Document emNJRok9nw5430XVZM0QQxgdE

m DODFEEPPHAAERRATTLMMTEEHNNTT OF HEALTH Health Risk Assessment UnHHie,eaalElitnhhvBiBaoasnsemeeddnGGtauulidHaienacdletfahfoorDrniWW vaictsaieteoernr Health Risk Assessment Unit, Environmental H6e5a1l.th20D1i.v4is8io9n0 651-201-4899 W Weebb PPuubblliiccaattiioonn DDaattee:: MMaayy 22001177 CTTAooSx:xiicc3o3o5ll-oo67gg-i1i(ccfaarelle SaSciuudm)mmmaarryy ffoorr:: PPeerrfflluuoorrooooccttaannooiicc AAcciidd CAS: 3333833325555.---66626676.--01-01(f((ara(eccaeiidmdamffcllouiudnoo)irriiuddmee))salt, APFO) 322333835929.5559.--23006-003---188(s(((iapplmoovtetmarasosssasnliiuituu)mmm sssaaallttl)t), APFO) 333No333t555e---:999535p---35e5r(((ussscoiolrvddoeiiourucmsmtaasslntaa)olltat))te anion doesnothave a specific CAS number] Synonym: PFOA [Note: perfluorooctanoate Synonym: PFOA anion does not have a specific CAS number.] MaMnDDdHHkcceooynnsddtuuuccdttyeeidddeaantffoiofcciuucssateeiddonrreec--oeonvvtaaalluiuaantteiidoonwniwwthhhiiincchhthrreeelEliiePedAd hhHeeoaaavvliitllhyy EuufppfooennctEEsPPSAAu'p'sspohhraatzzaaDrroddcaaussmsseeensstssmmfoeernntt aPPtoenexrdriffcikluoueoloyorrgosoiotocuccadttlaaylnniioodtieieccrnaAAtticucfriiiceddaw(t(aiPPosFFnOOncAAoo)t)nrcrteeoallnienedaeaussdceetwddediiitn.nhiMMnaatyyhe2200E11P66A((EHEPPeAAalt22h0011E66faaf)e).,ctAAs complete evaluation of Support Document for complete evaluation of tthhee toxicological literature was not conducted. SShhoorrtt-tteerrmm,, SSuubbcchhrroonniicc aanndd CChhrroonniicc*-- NNoonr-CCaanncceerr HHoeaalltthh BBaasseedd VVaalluuee ((n1HHBBVV)) == 00..003356 pggl/LL*TM* c*"DoDnuuceeettnootrtthaheteihhoiingghhallryyebbtiihooeaacmccocusumtmuuallpapatirtvoeeprnniaaatttuuerreedooosffePPmFFeOOtrAAicaannaddndhhtuuhmmeaasnntahhnaadlafl-rlidfeeeooqfuf aaatppipporrnooxxtioimmdaaelrtaeillvyye22t--he33 HyyeeBaaVrrss,w,assseerrnuuommt a`caaoppsnppircrnoogeplpnreritiraaHattetei.Bo. nSSshhhaoaosrrrett-bttteeeherremmnmreeoexxspcptooosasmupumrpreeernossdphheriaadavvteeefotrdthhoseeshoeppraotmnt-etieneitrrtaiimacl,lattsnooudbsscttthahafyeyoniisnintcatt,hnhedeaanbbrdoodddceyyhqrffuoooranraitaicnonndeuetrxxoatttedeinenodndriseev.dde TptphheeereriioHo2dd0B1ooVf7f wtiiHmmaBese.V.nTTwohhtaeesrreeffoorree dddaeeetsrraiiinivvlgeeslddeauubHssoiBiunnVtgg thaahaetosoxmxbiaieccdoeoeknkliinrnpeeerciteioccsme((nTmTtKKee))dnmmdboeeodlddeoewflo.l drdeesvhveeollroto-ppteeerddmbb,yysuMMbDDcHHhrowwniitichh, inputand input from an extemal peer chronic durations. The from an external peer review panel. See 2017 HBV was review panel. See details about the model presented below. *"n*aRRteileoalnatatilivvgeeeSnSeooruuarrlcceepoCCpoonunratirtbibiuunttsiioofnno ((rRReSSpCrC)o:)s:ebnbtaassneeoddn-oownnalcceuurrrrreeexnnpttobbsiuioormmeoson,nitiatoonrriiRnnggSCsseeorrufum0m5ccoo(nn5cc0ee%nn)ttrrwaaattisoinossnelfferrocomtmedlloofccoaarllwaaannldder ingestion national general populations to represent non-water exposures, an RSC of 0.5 (50%) was selected for water ingestion. oIInrnttauakpkepeeRRraatpteee:r:cIIennnkkteeieeeppbiirnneggaswwtiimthhilMMk DDinHHta''skepprrraacecttsiiccee(,,Ta99b55lthe pp1ee5r-rcc1,eennUttiiSleeEwwPaaAttee2rr01iinn1tt)aakkweeerrraeatteeussse((dTT.aabbBllreee33a--s11imaainnkdd c33o.-n33c,,eUUntSSrEEatPPiAAon22s00w11e11r)e), cIocnaartllucackuplelpaaetrtereatddpeesbbryycaenmmndautliblltterippelblayyrsiientnagigsettethmhdeeiilnkmmgaianptteteearrmkineaoadllraossfteeeorrsunum(emTayccbeooalnnerccew1en5ent-rtr1roaa,ttuiiUoosSnneEdbbPy2yAasa2rPPe0FFp1rO1Oe)AAsewbnbetrrraeeetaaissuvtisemmeoiidlfkk. tatBrrararneensaasfssefeotrmnrfaaiflabkccltcetooormrnooacfefxn55mt.2r2ua%%.tmi.onTTshheew: ere expose scenario. intake rates and breastfeeding exposure scenario. period of one year were used as representative of a reasonable maximum MsMiDgDnHHifittcyyappniitccaadlillglyiyt.uussHeeossweaavsseiirmm,ppltleeheee{qqouuxaaittciioooknnintteoolicccaalmlccouudllaaettlee uHHsBBeVVdSs0aadtehtrhieeveppaatrrhtteppHeerBr VbbiilllfilooornnPlleFevvOeelAl wwsiihthhowrreeessduullttthssatrroosuuennrddueemdd 0to oonnee significant digit. However, the toxicokinetic cHoBnVcenctornattaiionsnstwwoerdeigihmspacied by changes concentrations were impacted by changes in wate concentrations a the par model used to derive the HBV for in water concentrations at the part pr io level. Asa esul, PFOA showed that serum per trillion level. As a result, tthhee HBV contains two digits. RReeffeerreennccee DDoossee//CConocnecnetnrtartaitioonn:: HMiHEcEeDD)/./TTo[otTtaahlleUUcFFor==re00s..p00o00n55d33i//n33g000s0=e=00r.,u00m000c00o0n11c88enmmtgrgla/kktggi-o-ddn i((sCC3DD8--1/1300 = iMO0n..ia11cp3e3p)rmm.og[gpTAr/hLLiea((toocerroutprogrge/u/mmsslpeL)of.)no.rdNNiniOOngTdTisEEvei:rdttuuhhmaiilss cassoseesnrruecusmemsnmtccerooannnttcico.eenn*ntitr]sraa3ttii8oo/n3n0iis0s = SSoouurrcceeooffttooxxiciciittyy vvaalluuee:: Determined by MDH inappropriate to use Determined by MDH in 2017 for individual in 2017 assessment. ***] PPFFOOAA-- PPaagge1e10off 1122 Exhibit I ..o 33775533..00000011 STSATTAETE 0077553333099922 PPooiinntt ooff DDeeppaarrttuurree ((PPOODD):): DDoossee AAddjjuussttmmeenntt FFaaccttoorr ((DDAAFF):): Human Equivalent Dose (HED): Human Equivalent Dose (HED): TToottaall uunncceerrttaaiinnttyy ffaaccttoorr ((UUFF):): UUnncceertrtaaiinnttyy ffaaccttoorr aallllooccaattiioonn:: CCrriittiiccaall eeffffeecctt((ss)):: CCoo--cciritticcaall eeffffeecctt((ss)):: AAddddititiivviittyy eennddpopionitn(ts(s):): 3388 mmgg//LL sseerruumm ccoonncceenntrtraattiioonn ((EEPPAA 22001166aa pprreeddiicctteedd Sverage serum concentration fo maternal anmals fom average serum concentration for maternal animals from Cau et 1 2000) Lau et al 2006) 00..0000001144;; TTooxxiiccookkiinneettiicc AAddjjuussttmmeenntt bbaasseedd oonn CChheemmicicaall-- Speciic Claarance Rate = Volume of Distouton (Uh) x Specific Clearance Rate = Volume of Distribution (L/kg) x (LnzHal fe, days) = 0.17 Ukg x (0653/840 days) = 0.00014Ukg-day (US (Ln2/Half-life, days) = 0.00014 L/kg-day (US EPA 0.17 EPA 2016a) L/kg x (0.693/840 2016a) days) = OD x DAF = 33 mg x 0.00014 Ligiday = 0.0053 POD x DAF = 38 mg/L x 0.00014 L/kg/day = 0.0053 makg-day mg/kg-day 330000 33foforr iinntteerrssppeecciieess ddiifffefererenncceess ((ffoorr ttooxxiiccooddyynnaammiiccss));; 1100 ffoorr caspecies vanabity. Win he exception of accelerated intraspecies variability. With the exception of accelerated pprreeppuuttiiaall sseeppaarraattiioonn ((PPPPSS),), tthhee eeffffeeccttss oobbsseerrvveedd aatt tthhee LOAEL were mid A LOAEL-to-NOAEL uncertainty factor LOAEL were mild. A LOAEL-to-NOAEL uncertainty factor of was used, slong with a database uncerainy facor of of 3 was used, along with a database uncertainty factor of forthe lack of an acceptable 2generation study 3 for the lack of an acceptable 2-generation study. DDeellaayyeedd oossssiiffiiccaattiioonn,, aacccceelleerraatteedd PPPPSS iinn mmaallee ooffffsspprriinngg,, trend for decreased pup body weight, and increased trend for decreased pup body weight, and increased maternal ver went In offspring exposed maternal liver weight In offspring