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Has., , HA5KELL LABORATORY REPORT NO. 430-77
MR NO, --- " ---
Material Tested 0
Sample Ready For Test In
3-7-77
Material Submitted Textile Fibers
Department, Seaford
~ ^ SK.H IRRITATION AND SENSITIZATION Tr.T. ----- - p|GS
Procedure: The test for or Ima rv .I tr-r- ! 4-^0. _
--- ----- GUINEA PIGS
'
. --
s s bb,3B i' I - 1 <irop '"o -05 > - ca one each week over a three-week period ^h !+ *za+,? po+en+ial a series of four sacrb^intrldl3^ ! S?0li,der skln of 10 mal
Following a two-week rest perlodP the test
StSd f 0,1 ml of a ** solution (vol/vol) 0 ^ + 1 jnJe+,ons W8S given,
drop (0.05 ml) each of a 50* ,, ? ! 2 + ?nImals were challenged for sensitization
? f +es+ ma+erIal In 0.9* saline,
shoulder skin. A g?oup of 9 p ^ i o u s , ? Solu+," <vol/vol) of test m a t e H a \n ] | S l ' i * h9 ' a"d " 9h+lV TM bb'"9 "
provide a direct c ^ a f l s o n o f ^
mexpose* 9u '"a P<gs received Ilml lar a M H c I i ? t l a2 rJ?n Ibe shaved ,n+ac+
me
~
~anim-a-l--s---w-e--r-e---r--e:_c_h_a_l_l_e_nged
foolllloowwiinngg tthhee^sIamm *e0p*r1o0c"e5dunre Sak,s nTorf tsh,em,clahra an9g-e
aAfs ter In
add?+loni+ *ne f ?ha,,en9
f
Concentration In distilled water
Primary Irritation Test-24 Hours -48 Hours
Challenge Test-24 Hours -8 Hours
Sensitization Response Ratio**
^challenge Test-24 Hours ,, "48 Hours ^nslfixation Response Ratio**
Reactions* on Intact Gujnea Pin Skln
-n-- __- , Test Arens
I
H U Animals - Ih. Avg. Wt',,' - 589 g'
Control Areas for Challenge Test
n u
Av 9* Wt. = 738 g
Rechallenge Avg. Wt. * 758 g)
'9 New Animals - Average W+T = 6^7 g Rechallenge Average Wt. = 703 g)
50*
10 neg. 10 neg.
'++ 4+, 5 neg. 4+, 6 neg.
5*
10 neg. 10 neg.
I+ . 9 neg. 10 neg.
1/10
50*
9 neg. 9 neg.
5*
9 neg. 9 neg.
I++, G+, 3 neg 5+, 5 neg.
10 nog. 10 neg.
8 neg, 8 neg.
neg. 9 nog,
Bteadgiaaaannt mn fn ia JS S
2- -
Summary :| j | shaved frvfac " llu to v e r y ^ n d ^ e a c W o n / o b w r v M 'T s e ie r il o n e r T ' Jor s "s l , ' t ? o I n i l I s t M ^ l l s t ' ? / lo"a l ' ^
l 'a
" tf,e
A Other namejj Compos i11on :
* Reaction Code?" + ++ ++4. _ .. . ^
^ i t i t o t j o n 15 ; , ,, : M
I ; , T 0- stron9 t r r u ~ > *** srythe"a > -- . t + + + + . nacrosts.
ppl l.d initially or on the concurrent contras. '"Cr,,aSe at Cha" en9e 0v6r the response expected fro* the same amount
hrel imlnary range-f Inp, ,, 9 date Indicated
lrr|tatIon ^ ^ ^
Report No, 430-77 Date Issued,* June 10, 1977
1 uy;
Nancy C./jeoouman Technician
Approved by 1---------- l i U * U + i ------------------------------------------ --
. . . . n f / Raymond W. Morrow "
Chief, Derma I and Ocular Toxicology Section
% W.
M Company Sanitised. Does not contain T SC A
