Document emDeV9amJaEYBEOY5m0kLkYr4

November 11, 1976 MEMORANDUM TO: Hatthev M. Swetosie .FROM: Leonard S. Zohn SUBJECT: Session on Vinyl Chloride at AFCA Specialty Conference on "Toxic Substances in the Air Environment," Boston., Nov. ?--9, 1976 The program for this session was different from that in the program sailed recently by the Air Pollution Con trol Association. There were two additional reports from scientists at Laval University in Quebec and a B.F. Good rich Chemical Co. man replaced a scheduled speaker from Dow Chemical Co. The participation of four scientists from Laval in dicates increasing attention to vinyl chloride (VC) in Canada's Province of Quebec and perhaps throughout that country. The Laval people ere concentrating on the birth defect angle but are not excluding the cancer angle. Here are highlights from the comments made by tbe various speakers. The order is that of the actual.program. 1. "Progress in a community vinyl chloride mortality analysis' study" -- Gilles Theriault, `Laval University. He did not actually present a paper hut served instead as the coordinator for presentations by the Laval group. He in troduced each of his colleagues and made various comments, among them the following: There are three VC plants in Quebec (2 monomer, 1 poly merization). A survey begun in 1973 turned up 12 cases of primary liver cancer in Shawinigaa (S), which has had a VC plant in operation since 1943 One angiosarcoma was found in a non--VC community (Chicoutoaie?). VC is now linked with bladder cancer (on tbe basis of Tttura's findings -- see below). Another important aspect of VC toxicity is its mutagenic effect, as is seen in the birth defects reported in three Ohio*towns and in. the chro mosome breakages found in lymphocytes of VC workers. Data from death certificates are not too reliable. Hospital records provide more and better data. He hopes his group will be getting occupational data in regard to research involving VC with birth defects and cancer. (At one point, a man in the audience pointed out that a considerable industrial complex had been built up.around S.) Teonard <&7ahn.............-***?"* LU amt Ax&triatr^inr. < 0 BOX J7J1 n ItNCOLN *0X0 0*1AT NLCK. N T. IJ071 a US7441 BOR 00603 ! t i w T T O filQ c BOR-006038-00 BFG61167 2. "Comparaiivu st-dy ol cancer mortality between, the towns of Sliavini^nn (S) airt Drummondville (D) 1 n Quebec over a lO--year* |>ox*iod" -- Hilda Ittmvii I^ival Unxvei'sity She reported n study of total mortality, cancer mortality, and mortality from certain sites of cancer (lung, liver, bladder, pancreas, and brain) in the general population, in males and in the 20-64-year age group in the period 19?74 in S and 13. The study was based on data from death cer tificates. ' Xttura said her report was preliminary and that nothing could be concluded. However, the data provide enough clues to plan new research that would establish "the real effect over the workers and ov'es* the community exposed to PVC-" Her findings: Total mortality. (Per 1000 population) Higher in D than in S- D was 9*59 in 1965, 9.2 in 1974, with average of 9.07* S's average was 6.68, increasing froin 5-6? in 1965 to 8.SO in 1974. In the 20--64-year group, S's rate was 4.94 in 1964 and rose to 6.26 in 1974. D's rata was 5.22 in 1964 and dropped to 3-8i in 1974. In males of all ages, D had no great change (average of 11.03). In S the race was 6.94 in 1965t 10.70 in 1974 (aver age 8.28). In males aged 20--64, S's rate in 1965 was 7.0, in 1974 it was 8.81 (average 7.04). In D it. was 7-49 in 1965, 5-38 in 1974 (average 6.79). Cancer mortality. The average rate in D was 1.84, in S 1-55* The rates were similar in the 20--64 group, averaging 1.39 in D and 1.33 in S. In males of all ages the rates were similar, averaging 2.16 for 13, 1.89 for S. In males 20-64, D's rate was 1.13 in 1965, 1.93 in 1974 (average 1.47). S's rate was 1.37 in 1965, 2.39 in 1974 (average 1.79). Mortality bv cancer site. Rates.were higher in S than in D for mortality from cancer of the lung, liver, bladder, pancreas, and brain, especially in males aged 20-64. The rate in S was 5-0 in 1965, 13-50 in 1974 (average 8.78). It was 2.82 in D in 1963, 6.49 in 19~4 (average 5.22). Lung cancer -- The total population rate w^s 2.53. for S and 2.50 for D. In males 20-64, S's rate was 5.59, D's 3-99. Liver cancer -- The total population rate was 0.51 for S, 0-32 for D. In males 20-(4, the rate in S was 0.66, in D there was not a single .case. - -- BR 006039 l < i < i < ; 1 5018012 BOR-006039-00 BFG61168 3 Pancreas cnnccr -- The total population rates were 0.';0 for S and O.Gl for V. For. males 20-64, rates were 1.06 xn S and 0.72 in D. Bladder cancer -- The total population rate was O.51 in S, 0.29 in O. For nulet, 0.66 in S, 0.24 in D. Brain cancer -- There was a large difference in rates between the two communities but there were not sufficient cases to provide any statistical significance. 