exposed dduurriinngg ddeevveellooppmmeentn:t: cchhaannggeess iinn ilivveerr Weigh, histology. and tigycerdes, and delayed mammary weight, histology, and triglycerides, and delayed mammary and development gland development. In aut arimais: iver weight changes accomparied by In adult animals: liver weight changes accompanied by changes n ver enzyme level, changes in tighcerde and changes in liver enzyme levels, changes in triglyceride and Cholesterol lovels. and microscopic cvdence of alulr cholesterol levels, and microscopic evidence of cellular Gamage, decreased spleen weign decreased Speen damage, decreased spleen weight, decreased spleen llyymmpphhooccyytteess,, aanndd ddeeccrreeaasseedd IIggMM rreessppoonnssee,, aanndd kkiiddnneeyy weigh changes weight changes. DDeevveellooppmmenetnatall,, HHeeppaattiicc ((LLiivveerr)) ssyysstteemm,, IImmmmuunnee ssyysstteemm,, and Renal (Caney) system and Renal (Kidney) system. = Serum concentrations sfo fh ing pul: est oly and trot pepatn-bsed poses This vss *** Serum concentration is useful for informing public health policy and interpreting population-based exposures. This value is ese oss Saad aor a AGU ko ad Ce RETR An Se i based on population-based parameters and should not be used for clinical assessment or for interpreting serum levels in prvi individuals. TToxoicoskincetioc MMokoddeiell DDnesecsercirpitpttiiooinn:: STSheeirrsuumsmq uccaootnniccoeennntwtrraaatstiioounnsssedccaabnny bbEeePAcc,aallcfuoclcaiattelcedulffraotime hthheee HddEooDsseSe afarnnoddmcctlleheaearraPanOnccDee srraaettreeuuumssicinnoggnctthahenetfoaotllloownwisin.ngg equation equation. This equation was used by EPA, to calculate the HEDs from the POD serum concentrations. - Dose m(g129 Serum Concentration (52) =olin) Clearance Rate (p=) PrOA-Page 20112 PFOA - Page 2 of 12 33775533..00000022 SSTTAATTEE_0077553333999933 wore Where: DDoossee ((mmgg//kkgg--ddaayy)) ==WWataeterroorr BBrreeaassttmmiillkk IInnttaakkee ((LL//kkgg--ddaayy)) xx LLeevveell iinnWWataetreroorr BBrreeaassttmmiillkk ((mmgg//LL)) wsand Goran (Uk) = Volume Gsroution Uk) x i le (day Two sxposrs scenarios vere Clearance (L/kg-d) = Volume of distribution (L/kg) x (Ln 2/half-life (days))Two exposure scenarios were lamin an fat 106 wi oT contd wh coraminatod waar Sari ot bth examined: 1) an infant fed with formula reconstituted with contaminated water starting at birth aanndd ccoonnttiinnuuiinngg iinnggeessttiioonn ooff ccoonnttaammiinnaatteedd wwaatteerr tthhrroouugghh lliiffee;; aanndd 22)) aann iinnffaanntt eexxcclluussiivveellyy bbrreeaasstt-- fear 12 mom. ollwedb dking conamnated ale In both scars he Seles fed for 12 months, followed by drinking contaminated water. In both scenarios the simulated iinnddiivviidduuaallss bbeeggaann lliiffee wwiitthh aa pprree--eexxiissttiinngg bbooddyy bbuurrddeenn tthhrroouugghh ppllaacceennttaall ttrraannssffeerr ((mmaatteermnaall Seu Concariaion x 87%) based on average ord to alemal serum concent aioe serum concentration x 87%) based on average cord to maternal serum concentration ratios Topo na rare Th seu Conconraton fh thr 3 deer was seemed 050 reported in the literature. The serum concentration of the mother at delivery was assumed to be aatt sstteeaaddyy--ssttaattee.. CCoonnssiisstteenntt wwiitthh MMDDHH mmeetthhooddoolologgyy,, 9955t"h ppeerrcceenntitillee wwaatteerr iinnttaakkee aanndd uuppppeerr ppeerrcceennttiillee bbrreeaassttmmiillkk iinnttaakkee teweUs r1 Siaftesineadle manu exposed nl A rossi varia acoof rates were used to simulate a reasonable maximum exposed individual. A breastmilk transfer factor of S25 aged on average ream o lena Serum concave aos epee ne rare, 5.2%, based on average breastmilk to maternal serum concentration ratios reported in the literature, 8 Use 10 calc reas concenvaon According re 206 easieadng Repor Crs w((CCaDsDCCus22e00d1166to)) ncneaealacrrullyyla66te66 bppreeerraccseetnnmttiolokff cmmoootnthcheeernrsstraiintnioMMnii.nnnAneecscsooottraadinrreegppotoorrttthbberree2aa0sst1tff6eeeeBddriiennaggsaatfttesesiidxxinmmgoonRntthehsps,o, rwwtiiCtthhar33d11..44. orca excuse eastoatng Theperce eases dropped to. awe mort. OH percent exclusively breastfeeding. The percent breastfeeding dropped to 41% at twelve months. MDH Siac an cus breasiosond raionof ov yor rh eas fd an cena selected an exclusive breastfeeding duration of one year for the breast-fed infant scenario. aly postlminaton serum concanialon vas cated as Daily post-elimination serum concentration was calculated as: Serum cone. (m7y2) = fr day serum cone. (m2y ) Tvoada(y(ix'o)s I<ntmcawkesho(mg) xe Tioama2r5iwnelmaasssexbcarleatnocne,pdriyomsateernbayl iseruCmeacronacnecntaraet,iownesraendcaocsusi-aotfe.dchericl va rane to the To maintain mass balance, daily maternal serum concentrations and loss-of-chemical via transfer to the infant as well as excretion represented by the clearance rate, were calculated. Summary ofModel Parameters Model Parameter Summary of Model Parameters Model Parameter HaHlfa-llf-iliffee Va Ago Adm Factor VVoolluummee ooff ddiissttrriibbuuttiioonn ((VVdd)) Vd Age Adjustment Factor CClleeaarraannccee RRaattee ((CCRR)) acetal ranster factor Placental transfer factor ox rma sram oe (% ofmaternal serum level) Vaue ses Value Used 884400 ddaayyss ((UUSS EEPPAA 22001166aa)) | 2S.1hagSeu11:03ydoauyrss d(eicrseaasninigo0n11260a7go 10years and 10 00..1177 UL/kkgg ((UUSS EEPPAA 220011662a)) 2.1 age 1-30 days decreasing to 1.2 age 5-10 years and 1.0 after age 10 years (Friis-Hansen 1961) 7% (oom 20170) 00..0000001144 LLk/kgg--dd,, ccaallccuullaatteedd ffrroomm VVdd xx((LLnn 22/!hhaaiflf--iliiffee)) 87% (MDH 2017b) PrA-Page sor 12 PFOA - Page 3 of 12 33775533..00000033 staresvssone STATE 07533994 MMooddeell PPaarraammeetteerr BBrreeaassttmmiilkk ttrraannssffeerr ffaaccttoorr ((%3% ooff mmaatteorrnaall sseerruumm lleovveel)) WWaatteerr IInnttaakkee RRaattee ((LU/kkgg--dd)) BBrreeaassttmmililkk IInnttaakkee RRaattee ((LL--kkgg--dd)) BBooddyy wweeiigghhtt ((kkgo)) 5.2% (MDH 20175) 5.2% (MDH 2017b) VVaalluuee UUsseedd 99(55Tt"halppeee3rr-cce1entnilte3:cc3,oonnUssSuuEmmePerArss2oo0nn1ll1yy)((ddeeffaauulltt vvaalluueess,, MMODHH 22000088)) (Table 3-1 & 3-3, USEPA 2011) | UEUpPppApeer2r0pp1ee1rr)cceennttiilee eexxcclluussiivveellyy bbrreeaasst-tfeedd iinnffaannttss ((TTaabbllee 1155--11,, UUSS EPA 2011) CCaallccuullaatteedd ffrroomm wwaatteerr iinnttaakkee aanndd bbrreeaassttmmiillkk iinnttaakkee rraattee ttaabblleess AA`grurseildltaaitnivvceee vssaooluuurrecceetoccaoocnntctroriiubbnuutttiiofononrffnaaoccntto-orwra((tRReSSrCCe))xpsisosiinuncrceoosrrp.poorMraaDtteeHdd uiintnittoloiztthehseetddheeerriiEvvxaapttiiooosnnuroofef aaDehhceeiaalstlithon-bbaTasrseeeeddpwwraaotcteeerrss gprperurfeeildsseaecetnnntctreeeelddavtiianinlvueUUepSSotorEEtPPaicoAAncso22u00onf000t0wtfaototoreddrneeoarrniniv-vdweeanaatopeppnrprwreooapxptrpreioiarasttuereroeRRustSS.eCCssMos.Df. eHMMxDpDuoHHtsiliuzrrreeeellsii.eetddhTeuuhppeEooxvnnpaotlthshueeuesroppeeefrDrccteeehcnneitstadiaouggrneeatTmmireoeentet-hhsooppddreocctitoofeiscs