Document evN2ZOk0qBa9YLXM4bGGYXVKM
Aragg - 3297.
479
~
AR 226-3 297
`TRADE SECRET
Study Title
'H-25499 and H-25500: Subchronic Toxicity 90-Day Gavage Study in Male Rats.
Laboratory Project ID: DuPont-11671
AUTHOR: Linda A. Malley, Ph.D., D.A.B.T.
~
STUDY COMPLETED ON: September 4, 2003
PERFORMING LABORATORY: E.L du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50
WonkRecussr Nuva {gull Newark, Delaware 19714-0050
SERVICE Cove Novefal}
-- Coumpany Sentieed.Doesnot conte ene
ssn sarn
~
potion
We, the undersigned, declare that this report provides an accurate evaluationofdata obtained
from this study.
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910-D.ay2Gaanv5daHg-e42S5t5u90d0y:inSuMbaclhevoRnatisc Toxicity
~~ TABLE OF CONTENTS
DuPont 11671 Page
1
PR S------------------ EE. |
RISTOR TABLES. ...mmnmimmmmmssmmsnssmmmmmmmmssint
LIST OF APPENDICES...
STUDY INFORMATION... SUMMARY.
am ----------_
INTRODUCTwIcON
mms--------
OBIECTIVE consis
and]
MATERIALS AND METHODS...
T
A. TES SUBSHANCES rrr
7
B. Test SPECIES rrr
----------------
| ATIAYUBAIY cocummmmmmmmammmi------------"_
3. entfication
m--------
~~
4. Health MOBIONNE PROGRAM...
D. QuaraandnPrettesitPenrieod.
'
AD
A--
F. Assignment to Groupsand Study Start...
send
GAT TorkSIS DR csmmnmmmmmmmmmm---------------- 1
Roly WhlSh mmm
10
IL Clinical ObSerVationsand MORAY sri
10
AA --
RESANUDDILSCUTSSISON mmm l
RECORDS AND SAMPLE STORAGE sons |2
REFERENCE consumes
APPENDICES
----
wn
~~ --
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9205-4Da9y9GaavndagHe.2S5t5u0d0yi:nSMuablcehvRonsc Tricity
~~ LIST OF TABLES
DuPon-11671
Page
`TABLE 1 INCIDENCES OF GROSS OBSERVATIONISN MALE RATS SUBSET ONE... 15
TABLE 2INCIDENCES OFGROSS OBSERVATIONSIN MALERATSSUBSET TWO...
16
TABLE 3 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS SUBSET THREE ....
n
`NTEAOBPLLEA4SITNICCIADNENDCNEOSNO-FNEMOIPCLRAOSSTCIOCPILCESOIBOSNESRSVUABTSIEOTNSONIEN MALE RATS smsmmmm--
TNAEBOPLLEA5SITNICCIADNENDCNEOSNO-FNEMOIPCLRAOSSTCIOCPILCESOIBOSNESRSVUABTSIEOTNSTWION..M.A.LE RATS wmmmm--
N`TEAOBPLLEA6SITNICCIADNENDCNEOSNO-FNEMOIPCLRAOSSTCIOCPILCESOIBOSNESRSVUABTSIEOTNTSHIRNEME.A.L.E RcAcTSc
20
TNAOBN-LNEE7OIPNLCAISDTEINCCLEESSAINONDSLSEUSBISOENTGORANDEES.O.F.MICROSCOPIC OBSERVATIONS IN MA- LE RATS 21
'TNAOBNL-ENEOIPNLCAISDTEINCCLEESSAINONDSLSEUSBISOENTGTRWAOD..E.S..O.F..MICROSCOPIC OBSERVATcIwONeSrINmMeAmLEmR--A--TS--"--
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~ LIST OF APPENDICES Page
APPENDIX A INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS aime AAFPFPEECTNEDDI.X..B INDIVIDUAL ANIMAL MICROSCOPIC OBSERVAT--IONS LISTINGwIeNDIVIDUAL ANIMAoLdS
-- -- CompanySentizad. Dossnotcontain TSCA C81
a y-- s _
STUDY INFORMATION Test Substance 1
J sno occ m)
Synonyms/Codes: + H-25499) + H-24616]
puree
Haskell Number: 25499 /24616
eo
Psi] Charis: Opaque tan liquid
`Stability: The test substance appeared to be stable under the
conditionsof the study; no evidenceof instability was
observed.
--_--
"Test Substance 2
Substance Tested:
Ssnonyms/Codes{pE inN
Haskell Number: 25500
Phil Characters: Cleriuid Suiits The test substance apparetobe sable undethe ccoondviteidonsof the study; no evidenceof instability was Sponsor: W1i.midnugPioonns,dDeeNleawmaoruers19a8n9d5Company USA
--_
Ea iv Initiated/Completed: November 5, 2002 /(see report cover page)
ee eee e Gomnamy Sanitzed.Dossnotcontain TSCAC81
H90--Day2Gaa5nvdaH4g-e29S5t5u09d0y;iSnuMbaclhevoRnaitscToricity
Dupont 11671
--_
SUMMARY
A 90-day oral studyinrats was conductteod evaluate tJahndeHp-ot2ent5ia5las0al0
toxicity of H-25499" in
oCfrtlh:eCvDeh(icSlDe,)B7R0 mragt/s.kgGrHo-u2p5s5o00f,1o5rm1a0l0e0rmatgs/wkegorefHad-m2i5n4is9t9erfeodr d1a4i,l2y8d,oosrag9e1sdbayys.oraBlogdayvage
wAfetiegrht14w,a2s8,meaansdu9r1eddatywsiocefwtereeaktlmye.ntC,li5nircataslpoebrsegrrvoautpiopnesrwteirmee epovianltuawteerdethsarcoruigfhiocuetd tfohre study.
evaluationofnasal histopathology.
