinguished Ichievement Award in effecting control of noxious emronmenul emronmenul agents in HuantarianHuantarian Award of the National Nealth Medal of the Cancer Pramion Pramion Camar in Rome thoors of the mighty concrete concrete unui important role the in 7 Amul First Award at the Society than more a dozen y^'k^ honored , the Cane . Huoper moest have ork the NIH awand clied clciledied be leukemia bave pleased his former inducedinduced leukemia recognie bal posed canoe hazard mors by water Apri chemicals andhis 1942 of ththe e Nanoral Coupational Benture wasdedicated soldier dedicated in the manory of the war 22 of haut at atack age 84 nero call tolknero Most of his wating bis none He is probably Carson whose chapter on relied For relied heavily colaborative helped arrange a colaborative the specially be the wider public Stent Spring omina y pathologist ^'migr^p'athologist Carson to the Risaster contammmed contammmed water Hueper was Caser's conviction that we are comparison of the present cancer century when common killers of carcinogens carcinogens Hoeper was an activist arcinogens might pave wwe tie mtractable than biol^giu Gaul > " biol^ggiourms Now " Now fe a arcmogent testinternalized taken Ecally wat weething to be seriously wething with loudy ofthe Addestration OSHA and the Environmental Protection Agency in 1979 Hueper Addestration as having to clear the path helped contribution whatwe might political today must also notbe forgotten Hueper was aware thai what process and what thatmuchmuchof we knowor don't know je the product of whar opportunity and struggle Ignorance about what cases cancer and to whar is therefore not just a rotural consequence of the shifting boundary between unknown but a political consequence of doxisionsdoxisions concerting concerting how toto approach approach or neglext what can andshould be done Ignorance is sucially constructed by outright consorship admittedly are by Bilures fad cilors to absence or neglessnegless of interested parties and with noise Hueper was aware of och thang to jam the scientific mrwaves ensure that our memory of his labory does notfade with the passage