ddrmeeeaffgflaaenuuciltltttruRRedlSeaSotCiCvfsec((o0p0n..o5t5r,r,tibo00i.n.2t2s,i, ooaanfnnwddofa00tt..eh22reffsaooenrrdossthhnhooeorrrtnt---ettwexerarpmmtoe,,srussrruuoebbusccthehtrshrooanotnificoce,c,xcaapunnorddsduccurhrherir.oonnTgnihiccte,h, evrreearsseluppleeeecvsctatinoivvtfeeltelhyyxe))paoadrsrueeurrabbetaaiossdneue-rddsaptooeinnocntitfhhicee em((MliaDDmgiHHnniat22ut00id0o0e8n8)o.)h.fafcHH-oooiwnwfetr,evibveseururt,,icohiinnnttothhhafetethacceaaspsseeeerosoootffhneP'PsrFFeOOsxAeAp,r,ouaasmpupprpcleoliisncccaatethtiniaootntnroaootcfficoaaunnnr adRRtuSSariCCnnnygnegteehieveddessrntetalooegvaaeaccniccstooenuuonxnttptooofosnruryrttehtheehdeluloorrnaengsgtiuolnt of elimination half-life, phiasstor her current of his or her current or recent exposures within the such that a person's serum recent exposures within the duration of concern, concentration at any duration of concern, but also from exposure from years given age is not only the result of but also from exposure from years past. `SRSIeeDrruuimnm tcchooenncDceeencntitrsraaittoiinoonnTssreaaerreeprtthohceeesbbsee.ssttBmmieoeamasosunuirroeerooiffngccuurmmeusuluallatttsiivvfeeoreehxxppeoosgseuunrreeeraaalnnddpuccbaalnnicbbreeepuuossreetddediinnnpphllaaecceemooofsf ttthhee rrrReeefccpDerenenintstetNNnhataetntiiDooonnneaacwlliasRRitoeeenprpoTorerrtxtepeooonnspuHrHroueucsmme.saasnnM. DEEBxHxioppmoossesoulunreriecteotrtteoiodngEEannnrveviRsirruSoolnCntsmmeofefonntr5tata0hlle%CCghfhoeeermnmieecixrcaapallolsspsuu((rbCCeliDDcfCCrreo22pm00o1w1r7at7e)t)deccraianinnnthgbbeeeestmuuissooeensddt ttoo breapsreedseonnt non-water exposures. MDH selected an RSC of 50% for exposure from water ingestion + based oAn:high-end, conservative estimatofe background, non-water exposures represented by the 95 + ApTpeherhreccigeeUhnnS-tteiEilneePdssA, eecrDroueunmcmsiesccrioovonnanccteiTevnrnetetrreeaatstRiitoiomSnnCafftriecoeomiomlfi22nb00gao11c3f3k--g181r440o%uNNnHH(d0,AAeNNnnoEEsnSuS-rw(e(a00a.t.0e0m0r0a5e5r5x5g7p7ionmmsguog/frleLLssassfeereerrluupymmr)et,)os,eaaancnntceddodunbty the for 95th possible unknown sources The USEPA Decision Tree possible unknown sources of exposure RSC ceiling of exposure of 80% to ensure a margin of safety to account for AWAissthmmeceonnntttiioaonmneienddaaatbbeoodvvweea,,tttewwroosteeaxxrpptoionssguurareet bssiccretehnnaaarnriidoosscowwnaetrrieenueeixxnaagmmiinningeeedsd:t:io11)n) aaofnnciionnnffaatnnattmffieenddatffoeordrmmwuualltaaerrreetcchoornnsostutigitthuuttIeefedd; waaitnnietddh 2) an infant exclusively breastfed fo 12 contaminated water starting at birth and 2) an infant exclusively breast-fed for t2 months, followed by continuing ingestion months, followed by drinking contaminated of contaminated water drinking contaminated water through through life; water through life. cFFooonrrcttehhneterffaiirtssittossncceaentnarariribioou,t,attbhhleee fftooorrmimunulklaai--nffeegddwiianntffaaennrtt,,bttehhleeowwwaaatnteerRr ccSooCnnccoeefnnt5trr0aa%ttiiootnnhrttohhuaagtthmmoauaitinntftaaeiinnisss 0aa.ss1e5erruuumgm. Because oftcohofentthhcweeeantlloetornrnaggtcioohhnnaaclefal-nltfittfrer,ib,auttthithaoeebnlsse(ee0rrt.ouu1m6mdrgccin/ooknLnic)ncegenrntawtrirasaaetttesiiorotnnbheeccluusorrewvvreeauiinmss vvRceeoSrnrCyyceffnollaiafttr5aaa0tnn%iddonetehvvareebonnouvgaaehssotmmuhaetallll5life0iinnipcscerrer0emc.m1eee5nnnttItJhgiirn/neLcc.srrehBeaaaeslscedeaufiinnosre over ayear the water concentration over a year. (0.16 IJg/L) raises the serum concentration above the 50 percent threshold for PFOA Page 401 12 PFOA - Page 4 of 12 33775533..00000044 STSTAATTEE 0077553333099955 0,070 Formula-fed Scenaric (95th %tile) PFOA Serum Concentratioq at Water Concentration 0.15 ~g!L RSC 50% |ht db foe i o,oso 3 0.020 0.000 0 pe 10 20 ~,0 40 50 Age (years) AhaAapnnpappneellxyyxficiconneauggeerddthyhaaesinsnarccww.eeaatootiefefnrrttohhccereoondn55cce00eet%nr%onttrmrRRaaatSSitiinCoCotnnattohihofrnrfee00ss..hh1s1oo56elldrdgp,ugmbbL/uLucttoiinoonnfcfttehtthhneheteecrcoeaeontnntnitteioerexnexttarrooeeffffoereaarrebbebnenrrcleceeeoaawsssstea-etfrnreeuuddmRmiiSnnccCffooaannonncftcteernr0enetsstr%ruuaaitltttiiefoeooddnrn biiffnororerinaommtstotooorfrnneeelldyy infants,the water concentration should not exceed 0.036 gL than four years. In order to maintain a serum concentration at or infants, the water concentration should not exceed 0.035 pg/L. below an RSC of 50% for breast-fed 0.070 0.060 Som~ 0,050 f._O ~ 0.040 ~|W~ 0.030 E 0.020 Breast-fed Scenario (Upper %tile IR) PFOA Serum Concentration at Water Concentration 0.035 #giL 0.000 0 a 20 30 40 Age (years) iDnufeanttoecxhproosruircebsicoeancacruimoulsathion in the mother and subsequent transfer o breast thebreastfed Due to chronic bioaccumulation in the mother and subsequent transfer to breastmilk, the breast-fed e most Imig scanario terms of water concentrations To ensure infant exposure scenario is the most limiting scenario in terms of water concentrations. To ensure pprrootteeccttiioonn ooff aalll ssegmmeennttss ooff tthhee ppooppuulalattiioonn,, tthhe ffiinnaalhheeaalltthh--bbaasseeddvavlauluee ffoorr PPFFOOA iiss sseett aatt 00..003355 IpJgg//LL.. Cancer Health Based Value (CHEV) = Not Applicable Cancer Health Based Value (cHBV) = Not Applicable Cancer cassifcatio: Suggestive Evidence of Carcnogenic Potential (EPA Cancer classification: Stops factor (SF): Not Applicable. [EPA derived a slope factorof 0.07 (malkg- Slope factor (SF): Suggestive Evidence of Carcinogenic Potential (EPA 22001166bb)) Not Applicable. [EPA derived a slope factor of 0.07 (mg/kg- dd))"-1.. HHoowweevveerr,, tthhiiss ssllooppee ffaaccttoor ccaannnnoott bbee uusseedd ttoo ddeerriivvee PPRFOOAA--PPaaggee Sof 5 12of 12 3377533..0000055 SSTTAATTEE_0077553333999966 `SSoouurrccee ooff ccaanncceerr ssllooppee ffaaccttoorr ((SSFF)):: Tumor site(s): quantitative guidance for PFOA because it was based on body weight scaling rather than established chemical- specific toxicokinetic differences.] NNoott AApppplliiccaabbllee ((sseeee aabboovvee)) Leydig Cell Tumors* *An increased incidence of Leydig Cell Tumors (LCT) was observed in male rats. MDH considers the existing database to be inadequate for assessing carcinogenic potential of PFOA. No mode of action(s) (MOAs) has been identified, however, PFOA is not genotoxic and a hormonal cancer mechanism has been suggested. It is likely that the MA(s) would have a threshold. Leydig cell turmors are common in rats but rare in humans. In addition, the MOA for LCTs in rats has questionable relevance to humans (Cook 1999) (Steinbach 2015). Some epidemiology studies reported a possible link between PFOA and testicular cancer in humans. Most human testicular cancers are not Leydig cell tumors and the type of testicular tumor associated with PFOA in humans was not characterized in the published literature. MDH considers the noncancer-based water guidance value of 0.035 IJg/L to be protective for potential cancer effects, based on currently available data. rt sn Volatile: No Summary of Guidance Value History: A chronic nHBV of 7 IJg/L was first derived in 2002. A