NraatssaaldmleisniiosntserweedreH-p2r5od4u9c9ewdeirneracthsaraadcmtienriiszteedrbedy Hd-eg2e5n4e9r9atainond/Ha-tr2o5p5h0y0o.ftThheeonlafsaacltolreysions in eafpfietchteeldiurmatasnwdasdelgoenwerfoartiaonni/mraelgsensearcartiifiocnoedftafhteerr1es4poirra2t8ordyaeypsiothfetliruema.tmeTnht,ehionwceivdeenrc;eaollfthe rats treated with H-25499 were affected after 91 daysoftreatment
"wTihtehnHa-s2al54l9e9si,onwsitihn rtahtesaadddmiitnioinsatlerfeidndHi-n2g5t5ha0t0rwatesrteresaitmeidlawrittohtHh-o2s5e5o0b0sehravdedadihnersaitosntsreiantetdhe
nasal turbinates. The lesions observed in this study were similar 90-day study with H-24616|
to those observed in aprevious Based on the resultsofthis
~
swtiutdhy,a sthuerfnaacstaalntlecsainonbseoabtsterribvuetdedintothteheprseuvrfiaocutsansttucdoymwpiotnhenortgoafntofhleuomratiedreiaulr.ethane polymer
--~
s* uDpuprliynogfth2e5c4o9u9rs,e ofthe stady, second lot (H-24616)ofthe same test substance was used due 10 an insufficient
-- Comnany Santized,Doesnotcontain TSCACBI
9205-4Da9y9Gaavndag2e5S5u0d0y;inSMulbcehvRoaisc Toxicity
Duront-11671
--_ INTRODUCTION
hiseuseesdtassaucbarepert pcrootenctsantS .10 a previous 90-daS y oral study, rats wereE administeredda5i0ly) 1
dosagesof0, 50, 250,qf 1000 mg/kg/day(based on active ingredient) ofthis same
C-- was obse-- rved in male and femalebaytgsaavtaaglel.d"osNaagsesa,laonlfdacitnofrlyamepmiatthieolniuofmthdeegeonlefraacttioorny/necrosis
tephitthtehelisuumrfwaactsaontbsienrtvheediprnomdaulctemraatys ahdamvienicsontterriebdu2te5d0toort1h0e0n0asmga/klegs/idoanys..
It In
was hypothesized ordero est this
h(yGponthieseids,witn ethye c1ur0r0entmsytusdy,imyaloepismere administered daily dosagesofthe vehigle
formulation (H-25499), or 70 mg/dayofthe surfactant alone (H-25500). The dosage for the
surfactant was based on the concentrationofsurfactant in he fmmglormuiaiion.
dTuhreinsgtutdhyewcaousrosreiogifntahlelystiunidtyi,attehdeuasmionugntteosfsHub-s2t5a4n9ce9lwoatsiddeenttiefrimeidnaesdHt-o2b5e49i9ns.ufHfiocwieenvterfo,r the `rceommapilnedteertoheft9h0e-dsatuydtyr.eaTthmeernetfopreeri,odH.-24Al6l1r6ef(aerseenccoensdtolotthoeftetshtestuebststsaunbcsetainnceth)iwsarsepuorstedwitlol use H-25499.
--~
OBJECTIVE
H"T-h2e5o5b0j0e,ctwihveenoftahdimsinsitsutdeyried tboycgoamvpaagreetothmeaploeternattsi.alTnhasealortaolxircoiuttyeooffaHd-m2i5n4is9t9raatnidonsuwrfaasctant, selected because it was the routeofexposure in the previous studies
MATERIALS AND METHODS
A. Test Substances tTehstedtaesyt 5s2u,bstthaencqeu,anHti-t2y5o4f9)H-25499 was supplied by fheas5pdoenstoerramsineaodptaoqbueeintsaunffliicqiueindt. fOorn p= the reminderuosfedthuentisltusdyt.udyThteerremfinoartei,oan.second lot ofthe same test "san Twhaes uarsstiugcnaendY Haskell LaY boratory NumbseurppHl-i2e5d5b0y0t}he sponsoargaclear liquid. The surfactant "iTnshteabtielsittsy,ubssutcahncaessaacphpaeanrgeeditnocobleosrtoarblpehyusnidcearltshteatceo,nwdaitsioonbssoerfvtehd.e study. No evidence of --_
--e -- e ---- Comonm Sanired, Does net corain TSCA ST
H-25499 and H-25500; Subehvonic Toxicity 90-Day Gavage Study in Male Rats
--_
B. Test Species
DuPon-11671
MCaarloeliCnralw:eCrDe(uSsDed)IoGnSsBtuRdyr.ats received from Charles River Laboratories, Inc., Raleigh, North `The rat was selected for ths study because it is the recommended species specified in the igunifdoerlmianetsi.onTisheavCairlla:bCleD*f(rSoDm)tIhGeSliBteRratsutrrea,inthweassupcphloiseernabnedcparuesveieoxutsesntsuidvieesbaactkHgarsokuenlld Laboratory. This species/strain also is considered suitable relative to longevity, hardiness, sensitivity to the test substance, and low incidenceof spontaneous diseases.
C. Animal Husbandry 1. Housing
All rats were housed in stainless steel, wire-mesh cages suspended above cage boards. Rats were housedonepercage. Cage racks were relocated within the animal room each week and cages were repositioned on the racks every 2 weeks. Animal rooms were maintained on a 12-hour light/dark cycle (fluorescent light) and at a temperatureof22 3C and a relative humidity of 50-20%.
2. Feed and Water
~~
`Tap water was provided ad libitum. All rats were fed PMI Nutrition International, LLC
CwearstiifniceodrRpoordaetnetd LiantboDitheetfo5o0d02atacdonlciebnitturma.tioDnusrisnpegcitfheietdesbty(setxupodsyudrees)igpne.riod, test substance
3. ldentification
Priorto assignment to groups,eachrat was temporarily identified by cage identification. After assigament to groups, an individual identification number was tattooed on the tailofeach rat. `The information on the cage labels included the unique 6-digt Haskell animal number and the individual identification number assigned to each rat.
4. Health Monitoring Program
As specified in the Haskell Laboratory animal health and environmental monitoring program, the following procedures are performed periodically to ensure that contaminant levels are below those that would be expected to impact the scientific integrityofthe study:
+ Water samples are analyzed for total bacterial counts, and the presenceofcoliforms, lead, `and other contaminants.
+ Feed samples are analyzed for total bacterial, spore, and fungal counts.
