Document emrw3pJoDr3z7rdE1GBbBGr19

AR226-2714 AR226 20t04 431*0 SOT Annual Meeting You this may p rin t by clicking on browser window or click this the button. To return to 'X' button in the top the previous page, close right comer o f me page. rvMMraeRATTONS RELEVANTTO CONSTRUCTING A HUMAN PBPK D. Paustenbach1; G. Jepson a c id (PF0A) i td d .-t.r y tor Heal* .nd Environmental Sciences, Newark, DE, USA. . . ..j , DPnn\ c a surfactant, which has received significant Perfluorooctanolc add (^ A^ ftg eDOrted PreVaience In blood samples from interest in activity associated with many US citizens. ^ reiate inhalation and oral exposures to constructing a human PBPK mode! kinetic studies conducted on M ^ -a S 3 r s K B . ^ts brerha'vfitornIn bhioSlogi i'ccaall ssyvsstteemmssaenmdu has thus foerprcoonmdplPicFaOteAdIsanreypeofrftoerdtstotobe determine tissue tar explicit unmetabolized In n w m r i t a n a s s u e s Third, the elimination rate is ddersacmriapttiicoanll>yofdifferent between nu rodetnt2s. hTohuersreipnortedfehmalafl-elifreatIn. humans Is approximately 4 ,, rafces wnich do not appear to be Further, rate have relevant to humans. Fourth, controlled human P sPe?vQeArely"limlacitkeldn.aT; his tishefurertfhoerer,caonmyplfcated by the fact that eHminano mechani^sms haanvde gnaoptsb,enenthe completely elucidated n rats and hitmans. These ransraer^ , understanding of f * o ^ eSerlctinScrd el to predict PFOA construct and apply a human PBPK o g inhalation of PFOA. The basis for S S S S ' . v ^ S ^ "1'"TM "rapKmodel wr proAwa! evaluated. * and EID775276 EID775277