revised chronic nHBV of 0.3 IJg/L was derived in 2007 and promulgated as an nHRL in 2009. In 2016, EPA released a Health Advisory of 0.07 IJg/L for pert PFOA. MDH conducted a re-evaluation and derived a revised nHBV (applicable to all durations) of 0.035 IJg/L in 2017. The 2017 nHBV is lower than the previous value as the result of: 1) incorporating the most recent toxicological information and 2) addressing chemical-specific exposure concerns from breastmilk. S`Suummmmaarryyooffttooxxiicciittyy tteessttiinngg ffoorr hheeaalltthh eeffffeeccttss iiddeennttiiffiieeddiinn tthhee HHeeaalltthh SSttaannddaarrddss SSttaattuuttee ((114444..00775511)):: Even if testing for a specific health effect was not conducted for this chemical, information about that effect might be available from studies conducted for other purposes. MDH has considered the following information in developing health protective guidance. [TT EnEdnodcorcriinnee [imImmumnoutnooxtoixciictityy |DDeveevellooppmmeenntt| RReperpordoudcutcitivvee|NNeueruortootxoixciictityy| Tested for specific effect? Yes Yes Yes Yes Yes cremma Effects observed? Yes1 Yes2 Comments on extent of testing or effects: Yes3 Yes4 Yes5 [Note: MDH conducted a focused re-eva/uation which re/ied upon EPA's hazard assessment and key study identification (EPA 2016a). A complete evaluation of the toxicological literature was not conducted.] 1"TThhrreeee llaarrggee eeppiiddeemmioiollooggiiccaall ssttuuddiieess pprroovviiddee ssuuppppoorrtt ffoorr aann aassssoocciiaattiioonn bbeettwweeeenn PPFFOOAA eexxppoossuurree aanndd incidence or prevalence of thyroid disease in female adults or children, but not in males. In addition, associations between PFOA and Thyroid Stimulating Hormone (TSH) have also been reported in some populations of pregnant females. However, no significant associations were found between PFOA and TSH or thyroid hormones (T4 or T3) in people who have not been diagnosed with thyroid disease. Effects of PFOA on thyroid hormones in animals are generally not as well characterized as those of PFOS. Reduced total and free T4 were reported in adult male rats and monkeys at serum levels > 500- PFOA - Page 6 of 12 33775533..00000066 SSTTAATTEE_0077553333999977 dffooolldsdehhsiiggthheeesrtrettdhhawanintththihene tssheeerrusumtmudlleyevveaelnl dccootrrhrreeessdppooosnnedd-iirnneggspttooontthsheee rRRIefDlD.a.tiHHoonowswehevipevero,rf, sttheheresuseme dtdoootssaleessT4wweewrirteehtthPheeFlOlooAwweesstt `deeoxxpspeoosssuutrreeesthheaadsswyyietehtitnttoo bethe be ffsuutllullyydyeevvaaanlluduaatttheeded..dAoAssseaa-rerreessspuuollttn,sttehheerellolaowwtieeossnttsheefifpffeeccottfiivsveeerdduoomsseetorrteaemlmaTai4innwss ituuhnnkkPnnFooOwwnAn.. c`OoOtnthshieesrrteeennntdd.ooccArriifnneeeweesffffteeuccdttissesbbeeryyepooonnrddtetthdhyysrropoiieddrmhhaaavvbeenonnroomtatlbbieetieeenns,wweedlllel--cssrttueuaddisieeeddd., taaennsddtossstttuueddryyonrreeesasuntldtssiaanrrceerennaoostteeednnttiirreellyy ewcesohstentrrrsaadiedsiaitooesllnotiin.nthAmmearaflelseewturrsadattitussedsaaiennosnddlrymmeirpicceoeeproteaarttdtePPsdFFptOOehrAAemslleeaevvbeeefnllfsosercssmtiismmaialiiltltaaiehrrsitt,goohdtteherhocodsrsoeeesaewwsshe.hidicchhtesffootorrmsmtetthrhoeenbbeaasasinissdoofifnttchhreeeaRRsIfeDDd,, whereas other studies only reported these effects at higher doses. `a22 AAmssassrookcceiiarattoiiofonnissmmbbeeuttnwweeeeesunnpppprrreeensnasatitaaolnl,,)cchhhiailldvdhehoonoooddt,,booerreaandduculolttnsPPiFFstOOeAAntleeyxxppsooesesunurreein aaennpddidrreiimssikkooolfof giinincffeaecclttisiotouuusdsiddesiis,seeaaalssteehssou((agahss ttabhhuemetrrneaeorwwtkeaairsnsomssfaooilmmmeemechuiiinnnlddediriccesanau)tt.ipioopnnTrehoosfrfseeeiefofffnese)tcctuthdmmaioveodesidfeinfiixoccataamtbtiiioeonnenendbbcyyaogsgnseesonnicsdditeeeartrnit((loiyi.ne,ss.,ebaaeessntsswooincecieeiaanpttiiimodoanentssmersisoneelaoeelgnniaciinnandlff/eseomtrmuaadcllhieeeilsccd,hhsiailleldtdrhrreuoenmnugh dbPPuFFltOnsAAotrlleieenvvpeeomllrssatelaaednncddthhvaviltaadcrcaeccnirinen).edeuTrrchetesrisepopenoonnissnstueeadn((itemmiseebaoaesdsxyuuarrmreeeiddnsepbbdoyynaaassnnestti(obb0cooioddanyytieollenoefvvseetlblhsse)e)twtiinnhercceehhneiilldimdnrreafelntneureaannnnazddal aaasdtndurdluatlilsotn.srs cTTthehhisleedtesssdtteuuarddfuytymeriinn varreaedcccueeclitiisvvniinerneggrpettohshreepteoffdlnluusthevvaaawctcaccaisinnreeaesdwwsuaoaccsstiioaaantssessindooccwaiiinaatttthiebedPdodFwwyiOittAhrheisilnnpeccvorrenelesasaessiiinntnogtgholleenesvveeeelolsssftutoodhffieesssete,hrruruesmimemiPPilnFaFfrlOOuAreA,ens.zuWWlahthissiltwlreeaeirddneeesccatrreleessaaotsesoeedbddsaeftrevred wwviaittchhcoionttehheerrresppeperorffnllusuoeorriwinnaaastteedadsccshhoeecmmiaicitceaadllsswaaitnnhdd,P, tFthhOeerAreefflooerrveee,,lsccooinuulltddhennsooett be attributed specifically to PFOA. studies, similar results were also observed be attributed specifically to PFOA. `SiSmeevvmeeurrnaalel aarnneiismmpaoalnlsssett.uuddTiiehessesddeeemmeofonfenscsittrsraawtteeereeeffffoeebcctstsseroovnnettdhhaeetsssppellereeuennm aacnnonddceoonnnttrthahytymimouunsss wwseiemiiigglhhatrtsstoaassthwweeelcllrliataisscaddleescctruredeyaa.sseedd iLLmOOmAAEuELnL.e. The immune systemis sted as one of the response. These effects were observed at The immune system is listed as one of the cscoeo-r-cucrrmtitiicccaaollneecffeffenecctrttasstiaaonnndds Additvty similar to Additivity Endpoints. the critical Endpoints. study 2d3 eTTvhheeelrroeepmhheaanvvteealbbeeeeeffnnecnntsuu.mmeSeroroomuuess shhtuuummdiaaenns eerppeipiddoeermtmieoidollaoogngiiaccasalslosscttiuuaddtiiieeossn eebxxeaatmmwieinneiinnnggPFPPOFFOAOAAaneedxxppbooisrstuuhrreweeiaagnnhddt. while otdoottehhvpeererrelssonaphhtmaaavvleeenetnxnaopolt.ote.sfTTuferwwceootst.eeoppSiPioddFemeOmmAeio,iosllotohugogdiwiicceeaavslel rrsse,ttpuuotddhirieteeessdreeesaxxunaalmmtasisinnosefeoddctihaddeteesiovveneetllowbopoepmtmsweteenunedttniooefsPf ppFauurObbeAeecrrotatnyynfdiiinncbiffienregtmmh,aawlleeessigiihnnt,rreewllaahttiilioeonn to prenatal exposure to PFOA, however, the results of these two studies are conflicting. AAbommdooynnwggeitthghheet,aanndiiemmlaaallyssettduudediyieeess,,opddeeenccirrneegaa,sseedddelppaooyssettdnnaavtataagllinggarrloowwotpthhenllieenaagdd,iinnaggndttooaddceecveveleleloorpaptmmeeednntptaralelpeeuftfffieeacclttssse((peea..grg.a.,tlioloownwe)err `bhhcaoaovdvneeycebwbnteeereeiagnnthitooo,bbnsdsseeer~lrav3ve0yed0ed.