+ Samples from freshly washedcagesand cage racks are analyzetdo ensure adequate
--_
sanitation by the cagewashers.
_-- Company Santtzod. Doss not contain TSCA CBI
H90-.Day2Gao5nvda4gHe25S9t5u0d90y:inSMuablcherRoantisc Toricity
Dupont 11671
--
Certified animal feed was used, guaranteed by the manufacturer to meet specified nutritional
requirements and not 10 exceed stated maximum concentrationsofkey contaminants, including
specified heavy metal, aflatoxin, chlorinated hydrocarbons, and organophosphates. The
presenceofthese contaminants below the maximum concentration stated by the manufacturer
would not be expected to impact the integrityofthe study.
`The animal health and environmental monitoring program was administered by the attending laboratory animal veterinarian. Evaluation ofthese data did not indicate any conditions that affected the validity ofthe study.
D. Quarantine and Pretest Period Upon arrival at Haskell Laboratory, the rats were quarantined for at least days. The rats were observed daily for any clinically apparent signsofdisease or injury and weighed 3 times. On the basesofacceptable body weight gains and clinical observations, all rats were released from quarantine by the laboratory animal veterinarian
E. Study Design
Male NumberofMales
Daily Dosage
Dose Volume (mLkg)
~~
1
15
0 (Control)*
408
m
1s
70 meg Surfactant H-25500
1.00
bvee 15
1000mg /kg H-25499"
4.08
-GroupVreceived asecondlot(H:24616)ofthesumetest substancebeginingontestday52.
`Study animals consistedofthree subgroups: Subset | was sacrificed on test day 14 (5 rats/group), Subset 2 was sacrificedon est day 28 (5 rats/group), and Subset 3 was sacrificed on test day 91 (5 rats/group).
F. Assignment to Groups and Study Start The rats were selected forstudyuseon the basesofadequate body weight gain, freedom from any clinical signsofdisease or injury, and a body weight within + 20%ofthe mean. The selected rats were distributed by computerized, stratified randomization so that there were no statistically significant differences among group body weight means. Administrationof test substances beganontest da0y. The rats were between 6 and weeks of age on test day 0.
--
`Company Sanitized. Dossnotcontain TSCA CBI
9H0-.2D5a4y99GaavndagHe-2S5t5u0d0y;inSMuablcehrRoantisc Toriciy
DuPont11671
--
G. Administrationof Test Substances
H-25499 was administered undiluted, once daily by gavage to the study animals. Starting on test day 52, H-24616 replaced H-25499 and was administered daily to the study animals. H-25500 was diluted with deionized water and administered once daily by gavage. Animals designated for Subset 1 were dosed for 14 days. Animals designated for Subset 2 were dosed for 28 days. Animals designated for Subset 3 were dosed for 91 days. The volumeofthetest substances given to each rat daily was based on the most recently recorded weight. Control animals were similarly treated at the same dose volumeofdeionized water as the 1000 mg/kg H-25499 group.
H. Body Weights
All rats were weighed twice per week.
I Clinical Observations and Mortality `Cagesite examinations to detect moribund or dead rats and abnormal behavior and appearance among rats were conducted at least twice daily throughout the study. At every weighing, each rat was individually handled and examined for abnormal behavior and appearance.
J. Pathology Evaluations
~
Five animals from each group were sacrificed on test days 14, 28, and 91. Noses from all
sacrificed animals were processed and microscopically evaluated.
-- vo `Company Sanftized. Doss RotcontainTSCA CBI
S4o2yC5rodn10g2e5s500t: SciToi
Durr11
~
RESULTS AND DISCUSSION
CtOiMrBwiersirs aodmcirnetdsHn2s55o0E iat on-- y). Theser eiar| nmms r "Text Table 1.
TEXT TABLE 1
INCIDENCES OF COMPOUND-RELATED MICROSCOPIC LESIONS
IN THE NOSE OF MALE RATS*
TDTare vem _amw No abnormality detected
Degeneration/atrophy, olfactory mucosa Degeneration/regeneration, respiratory mucosa.
Control
3 1 1
70 mg/kg/day
3 1 1
aE
1000 mg/kg/day
1 3 2
Adhesion, turbinates.
-
1
-
Exudate, nasal cavity
-
1
1
28 Days
No abnormality detected
~
Degencration/atrophy, olfactory mucosa
4
2
1
1
2
2
Degeneration/regeneration, respiratory mucosa -
-
1
`Adhesions, turbinates
-
-
-
Exudate, nasal cavity
-
-
1
No abnormality detected ` - - 91 Days
Degeneration/atrophy, olfactory mucosa
1
5
s
Degeneration/regeneration, respiratory mucosa. -
1
-
Adhesion, turbinates.
-
5
-
Exudate, nasal cavity
-
=
1
*5 rats/groupitime point
`The primary finding in the nose ofmale rats administered 1000 mg/kg/day H-25499 by gavage
`was degeneration and atrophyofolfactory epithelium. Degeneration or regeneration of
respiratory epithelium and exudates within the nasal cavity (composedofproteinaceous material
and neutrophils) were also present in a few affected animals. Olfactory lesions were present in
low incidences at 14and 28 days, but all animals were affected after 91 days exposure. These
lesions were characterized by disorganization and thinningofthe olfactory epithelium especially
along the ventral one-hoaftlhfe nasal septum in the posterior nasal sections. Other areas more
commonly affected included the medial extentsof the ethmoturbonates. Minimal focal olfactory
--~
degeneration was noted in some controls; however, these lesions wererandomlydistributed and
ee
TT
--
Company Sanitized. Does not contain TSCA CBI
9102-5D4a9y9GaavnadgHe-2S5t5u0d0y:inSMuabclherRoantisc Toxicity
Dupont 1671
~
thus distinguishable from the compound-induced lesions.* The compound-related lesions
observed in the current study following exposure to 1000 mg/kg/dayof the
Lt`material.
aresimilar to those produced in a previous study with this.
