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SenMPLERIFGER: 7090576
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ENCLOSED: PRIMARY DERMAL RRoITAeTIOoN/nCOReROSsION STUDY IN RASBITS oi 3 kDeoyAmPeesrsonnel eEs T pent
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Patrhoilogry:e At study termination all animals were suthanatized and
StaT tistiL cal Hathods: ShOether than average dermal irritation scores; no other
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Date Tent Started: 11/02/87 Bote Test Completed:
1105/87
INDIVIDUAL DERMAL IRRITATION SCORES
Erythans
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EE sug
DBPoeesnms oomR ro12ob 311 131 da
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ean 03 07 0 0s
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PRINARY DERAL IRRITATION SCORES +
Orsaruat ion Period
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8ovi7y
= fo
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SAMPLE NUMBER: 70905763 SAMPLE: T-a102
BEST COPY AVAILABLE ===
OECD DERMAL IRRITATION
(CONTINUED)
References:
1. COfororrgraonTsieissoatnti,nigonadofofpotrCehdeEmcioMcnaaoylmsi1,c3, SCeo1co98tp1ie.ornati4o0n4, anAdcutDeeveDelrompamlentI'rsriGtuaitdieolnines
2. OECD's Principles of Good Laboratory Practice, Annex 2, C(81)30 (Final) 3. ODafnrdfaiiczCeio,aslmseJt.iHo.cf,s t-h"eADpeUpr.rmSaa.il,salpTpo.oxfic4i6tt-hy5s"9,Sa(fA1e9s7ts5yo)c.iofatiCohnemiofcalFsoodinanFdondDsr,ugDrugs,
4. NIH Publication No. 86-23 (revised 1985).
00569
BEST COPY AVAILABLE
HA No.
PersoRemuetle STiogxniactoulroegySheet
ane
Zeb Title
Becky Beckwith Sr. Lab. Antmal Asst.
Steve Belowngy Lab. Animal Asst.
Xen Bridges Pat Crary
Sr. Lab. Antmal Asst. Sr. Lab. Animal Asst.
Shane 1th Shawn Frazier
Lab Animal Asst. Lab Antmal Asst.
Steven W. Glaza Group Leader
KMeovlilny HHaamhinlton LAadba.tn.AniCmlaelrkAsst.
Jeff Hicks
Sr. Lab. Antmal Asst.
Calvin Horton
Sharen L. Hovery
Group Leader
Administrative Asst.
Gregory Jomsen Lab. Antaal Tech,
Paul Krebs
Lab. Antmal Asst.
Wayne Medison Section Supervisor
Scott McConnell
. Shelley NcComell
Lab. Animal Tech.
Lab. Animal Tech.
"bDaonnMaCvoinasnt, Lsra.b. tAabn.imaAlnimAaslst.Asst.
Robin Olson Lab. Animal Asst.
Patricta Padghen Team Leader
MJiocsheapehlJ.PatDzaukna LLaabb.. AAnniimmaall AAsssstt..
John Paulson Jane Potnow
Sr. Lab: Antal Asst. Lab. Antmal Tech.
Dennis 8. Steiner Lab. Animal Tech.
Michael Thestng Lab. Animal Asst.
MPaouelras6.otcVoanngen MAdeminnoisrtrative Asst.
Jim dirschele LTE
ABEeninnleeteHntaeleH,yR.McTCuornnneerllSMraA.ndpmoiLwnae.br.ACnliemrakl Asst.
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PRIMARY DE(RDMRAALTZIER!RITTEACTHINOINQUSEC)ORING SCALE
(1) Erythema and Eschar Formation
VNoeryerystlhiegnhat erythena (barely perceptible)
10
WMeoldle-rdaetfe itneod seerveyrtehemearythema Severe erythema (beet redness) to slight eschar
32 4
formation (Injuries in depth)
Highest possible erythema score
`
(2) Edema Formation
VNoeryedesm1eight edema (bar| ely perceptible) Slight edena (edges of area well-defined by
10 2
Moddeerfaitneiteedermaaisi(nrga)ised approxinately 1 mm) Severe edema (raised nore than 1 mm and
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extending beyond area of exposure)
Highest possible edema score
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