-d.foTTelhyhdeeeshsoieepgeheefenfffrieentccgtht,ssadnffoeotrlramhmeyettshdheeervubbaamagssinicissoanloocfofepntthetheernainRRtIgifDoD, naaancnnodddrarwweceescrrpeeeolenoordbabistsneeegdrrvtvpeoerddtehpaaeutttRssiIaeeDlrr.usumemparation) concentrations -300-fold higher than the serum concentration corresponding to the RfD. aDDneedllaaqyyueeaddntmmitaaamtmimvmaearsrycyorggillanangnddasddseeevvseelsloomppemmnetensntthiiannvffeeemmidaaellneetimmiieiccdeedieefxxfpperooessneetddthiinrneuusttheeorrloodshhaafsosr bbteeieesnnefrrfeeeppcootr.rtteeMdd.D.HQQuauhlaaildtitaatmitoivvreee.. wcacoeonnrndfefiiqdduueesannenccdteeitiaiinnntiviuudesseiinsnntcggioyrqqiiununagganntmaitiatstaasmttemiivsvaesermmmyeeenagatslssauunhrrdaeevmmdeeeenvindteteslsnoootpifffmimemedanatmmdmaimfsfaeararreyycnoggt-lltachainrnteddcsaddhleeovvledfeefslleoocftpop.mrmeAtehnnnitstaaaeddnnffiddetcitttho.hneeaMssleeDsHmmtueehdaayassduurmreeossre `ewegvveraarolelwuutaauhttseteedhddrttohihnueegihdccoeolrnrarrcteetiflalyaatiitntoiiogno.nnmbbNaeeomttwwsmieegaeenrnniyfimmgcalaaanmmntmdmiamdarperayyvcetddlsuuoccpwttmebbrerrenaatnnfoccauhhsniidnna.ggcoppa-acttrtteietirrcnnassl aaennffddecttthh.eeAaanbbiaillidttyyditttoioonssuauplpppsotorurtdt yppuupp. growth through lactation. No significant impacts were found. tDDoootssheeessRrrIeeDssuulrltetiisnnuggltiienndssieenrrudumemcrcceoonancsceeendnttrnraaetotiinooanntssal>>77s0u00r0v-i-fvfooallld.d hhiigghheerr tthhaann tthhee sseerruumm ccoonncceennttrraattiioonn ccoorrrreessppoonnddiinngg to the RfD resulted in decreased neonatal survival. "`4eAAxpssoeesrruiireeess aoonffdssttpuurddeiiegesnsaiinnncaay-hhiiigngdhhu--ecexexpdpoohssyuuprreeertssettunusddiyyoppnoooppruulplaartetiieoocnnlarrmeepppsooirratt.eeddLaaissmsisotocecidiaadttaiiootnnasssbbuegegttwewseeteenna PPcoFFrOOreAAlation ebbbuxeerpttwdoweeseneuenrnveihhaaiignbgihhdreetrphr raPPengFFdnOOalAAnaccllteyeavv-tieenillodssnuiiccnnoeffudelemdmhaayillpmeeepssartcaaetnnnddsthioddisenecccororrereraapesslraeeetessicoiinlnan. mffeNepccosuuinnacdld.ieitLtayyrimaaeinnftefddedcffteedsrrattioitlatfityy,Ps, uFhhgOoogwAweeesvovtenearrm,,caolllooresrsessflaeoortffitoibbntooyddyy `ebenundrddppeooniinnvttssiahhbaaivrvteeh been identified. and lactation could been identified. impact this correlation. No clear effects of PFOA on male fertility AArammtsoo.nnHggowttheheveeaarnn,iimmitaasllhssottuuuldddiieebss,e, ttnhhoeetrreeedwwtahaasst nnfooemeeafflffeeecctrtaootfsf PPhaFFvOOeAAaoovnnerrreyepphrrioogddhuucectltiiivvmeeinooarrtiffeoernrttiirliiattytyeppcaaorramampmaeetrteeerdrsstiionn mffeeammeaallee rats. However, it should be noted that female rats have a very high elimination rate compared to male PFOA Page 7 of 12. PFOA - Page 7 of 12 33775533..00000077 STSTAATTEE 0077553333099988 rmraaittcsseoorerxooptthoheesrer dssppaeetccisieeess.r.uIImnncccrroeenacasesenedtdrffauutlllil olIintttseerr>7rr0ee0ss-oofrropplttidioonhnissghaaennrddtiihnnaccnrreetaahsseeesddessrttuiillmlbbiicrrtothnhscsewwneterrreaetooibobnsseecrrovvreerddesiinpnoppnrrdeeiggnnngaatnnott the RID. mice exposed the RfD. at serum concentrations >700-fold higher than the serum concentration corresponding to `NNeooxpeeovvsiiedddeenntcoceedooofsf eaaslltteperrreeoddduttceeissnttiigccuuslleaarrr uaamnnddcossnppceeernrmtmrasstttrriuuoccnttsuurr>ee35oo0rr-fffuuonnlccdttiihooinnghwweaarssthrreaenppootrrhtteeeddseiinnruaadmduulcltot nmmcaealnleetrrraaatttisson crceeooxprrporroerestsseeppddoo,nntbodduiintdngogtsyttpeooiscttahphleelroyRRdaIfutDDc.s.ineIIgrnnuccsrmreeeracuaossmneecddecnosstpnprecearertmnimotraanasbbtnino1oo0nrr0smm-af>alo3lilit5tdiee0hss-ifogaalhnndeddrhddtigehehcacenrreretaathhsseaeendsdettthreeeussmttsooescsrottuenemrcroeonnnceteornhahctaaeivvoneentrbbaeetieeonnn corresponding to the RID. reported, but typically at serum corresponding to the RfD. concentrations 100-fold higher than the serum concentration lsiTTmihhteeedhh,uubmmutaadnnoddnaaotttaa pipneedrrittcaaaiintneiinntgghettoopnnreeeuusreroonttocoxexiciocifittyays((siinoncccilluaudtdiiinongngsnnbeeeuutrroowddeeeevnveePllooFppOmmeAennattanaldl eeaffffveeaccrttisse))tyooffofPPoFFuOOtcAAomaaerrese. plEEimrppeiiitdndeteedamm,iliboorluleootpggdoyyortssnsttuouodtdfiiieAnesDsdHiocoDfaf.tccehhiitllhdderreepnnreffosoueunnnddceaa owwfeeaaaskksosscttaaiattitisisottiinccsaallbaaesstswsooecceiianattiiPooFnnObbAeettwawneedeenna serum variety serum PFOA and of outcomes. PFOA and parental reports of ADHD. gIInenfsfotorarmtmiaaottniioohnnaffdrroodmmetaaenncitimmaaballlesslttueuvddeiielesssofiiss PaallFssoOo Aqquuiiintteethlleiimimriittbeerdd.a.iTnTshhaeetoobfiffftsshpp.rriinLnggoocofofmmmiocticeoerffaeecddtivPPitFFyO,OAAanxtthihrerotouyu-ggrhheooluauttted or dgdreeeeplspratrteaeestsdsiosidnoioinfnh-f-iaelidirkkeeednecbbeteeeshhcaiavtnaivbeoiorxle,rp,lloooerrrvaemmtluosurssyoccflblePeehFssaOttvrreAieonnriggnttphhtahtwweteeierrrrnebesr.annioonTttshaaelalsttteeerbreeidrddta.h.t.aCCLiisrrocuccagaogddmeiiasaontntoaaarcctnatiiecvviteiittvdyyiftttyoee,rssattassndxdrreiteevivteoyenaa-ralleelelddastgtgeueeddnnidodeerserr-t-o ffruuelllllayyteuudnndddeeirfrfssettraaennnddcetthsheeinnneeeuxurproolloloorgagiticcoaarlyl eebffeffeheccattvssiooorff PFOA. patterns. PFOA. These data suggest a need for additional studies to RReessoouurrcceess CCoonnssuulltteedd DDuurriinngg RReevviieeww:: iN[Ndoetonette:if:iMMcaDDtiHHoncc(ooEnnPddAuucc2tt0ee1dd64aa)f.fooccAuucssoeemddprrleee--teeevvaaellvuuaaalttuiioaotnniowwnhhioiccfhhthrreeetllioiexeddicuuopplooognniEEcaPPlAA'e'ssrahhtaauzzraaerrddwaaassssnesostsemcsoennsdtuamacnnteddekndke,etyy ssttuuddyy identification (EPA 2016a). A complete evaluation of the toxicological literature was not conducted.] AAPeSSrTfTlSSuWoWrMiMnOOate((d2200C11h55)e.)m.iAAcssasslooscci(iaaPttFiiCoosnn):ooffPSSettraafttleeuoaarnnoddocTTteearrnrroiititoocrryAycSSioodllii(ddPWWFaOasAst)tee&MMPaaennrafaglgueeommreoenonctttOOafnffefiiccSiiaaullfss.o.nate (PFOS) Information Paper. Perfluorinated Chemicals Information Paper. (PFCs): Perfluorooctanoic Acid (PFOA) & Perfluorooctane Sulfonate (PFOS) AAPeTTrSSfDlDuRRo.r.oa((l22k00y11l55s)..)." ""ARgAeetrngiceyevfefoodnrrATTcuoogxxyuiicsctSSu1u5bb,sst2taa0n1n5cc,eessfraaonnmdd hDDttiipss.eeaassee RReeagiigssistdrtrryy.c.dDDcrraGafoftvt/TToooxxpxiriccooofliloolggeisicc/aa1ll92PP0rr0oo.ffipilldeel.ffoorr Perfluoroalkyls." Retrieved August 15, 2015, from http://www.atsdr.cdc.,qov/toxprofiles/tp200.pdf. A`AugusustitrdraaalnliicaaennoHHneeahalulttmhhaPPnrroohtteeeaccltttiiohonnrePPfrreiinrncecinippcaaell vCCaoolmumeimsttiftoetereep,,eree.-. a((22n00d116p6)o)..ly""-eelnnuHHoereaoaallltthkhylSSttsaauttebesmmteeannnttc:eIIsnnttfeeorrrimiumsnneaatitinioosnniaatlle gihinniuvvtiedepssa/ttAniiwgcgwaaeattwiiooonnhnessahluiitnnmh.AAaununssstthwrraeaglaloiialvtah..""arfferurofoeemmrnevnciervoanlumeesnfotrfpaecr-iasnhdepeotlys-f/luDoorocaulkmylesnutbsst/ahpneafcleatshs-f-ovrailunusetese-irnahisoimpte-e pal, http://www.hea~th.nsw.q~v.au/envir~nment/factsheets/D~cuments/pfas-interim-hea~th-va~ues-ahppc.pdf. `BBOuultsteeennnh,hoofPfff,T, hJJ,o.,mfGGorCCdo.osstt(aa2,,00CC2).EEllc"coToommxbibecei,,tyDDofFFaaArrmrraamrro,, nKKiHHuaamnnssPeeenrn,f,lHHuoIIrwwoaaoiic,,tRaRnJcJuuantngeg,,inGGMaKKleeennnnCeeyddnyyomJJrro,,lPPguLLsiieeMddeoernr,,kGGeys aOafflttseeerrnOO,rraPallTDDhooossmiinnfoggrdffo.or(&r620MM0o2on)nt.hth"sTs..o""xTTicooixtxyiiccooofllooAgqmiiccmaallonSScicuiimeennccPeeessrf66lu99:o:r2o244o44c-t-2a25n57o7.a. te in Male Cynomolgus Monkeys BPBuJutteTenhnhohomoffffof,,rdJJ,.., G(G2LL00KK45ee)nn.nnee"ddPyyhaJJrRRm,,acPPoMMkinKKieinntddiereclsriltitoeefrr,,PePPrHHfiLLuiioeerddoeeorr,c,tRRanJJauutnnegg,,inKKCJJynHHoaanmnsoselengn,u, sGGSSMoGGnokoerrymmsaa.nn",, PPEE NNookkeerr,, TPoJxiTchoolomgfiocradl. S(c2i0e0n4cbe)s. "8P2:ha3r9m4-a4c0o6k.inetics of Perfluorooctanoate in Cynomolgus Monkeys." Toxicoloqical Sciences 82: 394-406. tBBouuxttieecnnohhlooofgfffy,,oJJf.,,aGGmLLmoKKneeinnnunemeddpyyerJJfrr.l,,uSSorRRooFFcrrtaaammnceei,,cJJ(CCAPOOF''OCCo)onninnnoortr,h,eRRrGGat"YYoTororkkx..ic((2o2l000o04g4aya).)1.96"":TThh9ee5-rr1ee1pp6rr.oodduuccttiivvee toxicology of ammonium perfluorooctanoic (APFO) in the rat." Toxicoloqy 196:95-116. PPFFOOAA-- PPaaggee 88 ooff 1122. 