ItnhoasneiombaslesravdemdinwiisttheHre-d257409m9g/wkegr/edoabysesrurvfeadctianntthaelnoonsee.(H-H2o5w5e0v0e)r,,oilnfatchteorsyurcfhaacntagnetsosnilmyilgarrotuop, obleftawceteornytcuhrabinngaetseswaenrde tahlesonaassaslocsieaptteudmw.itThhfeisberoaudsheasdihoenssiownesrbeeltiwkeeelynainsdeiqvuiedluaaloftufrobcianlaltyesmoarned sinevtehreesoulrffaaccttoarnyt-eopniltyhegliraolupnecwreorseisquaanlidtaultcievrealtyiosni.milTahruos,tmhiocsreoosfcroaptiscicnhtahnegpeoslyinmtehresnuorfsaecotfanrtats `cgornosuips,teanltthporuegshenlceesoiofntsuirnbitnhaetseurafdahcetsainotn-so.nlTyhgeromuepchaappneiasrmsuonmdeerwlhyaitngmothries aspepvaerreenbtalsyegdreoantetrhe severity is not known.
No studies have been conducted with potentialfornasal toxicity has not been determined.
Nevggtheless,based onotnhee,reasnuldtsthoufsthitiss
study, the nasal lesions observed in a previous study wi
CS<1 be largely,ifnot completely, attributed to the surfactant componenofthe
`material
_
RECORDS AND SAMPLE STORAGE
Ahlel dspaotnasaorn.d rLeacboorrdastofroyr-asnpaelcyitfiiccalocrhsairtaec-tsepreicizfaitciornaswcdoantdau,cstuecdhbaystpheerssopnonneslorfiwlielslabnedreeqtuaiinpemdenbty records will be retained by the facility where the work was done.
A sampleofthe test substance will be collected for archive purposes and retained at Haskell rLeatbaoirnaetdorayt,HaNsekwealrlkL,abDoerlaatwoarrye,.NeSwpaercikm,eDnesl(aiwfaarpeploircaabtleI)r,onraMwoudnattaa,inanRdecthoerdfsinaMlanreapgoermtewniltl,be: Wilmington, Delaware.
REFERENCE 1. DRautPsownittHhaOsnkeel-lGeLnaebroartaitoonryRe(p20r0o1d)u.ctiHo-n24E6v1a6lu:atSiuobnsc.hrUonnpiucbTloixsihceidtyre9p0-oDratg Gavage Study in
Fdaoycsa(lanmiimnailma#l66d5e9g6e5n)erwateisosnoimfiloalrfocotrhaytespeietnheilnicuomnitnroolnasnnthlus amdamyinriesptreerseednt1a00s0pomngta/nedoausyocHc.u2r5r4e9n9cefoorft2h8is
--
sepiiotnh.eliIunmaidndtihtiiosna,nismrailf.actual disruption ofthe olfactory mucosa precluded citical evaluation ofthe olfactory
--_-- `CompanySanized. DoesnotcontTSaEAiCna
H90.-Day2Gaa5nvdaH4g2e59S5t0u90dy:iSnuMbaclheroRnatiscToxicity
DuPont 11671
TABLES --~
-- EY Company Sanhized. Does not contain TSCA CBI
01.-2D5a4y99GaavnadgHe.2S5t5u0d0y:inSMuablcherRoantisc Tonicity --~
TABLES
Dupont 11671
EXPLANATORY NOTES
STUDY DESIGN
Male Number ofMales
Daily Dosage
Dose Volume (mL/kg)
1
1s
0 (Control)*
408
m
1s
70 mg/kg Surfactant H-25500
1.00
SVv.eema 15
1000 mg /kg H-25499"
4.08
b Group V received a second lot (H-24616) ofthe same tet substance beginning on test day 52.
Study animals consistedofthree subgroups: Subset 1 was sacrificed on test day 14 (5 ratsgroup), Subse2t was sacrificed on test day 28 (5 rats/group), and Subset 3 was sacrificed ontest day 91 (5 rats/group).
--~
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H-25499 and H-25500: Subehronic Toxicity D 90-Do ay Gay vageG Studyuin Mv ale Ra ats geSudyinMaleOR wDuoPe ownnte 1e167n1 --_
APPENDICES --_
_--_--nTemm,---- Compeny Sanitized. Doesnotcontain TSCA cal
9H:0D25a4y99GaavndagHe-2S5u5d00y:inSMuablehevoRnaisc Tosicty _
APPENDICES EXPLANATORY NOTES
Dupont 11671
STUDY DESIGN
Male NumberofMales
Daily Dosage
Dose Volume (mL/kg)
1 m
1s 15
70(0Cmongt/rkogl)S*urfactant H-25500
408 1.00
Tvbe 15
1000 mg /kg H-25499"
4.08
GrVorecueivpeda second lo H:24616) of he same est substance beginnoninesgtday 52
(S5turdatys/agnriomuapl)s, cSounbssiestte2dowfasthsraecreisfuibcgerdoounpst:estSduabyse2t81(5warsatss/agrcourp)i,faoinndcteeSsudtbsdeaty31w4as sacrificed ontestday 91 (5 rats/group).
-
-- Tm ------
`Company Sanhizod. DoesnotcontainTSCA CBI
H-25499 and H-25500: Suberonic Toricity 290D0ay GDavagoe StyudyGin Maole Rvats ageSuudyinMaloDRuDbuaoPownltti.e1s1n67n1 --~
APPENDIX A INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS --~
-- ---
= Company Sanhized. Does not contain TSCA CAI
H90--2D5a4y99GoavnadgHe-2S5t5u0d0y;inSMuableehrRoantisc Toxicity
DuPont 11671
--
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
EXPLANATORY NOTES
Lesion Grading
aHnisdtsoepvaetrhiotyl.ogiTchael dcihsatnrgiebustairocn d(eexstcernitboefdtiascscourediinnvgotlovethmeeinrtm)oirspihnodliocgatiecd,chwahreacrteera,ppdriosptrriiabtuet,iobny
`modifiers such appropriate, is
aalssofoacsasl,igmnueldtiafsocfaoll,lodwisf:fuse,
unilateral,
bilateral,
etc.;
A
severity
score,
if
Minimal: the normal limits
amountof
change
present
barely
exceeds
that
which
is
considered
to
be
within
*
Mild: in general, the lesion is easily identified butoflimited severity. does not produce any functional impairment.