3. "An epidemiological. description of 10 Canadian cases of angiosarcoma of the liver" -- Fernand Delomct Ilopital Regional dc la Mauricie and Laval University. In June 1974, after diagnosing an angiosarcoma in S, he undertook a sur vey that turned up 8 other cases, all in VC workers. He re cently found another case (the only one still alive) tor a total of IO cases. These are the only known cases of angio sarcoma in Canada at this time. His cases were described as follows: 4l--bl years old (average 50 years). 11-29 years of VC polymerization work (average 21 years, 1 month), considerable exposure to VC "gas" ranging from 3 years, 3 months, to 26 years (average 16 years, '10 months), average of 20.5 years from first ex posure to VC to diagnosis of angiosarcoma, all beer drinkers (only 2 drank more than a bottle daily), all cigarette smok ers (more than a pack daily), negative medical history, all lived near the VC plant. Delome also gave pathological descriptions of tissues from livers of the angiosarcoma patients. He said a liver angiosarcoma can develop after at least k years' exposure to VC and that it takes at least 10 years from the be ginning of exposure to tumor development. (He must have meant for clinical indication of the tumor's presence.) 4. "Birth defects associated with VC exposure" -- Lise Goulet, Laval University. Her x'cport was a description of a proposal for a study on birth defects associated with com munity expo.sure to VC. (It seems some preliminary work is already in progress.) In her opening she referred to two studies (Sclikoff and Infante) done on the effects in children of VC workers following the discovery of chromosome breakages in the work ers. Regarding the Infante study, she said the methods used (interviewing males only and then extrapolating to the J'>males) "make the results less convincing." However, both studies indicate something may be amiss. Finding of higher incidence rates of birth defects in a community where a VC plant is does not implicate VC os BOR 006040 L r: rI: r i: I' *0 CIJSTOC BOR-006040-00 BFG61169 It. be ins tha only agent rcs)ionsibX<ir Goulet said. The i Uniing.da*rvc attention /uni justify further rcs-cnrcli. Tha specifics of her proposal: Pjwsc_l. Xll eases of birth defects and stillbirths from women who lived in S (and South ShaviniRan) from 1966-75 will be collected. The same will be done for D, a town matched in all respects but one -- there is no VC plant there. A VC plant has been in S since. 19*0 and th wind blows from the plant over the populated area of the town 89'* of the time. Each case of birth defect and stillbirth will be pinpointed on maps of the two communities. The rates for both towns will be compared; the proportion of birtli defects and still births over live births also will be computed. The observed rates will be compared with expected rates on the basis of provincial and national statistics. The geographic distribution of cases around the VC plsnr in S will be plotted. Records will be otained of the annual census of the total population and newborns in the 1966--75 period. Hospital records will be studied because the data are not yet available from the provincial- record of birth de fects and stillbirths begun in 1970. There are five hospitals in the S area and she expects to be able to trace 95? of all birth defects. There is one hospital in D where, it's believed, most of the women of the area deliver their child ren . Three different hospital records will be checked: the mother's history at time of delivery; the baby's history (this usually covers the first five days of life): and spe cial records kept for stillbirths. It is exj.ected there will be about 400 births annually available for study from each community. There probably will be lees than lO birth defects and perhaps ope or two cases a year of CXS malformation. Phase 2. More detailed data will he needed in regard to residence, occupation and related information about the families of the births u-icJnr study. The study is expected to take about, eight mouths. 