33775533..00000088 STSATTAETE 0077553333099999 sBButututedenynhhwoioftfffh,, pJJo.,,tSSasCCsiCCuhhmaannpgeg,r,fGGiuWWoroOOolIcssteeannn,,ePPsJJulTTfhhoonomamftoeforidrnd..Sp((22r00a11g22)u.)e. ""DCCahhwrrlooennyiiccraddtiisee.tt"aaTrryyoxttioocxxioiccliiottygyyaa2nn9dd3:ccaa1rr-cc1ii5nn.ooggeenniciciittyy study with potassium perfiuorooctane sulfonate in Sprague Dawley rats." Toxicoloqy 293: 1-15. CCODCC ((22001166).). CCeenntteerrss ffoorr DDiisseeaassee CCoonnttrrooll aanndd PPrreevveenntitioonn.. BBrreeaassttifeeeeddiinngg RReeppoorrtt CCaarrdd.. CCExDDpCCos((u22r001e177t)o.). ECCnevenintrteeorrnssmeffonortraDDliisCsehaaesmsieecCCaolonsnt.trrooUllpaadnnaddtePPdrreeTvavebenlntetiisoo,nnJ((aCCnODuCaC)r.)y. 2FFo0ou1ur7rt,thhVNNoaalttuiioomnneaalOl nRRee:eppoorrtt oonn HHuummaann Exposure to Environmental Chemicals. Updated Tables, January 2017, Volume One. `CCToouoomkok,r,iJJg..e,,nGGesRRis:KKiliiAnneeRffeeellvteeirr,e, wJJFFofHHtaahredrdisPisthtyyy,s,iRRolMMogSSyh.haaPrrappteeh,,olPPoMMgyDD, MFFoeoscsthteerar.n. i((s119m99s99,9).).an""RdRooRddeeelnnettvLLaeenycyddeiiggtoCCeHelulllmans." Critical Reviews in Toxicology 29: 169-261 Tumorigenesis: A Review of the Physiology, Critical Reviews in Toxicoloqv 29: 169-261. Pathology, Mechanisms, and Relevance to Humans." EDDvaaannliiussahhtiMMoininnioissfttrrhyyeaoolffttthhheheaEEznanvrvidirrsoonanmnmedennpttro((2p200o11s5a5)l). oPPfeearrffhllueuaoolrrtoohaallbkkayylslaaettdeeddqussauulbibststytaaCnnrciceteses:ri: oPnPFFfoOOrAAd,,riPPnkFFiOOngSSwaaannteddr,PPFFsOoOSlSAaA.n. d `ground water. Environmental Evaluation of health hazards ground water. Environmental project No. 1665, and proposal of a project No. 1665, 2015. health 2015. based quality criterion for drinking water, soil and iDDemeWmWiutnitt,o,mJJ.o,.d,CuClBBatCCioooppneelilaannnAddd,u, lMMtJJCSS7t8trrLyynn/aa6rr,), RRorWWCLLSuu7eebBbkLkeeE,,N((22F00e008m8)a.)l. e""PPMeeirrcffellu.u"oorrEoonoovccittraaonnnooimiccenAAtccaiildc--HIIennaddluutccheedPderspeciives 16/5): 644-650. Immunomodulation 116(5): 644-650. in Adult C57BL/6J or C57BL/6N Female Mice." Environmental Health Perspectives rDDeeesWWpiotitnt.,sJeJ..s., W iWnCCmiWWcieilllieiaaxmmpsso,,seNNdJJ tCCorrpeeeserccfhhl,,uoRRroWWocLLtuaueneobbikkcee,a,ci((2d2:00115R5)o.)l. e""SSofuuppPppPrreAessRssaiiooannnoodff Taa-nntatiigngedenn-B-s-spcpeeeclicfitfiiaccrgaaennttitiinbgbo.o"ddyy Jreousrpnoanlseofs Iinmmmunicoetoerxipcoosleodgyto13p(e1)r:flu3o8r-o4o5.ctanoic acid: Role of PPARa and T- and B-cell targeting." Journal of Immunotoxicoloqy 13(1): 38-45. aEEcFFiSSd AA(P((F22O00A0088))).anEEduurrtoohpepieeraasnnaltFFsoo.ooSddciSSeaanffteefttiyycAAOuupthtihonroiirotitnyy..ofPPeterhrfeflluPuoaornrooeoolccottanannCeeossnuutllaffomoninanatateent((sPPFFiOnOStS)h),e, Fppeoerorffdlluuoccrhrooaoiocncttaanncoicic. (Question No EFSA-Q-2004-163) acid (PFOA) and their salts. Scientific (Question No EFSA-Q-2004-163). Opinion of the Panel on Contaminants in the Food chain. sEEugglefeoggnhhaytye:PPPPAaacnnoddmpMMarLLioosrrobbneerrof((22e00s11t11)i.)m.at""AeAdnn iaansstssaeekesssswmmieehnntvtaoolffuttehhseeieenfxxepproorsseudurrfeerooofmf AANmmHeeArriNiccEaaSnnssdattootapp.e"errJffloluuuoomrroaooloccottafannee Exposure sulfonate: Exposure Science and Environmental A comparison of estimated Science and Environmental Epidemiology. 21: intake with values Epidemioloqy. 21: 150-168. inferred from 150-168. NHANES data." Journal of (FFiPillgFgooO,,AA)A-..,inEEdMMucQQeuuidsistLt,i,vMMerJJLHHeosoeienonenersrffoionfff,T, wAAoEESBBtrrriiaxx,i,nGGsEEofKKMiiissscsielinngFg,o,lSSloEEwiFFneegnntDtooennv..el((22o00p11m5e5)n.).ta""PPleerErfxfllpuuoocsrruoorooeccstt:aannPooiiPcc AAAccRiiddIs Not Required." Toxicologic Pathology 43: 558-568. (PFOA)-induced Liver Lesions in Two Strains of Mice Not Required." Toxicoloqic Patholoqy 43: 558-568. Following Developmental Exposures: PPARa Is `FFCrrhiiisas-n-HHgaaennsssieennn,B,oBBd..y((1C19o96m61p1)o.)s.iBBtoiooddnyy.W WaPaetdteeirartCCrioocmmsp,pa2ar8rt(tmm2)ee,nnt1t6ss9-iinn16CC1h.hililddrreenn:: CChhaannggeess DDuurriinngg GGrroowwithh aanndd RReellaatteedd Changes in Body Composition. Pediatrics, 28(2), 169-181. `FFGrreoonmmzmemlee-,,BoHHr..o,CvCiczMMeoonsysc,chh,B, MMKolMMeotorzrokovovi,ittzWz, |IVAAolllbbkaea-l-A,All(ee2jj0aa1nn0d)dr.ree,",PSSreBB-ooaeenhhdmmePeror,s,tMMnatKKaiilrraaEnnoxoggplluuo,,sFFeFFtaaobbePerer,r,f|IluHHoaarnninnniabibtaaeldl,, OO Compounds (PFCs) * GenzeI-Boroviczeny, Compounds (PFCs)." Environmental Science & Technolo4g4y: 7123-7129. B Koletzko, W Volkel, (2010). "Pre- and Postnatal Exposure Environmental Science & Technology 44: 7123-7129. to Perfluorinated `GHGoecerhrmsmaaaunnerMMlianinniisdstktrrryyeioosff.HHeSeatlatalthth.e.m((e22n000t066)b.)y. tAAhssessDeerssissnmmkeiennngttWooafftPPeFFrOOcAAomiinmnittshhseeiddorrniinn(kkTiinrngginwwkaawttaeesrrosoeffrttkhhoeemiGGseesrrimmoana)nn of the GGPHreoeorrcvmmihsasaiannounMMaeilrnilnaiEisnvstdatrrlkyyureaootfifsi.HHoenSeaatolalfttthhePmFaattTettnhihtneebDFFyreietdnhdekeeriranaDlglriWEEnankntvivnieigrrrooW nwnimmateehtnenttrthcAAeoggGmeeunnmiccdiyysesJJSiouuunnnbees(tT22a1r1,inn,c2k2ew00s0a06sP6rselrreeefvrvlkiiuossomeerddomoJJicsuutsllayyinoon11i33),c,oa22fc00ti0h0d6e6.. (PFOA) and Perfluorooctane Sulfonate (PFOS) as Examples. Provisional Evaluation of PFT in Drinking Water with the Guide (PFA) and Perfluorooctane Sulfonate (PFOS) as Examples. Substances Perfluorooctanoic acid PFOA Page 9.01 12 PFOA - Page 9 of 12 33775533..00000099 STSTAATTEE 0707553344000000 "HHPaarrrreirdsisi,,ctMMo,r.,sSSoLLf PRReiirffa-assa--nSSdhhiiPmmoaalnynf,,lAuAoMMrcaCClaaklaylaflafatS,tu,bXXsYtYeae,n,cAAeMM(PMMFoAorSraa,), PTTlFFaWWsemebabstsCeoternrc,,eEEntOOrkaketenin,o,nSsSKKinSS6aa-ggi1viv0..Y((e22a001r177)O.)l.d AA"1Pm0mr.eee1rd0riii2ccca1tao/nnrascCCshoh.ifeillsddPtrreee6rnn-5.."0"a5nEE8dnn1vvP1iiorroolynnfmmlueeonnrtotaaalllkSSyccliiSeenuncbceest&a&nTTceeecch(hPnnFoolAlooSqg)yyPAAdladvsvamannacceCeoAAnccccceeesnssts:ra: tDDioOOnIIs: in 6-10 Year Old 10.1021/acs. est. 6b05811 HHeeaalltthh CCaannaaddaa ((22001100).). DDrriinnkkiinngg WWaatteerr GGuuiiddaannccee VVaalluuee PPeerrffliuuoorrooooccttaannee ssuullffoonnaattee ((PPFFOOSS).). SHHueeabalslttthhanCCcaaennsaadd(aaP.F. A((S22)00.11"66aa).)R.et""HrHieeeaavlletthdh CCMaaannyaad2da7a,''ss20DD1rr6iin,nkkfiinrngogmW Waatteerr SSccrreeeenniinngg VVaalluueess ffoorr PPeerrfflluuoorrooaallkkyytlaatteedd