The lesion probably
* MLoidmeirtaetdet:isstuheeolresoirognainsdpyrsofmuinncetnitonbuits ptohsesrieblies.significant potential for increased severity.
*
Severe: intensity
the or
edxetgernetetoofecxhpaecntgesiigsniefiitchaenrtatsiscsoumepolretoergaasncodynssfiudnecrteidonp.ossible
or
great
enough
in
~
Comment: `gcroandteisnmuuimniwmiatlh tmhirnoiumgahlsleevseiroensrebperiensgenttheprloegarsetssseivveereinavnodlvseemveenretsleevseironistybeailnogngthae
mthoesytaslesvoerien.dicWahtieltehetihrergelraatdievse rbeifoelrogtioctahlesimgonripfhiocalnocgei.cal characteristics of lesions,
dGroestcs)observations listing multiple masses for a tissue are distinguished with letters (i.e. 3, b,c,
Neoplasm Designations
*B: Benign neoplasm, primary site *M: Malignant neoplasm,primarysite
-rm `Company Sanitized. Doss not contain TSCA CBI
H90--2D5a4y99GaavndagHe.2S5t5u0d0y:inSuMbaelleroRantisc Toxicity
DuPon.11671
Showing anIinrdailvidduaatla AfnoirmailndiLviisdtuianlg animals sDtoospeyGroup: 1 0 ma/kgle (+ SAePxP:ROVMEaDlesPROTOCOL +)
Aninal Ret
Microscopic & Macroscopic Findings
ess927
TKeirlmliendalonSaDcaryif: ic1e4
AEnxipmoaslureisGrsoiugpne:d oSfufbseftrom1 necropsy
Grose Pathology :
Yo MaNcOrSEoscopic Abnormality Observed :
Histopathology
No Mircorsoescopic Abnormality Observed :
ssss28
TKeirlmliendalonSaDcaryi:fic1e4
ABnxipnoaslureisGrsoiugpned: oSfufbseftrom1 necropsy
~~
Gross pathology
No MaNcorseoscopic Abnormality Observed :
Histopathology
nose 'DEGENSRATION/ATROPHY, OLFACTORY, MUCOSA, minimal.
6ss929
TKeirlmliendalonSDaacyrif: ic1e4
.
AEnxipnoaslureisGrsoiugnpe:d oSfufbseftrom1 necropsy
Gross Pathology :
No MNaOcSrEoscopic Abnormality Observed
Histopathology +
No Mircosreoscopic Abnormality Observed :
--~
Te Company Santtized. Donotecontsain TSCA Cal
-- 9H0.-Day2Gaa5nvda4Hg-e29S5t5u09d0y:iSnuMbaclheroRnaE tisc Tox-- H icity a DuPont. 11671
--~
howing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals
DsoTsoeoyGroup : I 0 hg/kgle (+ ASePxP:ROVMaElDesPROTOCOL *)
Animal Ref
Microscopic & Macroscopic Findings
665930
TKeirlmliendalonSaDcaryif: ic1e
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom1 necropsy
Gross Pathology :
No MaNcosreoscopic Abnormality Observed :
Histopathology
No Moicsroscopic Abnormality Observed :
665931
TKeirlmliendalonSDaacryif: ic1e4
AEnxipmoaslureisGrsoigunpe:d oSfufbseftrom1 necropsy
Gross Pathology :
No MaNcosreoscopic Abnormality Observed :
Histopathology :
nose INFLAMMATION, SUBACUTE/CHRONIC, minimal DEGENERATION/REGENERATION, RESPIRATORY, MUCOSA, minimal
-_--
Te
`CompanySenhized.DossnotcontainTSCAcal
9H0--2D5a4y99GaavnadgHe-2S5t5u0d0y:inSMuablcehrRoantisc Toxicity
Dupont 11671
--_ spy
haloeuin(g+
anIinmdailvidduataal AfnoirmailndiLviisdtuianlg APPROVED PROTOCOL +)
animals
Dose Group : 11190 mg/kg Surfactant H-25500 Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
665942
TKeirlmliendalonSDaacyri:fic1e4
AEnxipmoaslureisGrsoiugpne:d oSfufbseftrom1 necropsy
Gross Pathology
No MNacorsoscopic Abnormality Observed :
Histopathology
No MNicorsoscopic Abnormality Observed :
s65943
KTeirlmliendalonSDaacryif: ic1e4
AEnxipmoaslureisGrsoigunpe:d oSfufbseftrom1 necropsy
--~
Gross pathology
No MNacorsoscopic Abnormality Observed
Histopathology :
No MNiocsreoscopic Abnormality Observed :
s65944
KTeirlmliendalonSDaacyrif: ic1e4
AEnxipmoaslureisGrsiogunped: oSfufbseftrom1 necropsy
Gross Pathology +
No MNaocsreoscopic Abnormality Observed :
Histopathology
wos D: EGENERATION/ATROPHY, OLFACTORY, MUCOSA, moderate. A'DDEHGEESNIEORNR,TITOONR/SRTENGAETNEESR,ATImiOlNd,. RESPIRATORY, MUCOSA, mild. EXUDATE, `NASAL CAVITY, minimal.
