Document e7xJwbEZx3EXx4ozYzNr8X4EE

Prefettura do Municipio de Piracicaba S e c re ta ria Municipal de Sade Estado de S io Paulo - Brasil Dear Administrator Pruitt, Prezado Administrador Pruitt, SECRETORIA DE PIRACICABA 1am writing in reference to the 0 X 5 1 3A FriendlyTM Mosquito that is currently going through the U.S. regulatory process and to support an expedited review and approval of Oxitec's pending Experimental Use Permit (EUP). The risk of vector borne disease transmission by mosquitoes is, and continues to be, a real, pervasive and escalating threat to public health and citizens globally. Advancing and deploying new innovative tools as soon as possible is absolutely critical to our fight against these vector borne diseases. As Secretary of Health of Piracicaba, Brazil, I oversaw and approved the successfully deployment the 0 X 5 13A mosquitoes for the last 3 years. During that time, we have experienced a greater than 80% suppression of Aedes aegypti mosquitoes in areas that received Oxitec mosquitoes. By releasing mate FriendlyTM Aedes mosquitoes carrying a self-limited gene, Oxitec's biological control technology has effectively suppressed wild mosquito populations to levels not achievable by conventional methods. This same technology was successfully authorized and can be deployed throughout Brazil following a thorough review of its health and safety by our federal expert biotech body, CTNBIO. Oxitec's technology has also been well accepted by the community as there is a keen understanding that the approach provides a favorable alternative to less effective control measures, particularly given that Oxitec mosquitoes do not persist in the environment and have no negative impact on the environment, animals or health. This makes Oxitec mosquitoes a great tool in the battle against dengue, Zika, and chikungunya. As a public health advocate who has seen the successful introduction and deployment of this novel value-added technology in recent years, I Estou escrevendo em referencia ao mosquito 0 X 5 1 3A Aedes do BemTM que est atualmente paseando pelo processo reguiatrio nos EUA e para apoiar urna anlise e aprovago aceleradas da Permisso de Uso Experimental (EUP) requerida peia Oxitec e que se encontra pendente. O risco de transmisso de doengas transmitidas por mosquitos , e continua a ser, urna ameaga real, generalizada e crescente sade pblica e aos cidadios em todo o mundo. Avangar e implantar novas ferramentas novadoras o quanto antes absolutamente essencial para nossa luta contra essas doengas transmitidas por vetares. Como Secretrio de Sade de Piracicaba, Brasil, supervisionei e aprovei a im plantado bem-sucedida dos mosquitos 0 X 5 1 3A nos ltimos 3 anos. Durante esse perodo, tivemos mas de 80% de supresso dos mosquitos Aedes aegypti as reas que receberam os mosquitos da Oxitec. Ao liberar mosquitos macho Aedes do BemTM, portadores de um gene auto limitante, a tecnologa de controle biolgico da Oxitec suprimiu efetivamente as popuages de mosquitos selvagens em nfveis n io aicangveis pelos mtodos convencionais. Essa mesma tecnologa tai autorizada com sucesso e pode ser implantada em todo o Brasil aps urna reviso completa em termos de sade e seguranza por nosso rgo federal especializado em biotecnologa, a CTNBIO. A tecnologa da Oxitec iambm foi bem aceita pela comunidade, pois h um claro entendimento de que a abordagem oferece urna alternativa favorvel a medidas de controle menos eficazes, particularmente dado que os mosquitos da Oxitec no persistem no meta ambiente e no tm impacto negativo no meio ambiente, nos animis ou na sade. isso faz dos mosquitos da Oxitec urna tima ferramenta na batalha contra a dengue, Zika e chikungunya. Sierra Club v. EPA 18cv3472 NDCA Tier 1 Scanned by CamScanner ED 002061 00044333-00001 Prefeltura do Municipio de Pfracicaba Secretaria Municipal de Sade Estado de SSo Paulo - Brasil SruECs RcEaTAiRriIfA SSS#'S-WSJ -iWy' ' s. few # DE RRACICABA encourage others to continue to advance novel vector control technologies as quickly as possible, especially when the public's health is at stake. The results obtained so far show that FriendlyTM Aedes works and is able to control a serious public health issue that has been affecting the health of Brazilian citizens for decades. W e are not only investing in the expansion of FriendlyTM Aedes because its success to date, but also because it is a safe, sustainable and an environm entally-friendly tool that has undergone rigorous review by Brazilian and global regulators. A timely review and approval of the pending Experimental Use Permit in the United States for the 0 X 5 13A FriendlyTM Mosquito w ill help our collective efforts to manage mosquito-borne diseases in thp Americas and around the world. Sincerely Dr, Pedro Antohio de Mello Secretary of Health Piracicaba Como defensor da sade pblica que assistiu ntrodugo e implantando bem-sucedidas dessa nova tecnologa de valor agregado nos ltimos anos, incentivo os outros a continuar avanzando o mais rpido possvel em novas tecnologias de controle de vetores, especialmente quando a sade pblica est em jogo. Os resultados obtidos at agora mostram que o Aedes do BemTM trabalha e capaz de controlar urna grave questo de sade pblica que vem atetando a sade do cidado brasileiro h dcadas. No estamos apenas investindo na expanso do Aedes do BemTM por conta do sucesso atingido at a presente data, mas tambm porque urna ferramenta segura, sustentvel e ecolgicamente correta que passou por urna revtsSo rigorosa dos rgios reguladores brasileiros e giobais. Urna reviso e aprovago oportuna da Permisso de Uso Experimental pendente nos Estados Unidos para o mosquito 0 X 5 13A Aedes do BemTM ajudar nossos estorbos coletivos no manejo de doengas transmitidas pop mosquitos as Amricas e em todo o mundo. A tenciosam entf, ^ yV----< Dr. Pedro Antohio de Mello Secretrio Municipal de Sade de P irateab a Sierra Club v. EPA 18cv3472 NDCA Tier 1 Scanned by CamScanner ED 002061 00044333-00002