ShShihtuttepbpe:sJ/t/t/assp3n3d.cfdd.eosocu(PmcFeAunStcm).lo"eudRn.oerttqri/edevoecldumMoeaunyt2sd7/2,.7250o6136r8,6fg/HrHoem/eaaldltthho-CCaacnnaauddaam-- PPeFFnAASSt--SSescrree/eenn2iinng,7q--VV5aal6luuees3s--F8Faac8ctt:- Sheet.pdf. DHHeoeaaclltuthhmCCeananntaaddfara.o. m((22h00i11t6o6b:b)/.)h.e""aPPleterhrfyfllcuuaoonrraoodooiccatntaasnn.oooiiccc. cAAaccliihddea((PiPtFFhOO-AAs)y) siitnneDDmr:risinnykksiintneggmW Wea:atseaternr.t.elPPcuuobbnlsliiucclCCtaootnnissounulsala/ttaiicooinndeDD-rraafftt perfiuorooctanoic-acid/document-eng, oho. Document." from http://healthcanadians.qc.ca/health-system-systeme-sante/consultations/acide- perfluorooctanoic-acid/document-enq, php. "LLEaafuuf,,ecCC.t,.s, oJJfRRPTTehrhifibibuoooddreeoaaouucxtx,a,nRRoiGGc AHHcaainndssooEnxn,p, oMMsGGureNNaadrruoorttissnkkgyy,,PrJJMeMgnRRaoonggeceryrssi,,n AAthBBe LLMiionnuddsssettr.roo"mmT,,oMMxiJJcoSSliotrrgyyinncaarar.l. S((2c20i00e06n6)c,).es 90(2): 510-518. "Effects of Perfluorooctanoic 90(2): 510-518. Acid Exposure during Pregnancy in the Mouse." Toxicoloqical Sciences RLLoaovtveselleeassnssd,, MSSi..,c, eDDAHHdomoibbnaainns,,tGeGreSSdyyLkkieesns,e,aSSrRRAmFFmrraoammneie,,umNNEEPEEevrveferlrdudsos.r.oo((22c0t00a08n8)c).a.t""eEE.v"vaaTllouuxaaittciiooonlnoogofifcttahhlee IImmmmuunnee Sciences SSyysstteemm 105(1): iinn x Rats and 86-96. Mice Administered Linear Ammonium Perfluorooctanoate." Toxicological Sciences 105(1): MFMeaancctooonnn,., MM(.2.,0,1L1L)RR. VV"iiPlllrlaaennnuuaeetvvaala,,PeKKrfTTlaauttouurmmo-o-GGcitibbabnbsos,i,cRRADDciZZdeeEhhrxr,p, oMMsJJurSSettrriyynnnaCardr,,-1JJPPMiSSctetaa:nnkkLooo,,wSS-DSSoW WshehitiDteee,,veLLlHHoepelmflfeaannnttt,,alSSEE FEEfefffneetccottnss.aa(nn2dd01II1nn)tte.err"nnPaarlleDDnoaostsiaimlmePteretryry.fl."u" oTTroooxxoiicccotoallnoogoqiiicccaaAll cSSidcciieEennxccpeeosssu11r22e22((i1n1):)C: d11-33144-M-114i4c55e..: Low-Dose Developmental MPMeaarifinnleeuoCCroeeonncttteearnroffioocrr.DDAiicssieedaasisneeDCCroionnntktriroonlgl&&WaPPtrreeervveeCnntAitioSonn.R.e((g22i00s11t4r4)y.).NMMuaamxxbiiemmruum(mFrEEexxeppAoocssiudu)rr:ee 3GGu3ui5idd-ee6ll7iin1nee ffoorr Perfluorooctanoic Acid in Drinking Water CAS Registry Number (Free Acid): 335-67-1. tMMhDDe HHMat((22t00e00r88)o).f. PMMriionnpnnoeesssoeotdtaaRDuDleeeppsaarRrtemtlametneitnnoogftftHHoeeaHaletlathhl..thSStRtaaittsekemmLeeinmntittoosfof fNNGeereeoddunaadnnwddatRReeeraa.ssoonnaabblleenneessss ((SSOONNAARR)) iinn the Matter of Proposed Rules Relating to Health Risk Limits of Groundwater. MIMnDDcoHHrp((oMMriainntnneeeHssouottmaaaDDneeEppqaaurirtvmtalmeenentnotoftfDoHHeseaelatltChh)a).l.c(u(22l00a1t17i7o2an))s.. i""MnMtIoDDHDHeHHreieavalaltththiRRoifinsskkOrAAasslsseeRsesfssemmreeennnttceMMeDettohhsooeddsss(ttoMoay 2011, rrIneecvvoiissrepeddor22a00t1e177)H)..u""mffraroonmmEhhqituttpipv::/a//wlwewwnwwtw,DhhoeesaaleltthhC,asstltcaauttelea, mmtinon.n.ususs/i/ncditoivvssD//eeehhr/i/vrriasitksio/k,inqquuoidif daOannrcacele/hhReeeddrfereerfefq,nqucuiedidee.D,oppdsdfef..s (May 2011, MMPFDDOHHS((22a00n11d775Pb).)F.O((MAMiiannnnneedssIoottstaaUDDseeeppianarrttmhtemeDneetnoroitfvf aHHteieaoalnltthho))f BBHauaccmkkaggnrrooHuuennaddltDDhoo-ccbuuammseenedtn:Wt:aTTtoeoxrxiiccGooukkiiidnnaeentiiccceMMVooadldeueellsf.foorr PFOS and PFOA and Its Use in the Derivation of Human Health-based Water Guidance Values. MPMeiirccfhhliigugoaarnnooDDcetepapanarorittmcmeaencntitdoo(ff PEEFnnOvvAiirr)oonnmmeennttaall QQuualailittyy ((22001111).). HHuummaann && W Wililddiliffee TTooxxiicciittyy SSuummmmarayry.. Perfluorooctanoic acid (PFOA). pNNreeolljsseoocnnt,,dJJa..ta((220b01a16s6).e).d""oPPneerrJssuoonnneaall9,CCo2om0mm1mu5nuiMnceieactatitiinoognn ArregegegaanrrdddaiinnaggnMMdDDMHHateMMriNNal((sEEoaasrstttMMheeettArrdoov))iPPsoFFrCCy bbPiiaoonmmeolonnittiotootrrhiinengg pEEnrnovvjieirrcootnndmmaeetnanttaabllasHHeeedaallotthnh TTJruraanccekkii9nn,gg2aa0nn1dd5 Biomonitoring Program. Meeting Agenda and Materials Biomonitoring Program. for the Advisory Panel to the hhitttpp::///wAvwwaww .hheeaalltthh .ssttaattee .mmnn..uuss//ddiivvss/hpcpdcrda/tcrakciknign/qo/apnaenle/l/22001155JJuunneemamtaetreiraiallss.poddf."" NDNreeiwwnkJJineegrrssWeeayyteDDreeppaatarrPttmemneennnsttgoorffoEEvnenvvWiirraootnnemmreenSntutapalpl lPPyrrooCttoeecmctptiiaoonnn.y. .((22000077)).. MMeemmoorraanndduumm:: GGuuiiddaannccee ffoorr PPFFOOAA iinn Drinking Water at Pennsgrove Water Supply Company. PPFFOOAA-- PPaaggee 1100 o0ff 1122 33775533..00001100 STSATTAETE 0077653344000011 `NNSeeupwwpoJJreetrrssDeeoyycuDDmrreiinnntkk:iinnggPeW WrafatiteuerorrQQououacaltilaittnyyciIInncsstAtiicttuiutdtee..(P2(F20O01A17))7..). HHeeaalltthh--bbaasseedd MMaaxxiimmuumm CCoonnttaammiinnaanntt LLeevveell Support Document: Perfluorooctanoic Acid (PFOA). wNNiTTthPPE((x22p001o16s62ua)r)..eNNtaoattiPiooennrafaliluTTcoorsoxioicccootccaonoclloiogcgyyAcPPirrdoogg(rrPaaFmmO..A)DDrroaafrfttPSSeyrysfstlteeummraoatotiiccciaRRneeevviiSeeuwwffoooffnaIImtnemm(uuPnnFooOttSoo)xx.iiciityy AAssssoocciiaatteedd with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS). APPemermrkkioinnnssi,, uRR.m,., PJJeLLrfBBluuuttoeernnchhooocfftf,,anGGcLaLtKKeee(nnAnnePedFdyOy,), MiMnJJMPaPalalelaazRzzaztoosll.oo,, ((D22r00u00g44)a.).nd""113C3:h-WWeemeieeckkalDDiTieeottraairrcyyoTTloooxgxiyicc2itt7yy(4SS)tt:uudd3yy61oo-f3f 78, Ammonium Perfluorooctanoate (APFO) in Male Rats." Drug and Chemical Toxicology 27(4): 361-378. wPPoaostste.t,rGGc.,o.,ntPPaDDmiCCnoaohnhntn:,, AKKRRciCCioocooappererer,,vi((2e20w0112o2)f.).re""cRReeenvvtiieeewwr:a:tPPuerererff.llu"oorEronoovocictrtaaonnncmoieiccntaaaccliddR((PePsFFeOOaAAr)c),,haa1nn16ee;mme9er3rg-g1ii1nn7gg. ddrriinnkkiinngg water contaminant: A critical review of recent literature." Environmental Research 116:93-117. QQMuiutiiossctt,hoEEn..d,rAAiJJalFFAiilllggeoor,,atCCiAAonCCiuunmmGmmDi-nin1ggssM,,icGGeEEAsKKsiisosssclliiinanggt,,edMMJwJitHHhooePenrneerenhrahotfoafflf,,ESSxEEpoFFseeunrntetoosnn.o. ((22L00o115w5).)D.o""sHHeeesppaaotftiicc Perfluorooctanoic Acid (PFOA)."Toxicologic Pathology 43: 548-557. Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures Perfluorooctanoic Acid (PFOA)." Toxicoloqic Patholoqy 43: 546-557. to Low Doses of `SBSicchhbeeaccutteemrr.,, AA(..3,0NN12)MM.alai"likPko-BlBayaslsussc,,roAAaMMlkyCClaalClaaoffaam,tp, oKKunKKadattsoo,,inJJAATeCCxooallsaaccCiihnniool,,drTTeLLnGGfeeonntmt,, BLLiSSthHHytynrnaoannu,,gThTRR12HHaYareriraissr,,soSSfMMAaglaielal.