Document ej6LZJJLy4E6LyEQm297bRVm

A.,4 BAXEUTE COMPANY A DIVISION or UNION CARBIDE AND CARBON CORPORATION IV '> -I*. 1 l/T>r. Carl tT* Dernehl-Roan 203300 Madison Janaary 27# 19S6 Or. Jeroets Klelnexnan Department of Medical Research Saint bike* a Hospital WU Shaker Boulevard CUnland It# Ohio , ' . ' VK f\ ' ' - . At tta request of or. Demehl, laalftnt Medical Director of oar mdsetrial Medloal and Tpadboology Departamt# m are tending yen wttfcmt ehsrga fire pounds f VIHTLITE raaln TTBB fl* fUa main la available In ea--h---Lai quantities and mgr be crdamd txm the Bakellte Company, P. 0* Box 5Mt# Mm York 8# I. Y. i. i ,*. - ., - - ' -' C : Yours my truly# I--'.;-. R. F. Robertson - *--f Mev nrodaot Knglneerlag Depertmnt ucc 063368 RECEIVED JAN 30 1956 INDUSTRIAL MEDICAL & TOXICOLOGY DEPARTMENT Saint Luke's Hospital Of THE METHODIST CHURCH 11311 Shaker Boulevard Cleveland 4, Ohio January 17, 1956 Dr. C. U. Dernahl, Assistant Medical Director Union Carbide and Carbon Corporation 30 East Forty-Second Street New York 17, New York Dear Dr. Dernehl: Thank you for your letter of January 12. We anticipate using "Vinylite"resin for injection studies of lungs in various experimental and clinical conditions. These procedures have been described by Dr. A. A. Liebow of the Department of Pathology at Yale University. We are now in the preparatory stages of this investigation, and we are not able to adequately foresee our ultimate needs for this compound. However, if you could furnish us with several pounds of this material, we would certainly be able to work out our methods. If it is not possible for you to furnish us with this compound, we of course would be very happy to reimburse you. We are extremely eager to start our work and would appreciate your prompt attention in this matter. Sincerely yours, JK:aer Jerome Kleinerman, M. D. Dept, of Medical Research RECEIVED !* ' ^ , INCU Mi i)ICAL & TOXICO-OCi DEPARTMENT UCC 063369 January 12, 1956 Or. Jerome JClelnerman Dept, of Medical Research Saint Luke's Hospital 11311 Shakor Boulevard Cleveland 4, Ohio Dear Dr. Kleinermani In reply to your letter of January 6, 1956 to our Bakolito Company regarding Information about "Vinylite" resin VTHH Specification 1, Z oan give you the following data. This material is a copolymer of vinyl chloride and vinyl acetate with the vinyl ehlorlde being present slightly in excess of 80 per oent. It is sold as a fine flour without added stabilisers or plasticizers*- It would be helpful to us to know the proposed application for this material. If it is Intended to convert the flour into film for use on humans, your attention should be directed to a recent publications `Further Studies of Polymers as Carcinogenic Agents in Animals,* B. S. Oppenhelmer, CANCEH RESEARCH, 15*333*340, June, 193$. While this paper demonstrates the development of malignancies after film implantation in animals, this is no proof that similar responses will occur in nan. Hven though such responses have not been observed in hwans, the possibility must be considered. Otherwise the resin is considered to be physiologically inert. ^ ;C Zf the quantity of material desired la not large Toad the application is suitable, Z feel sure that a supply can be made available without charge. Information on the proposed use will expedite notion on our part. , & Very truly yours. 0. 0. Dernehl, M. D. rs ASSISTART MEDICAL DIRECTOR UCC 063370 Saint Luke's Hospital OF THE METHODIST CHURCH 11311 Shaker Boulevard Cleveland 4, Ohio January 6, 1956 Union Carbon and Carbide Chemical Corporation Bakelite Division 437 MacCorkle Avenue South Charleston, West Virginia Gentlemen: We are interested in your product, VINYL.ITE, (VYHH, Specification #1) for purposes of Medical Research. Information as regards composition, cost, delivery dates, and other pertinent information will be greatly appreciated. kfey we hear from you soon? Sincerely yours JK:ar Jerome Kleinerman, M. D. Dept, of Medical Research RECEIVED JAN 11 INDUSTRIAL MEDICAL & TOXICOLOGY DEPARTMFNT ucc 063371