--
meee Company Seniizsd. Doss not contain TSCA Cal
S0.D2a5y49G9aaangde25S5t0y;inSiclhoRnts.Tovey
Dupo 11671
~
moving anIinndailvidduaatla AfnoirmailndiLviisdtuisnlg animals
stDoospeyC Groupo : TXn M0 m/kg Sa urfactr ant #2o 6500 ax Sex: Males
Saint ret Wicroscopic & Macroscopic Findings
pores
KTeirimliendalonsDaacyrit ic1e4
AEnxipmoaslureToGrsiogunped: oSfutbssttrom1 necropsy
Gross rathotosy
Yo Moacrrsoscopic Abnormality Observed :
Histopatholony +
wosz INFLAMMATION, SUBACUTE/CHRONIC, minimal
cessae
TKeirlmliendalonSbaacryific1e4
iExmpaoslure5sGrsoiugpned+ oSfufbseftrom3 necropsy
--_
Grose pathotosy
Yo Maocsreoscopic Abnormality Observed
sistopatholosy
No Moicsrsoscopic Rmormality Observed
_
reree-- =e-- eet-- osmm-- e------ ----e-- eee
"pany Sanitized. Does otcontain TSCA cBf
R 9HL025D09G9P osvdag2e5Sy 50y0,nSG iuebRuare i Toxs ic uaMicroe Dwwronns -eitern
--_ sroor
noTav.inSg AaenIrinmmdoaivlveiodd.uaatplaRoArFomorir.noasi)n+d)Liivsidteinntg animals
Dore Gra IO ark Heston oe Watas
raid net Microscopic 4 Waeroreopis Finings
Gases
EKTerirplmolirenadardeonGsrDaoacyurpifi: c5e1Subset 1
RoEoal Ss some off from necropsy
Grose pathology :
No Moacmreoscopic Abmormaicy observed
nistopatholosy
ose D+RGRNERNTLON/ATROPIY, OLPACTORY, MUCOSA, miniral.
cassss
EKTreiprtomenisinraelonGsrDaoacyurpit+i+c1e4Subset 1
Robo 1s Sioned off from necropsy
~
Gross pathology :
No Maocsxeoscopic Abnormality Observed :
Histopathology
oseDEDGREGNEEERRAATTIIOONNRNETGREGNPEHRYA,TIOOLNT,ACTROERSYP,IRANTOOCROYS,h, MUmCiOnSiAm,al,minimal.
EXGONTS, NASAL CAVITY, minima
cassss
EKTxelpromonisuncaelonGsraDocaurypi:ti+c1S1eubset 1
foal Lo siomed oft trom necropsy
Gross Pathology :
No Maocoroscopic Abnormality Observed :
Histopathology
oss SEGREGATION REGENERATION, RESPIRATORY, WOCOSA, minieal
~
e--e --s ------------ ro ------ sees e--eee Company Sanz. Dossnot conten Tsca cal
9F0--Day2Gaa5nvadg4Be-29S5t5u09d0y:iSnuMbaclheroRnaitcs Toxicity
DuPont 11671
--~ stupy
wing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals le (+ APPROVED PROTOCOL *)
Dose Group: V 1000 mg/kg H-25499 Sex: Males
Animal Re
Microscopic & Macroscopic Findings
se5960
TKeirlmliendalon SaDcaryif: ic1e4
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom1 necropsy
Gross Pathology :
No MaNocsreo.scopic Abnormality Observed :
Histopathology
sess61
Nos DEGENERATION/ATROPHY, OLFACTORY, MUCOSA, minimal. KTielrlmiendalonSaDcaryif: ic1e4 AEnxipmoaslureisGrsoiugpned: Sofufbseftrom1 necropsy
--~
Gross Pathology
No MNaocsreoscopic Abnormality Observed :
Histopathology
No MNiocsrsoscopic Abnormality Observed
--~
Tee. `CompanySentized. Doesnotcontain TSCA CBI
910.D2ay5Gaanv4dagHe-92S5u590d0y:iSnuMbiclheroRnaisc Toxicity
Dupont 11671
~
roving anIinndailvidduaatla AfnoirmailndiLviisdtuianlg anieals
Dsoosoe:GSroupo: m1 0mma/ekg ( ASrexp:novHealnesshores)
Animal Ret
Microscopic & Nacroseopic Findings
Pree
KTeirlmliendalonsbaacyrif: ic3e8
AEnxipmoaslureisGrsoiguhped Sofufbseftrom2 necropsy
Gross Pathology
Yo MaNcorssoscopic Abnormality Observed
sistopathology :
Yo Miocsrsoscopic Abnormality Observed
sess
KTeirlmliendalonSDaacyrif: ic2e6
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom2 necropsy
.
Gross pathol.ogy
Yo MaNcorsosscopic Abmormality Observed :
Histopathology :
soss DEGENERNTION/ATROPHY, OLFACTORY, MUCOSA, minimal.
sess
KTielrlmeidnalonSDaacyrif: ic2e6
AEnxipmoaslure1sGrsoiugpned: oSfufbseftro2m necropsy
Gross pathology +
Yo Moacsrsoscopic Abnormality observed :
Histopathology :
No Moicsrsoscopic Abnormality observed
eee CompanySanitized. Dossnotconta TSCA CBI
9H0--2D5a4y9G9aavnadgHe-S2t5u50d0y:inSMubaclheRroRenatiesc Toxicity
DDuupwoonwtn1i1e67n1
~ sTopy
howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals ale (* APPROVED PROTOCOL +)
Dose Group: 1 0 mg/kg Sex: Males
Animal Ref 565935
Microscopic & Macroscopic Findings KTeirlmliendalonSDaacyr:ific2e8 ABnxipnoaslureisGrsoiugpned: oSfufbseftrom2 necropsy
Gross Pathology
No MNaocsreo.scopic Abnormality Observed :
Histopathology
No MiNocsreo.scopic Abnormality observed
665936
KTeirlmliendalonSDaacyrif: ic28e
AEnxipmoaslureisGrsoigunped: oSfufbseftro2m necropsy
~~
Gross Pathology
No MNaocsreoscopic Abnormality Observed :
Ristopathology
No MiNcorsoEscopic Abnormality Observed :
-- -_--
TT Company Santtized. Does not contain TSCA cB
02-5D4ay59GaavnadgHe.S25t5y00:inSMulbecvoRntise Toxichy
Duron
Ps
sroor Com
roving anIiondaslvidcautaal afnoirmailndiLviisdtuianlg animals
AerroveD sRovocor +)
Dose Group + TTT WF mg/kg Surfactant N-7350 Sex: Males
minal nef Microscopic & Nacroseopic Findings
cesar
TEKexirplmolisenudarleonGsrbaoacwrypif:i+c3e8Subset 2
Simal 55 siomed off from necropsy
Gross pathology
No Moacrrsoscopic Abnormality Observed
siscopathology
woss C NFLNBATION, SUBACUTS/CHRONIC, minimal
sassas
EKTxeigrlomlnieandraelonGsrDaoactyreifi+ c3S3eubset 2
Animal 53 siomed off from necropsy
Ps
Gross pachotoay +
No Maocsrsoscopic Amommality Observed
Histopathology
ose INFLATION, SUBACUTE/CHRONIC, TOOTH, mild.