&,"LL BEnirvnibraounmme.n(t2a0l1H2e).al"tPholPyefrlusopreocatlikvyelsC1o2m0:po5u9n0d-5s0i4n Texas Children from Birth through 12 Years of Age." Environmental Health Perspectives 120: 590-594. SHStateemiiinnlbbtaaoccnhh,&, TTH,.a,rRRdyRR'sMMaIarnrdoounnsptporoitat,,l JJTFFoxHHiacarorlddoiigssytty,,, S((2i2x00t11h55))E.diHHtuounmm.aanMn. RRBee.lleeRvvDaannHccaeerbooiffsRRonoo,ddeeGnnTtt JLLoeehyyncdsiigognCC,eelllJl oTThuumnmoWroisrsl..ey & SHoanms,iltoInnc. & Hardy's Industrial Toxicolocly, Sixth Edition. M. B. RD Harbison, GT Johnson,, John Wiley & Sons, Inc. Suh, C., NK Cho, CK Lee, GH Lee, DH Kim, JH Kim, BC Son, JT Lee, (2011). "Perflorooctandic acidaSiinnnudddhuu,cCceeCeldd.l, uiiNlnnahhKriibbCEiittnhiiodoono,ncCooiffKippnlLllaaeocceege,nyntCta3aHl3l7pp:Lrreoo7el-laa,1cc5Di.tiiHnn--fKfaaimmmi,illyyJHhhooKrrmimmoo,nnBeeCaannSddonffe,ettJaalTl ggLrreooeww,tthh(2rr0ee1tt1aa)rr.ddaa"Pttiioeonrnfluiinnomrmoiioccece.t.a""nMMooiolcleeacccuuildlaa-rr and Cellular Endocrinoloqy 337: 7-15. TTPrCCoEEtQeQ.ct. i((v22e001C16o6)n)..ce""nTTteerxxaaatssioCCnoomLmemvmiesilssssii(ooPnnCoLo)nn.EEnnvvfiirrrooonmnmmeennttaall QQuuaaltliyty.. TTeexxaass RRiisskk RReedduuccttiioonn PPrrooggrraamm ((TTRRRRPP))-Hits www teed texas gouremediationAroAppcls him. Protective Concentration Levels (PCLs).", from https://www.tceq.texas.gov/remediation/trrp/trrppcls.html. TTisuucackkeserer,n,sDDi.i.,,veMMBBpubMMeaarctcoaonln,,taMMrJgJetSStitrrnyyCnnaDar-r,,1SaDDnadaggnCni5inn7oo8,,/EE6mAAinncddeeerfrssoeelnlno,,wiSSnEEg pFFeeernnitntooannt,a,l((2p20e01r15f5)l.).ur""oTTohhceetammnaoamimcmmaacarirydy ggllaanndd (PFOA) exposure." Reproductive Toxicology 54: 26-36 is a sensitive pubertal target in CD-1 and C57BI/6mice following (PFOA) exposure." Reproductive Toxicoloqy 54: 26-36. perinatal perfluorooctanoic acid URUnenigituteelddatKKiioinnnggsdd2oom0m.0.0/DD0rr1iinnkskpiinencggifWWiacattteeorrPIIFnnssOppSeecc(ttpooerrraaftteleu((o22r00a0o07c7)t.)a. nGGeuusiiuddlaapnnhccoeenaootnne)tthhaeendWWaPatFteeOrrASSuu(ppppeplrlyyfl((uWWoaratotoeecrrtQQaunuaolaiiclittayyc))id) concentrations in drinking water. Regulations 2000/01 specific to PFOS concentrations in drinking water. (perfluorooctane sulphonate) and PFOA (perfluorooctanoic acid) AUUmSSbiEEePPnAAt W((22a00t00e00)r,).QUUuSSaEEynnvCvirirriotoennrmmieaenfntotarallthPPerrooPttreeoccttteiiocotnnioAAnggeoefnnccHyyum((EEaPPnAA)H)..eaOOlftffhfii,cceeEoPofAf -WW5ata2e2ter-.r8.-MM0e0et-th0ho0o4dd.oollooOggcytyoffbooerrrDDe2er0ri0ivv0ii.nngg AUSmEbPiAe.nt W (20a1t6e2r)Q. u"aUliStyECnrviiterroianmfeonrttahlePProrotetecctitioonnAogf eHnucmy-anOHfeaflothfi. WEactPeAer-.82H2e-aBl-t0h0-E0ff0e4c.tsOScutopbpeorrt2000. hDUDioSotccEouuPsmm/Aewe.nvnt(wt2.ff0oo1err6pPPaae)er.grffo"llUvuusoSoirrtooEeoonscc/vitapiarrnnoocondiimcucceAAtnccitioiaddnl /((PfPPlrFFoeOOtsAe/)Ac2.t)0i.o1"n6-ARR0e5gel/etrdinioeeccvvyueem-ddeOnMMtfafsaicy/yeof11o9o9,fa, W22h00a1e1t8se6,dr,.ffrHfooiemnmaallt-hplaEifnfepcdrts. Support hRUUetSStspeEsEa:PP/r/AAwchw((22wa00n.11e1d1p),)aD..e,UUvqeSoSlvoEE/spnnimvtveeiisnrro/topn.nrm"moedefnurntcotaatmlilohnPPtr/trfooipltestees/cc/t/2tiico0ofn1no6uAAb-Og,geee5pnn/adccoqyyoc""vuEE/mxxneppceonoastssluu/irprseefkoiFFaaracechtcteooosrrrsdsisHHpfailannanadydlb-bpcooiloaomkik?n..d.peOOdiffffdf.ii=cc2ee36oof2f 62. Research and Development." from https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=236252. PFPOFOAA--PPaaggee 1111.off1122 33775533..00001111 STSATTAETE 0077853344000022 DUUoSScEEuPmPAeA.n. t((22f0o0r1166P)ae.r).fl""UuUoSSroEEoncnviviainrroconincmmeAencntitadall(PPPrroFottOeec)ctt"iioonnRAAeggleeinencvcyeyd-- MOOfafffyiiccee1o9of,f2WWa0t1ae6tre,.r.frHHoeemaalltthh EEffffeeccttss SSuuppppoorrtt hDiotcousm:e/nwtvfwoerpPaegrfolvuiosriotoecst/apnrooicduActciidon(/PfFlOesA/)2.0"16R-0e5t/rideovceudmeMntasy/o1f9o, a2.0h1e6s,d frfoimnal-plain pdf, https://www.epa.gov/sites/production/files/2016-O5/documents/pfoa hesd final-plain.pdf. AUUdSSviEEsPPoArAy.. f((o22r001P16e60rb)f.)i.u""oUrUoSSocEEtnnavnvicirrioocnnAmmceeinndttaa(llPFPPOrrAoo)tt.eaccttioonRneAAtrggieeennvcceydy M-- aOOfyfffii1cc9ee, oo2ff0W W1a6at,teerfr,r.oDDmrriinnkkiinngg WWaatteerr HHeeaalltthh hitos:/www epa govsites productions 2016-05/documents/oloa_health advisory Advisory for Perfluorooctanoic Acid (PFOA)." Retrieved May 19, 2016, from https://www.epa.gov/sites/production/files/2016-O5/documents/pfoa health advisory ffiinnaall--ppllaaiinn.ppadtf,. AUUdSSviEEsPPoArAy.. f((o22r001P16e64rd)f.)l.u""oUUrSoSocEEinnavvniierrooSnnummlefenontntaaaltlePP(rrooPttFeeOcctStii)oon"n AAgRgeeetnnrcciyyev--eOOdffMffiiacceye oo1ff8,W Wa2at0te1er6r..,DDfrrriionnmkkiinngg WWaatteerr HHeeaalltthh Aitdov:isowrywfwor ePpearflguoovrsoiotcetsa/nperoSduulcfotinoa/tefl(ePsF/2O0S1)6.."05R/deotcriuemveendtsMiaofyo1s9,h2ea0l1t6h, fardovmisoryfinal pain pdf. https://www.epa.gov/sites/production/files/2016-O5/documents/pfos health advisory final-plain.pdf. S`WiWpaaemmsb,baaMuuggMhh,a,tJJi..,,,RRKWWDSSaeset,tzzeJerCr,, DAAeMMWitPPtiit,trruuMzzzzSeetlllrlooy,n,aJJr,LLiiRu,,JDDudMMsoRRneei,fif,,kiNNCCHoKKuilceekiin,nsstCtrreeLuuaeeurr,,, (NN20CC1h3h)ii.nngg,",DYYosW Wiamaennlgrg,i,cNN TaSaonnipsccechhoosolr,roiiMngngigMcooaafflriitnSinnc,vviiieKvvnooDcaaeannssdd,1Jii3nn6C:vviDitt3rre0ooW 8.ssi3tttu2tu,7dd.MiieessSfftoroyrnppaeerr,rfflRluuoJoruroodoosccottanan,nooKaaAtteeHaaonnuddckpp,eerCrfflluLuoaourro,ooo(cc2tt0aa1nn3ees)s.uuf"olDfnooantsaeimt.e"e."tric Toxicoloqical Sciences 136: 308-327. WWDhohistiteee,,PSS.F,.,OJJAPPESSxtptaaonnskkuoor,,eKsK aKKanatdtoo,M, aAAmMMmCCaarallayaffaGatlt,,anEEdPPGHHriinonewests,,hSSaEEndFFeDeinnfttfooennr,,en((t22i00a1t11i1)o).n. i""nGGTehsertaesteiotGneaanleatarnnaiddtiCoCohnnhrsroaononfiliccCOLL-oo1ww-MDiocsee."PEFnOviAroEnxmpeonstualreHseaalntdhMPearmsmpeacriyivGeslan11d9(G8)ro:w1th07a0-n1d07D6i.fferentiation in Three Generations of CD-1 Mice." Environmental Health Perspectives 119(8): 1070-1076. WWWhooilft,,CC.,G.,SSSEELauFF,eennBttooDnn,A, bJJbEEoStSctchh(mm2i0di0d7,,).AAMM"DCCeavalealalfafoatpt,m, eZnKtuKakullkeTlenonyxiyicikki,,tyXXoAAf BBPreryyraafnlntut,,orJJoTTochhiiibabnoooddieecaaAuucxxi,,dKKnPPtDDhaaessC,,DSS-S$1 4WMM7o3ohu.uitsseee, after Cross-Foster and Restricted Gestational Exposures." ToxicologicalSciences 95(2): 462- CS Lau, BD Abbott, (2007). "Developmental Toxicity of Perfluorooctanoic Acid in the CD-1 after Cross-Foster and Restricted Gestational Exposures." Toxicoloqical Sciences 95(2): 462- W47u3,. X. DH Bennett, AM Galafat, K Kato, M Stryner,E Andersen, RE Moran, DJ Tancred, NS Tule, WHpHeoeurprt,utzlzX-a-.PPt,iiiccDoccnHiisoootBtftooec,,hnin((2l2e00dt1t1r,5e5)An.).Ma""nSSCdeearraluaudmfmiattc,csooKnnicncKeeCnaanttlotrir,aaftoMtiironoSninasstroy*ofnEfepnperve,rirfErfllouuAnoomnrreiidnnneaatrttaseeleddnR,cceooRsmmeEpapoMroucuohnnradd1nss3,6((:DPPJF2F6CCT4))a-naa2cmm7r3oeondnigg, selected NS Tulve, selected I populations of children and adults in California." Environmental Research 136: 264-273. YYpaeahrhifaila,u,oDDr.o.,ocMMtAaAnoEEiFIc--NNaacasissdseer(,rP, FMMOAAA)bbeeedxdepe-oIL-sLautaritie,f, tCCo pTTrsseuugkknuuabbnaat,, mMMicYYeoososhnhiidrdaea,p,ro|I dSSuaactttooi,,onTS.s"TuTsduhadea,J, o2(u20r01n10a)0l.)o. f""EEffffeeccttss of of TpoexrifcluoolroogoiccatalnSociiceanccisd 3(5P: F5O2A7)-5e3x3posure to pregnant mice on reproduction." The Journal of Toxicoloqical Sciencs 35: 527-533. oYYfaannigngh,,ibQQi.t.i,,oYYn oXXfeiec,e,lAAlMMproEElririfikkesrssastooinno,,n aBBnDDdNNdeeellvssooennl,,opJJmWWenDDteePiPnieiterhrrrysem,,ic((22a000n01d1).)s.p""lFFeuunrirttchhaeetrrreeovvpiihddyeeninnccdeeuffcooerrdtthbheey itinnhvveoollvveemmeenntt opfeirnohiibsitoiomne opfracleflel rpartoolrifepreartfiolunoraoncdtadnecivcelaocpimd einnmtiicne.t"hymBiicocahnedmiscpallenPihcaartmroapcholyoignydu6c2:ed11b3y3t-h1e140. peroxisome proliferator perfluoroctanoic acid in mice." Biochemical Pharmacoloqy 62:1133-1140. PFPOFOAA--PPaaggee 11220o1f 1122 33775533..00001122 STSATTAETE0706753344000033