5* "Occupational hazards: do they extend beyond plant boundaries?" -- Peter K. Infante, N10SI1, Cincinnati. At. the BOR 006041 ; *T08T0b: BOR-006041-00 BFG61170  ` 5. outset of h lh talli, lnl'onto spoke in impromptu fashion in regard to questions l>ont VC and birth delects that had been raised by Goulet. He said, it was virtually impossible to as sess an excess risk of birth defects from a cohort study of occupational exposures. There just aren't enough pregnancies, no women in the VC industry, he said. The CVC did a study of children bora with Ch'S abnormal ities in 17 cities that VC plants and birth defect monitor systems. Four cities had a significant excess and in two the excess was able to be determined by monitoring less than 1mlf the births. One would expect 5 out of lOO due to chance alone, he said. While we cannot say these findings are related to VC, Infante continued, it seems from the data that continue to come in that with women living in large industrial complexes there are excesses of children being born with birth defects. The thrust of Infante's formal presentation was that a number of toxic agents have spread from the work setting to the general environment and that many of them may have ad verse health effects now and in the future. He urged testing of new chemicals before they enter the marketplace. He briefly reviewed the toxic effects of a number of substance (lead, cadmium, asbestos, mercury, etc.) which are harmful to workers and to thoir offspring and also to the general public. Infante then discussed the genetic effects of VC, sum marizing the paper he and his colleagues published in The Lancet of last April 3. He said there were now at least four studies showing chromosome aberrrations in VC workers and an excess of miscarriages in wives of such workers. lie stressed that there are structural analogs of VC that could be harmful to man both as carcinogens and as muta gens. Vinylidene chloride is mutagenic, he said. Chloro-- prene seems to be both mutagenic and carcinogenic, he added, as do other substances chemically related to VC. He said vinylidene chloride had been cited as a mutagen in an article but that he.had been unable to get data on it. Someone in the audience said the reference apparently was to work done by Viola who had claimed induction of intestinal tumors in animals with massive doses of the substance. There is no real indication that vinylidene chloride is carcinogenie, the speaker said. Infante singled out chloroprone as a harmful agent with a structure similar to that of VC. An angiosarcoma had re cently been identified in a polychloroprenc worker, he said. BOR 006042 BOR-006042-00 BFG61171 ST-J8T05 r>. .During his talk, Infante pave what he Maid were new VC experinen tal data from Malt out- Followinj? arc the fifiurcs, which pertain to exposure'in rats: PPM Mammary Cancers Angio./>rconw?< 25 9 lO 11 5 13 17 3 o 0 0 Four mammary cancers verc found in the controls. Infante did not say hov many animals there were in each exposed group. 6. "Ultrasound as a diagnostic tool for VC damage assess ment" -- K.J. Taylor, Yale University. Ultrasound is useful in examining changes in the liver and spleen, he said, and in tests he did in a Vales (UK) VC plant the technique showed changes indicative of changes related to VC exposure. Much of his presentation consisted of slides of ultra sound scans (imaging). The technique is noninvasive, does not involve radiation and requires no injection of a contrast medium. VC exposure lead to portal hypertension which often results in massive fatal hemorrhage, Taylor said. The portal vein in the VC workers he examined often shewed up as a "tor tuous" vessel, he said. Exposure to VC can cause liver and spleen abnormalities and cancer of many sites, he said. Ultrasound is suitable for mass screening, Taylor said in recommending a study with this technique be done of VC workers and their families. 7. "New applied technology for VC control in PVC manu facture" -- V.C. Holbrook, B.F. Goodrich Co. He said at the outset that while VC is carcinogenic at c extain levels, a number of questions still remain to be answered. Exposure levels today' for both workers and cosmxunitics arc far below those of previous years. Industry is working effectively to control and contain exposure to VC by employees and the gen eral public. He described various control procedures being used in VC plants. Ho also made availablecopies of Good rich's 1976 booklet, "Vinyl chloride and cancer -- A study in prevention." 8. "Personal monitoring for VC exposure" -- Philip V. Vest, Uouisia.ia State University. Ills technical presentation dealt with a small, dimples personal mlnotor for VC exposure as well as exposure of other iinrardons gaseous materials, such as CO, NO , cliloroform, etc. He said the device, a hit l*J*ger than n silver dollar, was effective, reliable, hod BOR 006043 I I a*. S pl80is BOR-006043-00 BFG61172 t Jio moving parts, needed no power suppJv, oit. It Rivo a linear response 1 rc>ni 3 ppb to 50 ppm, he said. Material eojlecled by the monitor as analyzed by com cntiuiuil sa" chrom atographic techniques. Hr* said tlie device has boon field tested here and in England. (Tho "MiniMonitor" is manufactured and sold by the Ucis-- zner Environmental & Analytical Labs, Inc., Baton Kongo, La. Vest said a Dr. Rciszncr had worked on development of Lite monitor while studying for his doctorate.) / 25018017 BOR 006044 Sr. BOR-006044-00 BFG61173