665949
ASTKnxeiiprlmomlanielundzaelo55nGSaSDrciaoorywnief+di+ c3S3oefufbseftrom2 necropsy
-
Gross pathotony
No Maocsreoscopic Abnormality Observed
Atstopathotosy
oss:DEGENERATIONATRORIY, OLEACIORY, WICOSA, mila
reese------=eieemesimre------ `Compeny Sentzad. Doss not contain TSCA Ca
5205-0Da9y9Ga1v0adg1e.2S5t5u0d0y,inSiubltrRotisc Tovcy
Dupont 11671
~
orCom}!houin&g
anIinndailvidduaatla afnoirnailndiLviisdteisntg
ApeRovED sRoTOCOL +1
anisals
Dose Group 1 TIT 0 %a/kg Surfactant Bosses | Sex: Males
Aninal Ret Microscopic & acroseopic Findings
cosas
KTeirlmliendalonsbaacyrif: ic3e0
AEnxipmoaslure55Grso3u9p00d+ OSFuFbseFtrom2 necropsy
axoss sathology
Ho Maocsrsoscopic Abmomality Observed
Histopathology :
No Miocsrsoscopic Abnormality Observed
cases
TKeirlmliendalonsbaacyrif: ic3e6
AEnxipmoaslure53Gr3o1wp0d+ SOFuFbseftro2m necropsy
--_
Gross Pathology
No Maocsreoscopic Abnormality Observed
itatopathology :
No Miocsreoscopic Abnormality Observed :
--
-_------
`Company Sanitized. Does not contain TSCA CBI
9H0-D-ay2Gaav5nadgH4e-2S95509t0i:nuSMuabldcehRroayntiscToxicity
DuPont11671
--
howing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals
DsotsuepyGEOUP: V 1000 magl/ekg(+HA-P2P54R3O5VED PRSOeTxO:COMLal+e)s
Animal Ref
Microscopic & Macroscopic Findings
sesss2
KTielrlmeidnalonSDaacyrif: ic2e8
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom2 necropsy
Gross Pathology :
No MaNcorsoescopic Abnormality Observed
Histopathology
Nose
D: EGENERATION/ATROPHY, OLFACTORY, MUCOSA, 'DECENSRATION/REGENERATION, RESPIRATORY,
MUmCodOeSrAa,tem.inimal.
EXUDATE, NASAL CAVITY, moderate.
665963
KTielrlmeidnalonSaDcaryi:fic2e8
--~
.
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom2 necropsy
Gross Pathology :
No Moacsrzoscopic Abnormality Observed :
Histopathology
No MNicorsoscopic Abnormality Observed :
665364
TKeirlmliendalonsDaacyr:ific28e
AEnxipmoaslureisGrsoiugpned: oSfufbseftro2m necropsy
Gross Pathology :
No MaNocsreo.scopic Abnormality Observed :
Histopathology :
NoSE I: NFLAMMATION, SUBACUTZ/CHRONIC, minimal
--_
-
Company Sanitzed.Doos not contenTscAca
0H--2D5a4y99GaavnadgHe-2S5t5u0d0y:inSMuablcherRoantisc Toricity
DuPont11671
--~
bowing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals
sDtouspeyGroup: V 1000 mgl/ekg(+HA-P25P4R9O9VED PRSOeTxO:COLMal*)es
Animal Ref
Microscopic & Macroscopic Findings
ses96s
TKeirlmliendalonSDaacyrif: ic28e
AEnxipmoaslureisGrsoigunped:
Subset 2 off from
necropsy
Gross Pathology
No MaNcOrSEoscopic Abnormality Observed :
Histopathology +
Noss : DEGENERATION/ATROPHY, OLFACTORY, MUCOSA, minimal
sessss
TKeirlmliendalonSDaacryif: ic28e AEnxipmoaslureisGrsoiugpned: oSfufbseftro2m necropsy
--_
Gross Pathology :
No MaNcOrSoEscopic Abnormality Observed :
Histopathology
No MiNcorsoescopic Abnormality Observed :
--_ _--_--
Te `CompanySanftized.Doesnot contain TSCA CBI
9H0--2D5a4y99GaavnadgHe-2S5t5u0d0y:inSMuableterRoantisc Toxicity
DuPont 11671
--
howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals
Dsmoospey Group: I 0 WG/kgle (+ ASPexP:ROVMEalDesPROTOCOL +)
Animal Ref 665937
Microscopic & Macroscopic Findings KTeirlmliendalonsDaacry:ific91e AEnxipmoaslureisGrsoigunped: oSfufbseftrom3 necropsy
Gross Pathology
No MNaocsrgoscopic Abnormality Observed :
Histopathology :
No MNiocsrgo.scopic Abnormality Observed
ses938
KTeirlmliendalonSDaacryi:fic9e1 AEnxipmoaslureisGrsoigunped: oSfufbseftrom3 necropsy
~~
Gross Pathology
No MaNcosrEoscopic Abnormality Observed :
Histopathology
No MiNocsreo.scopic Abnormality observed :
665935
TKeirlmliendalonSaDcaryi:fic9e1
AEnxipmoaslureisGrsoiugpne:d oSfufbseftrom3 necropsy
Gross Pathology :
No MaNcosreoscopic Abnormality Observed :
Histopathology
No Moicsroscopic Abnormality Observed
--_
me Tiree `Company Sanitized. Doss not contain TSCA CBI
/
H90--Day2Gaa5nvda4Hg-e29S5t5u09d0y:inSMuabclherRoantisc Tonicity
DuPont.11671
-
howing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals
sDroospeyGroup : I 0 mg/kagle (x ASePxP:ROVMEalDesPROTOCOL +)
Animal Ret
Microscopic & Macroscopic Findings
ses940
KTielrlmeidnalonSDaacyrif: ic5e1
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
Gross Pathology :
No MaNcosreoscopic Abnormality Observed :
Histopathology
No
Microscopic Nose
Abnormality
Observed
:
sessa1
TKeirlmliendalonSaDcaryif: ic5e1 AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
--~
Gross Pathology
No MaNcosrzoscopic Abnormality Observed :
Histopathology
Nos D: EGENERATION/ATROPHY, OLFACTORY, MUCOSA, minimal INFLATION, SUBACUTE/CHRONIC, `minimal
~~ T ee r ------ CompanySanitized.Doesnotcontain TSCACBI
0H-D-ay2Gaanv5dagF-e42S5t5u90d0y:iSnuMbaclheroRnaitsc Tonicity
DuPont 11671
sTopy
holewin(g+
anIinmdailviddauatla AfnoirmailndiLviisdtuianlg APPROVED PROTOCOL +)
animals
Dose Group: III 0 mg/kg Surfactant K-25500 Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
ses9s2
KTeirlmliendalonSDaacyrif: ic9e1
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
Gross pathology :
No MaNocsreo.scopic Abnormality Observed
Histopathology
Noss:DEGENERATION/ATROPHY, OLFACTORY, MUCOSA, mild ADHESION, TURBINATES, minimal
cases
KTeirlmliendalonsDaacyrif: ic9e1
AEnxipmoaslureisGrsoiugpne:d oSfufbseftrom3 necropsy
--~
Gross pathology
No MaNcorsoescopic Abnormality Observed :
Histopathology :
Nose. 'DEGENERKTION/ATROPHY, OLFACTORY, MUCOSA, mild. ADHESION, TURBINATES, mild
ses950
KTeirlmliendalonSDaacyri:fic5e1
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
Gross Pathology :
No MaNocsrso.scopic Abnormality Observed :
Histopathology :
Nose
':DEGENERATION/ATROPHY, ADHESION, TURBINATES,
OmiLlFdA.CTORY,
MUCOSA,
mild.
