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HASKELL LABORATORY
AR226-3377
Common Name: Ammonium Perfluorononanoate
Chemical Name: Nonanoic acid, heptadecafluoro-, ammonium salt
CAS Registry No.: 4149-60-4
Chemical Structure:
0
CF3 - (CF2)7 - C - 0"^IH4
Physical Properties:
Form: Molecular Weight: Boiling Point: Melting Point: Specific Gravity:
Vapor Pressure: Conversion Factors:
White, dusty powder; Detergent-Like Odor 481
Sublimes
Bulk Density (Loose) = 0.49 kg/L
Recommended AEL 0.01 mg/m3 (8-hourTWA)
General Toxicjty
Ammonium perfluorononanoate (C-9) has moderate acute oral toxicity with an LD50 in rats of
407 mg/kg C------Bf 1984). No information is available on its effect of the skin or eyes
of animals. By the acute inhalation route, is C-9 also moderately toxic with a 4-hour ALC in the
rat of 590 mg/m'
1985a;
1989).
In a 14-day feeding study in mice, increased liver weight was seen at as low a dose as 1 ppm
(0.12 mg/kg/day) f----ff 1985b). Liver changes were also seen in rats acutely exposed to as
low a concentration as 67 mg/m3 ft----tt 1985a; H----ttl^T)- Liver effects were also produced by a similar compound, ammonium perfluoroctanoate (C-8) ^----1|1981).
Carcinogenic Potential
No information is available.
PoropatySanrffzed. Does nofew^n f^ r<^
Mutagenic Potential
In the Ames Salmonella bioassay, C-9 was not mutagenic (^--------1| 1984).
Developmental/ Reproductive Toxicity
No infonnation is available.
Basis for AEL
The toxicity of C-9 was compared to that ofC-8. Both compounds appear to produce similar toxic effects at similar dose levels. Based on a NOAEL of 1 mg/m3 in a subchronic inhalation study in rats, an AEL of 0.01 mg/m3 (8-hour TWA) was established for C-8. Based on analogy to C-8, the same 0.01 mg/m3 AEL was recommended for C-9.
C-9 was updated in 1991,1996, and again in 2001. No additional toxicity information was
found.
References (C-3564).
[Data (1984). Letter dated May 9,1984,,
DuPont Co., Haskell Laboratory:
1981. A------l|nL-205-81.
1985a.HBBHH HL-293-85.
w^^^w 1985b.|----------HL---40R1-85.
Rnnedy, G. L-, Jr. (1987). Toxicol. Lett.. 39:295-300.
Kinney, L. A. et al. (1989). Food Chem. Toxicol.. 27:465-468.
October 10, 1985 Updated by: March 12, 1991 August 19, 1996
Company Sanitized. Does not contain TSCA CB1