Document em2LQLO7ZLOLm5z5Qqpvp6Jmy

FILE NAME State of the Art Literature SAL DATE 1938 DOC SAL029 DOCUMENT DESCRIPTION Abstracts from The Journal of Industrial Hygiene & Toxicology LITERATURE OF INDUSTRIAL HYGIENE SUPPLEMENTARY TO THE JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY VOLUME 20 JANUARY DECEMBER 1938 me ome PUBLISHED BY e THE WILLIAMS & WILKINS COMPANY Baltimore Md 184 JOURNAL OF INDUSTRIAL HYGIENE AND TOXICOLOGY vol 20 no8 Anaesthetized cats were given intratracheal insuffiations of fine bismuth car- bonate biamuth subnitrate and lead glass powders by means of a powder blower inserted through a bronchoscope Fluoro- scopy and roentgenograms demonstrated that in the dry state these opaque minera awere not carried into the terminal air spaces but remained adherent to the walls of bronchi lined with ciliated epithe lium The process of removal could be readily followed The column of dust on the mucosal surface moved upward with spiral motion Neutral bismuth carbonate was usually completely eliminated in 1 to 4 days the acid subnitrate was excreted slightly more rapidly and the lead glass had disappeared in from 7 hrs to 2 days The reaction of the mineral did not affect the rate of elimination a result at variance with those of other observers If the particles were suspended in fluid either saline or thin syrup they were carried into the terminal alveoli from which they were alowly excreted by the bronchial route over periods of weeks No evidence of drainage to lymph nodes could be discovered The authors suggest that inhalation of dust in the dry state might be less dangerous than if ja were moist The presence of sufficient amounts of water might permit the mineral particles to penetrate beyond the protective ciliary epithelium and allow gradual accumulation in the lungs U.Gardner U.Gardner number of cancers found is a very high one Of these 8 cases the site of the cancer in cases was the lower lobes in five there was a squamous epithelioma Three of the victims were less than 43 yrs old in all work with asbestos had begun 15-21 yra before After all the author seeme quite right in seeing causal relation be- tween asbestosis and lung cancer Teleky . CLINICAL CONSIDERATIONS ON THE QUESTION WORKERS INDUSTRIAL CANCER OF ASBESTOS WORKERS F. Hornig Ztschr f Krebsforach vol 47 pp 281 2817 958 35 year old woman who worked in an asbestos factory from 1919 1928fell ill of asbestosia in 1937 a sharply defined shadow was seen roentgenologically in the upper left lobe This shadow was considered by the author to be a carcinoma and in the decision on the case a causal relation between the presence of asbestosis and the development of carcinoma was accepted Confirmation at autopsy of the diagnosis of lung carcinoma is presented in a paper by Nordman preceding abstract Teleky EXPERIMENTAL INVESTIGATION -- TE SCHNEEBERG LUNG CANCER QUESTION H. D^hnert Zischr f Krebaforack vol 47 pp 209 1319 938 In very exact manner with regard to the pertinent literature and with careful con- OccupationAL CANCER IN ASBESTOS WORK- Y Ens M. Nordmann Ztschr f Kreba forsch vol 47 pp 288-308 1938 j The author reports on 2 cases of lung cancer of which he made the pathological- anatomical examination He reporta like- wise on the clinical aspects of Hornig's case see following abatract and on a 55 yr old man who had worked in asbestos from his 36th to 43rd years Autopsy showed asbestosis and in the left upper lobe sideration of all factors the author reporta on the tumors found in mice kept in the Schneeberg mines In the experiment were 48 animals of whom 28 died Of these 28 were given careful pathological and ana- tomical examination the other two were sent to another Institute for examination of their radioactivity In 7 animals tumors were found in two of them multiple tumors in various organs Since the experimental animals came from almost tumor- markedly necrotic cornified squamous free stock the number of tumors found is a celled epithelioma The author mentione 4 additional cases of cancer with asbestosin in the literature and one must agree with high one In two cases there were true epithelial lung tumors in two ulcers of the mediastinum in the other 3 cases there were him that in view of the small number tumor more or less generalised changes observed and the very few cases of asbesto- of the lymphatic system After careful sia autopsied 12 cases in Germany the consideration the author blames the ra- Ue erty abe