--~
-
`Company Sanitized. Doesnotcontain TSCA CBI
9H0--2D5a4y99GaavnadgHe-2S5t5u0d0y:inSMuableherRoantisc Toricity
DoDumPonnt11e671
--~ stupy
ahloeuin(g+
anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg APPROVED PROTOCOL +)
animals
Dose GFouwp : III70 mg/kg Surfactant K-25500 Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
ses95s
KTeirlnliendalonSDaacyrif: ic9e1
AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
Gross pathology :
No MaNcorsozscopic Abnormality Observed :
Histopathology :
nose
D: EGENERATION/ATROPHY, ADHESION, TURBINATES,
mOiLlFdA.CTORY,
MUCOSA,
mild.
665956
KTeirlmliendalonSaDcaryif: ic5e1
AEnxipmoaslureisGrsoiugpne:d
Subset 3 off from
necropsy
~
Gross Pathology :
No MaNcorseoscopic Abnormality Observed :
Histopathology
Noss I: NFLAMMATION, SUBACOTS/CHRONIC, minimal. A''DDDHEEEGGSEENINEOSRRNAA,TTIITOOUNNR//BARITENRGAOETPNEHESYR,,ATIOmOLiNFn,AiCmTaROlER.SYP,IRAMTUOCROYS,A, UmCiOlSdA., mild.
~~ -
`Company Sanitized. Does not contain TSCA CBI
S 9H0--2D5a4D y99Gaavnw adgHe-2S5O t5u0d0y:iw nSMuabcli heroRaniiscgTorice ity SudvinMaer DDuuoPs owntn-i1s 1e67n1
--~
howing enIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals
DsorsuepyGi%p: V 100 magl/ekg(+HA-P2P5R49O9VED PRSOeTxO:COMLal*)es
Animal Ref 665967
Microscopic & Macroscopic Findings KTeirlmliendalonsDaacyrif: ic9e1 AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
Gross Pathology :
No MNaocsrEoscopic Abnormality Observed
Histopathology
ses968
nose ':DECENERATION/ATROPHY, OLEACTORY, MUCOSA, mild. TKeirlmliendalonSDaacyrif: ic9e1 AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
--
Gross Pathology :
No MaNcorsoescopic Abnormality Observed
Histopathology :
Nose D: EGENERATION/ATROPHY, OLFACTORY, MUCOSA, mild.
665965
TKeirlmliendalonSaDcaryif: ic5e1
:
AEnxipmoaslureisGrsoiugpne:d oSfufbseftrom3 necropsy
Gross Pathology :
No MaNcosreoscopic Abnormality Observed :
Histopathology
NosE : 'DEGENERATION/ATROPHY, OLFACTORY, MUCOSA, mild
~~ FE
Ere `CompanySanitized.Doesnotcontain TSCA GBI
9F0--Day2Gaa5vnadg4He-S29t5u5d090y:inMSuablcehRroantisc Toxicity
DuPont11671
--~ stop
howing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals ale (+ APPROVED PROTOCOL +)
Dose GYoup : V 1000 mg/kg H-25439 Sex: Males
Animal Ref,
Microscopic & Macroscopic Findings
ses970
KTeirlmliendalonSDaacyrif: ic9e1 AEnxipmoaslureisGrsoiugpned: oSfufbseftrom3 necropsy
Gross Pathology
No MaNocsreo.scopic Abnormality Observed :
Histopathology +
oss DEGENERATION/ATROPHY, OLFACTORY, MUCOSA, mild.
sess71
TKeirlmliendalonSDaacyrif: ic9e1
AEnxipmoaslureisGrsoigunped: oSfufbseftrom3 necropsy
--_
Gross Pathology
No MaNocsreo.scopic Abnormality Observed
Histopathology
Nos D: EGENERATION/ATROPHY, OLFACTORY, MUCOSA, mild EXUDATE, NASAL CAVITY, mild.
-- -_--
Te `CompanySanitized. DossnotcontTSaCAiCBnI
91D0.-2uD5ya4y9G9Gaaonvvdag2ee5SS5tu0udd0yy:innSMMuaablctheerRoRantaiscsToxicity --
DDuuPmonto-1n167t1
APPENDIX B
INDIVLIISDTUIANLGAINNIDMIAVILDMUIACLRAONSICMOAPILCS OABFSFEERCVTAETDIONS --~
--_ Teams CompanySanitized. DoesnotcontainTSCA CBI
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