Document emEa48149Qvk5EGgzBJrL9wKM

Interoffice Correspondence ubj ec t Fluorochemicals in Blood August 9, 1977 IS H. E. FREIER 201-1S J. D. LAZERTE 236-1 J. E. LONG 220-2E B. W. NIPPOLDT 201-1S R. A. PROKOP 236-3B J . SCHEUERMAN 220-12E F. A. UBEL 220-2E D. G. WEIBLEN 201-1S y$E X 'K i VETO I H q U $ 77 FROM: J. W. BELISLE 201-1S Since my letter of July 29, 1977 on the published report of perfluorooctanoic acid in human plasma, we have purchased and received a tape recording of Guy's presentation. I quote: "From analysis of the F/NMR spectrum, the fluorine containing part of the compounds in the isolate (from human plasma) resemble perfluorooctanoic acid. Derivatives of this compound are widely used as surfactants. No toxicological studies of these compounds appear to have been published. A complete list of all products in which these compounds are presently being incorporated is not generally available. At least in the past, these have been used in floor waxes, wax paper, leather conditioning agents and fabric conditioning agents. Two trade names which may come to mind are Scotch Gard and Zepel. Compounds of this nature might be expected to bind to plasma albumin because of their resemblance to fatty acids normally bound." "Human plasma may contain a number of types of organic fluoro compounds each distinct from the one characterized. We found multiple fluorine containing peaks in silicic acid chromatograms." That the major part of organic fluorine in human plasma is widespread environmental contaminant is consistent with our findings." A W. Belisle /jz 3MA10067223