Document emdOa18vnZOJvawqYxoJ29Lg

1 ! iGST(MfT f 1 56 systolic blood pressure results below (X,SE) were expressed as a X of their pre-test value. Significant differences froa the WKY group were designated with an asterlck. Croup WKY -2.5 i Hs -5.0 mtaHe 5 -13.9+2.4 -49.2+2.5 ~7'i wHa -69.5+6.2 SHU 9 -10.5+1.9 -24.1+5.9+ -39.1+3.9+ A-SHR 5 -15.9+2.9 -51.8+6.0 -86.1+_3.1+ These findings suggest that the vssoconstrlctlng ability of the SHP group was more responsive to a LBNP stress than the other two group# and that the antlhypertenalve agents employed were partially suc cessful In normalizing such a response. To whet effect these dif ferences are due to alterations In chemorecepcora, low or high pres sure baroreceptors. or resting sympathetic tone remains to be deter mined. (Supported In part by HL-01438B-5) * TOXIC EFFECTS OP POLYCHLORINATED BIPHENYLS ON MAfttALIAK HEART MITOCHONDRIAL ACTIVITY. Russell Rulon,* Decorah, Iowa, Jerry Dewey and Carlos Harrison, Rochester, Minn. The effects of 2 polychlorinated biphenyls (i'CBs) on oxidative phos phorylation were defined in isolated cat mitochondria utilizing .< Gilson oxygraph equipped with a vibrating platinum electrode. The PCBs investigated were Aroclor 10)6, a component of capicitors and Aroclor 1264 which is s major onvironmontnl contaminant. Using 13 mM glutematc as substrate, APP stimulated State 3 respiration was significantly depressed (p< .01J at 20, 50, and 100 ppm Aroclor 1254 and by Arocloi 1016 at S, 10, 20, 50 and 100 ppm. The Respira tory Control Indices (RC1), which measure the "tightness" of coupling in mitochondria, were depressed at 10 ppm and higher con centrations. At 50 ppm, both Aroclors depress tiic AI)P:0 ratios; however, 1016 seems to be more toxic. Much attention has focused on the long term toxic effects of PCBs. However, these data in dicute tlte potential the materia) has for acute toxic effects r. tissues, such as the heart, which arc highly dependent on oxid..i. metabolism. 4 . S. GROWTH AND SEXUAL DEVELOPMENT IN COTURNIX (Co turn lx C.J.iin>: AS AFFECTED BY CONTINUES FKCTCPERIOU. K.L.Arora, Dcs Hutu*-* Following 21 d of brooding under continuous light, some mala* .nut fe males were shifted to acandard lighting conditions (14L) leaving tnr remainder under continuous light (24L). Lighting wan provided '-v luO watt bulha fixed one foot above the level of blrda. Food and water were provided ad lib. Sexes were kept apart as groups. The bird* were weighed regularly and the enact of egg laying wax determined hv palpating egg in tlte uterus. At 72 d of age, the birds were killed and reproductive organa and visceral organa collected and welgbrJ. Sex and treatment differences in body vt were evident following 5 d HONS 051409